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Found 9 with Last Name = 'swier' and Initial = 'lj'
TargetD-3-phosphoglycerate dehydrogenase(Homo sapiens (Human))
Whitehead Institute For Biomedical Research

LigandPNGBDBM195606(NCT-503)
Affinity DataIC50:  2.50E+3nMpH: 8.0 T: 2°CAssay Description:PHGDH assay buffer contained 50 mM TEA pH 8.0, 10 mM MgCl2, 0.05% BSA, and 0.01% Tween-20. PHGDH enzyme buffer consisted of assay buffer with 20 nM P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD-3-phosphoglycerate dehydrogenase(Homo sapiens (Human))
Whitehead Institute For Biomedical Research

LigandPNGBDBM195605(NCT-502 | US11225469, Compound 72)
Affinity DataIC50:  3.70E+3nMpH: 8.0 T: 2°CAssay Description:PHGDH assay buffer contained 50 mM TEA pH 8.0, 10 mM MgCl2, 0.05% BSA, and 0.01% Tween-20. PHGDH enzyme buffer consisted of assay buffer with 20 nM P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD-3-phosphoglycerate dehydrogenase(Homo sapiens (Human))
Whitehead Institute For Biomedical Research

LigandPNGBDBM58473(MLS001172437 | N-(4-methyl-2-pyridinyl)-4-[3-(trif...)
Affinity DataIC50:  1.53E+4nMpH: 8.0 T: 2°CAssay Description:PHGDH assay buffer contained 50 mM TEA pH 8.0, 10 mM MgCl2, 0.05% BSA, and 0.01% Tween-20. PHGDH enzyme buffer consisted of assay buffer with 20 nM P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD-3-phosphoglycerate dehydrogenase(Homo sapiens (Human))
Whitehead Institute For Biomedical Research

LigandPNGBDBM195607(PHGDH-inactive | US11225469, Compound 71)
Affinity DataIC50: >5.70E+4nMpH: 8.0 T: 2°CAssay Description:PHGDH assay buffer contained 50 mM TEA pH 8.0, 10 mM MgCl2, 0.05% BSA, and 0.01% Tween-20. PHGDH enzyme buffer consisted of assay buffer with 20 nM P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThiamine transporter ThiT(Lactococcus lactis (Firmicutes))
University of Groningen

LigandPNGBDBM150803(2-(3-((4-Amino-2-methylpyrimidin-5-yl)methyl)pheny...)
Affinity DataKd:  528nMAssay Description:Purified ThiT was diluted in buffer E to a concentration of ~50 nM in a final volume of 800 無. The substrates were added in 1 無 steps. Using an exc...More data for this Ligand-Target Pair
TargetThiamine transporter ThiT(Lactococcus lactis (Firmicutes))
University of Groningen

LigandPNGBDBM150802((4-((4-Amino-2-methylpyrimidin-5-yl)methyl)-3-meth...)
Affinity DataKd:  5.21nMAssay Description:Purified ThiT was diluted in buffer E to a concentration of ~50 nM in a final volume of 800 無. The substrates were added in 1 無 steps. Using an exc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThiamine transporter ThiT(Lactococcus lactis (Firmicutes))
University of Groningen

LigandPNGBDBM150801((3-((4-Amino-2-methylpyrimidin-5-yl)methyl)phenyl)...)
Affinity DataKd:  266nMAssay Description:Purified ThiT was diluted in buffer E to a concentration of ~50 nM in a final volume of 800 無. The substrates were added in 1 無 steps. Using an exc...More data for this Ligand-Target Pair
TargetThiamine transporter ThiT(Lactococcus lactis (Firmicutes))
University of Groningen

LigandPNGBDBM50373886(3-Deazathiamine | CHEMBL401772)
Affinity DataKd:  4.23nMAssay Description:Purified ThiT was diluted in buffer E to a concentration of ~50 nM in a final volume of 800 無. The substrates were added in 1 無 steps. Using an exc...More data for this Ligand-Target Pair
TargetThiamine transporter ThiT(Lactococcus lactis (Firmicutes))
University of Groningen

LigandPNGBDBM150804(4-((4-Amino-2-methylpyrimidin-5-yl)methyl)-3-methy...)
Affinity DataKd:  7.44nMAssay Description:Purified ThiT was diluted in buffer E to a concentration of ~50 nM in a final volume of 800 無. The substrates were added in 1 無 steps. Using an exc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB