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Found 191 with Last Name = 'sundriyal' and Initial = 's'
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM50148827(CHEMBL3769975)
Affinity DataKi:  620nMAssay Description:Inhibition of recombinant human C-terminal His-tagged SIRT2 (50 to 389 end residues) expressed in Escherichia coli using tubulin-K40 peptide in prese...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-lactamase(Pseudomonas aeruginosa)
Baylor College Of Medicine

Curated by ChEMBL
LigandPNGBDBM21642((2S)-1-[(2S)-2-methyl-3-sulfanylpropanoyl]pyrrolid...)
Affinity DataKi:  2.40E+3nMAssay Description:Inhibition of recombinant Pseudomonas aeruginosa MBL IMP-1 using nitrocefin as substrate preincubated for 20 mins by UV-spectrophotometric analysisMore data for this Ligand-Target Pair
TargetBeta-lactamase(Pseudomonas aeruginosa)
Baylor College Of Medicine

Curated by ChEMBL
LigandPNGBDBM50421220(CHEMBL2087628)
Affinity DataKi:  3.30E+3nMAssay Description:Inhibition of recombinant Pseudomonas aeruginosa MBL IMP-1 using nitrocefin as substrate preincubated for 20 mins by UV-spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-lactamase(Bacillus anthracis)
Baylor College Of Medicine

Curated by ChEMBL
LigandPNGBDBM50421214(CHEMBL2087633)
Affinity DataKi:  5.10E+3nMAssay Description:Inhibition of Bacillus anthracis MBL Bla2 using nitrocefin as substrate preincubated for 20 mins by UV-spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-lactamase(Bacillus anthracis)
Baylor College Of Medicine

Curated by ChEMBL
LigandPNGBDBM21642((2S)-1-[(2S)-2-methyl-3-sulfanylpropanoyl]pyrrolid...)
Affinity DataKi:  1.79E+4nMAssay Description:Inhibition of Bacillus anthracis MBL Bla2 using nitrocefin as substrate preincubated for 20 mins by UV-spectrophotometric analysisMore data for this Ligand-Target Pair
LigandPNGBDBM84558(Phosphate analogue, 9)
Affinity DataKi:  6.50E+6nMAssay Description:Inhibitory activity against recombinant Trypanosoma cruzi (Trypanosoma cruzi) Trypanothione reductaseMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetHistone-lysine N-methyltransferase EHMT2(Homo sapiens (Human))
Imperial College London

Curated by ChEMBL
LigandPNGBDBM50353128(CHEMBL1231795)
Affinity DataIC50:  2.5nMAssay Description:Inhibition of G9a (unknown origin) using [histone H3 1 to 25 residues] and SAM substrate by scintillation proximity assayMore data for this Ligand-Target Pair
LigandPNGBDBM50028309(Fosmidomycin Sodium)
Affinity DataIC50:  8nMAssay Description:Inhibitory activity against recombinant Trypanosoma cruzi (Trypanosoma cruzi) Trypanothione reductaseMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetHistone-lysine N-methyltransferase EHMT2(Homo sapiens (Human))
Imperial College London

Curated by ChEMBL
LigandPNGBDBM50498658(CHEMBL3621579)
Affinity DataIC50:  13nMAssay Description:Inhibition of G9a (unknown origin) using [histone H3 1 to 25 residues] and SAM substrate by scintillation proximity assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50181153(3-(N-hydroxyacetamido)propylphosphonic acid | 3-(N...)
Affinity DataIC50:  30nMAssay Description:Inhibitory activity against recombinant Trypanosoma cruzi (Trypanosoma cruzi) Trypanothione reductaseMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetHistone-lysine N-methyltransferase EHMT2(Homo sapiens (Human))
Imperial College London

Curated by ChEMBL
LigandPNGBDBM50498656(CHEMBL3621580)
Affinity DataIC50:  31nMAssay Description:Inhibition of G9a (unknown origin) using [histone H3 1 to 25 residues] and SAM substrate by scintillation proximity assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50380000(CHEMBL258981)
Affinity DataIC50:  48nMAssay Description:Antagonism of norepinephrine induced contraction of rat isolated thoracic aorta.More data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM50028309(Fosmidomycin Sodium)
Affinity DataIC50:  49nMAssay Description:Antagonism of norepinephrine induced contraction of rat isolated thoracic aorta.More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetHistone-lysine N-methyltransferase EHMT2(Homo sapiens (Human))
Imperial College London

Curated by ChEMBL
LigandPNGBDBM50300028(CHEMBL569864 | N-(1-benzylpiperidin-4-yl)-6,7-dime...)
Affinity DataIC50:  67nMAssay Description:Inhibition of G9a (unknown origin) using [histone H3 1 to 25 residues] and SAM substrate by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target1-deoxy-D-xylulose 5-phosphate reductoisomerase(Mycobacterium tuberculosis)TBA
LigandPNGBDBM50028309(Fosmidomycin Sodium)
Affinity DataIC50:  80nMAssay Description:Inhibitory activity against recombinant Trypanosoma cruzi (Trypanosoma cruzi) Trypanothione reductaseMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetPeroxisome proliferator-activated receptor gamma(Mus musculus)
National Institute Of Pharmaceutical Education And Research

Curated by ChEMBL
LigandPNGBDBM50265301(5-(4-phenoxybenzylidene)pyrimidine-2,4,6(1H,3H,5H)...)
Affinity DataIC50:  100nMAssay Description:Displacement of [3H]rosiglitazone from mouse PPARgamma receptor by scintillation proximation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase EHMT2(Homo sapiens (Human))
Imperial College London

Curated by ChEMBL
LigandPNGBDBM50498655(CHEMBL1895209)
Affinity DataIC50:  101nMAssay Description:Inhibition of G9a (unknown origin) using [histone H3 1 to 25 residues] and SAM substrate by scintillation proximity assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target1-deoxy-D-xylulose 5-phosphate reductoisomerase(Mycobacterium tuberculosis)TBA
LigandPNGBDBM50181153(3-(N-hydroxyacetamido)propylphosphonic acid | 3-(N...)
Affinity DataIC50:  160nMAssay Description:Antagonism of phenylephrine stimulated contraction of the rat isolated spleen.More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM50148827(CHEMBL3769975)
Affinity DataIC50:  170nMAssay Description:Inhibition of recombinant human C-terminal His-tagged SIRT2 (50 to 389 end residues) expressed in Escherichia coli in presence of NAD+ by enzyme coup...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50379999(CHEMBL1161784)
Affinity DataIC50:  170nMAssay Description:Antagonism of norepinephrine induced contraction of rat isolated thoracic aorta.More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetPeroxisome proliferator-activated receptor gamma(Mus musculus)
National Institute Of Pharmaceutical Education And Research

Curated by ChEMBL
LigandPNGBDBM50265171(4-(4-((2,4,6-trioxotetrahydropyrimidin-5(6H)-ylide...)
Affinity DataIC50:  200nMAssay Description:Displacement of [3H]rosiglitazone from mouse PPARgamma receptor by scintillation proximation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor gamma(Rattus norvegicus)
National Institute Of Pharmaceutical Education And Research

Curated by ChEMBL
LigandPNGBDBM50271605(2-(4-(2-fluorobenzyloxy)benzyl)-3-hydroxynaphthale...)
Affinity DataIC50:  200nMAssay Description:Displacement of [3H]rosigliatzone from PPARgamma in rat adipocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor gamma(Mus musculus)
National Institute Of Pharmaceutical Education And Research

Curated by ChEMBL
LigandPNGBDBM50265213(5-(4-((4-methoxyphenoxy)methyl)benzylidene)pyrimid...)
Affinity DataIC50:  200nMAssay Description:Displacement of [3H]rosiglitazone from mouse PPARgamma receptor by scintillation proximation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM50501437(CHEMBL4101347)
Affinity DataIC50:  390nMAssay Description:Inhibition of recombinant human C-terminal His-tagged SIRT2 (50 to 389 end residues) expressed in Escherichia coli using p53 derived (379 to 382 resi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM50148781(CHEMBL3770903)
Affinity DataIC50:  400nMAssay Description:Inhibition of human SIRT2 (25 to 389 residues) using (Z-Lys(Acetyl)-AMC) as substrate after 4 hrs in presence of NAD+ by fluorescence assayMore data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EHMT2(Homo sapiens (Human))
Imperial College London

Curated by ChEMBL
LigandPNGBDBM50498659(CHEMBL1902352)
Affinity DataIC50:  472nMAssay Description:Inhibition of G9a (unknown origin) using [histone H3 1 to 25 residues] and SAM substrate by scintillation proximity assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor gamma(Mus musculus)
National Institute Of Pharmaceutical Education And Research

Curated by ChEMBL
LigandPNGBDBM50265270(5-(4-((10H-phenoxazin-10-yl)methyl)benzylidene)pyr...)
Affinity DataIC50:  500nMAssay Description:Displacement of [3H]rosiglitazone from mouse PPARgamma receptor by scintillation proximation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM50501456(CHEMBL4088755)
Affinity DataIC50:  580nMAssay Description:Inhibition of recombinant human C-terminal His-tagged SIRT2 (50 to 389 end residues) expressed in Escherichia coli using p53 derived (379 to 382 resi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetHistone-lysine N-methyltransferase Su(var)3-9(Drosophila melanogaster)
Imperial College

Curated by ChEMBL
LigandPNGBDBM50315537(CHEMBL1089316 | chaetocin)
Affinity DataIC50:  600nMAssay Description:Inhibition of Drosophila melanogaster Histone-lysine N-methyltransferase Su(var)3-9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM50501455(CHEMBL4091659)
Affinity DataIC50:  650nMAssay Description:Inhibition of recombinant human C-terminal His-tagged SIRT2 (50 to 389 end residues) expressed in Escherichia coli using p53 derived (379 to 382 resi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor gamma(Rattus norvegicus)
National Institute Of Pharmaceutical Education And Research

Curated by ChEMBL
LigandPNGBDBM50049240((+-)-5-((4-(2-(5-ethyl-2-pyridinyl)ethoxy)phenyl)m...)
Affinity DataIC50:  700nMAssay Description:Displacement of [3H]rosigliatzone from PPARgamma in rat adipocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor gamma(Mus musculus)
National Institute Of Pharmaceutical Education And Research

Curated by ChEMBL
LigandPNGBDBM50049240((+-)-5-((4-(2-(5-ethyl-2-pyridinyl)ethoxy)phenyl)m...)
Affinity DataIC50:  700nMAssay Description:Displacement of [3H]rosiglitazone from mouse PPARgamma receptor by scintillation proximation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM50501451(CHEMBL4078889)
Affinity DataIC50:  730nMAssay Description:Inhibition of recombinant human C-terminal His-tagged SIRT2 (50 to 389 end residues) expressed in Escherichia coli using p53 derived (379 to 382 resi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase SUV39H1(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM50315537(CHEMBL1089316 | chaetocin)
Affinity DataIC50:  800nMAssay Description:Inhibition of human Histone-lysine N-methyltransferase SUV39H1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor gamma(Mus musculus)
National Institute Of Pharmaceutical Education And Research

Curated by ChEMBL
LigandPNGBDBM50265211(5-(3-(2-(p-tolyloxy)ethoxy)benzylidene)pyrimidine-...)
Affinity DataIC50:  800nMAssay Description:Displacement of [3H]rosiglitazone from mouse PPARgamma receptor by scintillation proximation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM50501499(CHEMBL4064852)
Affinity DataIC50:  970nMAssay Description:Inhibition of recombinant human C-terminal His-tagged SIRT2 (50 to 389 end residues) expressed in Escherichia coli using p53 derived (379 to 382 resi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM50501453(CHEMBL4094485)
Affinity DataIC50:  1.11E+3nMAssay Description:Inhibition of recombinant human C-terminal His-tagged SIRT2 (50 to 389 end residues) expressed in Escherichia coli using p53 derived (379 to 382 resi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM50501450(CHEMBL4091606)
Affinity DataIC50:  1.18E+3nMAssay Description:Inhibition of recombinant human C-terminal His-tagged SIRT2 (50 to 389 end residues) expressed in Escherichia coli using p53 derived (379 to 382 resi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM50501494(CHEMBL4105292)
Affinity DataIC50:  1.20E+3nMAssay Description:Inhibition of recombinant human C-terminal His-tagged SIRT2 (50 to 389 end residues) expressed in Escherichia coli using p53 derived (379 to 382 resi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM50501435(CHEMBL4078845)
Affinity DataIC50:  1.27E+3nMAssay Description:Inhibition of recombinant human C-terminal His-tagged SIRT2 (50 to 389 end residues) expressed in Escherichia coli using p53 derived (379 to 382 resi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM50148827(CHEMBL3769975)
Affinity DataIC50:  1.45E+3nMAssay Description:Inhibition of recombinant human C-terminal His-tagged SIRT2 (50 to 389 end residues) expressed in Escherichia coli using p53 derived (379 to 382 resi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM50501452(CHEMBL4073924)
Affinity DataIC50:  1.52E+3nMAssay Description:Inhibition of recombinant human C-terminal His-tagged SIRT2 (50 to 389 end residues) expressed in Escherichia coli using p53 derived (379 to 382 resi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM50501485(CHEMBL4061689)
Affinity DataIC50:  1.65E+3nMAssay Description:Inhibition of recombinant human C-terminal His-tagged SIRT2 (50 to 389 end residues) expressed in Escherichia coli using p53 derived (379 to 382 resi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM50501507(CHEMBL4093162)
Affinity DataIC50:  1.72E+3nMAssay Description:Inhibition of recombinant human C-terminal His-tagged SIRT2 (50 to 389 end residues) expressed in Escherichia coli using p53 derived (379 to 382 resi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM50501472(CHEMBL4092831)
Affinity DataIC50:  1.74E+3nMAssay Description:Inhibition of recombinant human C-terminal His-tagged SIRT2 (50 to 389 end residues) expressed in Escherichia coli using p53 derived (379 to 382 resi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM50501491(CHEMBL4094149)
Affinity DataIC50:  1.83E+3nMAssay Description:Inhibition of recombinant human C-terminal His-tagged SIRT2 (50 to 389 end residues) expressed in Escherichia coli using p53 derived (379 to 382 resi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM50501510(CHEMBL4071269)
Affinity DataIC50:  1.85E+3nMAssay Description:Inhibition of recombinant human C-terminal His-tagged SIRT2 (50 to 389 end residues) expressed in Escherichia coli using p53 derived (379 to 382 resi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM50501481(CHEMBL4104283)
Affinity DataIC50:  1.90E+3nMAssay Description:Inhibition of recombinant human C-terminal His-tagged SIRT2 (50 to 389 end residues) expressed in Escherichia coli using p53 derived (379 to 382 resi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor gamma(Rattus norvegicus)
National Institute Of Pharmaceutical Education And Research

Curated by ChEMBL
LigandPNGBDBM50271732(4-(2-(4-((3-hydroxy-1,4-dioxo-1,4-dihydronaphthale...)
Affinity DataIC50:  1.90E+3nMAssay Description:Displacement of [3H]rosigliatzone from PPARgamma in rat adipocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM50501457(CHEMBL4084437)
Affinity DataIC50:  1.90E+3nMAssay Description:Inhibition of recombinant human C-terminal His-tagged SIRT2 (50 to 389 end residues) expressed in Escherichia coli using p53 derived (379 to 382 resi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
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