Compile Data Set for Download or QSAR
maximum 50k data
Found 51 with Last Name = 'stern' and Initial = 'mk'
TargetMuscarinic acetylcholine receptor M3 [1-273,470-589,N6Q,N15Q,N41Q,N48Q,N52Q,F550C](Rattus norvegicus (Rat))
National Institutes of Health

LigandPNGBDBM50004656((2-Carbamoyloxy-ethyl)-trimethyl-ammonium | (2-Car...)
Affinity DataKi:  6.70E+3nMpH: 7.4Assay Description:In brief, binding reactions containing ~10 μg of membrane protein per tube were carried out for 2 h (22 °C) in 1 ml of binding buffer containing...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M3 [1-273,470-589,N6Q,N15Q,N41Q,N48Q,N52Q,F554C](Rattus norvegicus (Rat))
National Institutes of Health

LigandPNGBDBM50004656((2-Carbamoyloxy-ethyl)-trimethyl-ammonium | (2-Car...)
Affinity DataKi:  8.20E+3nMpH: 7.4Assay Description:In brief, binding reactions containing ~10 μg of membrane protein per tube were carried out for 2 h (22 °C) in 1 ml of binding buffer containing...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M3 [1-273,470-589,N6Q,N15Q,N41Q,N48Q,N52Q,R179C](Rattus norvegicus (Rat))
National Institutes of Health

LigandPNGBDBM50004656((2-Carbamoyloxy-ethyl)-trimethyl-ammonium | (2-Car...)
Affinity DataKi:  8.20E+3nMpH: 7.4Assay Description:In brief, binding reactions containing ~10 μg of membrane protein per tube were carried out for 2 h (22 °C) in 1 ml of binding buffer containing...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M3 [1-273,470-589,N6Q,N15Q,N41Q,N48Q,N52Q,R176C](Rattus norvegicus (Rat))
National Institutes of Health

LigandPNGBDBM50004656((2-Carbamoyloxy-ethyl)-trimethyl-ammonium | (2-Car...)
Affinity DataKi:  9.00E+3nMAssay Description:In brief, membranes from COS-7 cells expressing different Cys-substituted mutant M3R constructs were first treated with CuPhen (100 μM; 10 min a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M3 [1-273,470-589,N6Q,N15Q,N41Q,N48Q,N52Q,T549C](Rattus norvegicus (Rat))
National Institutes of Health

LigandPNGBDBM50004656((2-Carbamoyloxy-ethyl)-trimethyl-ammonium | (2-Car...)
Affinity DataKi:  1.26E+4nMpH: 7.4Assay Description:In brief, binding reactions containing ~10 μg of membrane protein per tube were carried out for 2 h (22 °C) in 1 ml of binding buffer containing...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M3 [1-273,470-589,N6Q,N15Q,N41Q,N48Q,N52Q,T553C](Rattus norvegicus (Rat))
National Institutes of Health

LigandPNGBDBM50004656((2-Carbamoyloxy-ethyl)-trimethyl-ammonium | (2-Car...)
Affinity DataKi:  1.37E+4nMpH: 7.4Assay Description:In brief, binding reactions containing ~10 μg of membrane protein per tube were carried out for 2 h (22 °C) in 1 ml of binding buffer containing...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M3 [1-273,470-589,N6Q,N15Q,N41Q,N48Q,N52Q,T552C](Rattus norvegicus (Rat))
National Institutes of Health

LigandPNGBDBM50004656((2-Carbamoyloxy-ethyl)-trimethyl-ammonium | (2-Car...)
Affinity DataKi:  1.46E+4nMpH: 7.4Assay Description:In brief, binding reactions containing ~10 μg of membrane protein per tube were carried out for 2 h (22 °C) in 1 ml of binding buffer containing...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M3 [1-273,470-589,N6Q,N15Q,N41Q,N48Q,N52Q,K548C](Rattus norvegicus (Rat))
National Institutes of Health

LigandPNGBDBM50004656((2-Carbamoyloxy-ethyl)-trimethyl-ammonium | (2-Car...)
Affinity DataKi:  1.70E+4nMpH: 7.4Assay Description:In brief, binding reactions containing ~10 μg of membrane protein per tube were carried out for 2 h (22 °C) in 1 ml of binding buffer containing...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M3 [1-273,470-589,N6Q,N15Q,N41Q,N48Q,N52Q,T556C](Rattus norvegicus (Rat))
National Institutes of Health

LigandPNGBDBM50004656((2-Carbamoyloxy-ethyl)-trimethyl-ammonium | (2-Car...)
Affinity DataKi:  1.82E+4nMpH: 7.4Assay Description:In brief, binding reactions containing ~10 μg of membrane protein per tube were carried out for 2 h (22 °C) in 1 ml of binding buffer containing...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M3 [1-273,470-589,N6Q,N15Q,N41Q,N48Q,N52Q,K555C](Rattus norvegicus (Rat))
National Institutes of Health

LigandPNGBDBM50004656((2-Carbamoyloxy-ethyl)-trimethyl-ammonium | (2-Car...)
Affinity DataKi:  1.85E+4nMpH: 7.4Assay Description:In brief, binding reactions containing ~10 μg of membrane protein per tube were carried out for 2 h (22 °C) in 1 ml of binding buffer containing...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M3 [1-273,470-589,N6Q,N15Q,N41Q,N48Q,N52Q,F550C](Rattus norvegicus (Rat))
National Institutes of Health

LigandPNGBDBM50004656((2-Carbamoyloxy-ethyl)-trimethyl-ammonium | (2-Car...)
Affinity DataKi:  1.93E+4nMAssay Description:In brief, membranes from COS-7 cells expressing different Cys-substituted mutant M3R constructs were first treated with CuPhen (100 μM; 10 min a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M3 [1-273,470-589,N6Q,N15Q,N41Q,N48Q,N52Q,R551C](Rattus norvegicus (Rat))
National Institutes of Health

LigandPNGBDBM50004656((2-Carbamoyloxy-ethyl)-trimethyl-ammonium | (2-Car...)
Affinity DataKi:  1.95E+4nMpH: 7.4Assay Description:In brief, binding reactions containing ~10 μg of membrane protein per tube were carried out for 2 h (22 °C) in 1 ml of binding buffer containing...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M3 [1-273,470-589,N6Q,N15Q,N41Q,N48Q,N52Q,T553C](Rattus norvegicus (Rat))
National Institutes of Health

LigandPNGBDBM50004656((2-Carbamoyloxy-ethyl)-trimethyl-ammonium | (2-Car...)
Affinity DataKi:  1.97E+4nMAssay Description:In brief, membranes from COS-7 cells expressing different Cys-substituted mutant M3R constructs were first treated with CuPhen (100 μM; 10 min a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M3 [1-273,470-589,N6Q,N15Q,N41Q,N48Q,N52Q,T180C](Rattus norvegicus (Rat))
National Institutes of Health

LigandPNGBDBM50004656((2-Carbamoyloxy-ethyl)-trimethyl-ammonium | (2-Car...)
Affinity DataKi:  2.04E+4nMpH: 7.4Assay Description:In brief, binding reactions containing ~10 μg of membrane protein per tube were carried out for 2 h (22 °C) in 1 ml of binding buffer containing...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M3 [1-273,470-589,N6Q,N15Q,N41Q,N48Q,N52Q,R176C](Rattus norvegicus (Rat))
National Institutes of Health

LigandPNGBDBM50004656((2-Carbamoyloxy-ethyl)-trimethyl-ammonium | (2-Car...)
Affinity DataKi:  2.20E+4nMpH: 7.4Assay Description:In brief, binding reactions containing ~10 μg of membrane protein per tube were carried out for 2 h (22 °C) in 1 ml of binding buffer containing...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M3 [1-273,470-589,N6Q,N15Q,N41Q,N48Q,N52Q](Rattus norvegicus (Rat))
National Institutes of Health

LigandPNGBDBM50004656((2-Carbamoyloxy-ethyl)-trimethyl-ammonium | (2-Car...)
Affinity DataKi:  2.38E+4nMpH: 7.4Assay Description:In brief, binding reactions containing ~10 μg of membrane protein per tube were carried out for 2 h (22 °C) in 1 ml of binding buffer containing...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M3 [1-273,470-589,N6Q,N15Q,N41Q,N48Q,N52Q](Rattus norvegicus (Rat))
National Institutes of Health

LigandPNGBDBM50004656((2-Carbamoyloxy-ethyl)-trimethyl-ammonium | (2-Car...)
Affinity DataKi:  2.46E+4nMpH: 7.4Assay Description:In brief, binding reactions containing ~10 μg of membrane protein per tube were carried out for 2 h (22 °C) in 1 ml of binding buffer containing...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M3 [1-273,470-589,N6Q,N15Q,N41Q,N48Q,N52Q,T180C](Rattus norvegicus (Rat))
National Institutes of Health

LigandPNGBDBM50004656((2-Carbamoyloxy-ethyl)-trimethyl-ammonium | (2-Car...)
Affinity DataKi:  2.79E+4nMAssay Description:In brief, membranes from COS-7 cells expressing different Cys-substituted mutant M3R constructs were first treated with CuPhen (100 μM; 10 min a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M3 [1-273,470-589,N6Q,N15Q,N41Q,N48Q,N52Q,K178C](Rattus norvegicus (Rat))
National Institutes of Health

LigandPNGBDBM50004656((2-Carbamoyloxy-ethyl)-trimethyl-ammonium | (2-Car...)
Affinity DataKi:  2.95E+4nMpH: 7.4Assay Description:In brief, binding reactions containing ~10 μg of membrane protein per tube were carried out for 2 h (22 °C) in 1 ml of binding buffer containing...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M3 [1-273,470-589,N6Q,N15Q,N41Q,N48Q,N52Q](Rattus norvegicus (Rat))
National Institutes of Health

LigandPNGBDBM50004656((2-Carbamoyloxy-ethyl)-trimethyl-ammonium | (2-Car...)
Affinity DataKi:  3.32E+4nMAssay Description:In brief, membranes from COS-7 cells expressing different Cys-substituted mutant M3R constructs were first treated with CuPhen (100 μM; 10 min a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M3 [1-273,470-589,N6Q,N15Q,N41Q,N48Q,N52Q,T556C](Rattus norvegicus (Rat))
National Institutes of Health

LigandPNGBDBM50004656((2-Carbamoyloxy-ethyl)-trimethyl-ammonium | (2-Car...)
Affinity DataKi:  4.13E+4nMAssay Description:In brief, membranes from COS-7 cells expressing different Cys-substituted mutant M3R constructs were first treated with CuPhen (100 μM; 10 min a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M3 [1-273,470-589,N6Q,N15Q,N41Q,N48Q,N52Q,A177C](Rattus norvegicus (Rat))
National Institutes of Health

LigandPNGBDBM50004656((2-Carbamoyloxy-ethyl)-trimethyl-ammonium | (2-Car...)
Affinity DataKi:  4.13E+4nMpH: 7.4Assay Description:In brief, binding reactions containing ~10 μg of membrane protein per tube were carried out for 2 h (22 °C) in 1 ml of binding buffer containing...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-converting enzyme 1(Homo sapiens (Human))
Monsanto

Curated by ChEMBL
LigandPNGBDBM50046132(2-[propyl-hydroxy-phosphorylamino)-4-methyl-pentan...)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of endothelin converting enzyme in an RIA assay using ET-1 as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-converting enzyme 1(Homo sapiens (Human))
Monsanto

Curated by ChEMBL
LigandPNGBDBM50251742((3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyl-tetrahydro...)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of endothelin converting enzyme in an RIA assay using ET-1 as substrate (value corresponds to <25% inhibition when assayed at a 100 uM scr...More data for this Ligand-Target Pair
TargetEndothelin-converting enzyme 1(Homo sapiens (Human))
Monsanto

Curated by ChEMBL
LigandPNGBDBM50046138(2-[2-(Cyclohexylmethyl-hydroxy-phosphorylamino)-4-...)
Affinity DataIC50:  4.80E+3nMAssay Description:Inhibition of endothelin converting enzyme in an RIA assay using ET-1 as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-converting enzyme 1(Homo sapiens (Human))
Monsanto

Curated by ChEMBL
LigandPNGBDBM50046137(2-[2-(Hydroxy-phenoxy-phosphorylamino)-4-methyl-pe...)
Affinity DataIC50:  3.70E+4nMAssay Description:Inhibition of endothelin converting enzyme in an RIA assay using ET-1 as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-converting enzyme 1(Homo sapiens (Human))
Monsanto

Curated by ChEMBL
LigandPNGBDBM50046134(2-[2-(Cyclohexyloxy-hydroxy-phosphorylamino)-4-met...)
Affinity DataIC50:  4.80E+4nMAssay Description:Inhibition of endothelin converting enzyme in an RIA assay using ET-1 as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-converting enzyme 1(Homo sapiens (Human))
Monsanto

Curated by ChEMBL
LigandPNGBDBM50046133(2-[2-(Hydroxy-benzyl-phosphorylamino)-4-methyl-pen...)
Affinity DataIC50:  6.10E+4nMAssay Description:Inhibition of endothelin converting enzyme in an RIA assay using ET-1 as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-converting enzyme 1(Homo sapiens (Human))
Monsanto

Curated by ChEMBL
LigandPNGBDBM50046135(2-[2-(Ethoxy-hydroxy-phosphorylamino)-4-methyl-pen...)
Affinity DataIC50:  1.09E+5nMAssay Description:Inhibition of endothelin converting enzyme in an RIA assay using ET-1 as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M3 [1-273,470-589,N6Q,N15Q,N41Q,N48Q,N52Q,T556C](Rattus norvegicus (Rat))
National Institutes of Health

LigandPNGBDBM214800(N-methylscopolamine (NMS))
Affinity DataKd:  0.640nMAssay Description:In brief, membranes from COS-7 cells expressing different Cys-substituted mutant M3R constructs were first treated with CuPhen (100 μM; 10 min a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M3 [1-273,470-589,N6Q,N15Q,N41Q,N48Q,N52Q](Rattus norvegicus (Rat))
National Institutes of Health

LigandPNGBDBM214800(N-methylscopolamine (NMS))
Affinity DataKd:  0.440nMAssay Description:In brief, membranes from COS-7 cells expressing different Cys-substituted mutant M3R constructs were first treated with CuPhen (100 μM; 10 min a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M3 [1-273,470-589,N6Q,N15Q,N41Q,N48Q,N52Q,T556C](Rattus norvegicus (Rat))
National Institutes of Health

LigandPNGBDBM214800(N-methylscopolamine (NMS))
Affinity DataKd:  0.462nMpH: 7.4Assay Description:In brief, binding reactions containing ~10 μg of membrane protein per tube were carried out for 2 h (22 °C) in 1 ml of binding buffer containing...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M3 [1-273,470-589,N6Q,N15Q,N41Q,N48Q,N52Q,K555C](Rattus norvegicus (Rat))
National Institutes of Health

LigandPNGBDBM214800(N-methylscopolamine (NMS))
Affinity DataKd:  0.553nMpH: 7.4Assay Description:In brief, binding reactions containing ~10 μg of membrane protein per tube were carried out for 2 h (22 °C) in 1 ml of binding buffer containing...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M3 [1-273,470-589,N6Q,N15Q,N41Q,N48Q,N52Q,F554C](Rattus norvegicus (Rat))
National Institutes of Health

LigandPNGBDBM214800(N-methylscopolamine (NMS))
Affinity DataKd:  0.583nMpH: 7.4Assay Description:In brief, binding reactions containing ~10 μg of membrane protein per tube were carried out for 2 h (22 °C) in 1 ml of binding buffer containing...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M3 [1-273,470-589,N6Q,N15Q,N41Q,N48Q,N52Q,T553C](Rattus norvegicus (Rat))
National Institutes of Health

LigandPNGBDBM214800(N-methylscopolamine (NMS))
Affinity DataKd:  0.548nMpH: 7.4Assay Description:In brief, binding reactions containing ~10 μg of membrane protein per tube were carried out for 2 h (22 °C) in 1 ml of binding buffer containing...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M3 [1-273,470-589,N6Q,N15Q,N41Q,N48Q,N52Q,T552C](Rattus norvegicus (Rat))
National Institutes of Health

LigandPNGBDBM214800(N-methylscopolamine (NMS))
Affinity DataKd:  0.438nMpH: 7.4Assay Description:In brief, binding reactions containing ~10 μg of membrane protein per tube were carried out for 2 h (22 °C) in 1 ml of binding buffer containing...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M3 [1-273,470-589,N6Q,N15Q,N41Q,N48Q,N52Q](Rattus norvegicus (Rat))
National Institutes of Health

LigandPNGBDBM214800(N-methylscopolamine (NMS))
Affinity DataKd:  0.403nMpH: 7.4Assay Description:In brief, binding reactions containing ~10 μg of membrane protein per tube were carried out for 2 h (22 °C) in 1 ml of binding buffer containing...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M3 [1-273,470-589,N6Q,N15Q,N41Q,N48Q,N52Q,R176C](Rattus norvegicus (Rat))
National Institutes of Health

LigandPNGBDBM214800(N-methylscopolamine (NMS))
Affinity DataKd:  0.484nMpH: 7.4Assay Description:In brief, binding reactions containing ~10 μg of membrane protein per tube were carried out for 2 h (22 °C) in 1 ml of binding buffer containing...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M3 [1-273,470-589,N6Q,N15Q,N41Q,N48Q,N52Q,A177C](Rattus norvegicus (Rat))
National Institutes of Health

LigandPNGBDBM214800(N-methylscopolamine (NMS))
Affinity DataKd:  0.521nMpH: 7.4Assay Description:In brief, binding reactions containing ~10 μg of membrane protein per tube were carried out for 2 h (22 °C) in 1 ml of binding buffer containing...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M3 [1-273,470-589,N6Q,N15Q,N41Q,N48Q,N52Q,K178C](Rattus norvegicus (Rat))
National Institutes of Health

LigandPNGBDBM214800(N-methylscopolamine (NMS))
Affinity DataKd:  0.499nMpH: 7.4Assay Description:In brief, binding reactions containing ~10 μg of membrane protein per tube were carried out for 2 h (22 °C) in 1 ml of binding buffer containing...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M3 [1-273,470-589,N6Q,N15Q,N41Q,N48Q,N52Q,R179C](Rattus norvegicus (Rat))
National Institutes of Health

LigandPNGBDBM214800(N-methylscopolamine (NMS))
Affinity DataKd:  0.493nMpH: 7.4Assay Description:In brief, binding reactions containing ~10 μg of membrane protein per tube were carried out for 2 h (22 °C) in 1 ml of binding buffer containing...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M3 [1-273,470-589,N6Q,N15Q,N41Q,N48Q,N52Q,T180C](Rattus norvegicus (Rat))
National Institutes of Health

LigandPNGBDBM214800(N-methylscopolamine (NMS))
Affinity DataKd:  0.751nMpH: 7.4Assay Description:In brief, binding reactions containing ~10 μg of membrane protein per tube were carried out for 2 h (22 °C) in 1 ml of binding buffer containing...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M3 [1-273,470-589,N6Q,N15Q,N41Q,N48Q,N52Q,R551C](Rattus norvegicus (Rat))
National Institutes of Health

LigandPNGBDBM214800(N-methylscopolamine (NMS))
Affinity DataKd:  0.524nMpH: 7.4Assay Description:In brief, binding reactions containing ~10 μg of membrane protein per tube were carried out for 2 h (22 °C) in 1 ml of binding buffer containing...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M3 [1-273,470-589,N6Q,N15Q,N41Q,N48Q,N52Q,F550C](Rattus norvegicus (Rat))
National Institutes of Health

LigandPNGBDBM214800(N-methylscopolamine (NMS))
Affinity DataKd:  0.556nMpH: 7.4Assay Description:In brief, binding reactions containing ~10 μg of membrane protein per tube were carried out for 2 h (22 °C) in 1 ml of binding buffer containing...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M3 [1-273,470-589,N6Q,N15Q,N41Q,N48Q,N52Q,T549C](Rattus norvegicus (Rat))
National Institutes of Health

LigandPNGBDBM214800(N-methylscopolamine (NMS))
Affinity DataKd:  0.564nMpH: 7.4Assay Description:In brief, binding reactions containing ~10 μg of membrane protein per tube were carried out for 2 h (22 °C) in 1 ml of binding buffer containing...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M3 [1-273,470-589,N6Q,N15Q,N41Q,N48Q,N52Q,K548C](Rattus norvegicus (Rat))
National Institutes of Health

LigandPNGBDBM214800(N-methylscopolamine (NMS))
Affinity DataKd:  0.555nMpH: 7.4Assay Description:In brief, binding reactions containing ~10 μg of membrane protein per tube were carried out for 2 h (22 °C) in 1 ml of binding buffer containing...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M3 [1-273,470-589,N6Q,N15Q,N41Q,N48Q,N52Q](Rattus norvegicus (Rat))
National Institutes of Health

LigandPNGBDBM214800(N-methylscopolamine (NMS))
Affinity DataKd:  0.555nMpH: 7.4Assay Description:In brief, binding reactions containing ~10 μg of membrane protein per tube were carried out for 2 h (22 °C) in 1 ml of binding buffer containing...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M3 [1-273,470-589,N6Q,N15Q,N41Q,N48Q,N52Q,T553C](Rattus norvegicus (Rat))
National Institutes of Health

LigandPNGBDBM214800(N-methylscopolamine (NMS))
Affinity DataKd:  1.02nMAssay Description:In brief, membranes from COS-7 cells expressing different Cys-substituted mutant M3R constructs were first treated with CuPhen (100 μM; 10 min a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M3 [1-273,470-589,N6Q,N15Q,N41Q,N48Q,N52Q,R176C](Rattus norvegicus (Rat))
National Institutes of Health

LigandPNGBDBM214800(N-methylscopolamine (NMS))
Affinity DataKd:  0.470nMAssay Description:In brief, membranes from COS-7 cells expressing different Cys-substituted mutant M3R constructs were first treated with CuPhen (100 μM; 10 min a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M3 [1-273,470-589,N6Q,N15Q,N41Q,N48Q,N52Q,T180C](Rattus norvegicus (Rat))
National Institutes of Health

LigandPNGBDBM214800(N-methylscopolamine (NMS))
Affinity DataKd:  1.11nMAssay Description:In brief, membranes from COS-7 cells expressing different Cys-substituted mutant M3R constructs were first treated with CuPhen (100 μM; 10 min a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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