Compile Data Set for Download or QSAR
maximum 50k data
Found 1101 with Last Name = 'stein' and Initial = 'g'
Target5-hydroxytryptamine receptor 1B(Homo sapiens (Human))
Abbott

Curated by ChEMBL
LigandPNGBDBM50175484(3-[2-(4-isoquinolin-8-yl-piperazin-1-yl)-ethyl]-7-...)
Affinity DataKi:  0.100nMAssay Description:Inhibitory activity against human recombinant 5HT1B receptor co-expressed with G-protein chimera Gqo5 in HEK293 cells by FLIPRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Abbott

Curated by ChEMBL
LigandPNGBDBM50175479(7-methyl-3-[2-(4-quinolin-8-yl-piperazin-1-yl)-eth...)
Affinity DataKi:  0.200nMAssay Description:Displacement of [35S]GTPgammaS from human recombinant 5HT1A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Abbott

Curated by ChEMBL
LigandPNGBDBM50175484(3-[2-(4-isoquinolin-8-yl-piperazin-1-yl)-ethyl]-7-...)
Affinity DataKi:  0.300nMAssay Description:Displacement of [35S]GTPgammaS from human recombinant 5HT1A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuromedin-K receptor(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50299467((5S,8S,14S,17S,20S,23S,26S,29S,32S)-26-((1H-imidaz...)
Affinity DataKi:  0.300nMAssay Description:Binding affinity to human NK3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1B(Homo sapiens (Human))
Abbott

Curated by ChEMBL
LigandPNGBDBM50175479(7-methyl-3-[2-(4-quinolin-8-yl-piperazin-1-yl)-eth...)
Affinity DataKi:  0.300nMAssay Description:Inhibitory activity against human recombinant 5HT1B receptor co-expressed with G-protein chimera Gqo5 in HEK293 cells by FLIPRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Abbott

Curated by ChEMBL
LigandPNGBDBM50175485(3-[2-(4-benzo[b]thiophen-7-yl-piperazin-1-yl)-ethy...)
Affinity DataKi:  0.400nMAssay Description:Displacement of [35S]GTPgammaS from human recombinant 5HT1A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1B(Homo sapiens (Human))
Abbott

Curated by ChEMBL
LigandPNGBDBM50175485(3-[2-(4-benzo[b]thiophen-7-yl-piperazin-1-yl)-ethy...)
Affinity DataKi:  0.400nMAssay Description:Inhibitory activity against human recombinant 5HT1B receptor co-expressed with G-protein chimera Gqo5 in HEK293 cells by FLIPRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1B(Homo sapiens (Human))
Abbott

Curated by ChEMBL
LigandPNGBDBM50175463(3-{2-[4-(3-chloro-2-methoxy-phenyl)-piperazin-1-yl...)
Affinity DataKi:  0.5nMAssay Description:Inhibitory activity against human recombinant 5HT1B receptor co-expressed with G-protein chimera Gqo5 in HEK293 cells by FLIPRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1B(Homo sapiens (Human))
Abbott

Curated by ChEMBL
LigandPNGBDBM50175489(7-methyl-3-[2-(4-naphthalen-1-yl-piperazin-1-yl)-e...)
Affinity DataKi:  0.5nMAssay Description:Inhibitory activity against human recombinant 5HT1B receptor co-expressed with G-protein chimera Gqo5 in HEK293 cells by FLIPRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1B(Homo sapiens (Human))
Abbott

Curated by ChEMBL
LigandPNGBDBM50175467(3-[2-(4-isoquinolin-1-yl-piperazin-1-yl)-ethyl]-7-...)
Affinity DataKi:  0.5nMAssay Description:Inhibitory activity against human recombinant 5HT1B receptor co-expressed with G-protein chimera Gqo5 in HEK293 cells by FLIPRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuromedin-K receptor(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50291261((S)-(+)-N-((3-[1-Benzoyl-3-(3,4-dichlorophenyl)pip...)
Affinity DataKi:  0.5nMAssay Description:Displacement of [3H]osanetant from human recombinant NK3 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1B(Homo sapiens (Human))
Abbott

Curated by ChEMBL
LigandPNGBDBM50175477(3-{2-[4-(2,3-dihydro-benzofuran-7-yl)-piperazin-1-...)
Affinity DataKi:  0.5nMAssay Description:Inhibitory activity against human recombinant 5HT1B receptor co-expressed with G-protein chimera Gqo5 in HEK293 cells by FLIPRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuromedin-K receptor(GUINEA PIG)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50291261((S)-(+)-N-((3-[1-Benzoyl-3-(3,4-dichlorophenyl)pip...)
Affinity DataKi:  0.600nMAssay Description:Displacement of [3H]osanetant from guinea pig recombinant NK3 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Abbott

Curated by ChEMBL
LigandPNGBDBM50175477(3-{2-[4-(2,3-dihydro-benzofuran-7-yl)-piperazin-1-...)
Affinity DataKi:  0.600nMAssay Description:Displacement of [35S]GTPgammaS from human recombinant 5HT1A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Abbott

Curated by ChEMBL
LigandPNGBDBM50175467(3-[2-(4-isoquinolin-1-yl-piperazin-1-yl)-ethyl]-7-...)
Affinity DataKi:  0.700nMAssay Description:Displacement of [35S]GTPgammaS from human recombinant 5HT1A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Abbott

Curated by ChEMBL
LigandPNGBDBM50175460(3-{2-[4-(2-isopropoxy-phenyl)-piperazin-1-yl]-ethy...)
Affinity DataKi:  0.700nMAssay Description:Displacement of [35S]GTPgammaS from human recombinant 5HT1A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Abbott

Curated by ChEMBL
LigandPNGBDBM50175486(3-{2-[4-(2-methoxy-phenyl)-piperazin-1-yl]-ethyl}-...)
Affinity DataKi:  0.700nMAssay Description:Displacement of [35S]GTPgammaS from human recombinant 5HT1A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Abbott

Curated by ChEMBL
LigandPNGBDBM50175489(7-methyl-3-[2-(4-naphthalen-1-yl-piperazin-1-yl)-e...)
Affinity DataKi:  0.700nMAssay Description:Displacement of [35S]GTPgammaS from human recombinant 5HT1A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
Abbott

Curated by ChEMBL
LigandPNGBDBM50176440(1-(4-(4-(2-tert-butyl-6-(trifluoromethyl)pyrimidin...)
Affinity DataKi:  0.800nMAssay Description:Binding affinity to human cloned dopamine D3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuromedin-K receptor(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50299468(2-(3,4-dichlorophenyl)-N-(4-fluoro-3-trifluorometh...)
Affinity DataKi:  0.800nMAssay Description:Displacement of [3H]osanetant from human recombinant NK3 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuromedin-K receptor(GUINEA PIG)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50291261((S)-(+)-N-((3-[1-Benzoyl-3-(3,4-dichlorophenyl)pip...)
Affinity DataKi:  0.800nMAssay Description:Displacement of [3H]osanetant from guinea pig recombinant NK3 receptor A1142.58T expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Abbott

Curated by ChEMBL
LigandPNGBDBM50175473(3-[2-(4-isoquinolin-5-yl-piperazin-1-yl)-ethyl]-7-...)
Affinity DataKi:  0.900nMAssay Description:Displacement of [35S]GTPgammaS from human recombinant 5HT1A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1B(Homo sapiens (Human))
Abbott

Curated by ChEMBL
LigandPNGBDBM50175473(3-[2-(4-isoquinolin-5-yl-piperazin-1-yl)-ethyl]-7-...)
Affinity DataKi:  0.900nMAssay Description:Inhibitory activity against human recombinant 5HT1B receptor co-expressed with G-protein chimera Gqo5 in HEK293 cells by FLIPRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Abbott

Curated by ChEMBL
LigandPNGBDBM50175470(7-methyl-3-{2-[4-(2-phenoxy-phenyl)-piperazin-1-yl...)
Affinity DataKi:  0.900nMAssay Description:Displacement of [35S]GTPgammaS from human recombinant 5HT1A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 5A(Homo sapiens (Human))
Abbott

Curated by ChEMBL
LigandPNGBDBM50175465(7-methyl-3-[2-(4-quinolin-4-yl-piperazin-1-yl)-eth...)
Affinity DataKi: >1nMAssay Description:Inhibitory activity against 5HT5A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1B(Homo sapiens (Human))
Abbott

Curated by ChEMBL
LigandPNGBDBM50175471(3-[2-(4-biphenyl-2-yl-piperazin-1-yl)-ethyl]-7-met...)
Affinity DataKi:  1.10nMAssay Description:Inhibitory activity against human recombinant 5HT1B receptor co-expressed with G-protein chimera Gqo5 in HEK293 cells by FLIPRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1B(Homo sapiens (Human))
Abbott

Curated by ChEMBL
LigandPNGBDBM50175470(7-methyl-3-{2-[4-(2-phenoxy-phenyl)-piperazin-1-yl...)
Affinity DataKi:  1.10nMAssay Description:Inhibitory activity against human recombinant 5HT1B receptor co-expressed with G-protein chimera Gqo5 in HEK293 cells by FLIPRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
Abbott

Curated by ChEMBL
LigandPNGBDBM50175461(3-[2-(4-isoquinolin-4-yl-piperazin-1-yl)-ethyl]-7-...)
Affinity DataKi:  1.18nMAssay Description:Inhibitory activity against dopamine D3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1B(Homo sapiens (Human))
Abbott

Curated by ChEMBL
LigandPNGBDBM50175464(3-{2-[4-(2-benzyloxy-phenyl)-piperazin-1-yl]-ethyl...)
Affinity DataKi:  1.20nMAssay Description:Inhibitory activity against human recombinant 5HT1B receptor co-expressed with G-protein chimera Gqo5 in HEK293 cells by FLIPRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Abbott

Curated by ChEMBL
LigandPNGBDBM50175461(3-[2-(4-isoquinolin-4-yl-piperazin-1-yl)-ethyl]-7-...)
Affinity DataKi:  1.20nMAssay Description:Inhibitory activity against dopamine D2(long) receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Abbott

Curated by ChEMBL
LigandPNGBDBM50175465(7-methyl-3-[2-(4-quinolin-4-yl-piperazin-1-yl)-eth...)
Affinity DataKi:  1.20nMAssay Description:Inhibitory activity against 5HT2A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
Abbott

Curated by ChEMBL
LigandPNGBDBM50175465(7-methyl-3-[2-(4-quinolin-4-yl-piperazin-1-yl)-eth...)
Affinity DataKi:  1.30nMAssay Description:Inhibitory activity against dopamine D3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1B(Homo sapiens (Human))
Abbott

Curated by ChEMBL
LigandPNGBDBM50175487(2-{4-[2-(7-methyl-4-oxo-5,6,7,8-tetrahydro-4H-pyri...)
Affinity DataKi:  1.40nMAssay Description:Inhibitory activity against human recombinant 5HT1B receptor co-expressed with G-protein chimera Gqo5 in HEK293 cells by FLIPRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1B(Homo sapiens (Human))
Abbott

Curated by ChEMBL
LigandPNGBDBM50175486(3-{2-[4-(2-methoxy-phenyl)-piperazin-1-yl]-ethyl}-...)
Affinity DataKi:  1.40nMAssay Description:Inhibitory activity against human recombinant 5HT1B receptor co-expressed with G-protein chimera Gqo5 in HEK293 cells by FLIPRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Abbott

Curated by ChEMBL
LigandPNGBDBM50175465(7-methyl-3-[2-(4-quinolin-4-yl-piperazin-1-yl)-eth...)
Affinity DataKi:  1.46nMAssay Description:Inhibitory activity against dopamine D2(long) receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Abbott

Curated by ChEMBL
LigandPNGBDBM50175480(7-methyl-3-[2-(4-quinolin-5-yl-piperazin-1-yl)-eth...)
Affinity DataKi:  1.5nMAssay Description:Displacement of [35S]GTPgammaS from human recombinant 5HT1A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50054826(CHEMBL144474 | [7-([4,4']Bipiperidinyl-1-carbonyl)...)
Affinity DataKi:  1.5nMAssay Description:Inhibition of binding to purified integrin alphaIIb-beta3 of human plateletsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50054827(CHEMBL85094 | SB-208651 | {8-[(4-Carbamimidoyl-phe...)
Affinity DataKi:  1.60nMAssay Description:Inhibition of binding to purified integrin alphaIIb-beta3 of human plateletsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuromedin-K receptor(GUINEA PIG)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50299468(2-(3,4-dichlorophenyl)-N-(4-fluoro-3-trifluorometh...)
Affinity DataKi:  1.60nMAssay Description:Displacement of [3H]osanetant from guinea pig recombinant NK3 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1/2(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50025450(CHEMBL1790294 | Sodium; 1,4a,6a-trimethyl-2-oxo-he...)
Affinity DataKi:  1.70nMAssay Description:Apparent inhibitory constant value for rat prostatic steroid 5-alpha reductase was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1B(Homo sapiens (Human))
Abbott

Curated by ChEMBL
LigandPNGBDBM50175474(3-{2-[4-(2-chloro-phenyl)-piperazin-1-yl]-ethyl}-7...)
Affinity DataKi:  1.70nMAssay Description:Inhibitory activity against human recombinant 5HT1B receptor co-expressed with G-protein chimera Gqo5 in HEK293 cells by FLIPRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1B(Homo sapiens (Human))
Abbott

Curated by ChEMBL
LigandPNGBDBM50175480(7-methyl-3-[2-(4-quinolin-5-yl-piperazin-1-yl)-eth...)
Affinity DataKi:  1.70nMAssay Description:Inhibitory activity against human recombinant 5HT1B receptor co-expressed with G-protein chimera Gqo5 in HEK293 cells by FLIPRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuromedin-K receptor(GUINEA PIG)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50299468(2-(3,4-dichlorophenyl)-N-(4-fluoro-3-trifluorometh...)
Affinity DataKi:  1.80nMAssay Description:Displacement of [3H]osanetant from guinea pig recombinant NK3 receptor A1142.58T expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Abbott

Curated by ChEMBL
LigandPNGBDBM50175464(3-{2-[4-(2-benzyloxy-phenyl)-piperazin-1-yl]-ethyl...)
Affinity DataKi:  1.90nMAssay Description:Displacement of [35S]GTPgammaS from human recombinant 5HT1A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Abbott

Curated by ChEMBL
LigandPNGBDBM50175483(3-{2-[4-(4,5-dichloro-2-methoxy-phenyl)-piperazin-...)
Affinity DataKi:  2.5nMAssay Description:Displacement of [35S]GTPgammaS from human recombinant 5HT1A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1B(Homo sapiens (Human))
Abbott

Curated by ChEMBL
LigandPNGBDBM50175460(3-{2-[4-(2-isopropoxy-phenyl)-piperazin-1-yl]-ethy...)
Affinity DataKi:  2.5nMAssay Description:Inhibitory activity against human recombinant 5HT1B receptor co-expressed with G-protein chimera Gqo5 in HEK293 cells by FLIPRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50054830(CHEMBL356986 | [(R)-7-([4,4']Bipiperidinyl-1-carbo...)
Affinity DataKi:  2.5nMAssay Description:Inhibition of binding to purified integrin alphaIIb-beta3 of human plateletsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1B(Homo sapiens (Human))
Abbott

Curated by ChEMBL
LigandPNGBDBM50175461(3-[2-(4-isoquinolin-4-yl-piperazin-1-yl)-ethyl]-7-...)
Affinity DataKi:  2.5nMAssay Description:Inhibitory activity against human recombinant 5HT1B receptor co-expressed with G-protein chimera Gqo5 in HEK293 cells by FLIPRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Abbott

Curated by ChEMBL
LigandPNGBDBM50175463(3-{2-[4-(3-chloro-2-methoxy-phenyl)-piperazin-1-yl...)
Affinity DataKi:  2.5nMAssay Description:Displacement of [35S]GTPgammaS from human recombinant 5HT1A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Abbott

Curated by ChEMBL
LigandPNGBDBM50175472(3-(2-{4-[2-(2,2-dimethyl-propoxy)-phenyl]-piperazi...)
Affinity DataKi:  2.5nMAssay Description:Displacement of [35S]GTPgammaS from human recombinant 5HT1A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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