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Found 131 with Last Name = 'stiff' and Initial = 'cm'
TargetPresenilin-1(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM193022(US9193726, 10)
Affinity DataIC50:  3.34nMT: 2°CAssay Description:The ability of compounds to modulate production of amyloid beta protein Abeta(1-42) was determined using human WT-APP overexpressing CHO cells. Cel...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetPresenilin-1(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM193067(US9193726, 55)
Affinity DataIC50:  5.48nMT: 2°CAssay Description:The ability of compounds to modulate production of amyloid beta protein Abeta(1-42) was determined using human WT-APP overexpressing CHO cells. Cel...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetPresenilin-1(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM193079(US9193726, 67)
Affinity DataIC50:  5.78nMT: 2°CAssay Description:The ability of compounds to modulate production of amyloid beta protein Abeta(1-42) was determined using human WT-APP overexpressing CHO cells. Cel...More data for this Ligand-Target Pair
In DepthDetails US Patent
LigandPNGBDBM50096851(CHEMBL3580774)
Affinity DataIC50:  6nMAssay Description:Modulation of human gamma secretase overexpressed in CHO cells co-expressing wild type human APP assessed as inhibition of amyloid beta-42 production...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50101747(CHEMBL3394946)
Affinity DataIC50:  6nMAssay Description:Inhibition of gamma-secretase (unknown origin) expressed in CHO cells overexpressing human wild type APP assessed as reduction of amyloid beta 42 lev...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM193081(US9193726, 69)
Affinity DataIC50:  7.84nMT: 2°CAssay Description:The ability of compounds to modulate production of amyloid beta protein Abeta(1-42) was determined using human WT-APP overexpressing CHO cells. Cel...More data for this Ligand-Target Pair
In DepthDetails US Patent
LigandPNGBDBM50101749(CHEMBL3394944)
Affinity DataIC50:  8nMAssay Description:Inhibition of gamma-secretase (unknown origin) expressed in CHO cells overexpressing human wild type APP assessed as reduction of amyloid beta 42 lev...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM193063(US9193726, 51)
Affinity DataIC50:  8.35nMT: 2°CAssay Description:The ability of compounds to modulate production of amyloid beta protein Abeta(1-42) was determined using human WT-APP overexpressing CHO cells. Cel...More data for this Ligand-Target Pair
In DepthDetails US Patent
LigandPNGBDBM50101748(CHEMBL3394945)
Affinity DataIC50:  9nMAssay Description:Inhibition of gamma-secretase (unknown origin) expressed in CHO cells overexpressing human wild type APP assessed as reduction of amyloid beta 42 lev...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM193021(US9193726, 9)
Affinity DataIC50:  9.10nMT: 2°CAssay Description:The ability of compounds to modulate production of amyloid beta protein Abeta(1-42) was determined using human WT-APP overexpressing CHO cells. Cel...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetPresenilin-1(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM193082(US9193726, 70)
Affinity DataIC50:  10nMT: 2°CAssay Description:The ability of compounds to modulate production of amyloid beta protein Abeta(1-42) was determined using human WT-APP overexpressing CHO cells. Cel...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetPresenilin-1(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM193062(US9193726, 50)
Affinity DataIC50:  11nMT: 2°CAssay Description:The ability of compounds to modulate production of amyloid beta protein Abeta(1-42) was determined using human WT-APP overexpressing CHO cells. Cel...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetPresenilin-1(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM193069(US9193726, 57)
Affinity DataIC50:  11.1nMT: 2°CAssay Description:The ability of compounds to modulate production of amyloid beta protein Abeta(1-42) was determined using human WT-APP overexpressing CHO cells. Cel...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetPresenilin-1(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM193066(US9193726, 54)
Affinity DataIC50:  11.4nMT: 2°CAssay Description:The ability of compounds to modulate production of amyloid beta protein Abeta(1-42) was determined using human WT-APP overexpressing CHO cells. Cel...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetPresenilin-1(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM193074(US9193726, 62)
Affinity DataIC50:  13.3nMT: 2°CAssay Description:The ability of compounds to modulate production of amyloid beta protein Abeta(1-42) was determined using human WT-APP overexpressing CHO cells. Cel...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetPresenilin-1(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM193020(US9193726, 8)
Affinity DataIC50:  14.3nMT: 2°CAssay Description:The ability of compounds to modulate production of amyloid beta protein Abeta(1-42) was determined using human WT-APP overexpressing CHO cells. Cel...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetPresenilin-1(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM193070(US9193726, 58)
Affinity DataIC50:  14.5nMT: 2°CAssay Description:The ability of compounds to modulate production of amyloid beta protein Abeta(1-42) was determined using human WT-APP overexpressing CHO cells. Cel...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetPresenilin-1(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM193064(US9193726, 52)
Affinity DataIC50:  15nMT: 2°CAssay Description:The ability of compounds to modulate production of amyloid beta protein Abeta(1-42) was determined using human WT-APP overexpressing CHO cells. Cel...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetPresenilin-1(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM193059(US9193726, 47)
Affinity DataIC50:  15.7nMT: 2°CAssay Description:The ability of compounds to modulate production of amyloid beta protein Abeta(1-42) was determined using human WT-APP overexpressing CHO cells. Cel...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetPresenilin-1(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM193030(US9193726, 18)
Affinity DataIC50:  16nMT: 2°CAssay Description:The ability of compounds to modulate production of amyloid beta protein Abeta(1-42) was determined using human WT-APP overexpressing CHO cells. Cel...More data for this Ligand-Target Pair
In DepthDetails US Patent
LigandPNGBDBM50101800(CHEMBL3394934)
Affinity DataIC50:  17nMAssay Description:Inhibition of gamma-secretase (unknown origin) expressed in CHO cells overexpressing human wild type APP assessed as reduction of amyloid beta 42 lev...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50096863(CHEMBL3580766)
Affinity DataIC50:  17nMAssay Description:Modulation of human gamma secretase overexpressed in CHO cells co-expressing wild type human APP assessed as inhibition of amyloid beta-42 production...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50096865(CHEMBL3580764)
Affinity DataIC50:  18nMAssay Description:Modulation of human gamma secretase overexpressed in CHO cells co-expressing wild type human APP assessed as inhibition of amyloid beta-42 production...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50103134(CHEMBL3394928)
Affinity DataIC50:  19nMAssay Description:Inhibition of gamma-secretase (unknown origin) expressed in CHO cells overexpressing human wild type APP assessed as reduction of amyloid beta 42 lev...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM193085(US9193726, 73)
Affinity DataIC50:  19.8nMT: 2°CAssay Description:The ability of compounds to modulate production of amyloid beta protein Abeta(1-42) was determined using human WT-APP overexpressing CHO cells. Cel...More data for this Ligand-Target Pair
In DepthDetails US Patent
LigandPNGBDBM50096853(CHEMBL3580772)
Affinity DataIC50:  20nMAssay Description:Modulation of human gamma secretase overexpressed in CHO cells co-expressing wild type human APP assessed as inhibition of amyloid beta-42 production...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM193061(US9193726, 49)
Affinity DataIC50:  21.6nMT: 2°CAssay Description:The ability of compounds to modulate production of amyloid beta protein Abeta(1-42) was determined using human WT-APP overexpressing CHO cells. Cel...More data for this Ligand-Target Pair
In DepthDetails US Patent
LigandPNGBDBM50101792(CHEMBL3394942)
Affinity DataIC50:  22nMAssay Description:Inhibition of gamma-secretase (unknown origin) expressed in CHO cells overexpressing human wild type APP assessed as reduction of amyloid beta 42 lev...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM193080(US9193726, 68)
Affinity DataIC50:  24.2nMT: 2°CAssay Description:The ability of compounds to modulate production of amyloid beta protein Abeta(1-42) was determined using human WT-APP overexpressing CHO cells. Cel...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetPresenilin-1(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM193073(US9193726, 61)
Affinity DataIC50:  24.6nMT: 2°CAssay Description:The ability of compounds to modulate production of amyloid beta protein Abeta(1-42) was determined using human WT-APP overexpressing CHO cells. Cel...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetPresenilin-1(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM193018(US9193726, 6)
Affinity DataIC50:  25nMT: 2°CAssay Description:The ability of compounds to modulate production of amyloid beta protein Abeta(1-42) was determined using human WT-APP overexpressing CHO cells. Cel...More data for this Ligand-Target Pair
In DepthDetails US Patent
LigandPNGBDBM50096858(CHEMBL3580767)
Affinity DataIC50:  25nMAssay Description:Modulation of human gamma secretase overexpressed in CHO cells co-expressing wild type human APP assessed as inhibition of amyloid beta-42 production...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM193057(US9193726, 45)
Affinity DataIC50:  26.6nMT: 2°CAssay Description:The ability of compounds to modulate production of amyloid beta protein Abeta(1-42) was determined using human WT-APP overexpressing CHO cells. Cel...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetPresenilin-1(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM193077(US9193726, 65)
Affinity DataIC50:  26.8nMT: 2°CAssay Description:The ability of compounds to modulate production of amyloid beta protein Abeta(1-42) was determined using human WT-APP overexpressing CHO cells. Cel...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetPresenilin-1(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM193055(US9193726, 43)
Affinity DataIC50:  27.6nMT: 2°CAssay Description:The ability of compounds to modulate production of amyloid beta protein Abeta(1-42) was determined using human WT-APP overexpressing CHO cells. Cel...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetPresenilin-1(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM193065(US9193726, 53)
Affinity DataIC50:  29.1nMT: 2°CAssay Description:The ability of compounds to modulate production of amyloid beta protein Abeta(1-42) was determined using human WT-APP overexpressing CHO cells. Cel...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetPresenilin-1(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM193027(US9193726, 15)
Affinity DataIC50:  29.9nMT: 2°CAssay Description:The ability of compounds to modulate production of amyloid beta protein Abeta(1-42) was determined using human WT-APP overexpressing CHO cells. Cel...More data for this Ligand-Target Pair
In DepthDetails US Patent
LigandPNGBDBM50096854(CHEMBL3580771)
Affinity DataIC50:  30nMAssay Description:Modulation of human gamma secretase overexpressed in CHO cells co-expressing wild type human APP assessed as inhibition of amyloid beta-42 production...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM193078(US9193726, 66)
Affinity DataIC50:  33.5nMT: 2°CAssay Description:The ability of compounds to modulate production of amyloid beta protein Abeta(1-42) was determined using human WT-APP overexpressing CHO cells. Cel...More data for this Ligand-Target Pair
In DepthDetails US Patent
LigandPNGBDBM50101791(CHEMBL3394943)
Affinity DataIC50:  35nMAssay Description:Inhibition of gamma-secretase (unknown origin) expressed in CHO cells overexpressing human wild type APP assessed as reduction of amyloid beta 42 lev...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50101801(CHEMBL3394933)
Affinity DataIC50:  38nMAssay Description:Inhibition of gamma-secretase (unknown origin) expressed in CHO cells overexpressing human wild type APP assessed as reduction of amyloid beta 42 lev...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM193029(US9193726, 17)
Affinity DataIC50:  38.4nMT: 2°CAssay Description:The ability of compounds to modulate production of amyloid beta protein Abeta(1-42) was determined using human WT-APP overexpressing CHO cells. Cel...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetPresenilin-1(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM193023(US9193726, 11)
Affinity DataIC50:  40.5nMT: 2°CAssay Description:The ability of compounds to modulate production of amyloid beta protein Abeta(1-42) was determined using human WT-APP overexpressing CHO cells. Cel...More data for this Ligand-Target Pair
In DepthDetails US Patent
LigandPNGBDBM50103135(CHEMBL3394927)
Affinity DataIC50:  42nMAssay Description:Inhibition of gamma-secretase (unknown origin) expressed in CHO cells overexpressing human wild type APP assessed as reduction of amyloid beta 42 lev...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50103132(CHEMBL3394932)
Affinity DataIC50:  44nMAssay Description:Inhibition of gamma-secretase (unknown origin) expressed in CHO cells overexpressing human wild type APP assessed as reduction of amyloid beta 42 lev...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM193084(US9193726, 72)
Affinity DataIC50:  46.4nMT: 2°CAssay Description:The ability of compounds to modulate production of amyloid beta protein Abeta(1-42) was determined using human WT-APP overexpressing CHO cells. Cel...More data for this Ligand-Target Pair
In DepthDetails US Patent
LigandPNGBDBM50101795(CHEMBL3394939)
Affinity DataIC50:  52nMAssay Description:Inhibition of gamma-secretase (unknown origin) expressed in CHO cells overexpressing human wild type APP assessed as reduction of amyloid beta 42 lev...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM193056(US9193726, 44)
Affinity DataIC50:  52.1nMT: 2°CAssay Description:The ability of compounds to modulate production of amyloid beta protein Abeta(1-42) was determined using human WT-APP overexpressing CHO cells. Cel...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetPresenilin-1(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM193083(US9193726, 71)
Affinity DataIC50:  52.4nMT: 2°CAssay Description:The ability of compounds to modulate production of amyloid beta protein Abeta(1-42) was determined using human WT-APP overexpressing CHO cells. Cel...More data for this Ligand-Target Pair
In DepthDetails US Patent
LigandPNGBDBM50096855(CHEMBL3580770)
Affinity DataIC50:  59nMAssay Description:Modulation of human gamma secretase overexpressed in CHO cells co-expressing wild type human APP assessed as inhibition of amyloid beta-42 production...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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