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Found 319 with Last Name = 'suh' and Initial = 'kh'
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Hanmi Pharm.

US Patent
LigandPNGBDBM476704( (3-(5-chloro-2-((3-cyclopropyl-5-(((3R,5S)-3,5-di...)
Affinity DataIC50:  0.400nMAssay Description:The inhibitory activity of some of the compounds described above against FLT3-ITD, FLT3 wild type (WT), VEGFR2 (KDR), and SYK kinase was measured.The...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Hanmi Pharm.

US Patent
LigandPNGBDBM476709(2-((5-chloro-4-(6-methyl-1H-indole-3-yl)pyrimidine...)
Affinity DataIC50:  0.400nMAssay Description:The inhibitory activity of some of the compounds described above against FLT3-ITD, FLT3 wild type (WT), VEGFR2 (KDR), and SYK kinase was measured.The...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Hanmi Pharm.

US Patent
LigandPNGBDBM476709(2-((5-chloro-4-(6-methyl-1H-indole-3-yl)pyrimidine...)
Affinity DataIC50:  0.400nMAssay Description:The inhibitory activity of some of the compounds described above against FLT3-ITD, FLT3 wild type (WT), VEGFR2 (KDR), and SYK kinase was measured. Th...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Hanmi Pharm.

US Patent
LigandPNGBDBM546731((3-(5-chloro-2-((3-cyclopropyl-5-(((3R, 5S)-3,5-di...)
Affinity DataIC50:  0.400nMAssay Description:The inhibitory activity of some of the compounds described above against FLT3-ITD, FLT3 wild type (WT), VEGFR2 (KDR), and SYK kinase was measured. Th...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDimer of Receptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Hanmi Pharm.

US Patent
LigandPNGBDBM476704( (3-(5-chloro-2-((3-cyclopropyl-5-(((3R,5S)-3,5-di...)
Affinity DataIC50:  0.5nMAssay Description:The inhibitory activity of some of the compounds described above against FLT3-ITD, FLT3 wild type (WT), VEGFR2 (KDR), and SYK kinase was measured.The...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDimer of Receptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Hanmi Pharm.

US Patent
LigandPNGBDBM546731((3-(5-chloro-2-((3-cyclopropyl-5-(((3R, 5S)-3,5-di...)
Affinity DataIC50:  0.5nMAssay Description:The inhibitory activity of some of the compounds described above against FLT3-ITD, FLT3 wild type (WT), VEGFR2 (KDR), and SYK kinase was measured. Th...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Athenex

Curated by ChEMBL
LigandPNGBDBM50567579(Encequidar | HM-30181 | HM30181 | HM30181AK | Pgp ...)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of paclitaxel stimulated- P-gp ATPase activity (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Hanmi Pharm.

US Patent
LigandPNGBDBM185584(US9156852, 1 | USRE47451, Example 1)
Affinity DataIC50:  1nMAssay Description:As such, the compounds prepared in Examples were tested for inhibitory activity against FMS, DDR1 and DDR2 kinases using Kinase Screening and Profili...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Hanmi Pharm.

US Patent
LigandPNGBDBM185584(US9156852, 1 | USRE47451, Example 1)
Affinity DataIC50:  1nMAssay Description:The compounds prepared in Examples were tested for inhibitory activity against FMS, DDR1 and DDR2 kinases using Kinase Screening and Profiling Servic...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Hanmi Pharm.

US Patent
LigandPNGBDBM476700(5-chloro-N-(3-cyclopropyl-5-(((3R,5S)-3,5-dimethyl...)
Affinity DataIC50:  1.10nMAssay Description:The inhibitory activity of some of the compounds described above against FLT3-ITD, FLT3 wild type (WT), VEGFR2 (KDR), and SYK kinase was measured.The...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Hanmi Pharm.

US Patent
LigandPNGBDBM476700(5-chloro-N-(3-cyclopropyl-5-(((3R,5S)-3,5-dimethyl...)
Affinity DataIC50:  1.10nMAssay Description:The inhibitory activity of some of the compounds described above against FLT3-ITD, FLT3 wild type (WT), VEGFR2 (KDR), and SYK kinase was measured. Th...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Hanmi Pharm.

US Patent
LigandPNGBDBM476702(N-(3-cyclopropyl-5-(((3R,5S)-3,5-dimethylpiperazin...)
Affinity DataIC50:  1.20nMAssay Description:The inhibitory activity of some of the compounds described above against FLT3-ITD, FLT3 wild type (WT), VEGFR2 (KDR), and SYK kinase was measured.The...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Hanmi Pharm.

US Patent
LigandPNGBDBM476702(N-(3-cyclopropyl-5-(((3R,5S)-3,5-dimethylpiperazin...)
Affinity DataIC50:  1.20nMAssay Description:The inhibitory activity of some of the compounds described above against FLT3-ITD, FLT3 wild type (WT), VEGFR2 (KDR), and SYK kinase was measured. Th...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Hanmi Pharm.

US Patent
LigandPNGBDBM476711( ((2R,6R)-4-(3-((5-chloro-4-(6-methyl-1H-indole-3-...)
Affinity DataIC50:  1.5nMAssay Description:The inhibitory activity of some of the compounds described above against FLT3-ITD, FLT3 wild type (WT), VEGFR2 (KDR), and SYK kinase was measured. Th...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDimer of Receptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Hanmi Pharm.

US Patent
LigandPNGBDBM476695(5-chloro-4-(6-chloro-1H-indole-3-yl)-N-(3-cyclopro...)
Affinity DataIC50:  1.5nMAssay Description:The inhibitory activity of some of the compounds described above against FLT3-ITD, FLT3 wild type (WT), VEGFR2 (KDR), and SYK kinase was measured. Th...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDimer of Receptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Hanmi Pharm.

US Patent
LigandPNGBDBM476695(5-chloro-4-(6-chloro-1H-indole-3-yl)-N-(3-cyclopro...)
Affinity DataIC50:  1.5nMAssay Description:The inhibitory activity of some of the compounds described above against FLT3-ITD, FLT3 wild type (WT), VEGFR2 (KDR), and SYK kinase was measured.The...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Hanmi Pharm.

US Patent
LigandPNGBDBM476711( ((2R,6R)-4-(3-((5-chloro-4-(6-methyl-1H-indole-3-...)
Affinity DataIC50:  1.5nMAssay Description:The inhibitory activity of some of the compounds described above against FLT3-ITD, FLT3 wild type (WT), VEGFR2 (KDR), and SYK kinase was measured.The...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDimer of Receptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Hanmi Pharm.

US Patent
LigandPNGBDBM476700(5-chloro-N-(3-cyclopropyl-5-(((3R,5S)-3,5-dimethyl...)
Affinity DataIC50:  1.80nMAssay Description:The inhibitory activity of some of the compounds described above against FLT3-ITD, FLT3 wild type (WT), VEGFR2 (KDR), and SYK kinase was measured.The...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDimer of Receptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Hanmi Pharm.

US Patent
LigandPNGBDBM476700(5-chloro-N-(3-cyclopropyl-5-(((3R,5S)-3,5-dimethyl...)
Affinity DataIC50:  1.80nMAssay Description:The inhibitory activity of some of the compounds described above against FLT3-ITD, FLT3 wild type (WT), VEGFR2 (KDR), and SYK kinase was measured. Th...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDimer of Receptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Hanmi Pharm.

US Patent
LigandPNGBDBM476699((R)-5-chloro-N-(3-cyclopropyl-5-((3-methylpiperazi...)
Affinity DataIC50:  1.80nMAssay Description:The inhibitory activity of some of the compounds described above against FLT3-ITD, FLT3 wild type (WT), VEGFR2 (KDR), and SYK kinase was measured. Th...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDimer of Receptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Hanmi Pharm.

US Patent
LigandPNGBDBM476699((R)-5-chloro-N-(3-cyclopropyl-5-((3-methylpiperazi...)
Affinity DataIC50:  1.80nMAssay Description:The inhibitory activity of some of the compounds described above against FLT3-ITD, FLT3 wild type (WT), VEGFR2 (KDR), and SYK kinase was measured.The...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Hanmi Pharm.

US Patent
LigandPNGBDBM476695(5-chloro-4-(6-chloro-1H-indole-3-yl)-N-(3-cyclopro...)
Affinity DataIC50:  1.90nMAssay Description:The inhibitory activity of some of the compounds described above against FLT3-ITD, FLT3 wild type (WT), VEGFR2 (KDR), and SYK kinase was measured. Th...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Hanmi Pharm.

US Patent
LigandPNGBDBM476695(5-chloro-4-(6-chloro-1H-indole-3-yl)-N-(3-cyclopro...)
Affinity DataIC50:  1.90nMAssay Description:The inhibitory activity of some of the compounds described above against FLT3-ITD, FLT3 wild type (WT), VEGFR2 (KDR), and SYK kinase was measured.The...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpithelial discoidin domain-containing receptor 1(Homo sapiens (Human))
Hanmi Pharm.

US Patent
LigandPNGBDBM185584(US9156852, 1 | USRE47451, Example 1)
Affinity DataIC50:  2nMAssay Description:The compounds prepared in Examples were tested for inhibitory activity against FMS, DDR1 and DDR2 kinases using Kinase Screening and Profiling Servic...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Hanmi Pharm.

US Patent
LigandPNGBDBM50518408(CHEMBL4483816)
Affinity DataIC50:  2nMAssay Description:Antagonist activity at recombinant human N-terminal His6-tagged FMS (538 to end residues) expressed in baculovirus infected Sf21 insect cells using I...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpithelial discoidin domain-containing receptor 1(Homo sapiens (Human))
Hanmi Pharm.

US Patent
LigandPNGBDBM185584(US9156852, 1 | USRE47451, Example 1)
Affinity DataIC50:  2nMAssay Description:As such, the compounds prepared in Examples were tested for inhibitory activity against FMS, DDR1 and DDR2 kinases using Kinase Screening and Profili...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDimer of Receptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Hanmi Pharm.

US Patent
LigandPNGBDBM476711( ((2R,6R)-4-(3-((5-chloro-4-(6-methyl-1H-indole-3-...)
Affinity DataIC50:  2.30nMAssay Description:The inhibitory activity of some of the compounds described above against FLT3-ITD, FLT3 wild type (WT), VEGFR2 (KDR), and SYK kinase was measured. Th...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDimer of Receptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Hanmi Pharm.

US Patent
LigandPNGBDBM476711( ((2R,6R)-4-(3-((5-chloro-4-(6-methyl-1H-indole-3-...)
Affinity DataIC50:  2.30nMAssay Description:The inhibitory activity of some of the compounds described above against FLT3-ITD, FLT3 wild type (WT), VEGFR2 (KDR), and SYK kinase was measured.The...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Hanmi Pharm.

US Patent
LigandPNGBDBM476710((R)-5-chloro-N-(3-cyclopropyl-5-((3,3,5-trimethylp...)
Affinity DataIC50:  2.30nMAssay Description:The inhibitory activity of some of the compounds described above against FLT3-ITD, FLT3 wild type (WT), VEGFR2 (KDR), and SYK kinase was measured.The...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Hanmi Pharm.

US Patent
LigandPNGBDBM476710((R)-5-chloro-N-(3-cyclopropyl-5-((3,3,5-trimethylp...)
Affinity DataIC50:  2.30nMAssay Description:The inhibitory activity of some of the compounds described above against FLT3-ITD, FLT3 wild type (WT), VEGFR2 (KDR), and SYK kinase was measured. Th...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDimer of Receptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Hanmi Pharm.

US Patent
LigandPNGBDBM476708(3-(5-chloro-2-((3-cyclopropyl-5-(((3R,5S)-3,5-dime...)
Affinity DataIC50:  2.40nMAssay Description:The inhibitory activity of some of the compounds described above against FLT3-ITD, FLT3 wild type (WT), VEGFR2 (KDR), and SYK kinase was measured.The...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDimer of Receptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Hanmi Pharm.

US Patent
LigandPNGBDBM476708(3-(5-chloro-2-((3-cyclopropyl-5-(((3R,5S)-3,5-dime...)
Affinity DataIC50:  2.40nMAssay Description:The inhibitory activity of some of the compounds described above against FLT3-ITD, FLT3 wild type (WT), VEGFR2 (KDR), and SYK kinase was measured. Th...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDimer of Receptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Hanmi Pharm.

US Patent
LigandPNGBDBM476702(N-(3-cyclopropyl-5-(((3R,5S)-3,5-dimethylpiperazin...)
Affinity DataIC50:  2.5nMAssay Description:The inhibitory activity of some of the compounds described above against FLT3-ITD, FLT3 wild type (WT), VEGFR2 (KDR), and SYK kinase was measured. Th...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDimer of Receptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Hanmi Pharm.

US Patent
LigandPNGBDBM476702(N-(3-cyclopropyl-5-(((3R,5S)-3,5-dimethylpiperazin...)
Affinity DataIC50:  2.5nMAssay Description:The inhibitory activity of some of the compounds described above against FLT3-ITD, FLT3 wild type (WT), VEGFR2 (KDR), and SYK kinase was measured.The...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRAF proto-oncogene serine/threonine-protein kinase [Y340D,Y341D](Homo sapiens (Human))
Hanmi Pharm.

US Patent
LigandPNGBDBM238347(US9388165, 3)
Affinity DataIC50:  2.80nMAssay Description:The compounds prepared in Examples were tested for inhibitory activities against three subtypes of RAF, i.e. RAF1 Y340D Y341D, BRAF normal type and B...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Hanmi Pharm.

US Patent
LigandPNGBDBM32362(5-[[3-methoxy-4-[(4-methoxyphenyl)methoxy]phenyl]m...)
Affinity DataIC50:  3nMAssay Description:Antagonist activity at recombinant human N-terminal His6-tagged FMS (538 to end residues) expressed in baculovirus infected Sf21 insect cells using I...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Receptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Hanmi Pharm.

US Patent
LigandPNGBDBM476701(US10870639, Example 10 | US11292786, Example 10 | ...)
Affinity DataIC50:  3.60nMAssay Description:The inhibitory activity of some of the compounds described above against FLT3-ITD, FLT3 wild type (WT), VEGFR2 (KDR), and SYK kinase was measured. Th...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDimer of Receptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Hanmi Pharm.

US Patent
LigandPNGBDBM476697(2-((2R,6S)-4-(3-((5-chloro-4-(1H-indole-3-yl)pyrim...)
Affinity DataIC50:  3.60nMAssay Description:The inhibitory activity of some of the compounds described above against FLT3-ITD, FLT3 wild type (WT), VEGFR2 (KDR), and SYK kinase was measured.The...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDimer of Receptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Hanmi Pharm.

US Patent
LigandPNGBDBM476701(US10870639, Example 10 | US11292786, Example 10 | ...)
Affinity DataIC50:  3.60nMAssay Description:The inhibitory activity of some of the compounds described above against FLT3-ITD, FLT3 wild type (WT), VEGFR2 (KDR), and SYK kinase was measured.The...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDimer of Receptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Hanmi Pharm.

US Patent
LigandPNGBDBM476697(2-((2R,6S)-4-(3-((5-chloro-4-(1H-indole-3-yl)pyrim...)
Affinity DataIC50:  3.60nMAssay Description:The inhibitory activity of some of the compounds described above against FLT3-ITD, FLT3 wild type (WT), VEGFR2 (KDR), and SYK kinase was measured. Th...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Hanmi Pharm.

US Patent
LigandPNGBDBM476706(3-(5-chloro-2-((3-cyclopropyl-5-(((3R,5S)-3,5-dime...)
Affinity DataIC50:  3.70nMAssay Description:The inhibitory activity of some of the compounds described above against FLT3-ITD, FLT3 wild type (WT), VEGFR2 (KDR), and SYK kinase was measured. Th...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Hanmi Pharm.

US Patent
LigandPNGBDBM476706(3-(5-chloro-2-((3-cyclopropyl-5-(((3R,5S)-3,5-dime...)
Affinity DataIC50:  3.70nMAssay Description:The inhibitory activity of some of the compounds described above against FLT3-ITD, FLT3 wild type (WT), VEGFR2 (KDR), and SYK kinase was measured.The...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Hanmi Pharm.

US Patent
LigandPNGBDBM185589(US9156852, 83 | USRE47451, Example 83)
Affinity DataIC50:  4nMAssay Description:As such, the compounds prepared in Examples were tested for inhibitory activity against FMS, DDR1 and DDR2 kinases using Kinase Screening and Profili...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Hanmi Pharm.

US Patent
LigandPNGBDBM185589(US9156852, 83 | USRE47451, Example 83)
Affinity DataIC50:  4nMAssay Description:The compounds prepared in Examples were tested for inhibitory activity against FMS, DDR1 and DDR2 kinases using Kinase Screening and Profiling Servic...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Athenex

Curated by ChEMBL
LigandPNGBDBM50206310(5-Methoxy-9-oxo-9,10-dihydro-acridine-4-carboxylic...)
Affinity DataIC50:  4.90nMAssay Description:Inhibition of paclitaxel stimulated- P-gp ATPase activity (unknown origin)More data for this Ligand-Target Pair
TargetEpithelial discoidin domain-containing receptor 1(Homo sapiens (Human))
Hanmi Pharm.

US Patent
LigandPNGBDBM185589(US9156852, 83 | USRE47451, Example 83)
Affinity DataIC50:  5nMAssay Description:As such, the compounds prepared in Examples were tested for inhibitory activity against FMS, DDR1 and DDR2 kinases using Kinase Screening and Profili...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase B-raf [V600E](Homo sapiens (Human))
Hanmi Pharm.

US Patent
LigandPNGBDBM185589(US9156852, 83 | USRE47451, Example 83)
Affinity DataIC50:  5nMAssay Description:The compounds prepared in Examples were tested for inhibitory activity against three subtypes of RAF, i.e., RAF1 Y340D Y341D (C-RAF), B-RAF normal ty...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Hanmi Pharm.

US Patent
LigandPNGBDBM185585(US9156852, 16 | USRE47451, Example 16)
Affinity DataIC50:  5nMAssay Description:The compounds prepared in Examples were tested for inhibitory activity against three subtypes of RAF, i.e., RAF1 Y340D Y341D (C-RAF), B-RAF normal ty...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Hanmi Pharm.

US Patent
LigandPNGBDBM185586(US9156852, 38 | USRE47451, Example 38)
Affinity DataIC50:  5nMAssay Description:The compounds prepared in Examples were tested for inhibitory activity against three subtypes of RAF, i.e., RAF1 Y340D Y341D (C-RAF), B-RAF normal ty...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Hanmi Pharm.

US Patent
LigandPNGBDBM185591(US9156852, 116 | USRE47451, Example 116)
Affinity DataIC50:  5nMAssay Description:The compounds prepared in Examples were tested for inhibitory activity against three subtypes of RAF, i.e., RAF1 Y340D Y341D (C-RAF), B-RAF normal ty...More data for this Ligand-Target Pair
In DepthDetails US Patent
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