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Found 42 with Last Name = 'svensson' and Initial = 'c'
TargetDelta-type opioid receptor(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50117263((3R,6S,12S)-12-[(S)-2-Amino-3-(4-hydroxy-phenyl)-p...)
Affinity DataKi:  0.630nMAssay Description:Inhibition of binding of [3H]diprenorphine to cloned human Opioid receptor delta 1 expressed in CHO cell membrane;Range is in between (0.62-0.65)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50117262(12-[2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-6...)
Affinity DataKi:  0.790nMAssay Description:Inhibition of binding of [3H]-diprenorphine to cloned human Opioid receptor delta 1 expressed in CHO cell membrane;Range is between (0.66-0.95)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50117264(12-[2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-6...)
Affinity DataKi:  0.930nMAssay Description:Inhibition of binding of [3H]-diprenorphine to cloned human Opioid receptor delta 1 expressed in CHO cell membrane;Range is between (0.35-2.5)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50117261(12-[2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-6...)
Affinity DataKi:  2nMAssay Description:Inhibition of binding of [3H]-diprenorphine to cloned human Opioid receptor mu 1 expressed in CHO cell membrane;Range is in between (1.8-2.2)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50117261(12-[2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-6...)
Affinity DataKi:  2nMAssay Description:Inhibition of binding of [3H]-diprenorphine to cloned human Opioid receptor delta 1 expressed in CHO cell membrane;Range is between (1.7-2.3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50001683(13-[2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-7...)
Affinity DataKi:  2.20nMAssay Description:Inhibition of binding of [3H]diprenorphine to cloned human Opioid receptor delta 1 expressed in CHO cell membrane;Range is between (1-3.9)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50117263((3R,6S,12S)-12-[(S)-2-Amino-3-(4-hydroxy-phenyl)-p...)
Affinity DataKi:  2.30nMAssay Description:Inhibition of binding of [3H]-diprenorphine to cloned human Opioid receptor mu 1 expressed in CHO cell membrane;Range is in between (1.3-3.7)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50000092((-)-(etorphine) | (-)-morphine | (1S,5R,13R,14S)-1...)
Affinity DataKi:  17nMAssay Description:Inhibition of binding of [3H]-diprenorphine to cloned human Opioid receptor mu 1 expressed in CHO cell membrane;Range is in between (6.8-43)More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Rattus norvegicus (rat))
Pharmacia

LigandPNGBDBM13614(2-(carboxymethoxy)-5-[(2S)-2-(pentylcarbamoyl)-2-[...)
Affinity DataKi:  120nM ΔG°:  -39.1kJ/molepH: 7.2 T: 2°CAssay Description:Hydrolysis of substrate p-nitrophenyl phosphate was monitored on a 96-well microplate reader. Concentrations of PTP1B inhibitors that resulted in 50%...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50117262(12-[2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-6...)
Affinity DataKi:  130nMAssay Description:Inhibition of binding of [3H]-diprenorphine to cloned human Opioid receptor mu 1 expressed in CHO cell membrane;Range is in between (110-150)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50000092((-)-(etorphine) | (-)-morphine | (1S,5R,13R,14S)-1...)
Affinity DataKi:  150nMAssay Description:Inhibition of binding of [3H]-diprenorphine to cloned human Opioid receptor delta 1 expressed in CHO cell membrane;Range is between (63-360)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetTyrosine-protein phosphatase non-receptor type 1(Rattus norvegicus (rat))
Pharmacia

LigandPNGBDBM13611(2-(carboxymethoxy)-5-[(2S)-2-[(2S)-2-(3-formamidop...)
Affinity DataKi:  250nM ΔG°:  -37.3kJ/molepH: 7.2 T: 2°CAssay Description:Hydrolysis of substrate p-nitrophenyl phosphate was monitored on a 96-well microplate reader. Concentrations of PTP1B inhibitors that resulted in 50%...More data for this Ligand-Target Pair
TargetKappa-type opioid receptor(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50000092((-)-(etorphine) | (-)-morphine | (1S,5R,13R,14S)-1...)
Affinity DataKi:  260nMAssay Description:Inhibition of binding of [3H]diprenorphine to cloned human Opioid receptor kappa 1 expressed in CHO cell membrane;Range is in between (1400-1900)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetMu-type opioid receptor(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50117264(12-[2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-6...)
Affinity DataKi:  630nMAssay Description:Inhibition of binding of [3H]-diprenorphine to cloned human Opioid receptor mu 1 expressed in CHO cell membrane;Range is in between (580-680)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50117262(12-[2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-6...)
Affinity DataKi: >1.00E+3nMAssay Description:Inhibition of binding of [3H]diprenorphine to cloned human Opioid receptor kappa 1 expressed in CHO cell membrane;Range is in between (1400-1900)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Rattus norvegicus (rat))
Pharmacia

LigandPNGBDBM13609(2-{4-[(2S)-2-[(2S)-2-(3-formamidopropanoic acid)-3...)
Affinity DataKi:  1.20E+3nM ΔG°:  -33.5kJ/molepH: 7.2 T: 2°CAssay Description:Hydrolysis of substrate p-nitrophenyl phosphate was monitored on a 96-well microplate reader. Concentrations of PTP1B inhibitors that resulted in 50%...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50117261(12-[2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-6...)
Affinity DataKi:  1.60E+3nMAssay Description:Inhibition of binding of [3H]-diprenorphine to cloned human Opioid receptor kappa 1 expressed in CHO cell membrane;Range is in between (1400-1900)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Rattus norvegicus (rat))
Pharmacia

LigandPNGBDBM13610(2-(carboxymethoxy)-5-[(2S)-2-(3-formamidopropanoic...)
Affinity DataKi:  2.80E+3nM ΔG°:  -31.4kJ/molepH: 7.2 T: 2°CAssay Description:Hydrolysis of substrate p-nitrophenyl phosphate was monitored on a 96-well microplate reader. Concentrations of PTP1B inhibitors that resulted in 50%...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Rattus norvegicus (rat))
Pharmacia

LigandPNGBDBM13613(2-{4-[(2S)-2-({[(1S)-1-carboxy-2-phenylethyl]carba...)
Affinity DataKi:  3.40E+3nM ΔG°:  -30.9kJ/molepH: 7.2 T: 2°CAssay Description:Hydrolysis of substrate p-nitrophenyl phosphate was monitored on a 96-well microplate reader. Concentrations of PTP1B inhibitors that resulted in 50%...More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Rattus norvegicus (rat))
Pharmacia

LigandPNGBDBM13606((3S)-3-{[(1S)-1-{[(1S)-1-carbamoylpentyl]carbamoyl...)
Affinity DataKi:  5.00E+3nM ΔG°:  -30.0kJ/molepH: 7.2 T: 2°CAssay Description:Hydrolysis of substrate p-nitrophenyl phosphate was monitored on a 96-well microplate reader. Concentrations of PTP1B inhibitors that resulted in 50%...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50117263((3R,6S,12S)-12-[(S)-2-Amino-3-(4-hydroxy-phenyl)-p...)
Affinity DataKi:  6.40E+3nMAssay Description:Inhibition of binding of [3H]-diprenorphine to cloned human Opioid receptor kappa 1 expressed in CHO cell membrane; range is in between (4700-8500)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50001683(13-[2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-7...)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of binding of [3H]diprenorphine to cloned human Opioid receptor kappa 1 expressed in CHO cell membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50117264(12-[2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-6...)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of binding of [3H]diprenorphine to cloned human Opioid receptor kappa 1 expressed in CHO cell membrane;Range is in between (1400-1900)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50001683(13-[2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-7...)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of binding of [3H]diprenorphine to cloned human Opioid receptor mu 1 expressed in CHO cell membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Rattus norvegicus (rat))
Pharmacia

LigandPNGBDBM13608(2-{4-[(2S)-2-(3-formamidopropanoic acid)-2-(pentyl...)
Affinity DataKi:  1.20E+4nM ΔG°:  -27.8kJ/molepH: 7.2 T: 2°CAssay Description:Hydrolysis of substrate p-nitrophenyl phosphate was monitored on a 96-well microplate reader. Concentrations of PTP1B inhibitors that resulted in 50%...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Rattus norvegicus (rat))
Pharmacia

LigandPNGBDBM13607(3-{[(1S)-1-(pentylcarbamoyl)-2-[4-(sulfooxy)phenyl...)
Affinity DataKi:  3.00E+4nM ΔG°:  -25.6kJ/molepH: 7.2 T: 2°CAssay Description:Hydrolysis of substrate p-nitrophenyl phosphate was monitored on a 96-well microplate reader. Concentrations of PTP1B inhibitors that resulted in 50%...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Rattus norvegicus (rat))
Pharmacia

LigandPNGBDBM13612(Compound VII | methyl 2-(2-methoxy-2-oxoethoxy)-5-...)
Affinity DataKi: >1.00E+5nM ΔG°: >-22.6kJ/molepH: 7.2 T: 2°CAssay Description:Hydrolysis of substrate p-nitrophenyl phosphate was monitored on a 96-well microplate reader. Concentrations of PTP1B inhibitors that resulted in 50%...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(MOUSE)
University Of California

Curated by ChEMBL
LigandPNGBDBM50117262(12-[2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-6...)
Affinity DataIC50:  0.260nMAssay Description:Ability to inhibit electrically evoked contractions of isolated muscle preparations of mouse vas deference (MVD, delta receptor)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(MOUSE)
University Of California

Curated by ChEMBL
LigandPNGBDBM50117263((3R,6S,12S)-12-[(S)-2-Amino-3-(4-hydroxy-phenyl)-p...)
Affinity DataIC50:  0.350nMAssay Description:Ability to inhibit electrically evoked contractions of isolated muscle preparations of mouse vas deferens (MVD, delta receptor)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(GUINEA PIG)
University Of California

Curated by ChEMBL
LigandPNGBDBM50117261(12-[2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-6...)
Affinity DataIC50:  0.560nMAssay Description:Ability to inhibit electrically evoked contractions of isolated muscle preparations of guinea pig ileum (GPI, mu receptor)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(GUINEA PIG)
University Of California

Curated by ChEMBL
LigandPNGBDBM50117263((3R,6S,12S)-12-[(S)-2-Amino-3-(4-hydroxy-phenyl)-p...)
Affinity DataIC50:  1.10nMAssay Description:Ability to inhibit electrically evoked contractions of isolated muscle preparations of guinea pig ileum (GPI, mu receptor)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(MOUSE)
University Of California

Curated by ChEMBL
LigandPNGBDBM50117261(12-[2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-6...)
Affinity DataIC50:  1.60nMAssay Description:Ability to inhibit electrically evoked contractions of isolated muscle preparations of mouse vas deferens (MVD, delta receptor)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(MOUSE)
University Of California

Curated by ChEMBL
LigandPNGBDBM50117264(12-[2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-6...)
Affinity DataIC50:  2.30nMAssay Description:Ability to inhibit electrically evoked contractions of isolated muscle preparations of mouse vas deference (MVD, delta receptor)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(MOUSE)
University Of California

Curated by ChEMBL
LigandPNGBDBM50001683(13-[2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-7...)
Affinity DataIC50:  4.10nMAssay Description:Ability to inhibit electrically evoked contractions of isolated muscle preparations of mouse vas deference (MVD, delta receptor)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(GUINEA PIG)
University Of California

Curated by ChEMBL
LigandPNGBDBM50000092((-)-(etorphine) | (-)-morphine | (1S,5R,13R,14S)-1...)
Affinity DataIC50:  59nMAssay Description:Ability to inhibit electrically evoked contractions of isolated muscle preparations of guinea pig ileum (GPI, mu receptor)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(GUINEA PIG)
University Of California

Curated by ChEMBL
LigandPNGBDBM50117262(12-[2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-6...)
Affinity DataIC50:  82nMAssay Description:Ability to inhibit electrically evoked contractions of isolated muscle preparations of guinea pig ileum (GPI, mu receptor)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Targetvon Hippel-Lindau disease tumor suppressor(Homo sapiens (Human))
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50559446(CHEMBL4779321)
Affinity DataIC50:  307nMAssay Description:Inhibition of VHL (unknown origin) assessed as phosphorylated peptide substrate incubated for 60 mins by TR-FRET based biochemical assayMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(MOUSE)
University Of California

Curated by ChEMBL
LigandPNGBDBM50000092((-)-(etorphine) | (-)-morphine | (1S,5R,13R,14S)-1...)
Affinity DataIC50:  644nMAssay Description:Ability to inhibit electrically evoked contractions of isolated muscle preparations of mouse vas deference (MVD, delta receptor)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(GUINEA PIG)
University Of California

Curated by ChEMBL
LigandPNGBDBM50117264(12-[2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-6...)
Affinity DataIC50:  730nMAssay Description:Ability to inhibit electrically evoked contractions of isolated muscle preparations of guinea pig ileum (GPI, mu receptor)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 7(Homo sapiens (Human))
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50559446(CHEMBL4779321)
Affinity DataIC50:  1.23E+3nMAssay Description:Inhibition of recombinant human GST-tagged ERK5 (1 to 398 assessed as phosphorylated peptide substrate incubated for 60 mins by TR-FRET based biochem...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
Targetvon Hippel-Lindau disease tumor suppressor(Homo sapiens (Human))
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50559446(CHEMBL4779321)
Affinity DataIC50:  4.31E+3nMAssay Description:Inhibition of NanoLuc-tagged VHL in HEK293 cells incubated for 2 hrs by NanoBRET live cell assayMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(GUINEA PIG)
University Of California

Curated by ChEMBL
LigandPNGBDBM50001683(13-[2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-7...)
Affinity DataIC50:  7.30E+3nMAssay Description:Ability to inhibit electrically evoked contractions of isolated muscle preparations of guinea pig ileum (GPI, mu receptor)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed