Found 15 Enz. Inhib. hit(s) with Target = 'NAD-dependent protein deacetylase sirtuin-2' and Ligand = 'BDBM50148781' TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Nagoya City University
Curated by ChEMBL
Nagoya City University
Curated by ChEMBL
Affinity DataIC50: 140nMAssay Description:Inhibition of SIRT2 deacylation activity (unknown origin)More data for this Ligand-Target Pair
3D Structure (crystal)TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Nagoya City University
Curated by ChEMBL
Nagoya City University
Curated by ChEMBL
Affinity DataIC50: 140nMAssay Description:Inhibition of human SIRT2 (25 to 389 amino acid residues) expressed in Escherichia coli BL21 (DE3) assessed as deacetylation using Z-Lys(Acetyl)-AMC ...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Nagoya City University
Curated by ChEMBL
Nagoya City University
Curated by ChEMBL
Affinity DataIC50: 210nMAssay Description:Inhibition of recombinant SIRT2 (unknown origin) using FAM-RHKK(Ac)LM as substrate measured after 60 mins by electrophoretic mobility shift assayMore data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Nagoya City University
Curated by ChEMBL
Nagoya City University
Curated by ChEMBL
Affinity DataIC50: 300nMAssay Description:Inhibition of human N-terminal His-tagged SIRT2 expressed in Escherichia coli using p53 (Gln-Pro-Lys-Lys(Ac)) (317 to 320 residues) as substrate incu...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Nagoya City University
Curated by ChEMBL
Nagoya City University
Curated by ChEMBL
Affinity DataIC50: 400nMAssay Description:Inhibition of human sirtuin 2 (25 to 389 residues) assessed as inhibition of substrate deacetylation using ZMAL as substrate incubated for 4 hrs by f...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Nagoya City University
Curated by ChEMBL
Nagoya City University
Curated by ChEMBL
Affinity DataIC50: 400nMAssay Description:Inhibition of human SIRT2 (25 to 389 residues) using (Z-Lys(Acetyl)-AMC) as substrate after 4 hrs in presence of NAD+ by fluorescence assayMore data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Nagoya City University
Curated by ChEMBL
Nagoya City University
Curated by ChEMBL
Affinity DataIC50: 440nMAssay Description:Inhibition of recombinant human His10-tagged Sirt2 (56 to 356 residues) expressed in Escherichia coli BL21(DE3) using Z-(Ac)Lys-AMC as substrate meas...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Nagoya City University
Curated by ChEMBL
Nagoya City University
Curated by ChEMBL
Affinity DataIC50: 440nMAssay Description:Inhibition of N-terminal his6-tagged human SIRT2 (25 to 389 amino acids) using ZMAL as substrate after 4 hrs by fluorescence-based microplate reader ...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Nagoya City University
Curated by ChEMBL
Nagoya City University
Curated by ChEMBL
Affinity DataIC50: 600nMAssay Description:Inhibition of SIRT2 deacetylation activity (unknown origin) using H3K9Ac ( 4 to 15 residues) as substrate by HPLC analysisMore data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Nagoya City University
Curated by ChEMBL
Nagoya City University
Curated by ChEMBL
Affinity DataIC50: 700nMAssay Description:Inhibition of recombinant human SIRT2 deacylation activity using Fluor de Lys Sirt2 as substrate measured at 5 mins interval for 30 mins in presence ...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Nagoya City University
Curated by ChEMBL
Nagoya City University
Curated by ChEMBL
Affinity DataIC50: 3.38E+3nMAssay Description:Inhibition of recombinant His-tagged SIRT2 (56 to 356 residues) (unknown origin) expressed in Escherichia coli Transetta(DE3) using AcIQF as substrat...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Nagoya City University
Curated by ChEMBL
Nagoya City University
Curated by ChEMBL
Affinity DataIC50: 3.39E+3nMAssay Description:Inhibition of recombinant His-tagged SIRT2 (56 to 356 residues) (unknown origin) expressed in Escherichia coli Transetta(DE3) using AcIQF as substrat...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Nagoya City University
Curated by ChEMBL
Nagoya City University
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of recombinant human SIRT2 defatty-acylase activity using SFP3 as substrate measured at 5 mins interval for 60 mins in presence of NAD+ by...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Nagoya City University
Curated by ChEMBL
Nagoya City University
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of recombinant human SIRT2 demyristoylase activity using p53(Myr)-AMC as substrate measured after 3 hrs in presence of NAD+ and trypsin by...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Nagoya City University
Curated by ChEMBL
Nagoya City University
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged/SUMO-fused SIRT2 (38 to 356 residues) expressed in Escherichia coli BL21 using acetyl-H3K9 as ...More data for this Ligand-Target Pair
