Affinity DataIC50: 3.34nMT: 2°CAssay Description:The ability of compounds to modulate production of amyloid beta protein
Abeta(1-42) was determined using human WT-APP overexpressing CHO cells.
Cel...More data for this Ligand-Target Pair
Affinity DataIC50: 5.48nMT: 2°CAssay Description:The ability of compounds to modulate production of amyloid beta protein
Abeta(1-42) was determined using human WT-APP overexpressing CHO cells.
Cel...More data for this Ligand-Target Pair
Affinity DataIC50: 5.78nMT: 2°CAssay Description:The ability of compounds to modulate production of amyloid beta protein
Abeta(1-42) was determined using human WT-APP overexpressing CHO cells.
Cel...More data for this Ligand-Target Pair
TargetGamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2(Homo sapiens (Human))
Pfizer
Curated by ChEMBL
Pfizer
Curated by ChEMBL
Affinity DataIC50: 6nMAssay Description:Modulation of human gamma secretase overexpressed in CHO cells co-expressing wild type human APP assessed as inhibition of amyloid beta-42 production...More data for this Ligand-Target Pair
TargetGamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2(Homo sapiens (Human))
Pfizer
Curated by ChEMBL
Pfizer
Curated by ChEMBL
Affinity DataIC50: 6nMAssay Description:Inhibition of gamma-secretase (unknown origin) expressed in CHO cells overexpressing human wild type APP assessed as reduction of amyloid beta 42 lev...More data for this Ligand-Target Pair
Affinity DataIC50: 7.84nMT: 2°CAssay Description:The ability of compounds to modulate production of amyloid beta protein
Abeta(1-42) was determined using human WT-APP overexpressing CHO cells.
Cel...More data for this Ligand-Target Pair
TargetGamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2(Homo sapiens (Human))
Pfizer
Curated by ChEMBL
Pfizer
Curated by ChEMBL
Affinity DataIC50: 8nMAssay Description:Inhibition of gamma-secretase (unknown origin) expressed in CHO cells overexpressing human wild type APP assessed as reduction of amyloid beta 42 lev...More data for this Ligand-Target Pair
Affinity DataIC50: 8.35nMT: 2°CAssay Description:The ability of compounds to modulate production of amyloid beta protein
Abeta(1-42) was determined using human WT-APP overexpressing CHO cells.
Cel...More data for this Ligand-Target Pair
TargetGamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2(Homo sapiens (Human))
Pfizer
Curated by ChEMBL
Pfizer
Curated by ChEMBL
Affinity DataIC50: 9nMAssay Description:Inhibition of gamma-secretase (unknown origin) expressed in CHO cells overexpressing human wild type APP assessed as reduction of amyloid beta 42 lev...More data for this Ligand-Target Pair
Affinity DataIC50: 9.10nMT: 2°CAssay Description:The ability of compounds to modulate production of amyloid beta protein
Abeta(1-42) was determined using human WT-APP overexpressing CHO cells.
Cel...More data for this Ligand-Target Pair
Affinity DataIC50: 10nMT: 2°CAssay Description:The ability of compounds to modulate production of amyloid beta protein
Abeta(1-42) was determined using human WT-APP overexpressing CHO cells.
Cel...More data for this Ligand-Target Pair
Affinity DataIC50: 11nMT: 2°CAssay Description:The ability of compounds to modulate production of amyloid beta protein
Abeta(1-42) was determined using human WT-APP overexpressing CHO cells.
Cel...More data for this Ligand-Target Pair
Affinity DataIC50: 11.1nMT: 2°CAssay Description:The ability of compounds to modulate production of amyloid beta protein
Abeta(1-42) was determined using human WT-APP overexpressing CHO cells.
Cel...More data for this Ligand-Target Pair
Affinity DataIC50: 11.4nMT: 2°CAssay Description:The ability of compounds to modulate production of amyloid beta protein
Abeta(1-42) was determined using human WT-APP overexpressing CHO cells.
Cel...More data for this Ligand-Target Pair
Affinity DataIC50: 13.3nMT: 2°CAssay Description:The ability of compounds to modulate production of amyloid beta protein
Abeta(1-42) was determined using human WT-APP overexpressing CHO cells.
Cel...More data for this Ligand-Target Pair
Affinity DataIC50: 14.3nMT: 2°CAssay Description:The ability of compounds to modulate production of amyloid beta protein
Abeta(1-42) was determined using human WT-APP overexpressing CHO cells.
Cel...More data for this Ligand-Target Pair
Affinity DataIC50: 14.5nMT: 2°CAssay Description:The ability of compounds to modulate production of amyloid beta protein
Abeta(1-42) was determined using human WT-APP overexpressing CHO cells.
Cel...More data for this Ligand-Target Pair
Affinity DataIC50: 15nMT: 2°CAssay Description:The ability of compounds to modulate production of amyloid beta protein
Abeta(1-42) was determined using human WT-APP overexpressing CHO cells.
Cel...More data for this Ligand-Target Pair
Affinity DataIC50: 15.7nMT: 2°CAssay Description:The ability of compounds to modulate production of amyloid beta protein
Abeta(1-42) was determined using human WT-APP overexpressing CHO cells.
Cel...More data for this Ligand-Target Pair
Affinity DataIC50: 16nMT: 2°CAssay Description:The ability of compounds to modulate production of amyloid beta protein
Abeta(1-42) was determined using human WT-APP overexpressing CHO cells.
Cel...More data for this Ligand-Target Pair
TargetGamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2(Homo sapiens (Human))
Pfizer
Curated by ChEMBL
Pfizer
Curated by ChEMBL
Affinity DataIC50: 17nMAssay Description:Inhibition of gamma-secretase (unknown origin) expressed in CHO cells overexpressing human wild type APP assessed as reduction of amyloid beta 42 lev...More data for this Ligand-Target Pair
TargetGamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2(Homo sapiens (Human))
Pfizer
Curated by ChEMBL
Pfizer
Curated by ChEMBL
Affinity DataIC50: 17nMAssay Description:Modulation of human gamma secretase overexpressed in CHO cells co-expressing wild type human APP assessed as inhibition of amyloid beta-42 production...More data for this Ligand-Target Pair
TargetGamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2(Homo sapiens (Human))
Pfizer
Curated by ChEMBL
Pfizer
Curated by ChEMBL
Affinity DataIC50: 18nMAssay Description:Modulation of human gamma secretase overexpressed in CHO cells co-expressing wild type human APP assessed as inhibition of amyloid beta-42 production...More data for this Ligand-Target Pair
TargetGamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2(Homo sapiens (Human))
Pfizer
Curated by ChEMBL
Pfizer
Curated by ChEMBL
Affinity DataIC50: 19nMAssay Description:Inhibition of gamma-secretase (unknown origin) expressed in CHO cells overexpressing human wild type APP assessed as reduction of amyloid beta 42 lev...More data for this Ligand-Target Pair
Affinity DataIC50: 19.8nMT: 2°CAssay Description:The ability of compounds to modulate production of amyloid beta protein
Abeta(1-42) was determined using human WT-APP overexpressing CHO cells.
Cel...More data for this Ligand-Target Pair
TargetGamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2(Homo sapiens (Human))
Pfizer
Curated by ChEMBL
Pfizer
Curated by ChEMBL
Affinity DataIC50: 20nMAssay Description:Modulation of human gamma secretase overexpressed in CHO cells co-expressing wild type human APP assessed as inhibition of amyloid beta-42 production...More data for this Ligand-Target Pair
Affinity DataIC50: 21.6nMT: 2°CAssay Description:The ability of compounds to modulate production of amyloid beta protein
Abeta(1-42) was determined using human WT-APP overexpressing CHO cells.
Cel...More data for this Ligand-Target Pair
TargetGamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2(Homo sapiens (Human))
Pfizer
Curated by ChEMBL
Pfizer
Curated by ChEMBL
Affinity DataIC50: 22nMAssay Description:Inhibition of gamma-secretase (unknown origin) expressed in CHO cells overexpressing human wild type APP assessed as reduction of amyloid beta 42 lev...More data for this Ligand-Target Pair
Affinity DataIC50: 24.2nMT: 2°CAssay Description:The ability of compounds to modulate production of amyloid beta protein
Abeta(1-42) was determined using human WT-APP overexpressing CHO cells.
Cel...More data for this Ligand-Target Pair
Affinity DataIC50: 24.6nMT: 2°CAssay Description:The ability of compounds to modulate production of amyloid beta protein
Abeta(1-42) was determined using human WT-APP overexpressing CHO cells.
Cel...More data for this Ligand-Target Pair
Affinity DataIC50: 25nMT: 2°CAssay Description:The ability of compounds to modulate production of amyloid beta protein
Abeta(1-42) was determined using human WT-APP overexpressing CHO cells.
Cel...More data for this Ligand-Target Pair
TargetGamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2(Homo sapiens (Human))
Pfizer
Curated by ChEMBL
Pfizer
Curated by ChEMBL
Affinity DataIC50: 25nMAssay Description:Modulation of human gamma secretase overexpressed in CHO cells co-expressing wild type human APP assessed as inhibition of amyloid beta-42 production...More data for this Ligand-Target Pair
Affinity DataIC50: 26.6nMT: 2°CAssay Description:The ability of compounds to modulate production of amyloid beta protein
Abeta(1-42) was determined using human WT-APP overexpressing CHO cells.
Cel...More data for this Ligand-Target Pair
Affinity DataIC50: 26.8nMT: 2°CAssay Description:The ability of compounds to modulate production of amyloid beta protein
Abeta(1-42) was determined using human WT-APP overexpressing CHO cells.
Cel...More data for this Ligand-Target Pair
Affinity DataIC50: 27.6nMT: 2°CAssay Description:The ability of compounds to modulate production of amyloid beta protein
Abeta(1-42) was determined using human WT-APP overexpressing CHO cells.
Cel...More data for this Ligand-Target Pair
Affinity DataIC50: 29.1nMT: 2°CAssay Description:The ability of compounds to modulate production of amyloid beta protein
Abeta(1-42) was determined using human WT-APP overexpressing CHO cells.
Cel...More data for this Ligand-Target Pair
Affinity DataIC50: 29.9nMT: 2°CAssay Description:The ability of compounds to modulate production of amyloid beta protein
Abeta(1-42) was determined using human WT-APP overexpressing CHO cells.
Cel...More data for this Ligand-Target Pair
TargetGamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2(Homo sapiens (Human))
Pfizer
Curated by ChEMBL
Pfizer
Curated by ChEMBL
Affinity DataIC50: 30nMAssay Description:Modulation of human gamma secretase overexpressed in CHO cells co-expressing wild type human APP assessed as inhibition of amyloid beta-42 production...More data for this Ligand-Target Pair
Affinity DataIC50: 33.5nMT: 2°CAssay Description:The ability of compounds to modulate production of amyloid beta protein
Abeta(1-42) was determined using human WT-APP overexpressing CHO cells.
Cel...More data for this Ligand-Target Pair
TargetGamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2(Homo sapiens (Human))
Pfizer
Curated by ChEMBL
Pfizer
Curated by ChEMBL
Affinity DataIC50: 35nMAssay Description:Inhibition of gamma-secretase (unknown origin) expressed in CHO cells overexpressing human wild type APP assessed as reduction of amyloid beta 42 lev...More data for this Ligand-Target Pair
TargetGamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2(Homo sapiens (Human))
Pfizer
Curated by ChEMBL
Pfizer
Curated by ChEMBL
Affinity DataIC50: 38nMAssay Description:Inhibition of gamma-secretase (unknown origin) expressed in CHO cells overexpressing human wild type APP assessed as reduction of amyloid beta 42 lev...More data for this Ligand-Target Pair
Affinity DataIC50: 38.4nMT: 2°CAssay Description:The ability of compounds to modulate production of amyloid beta protein
Abeta(1-42) was determined using human WT-APP overexpressing CHO cells.
Cel...More data for this Ligand-Target Pair
Affinity DataIC50: 40.5nMT: 2°CAssay Description:The ability of compounds to modulate production of amyloid beta protein
Abeta(1-42) was determined using human WT-APP overexpressing CHO cells.
Cel...More data for this Ligand-Target Pair
TargetGamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2(Homo sapiens (Human))
Pfizer
Curated by ChEMBL
Pfizer
Curated by ChEMBL
Affinity DataIC50: 42nMAssay Description:Inhibition of gamma-secretase (unknown origin) expressed in CHO cells overexpressing human wild type APP assessed as reduction of amyloid beta 42 lev...More data for this Ligand-Target Pair
TargetGamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2(Homo sapiens (Human))
Pfizer
Curated by ChEMBL
Pfizer
Curated by ChEMBL
Affinity DataIC50: 44nMAssay Description:Inhibition of gamma-secretase (unknown origin) expressed in CHO cells overexpressing human wild type APP assessed as reduction of amyloid beta 42 lev...More data for this Ligand-Target Pair
Affinity DataIC50: 46.4nMT: 2°CAssay Description:The ability of compounds to modulate production of amyloid beta protein
Abeta(1-42) was determined using human WT-APP overexpressing CHO cells.
Cel...More data for this Ligand-Target Pair
TargetGamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2(Homo sapiens (Human))
Pfizer
Curated by ChEMBL
Pfizer
Curated by ChEMBL
Affinity DataIC50: 52nMAssay Description:Inhibition of gamma-secretase (unknown origin) expressed in CHO cells overexpressing human wild type APP assessed as reduction of amyloid beta 42 lev...More data for this Ligand-Target Pair
Affinity DataIC50: 52.1nMT: 2°CAssay Description:The ability of compounds to modulate production of amyloid beta protein
Abeta(1-42) was determined using human WT-APP overexpressing CHO cells.
Cel...More data for this Ligand-Target Pair
Affinity DataIC50: 52.4nMT: 2°CAssay Description:The ability of compounds to modulate production of amyloid beta protein
Abeta(1-42) was determined using human WT-APP overexpressing CHO cells.
Cel...More data for this Ligand-Target Pair
TargetGamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2(Homo sapiens (Human))
Pfizer
Curated by ChEMBL
Pfizer
Curated by ChEMBL
Affinity DataIC50: 59nMAssay Description:Modulation of human gamma secretase overexpressed in CHO cells co-expressing wild type human APP assessed as inhibition of amyloid beta-42 production...More data for this Ligand-Target Pair