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Found 380 with Last Name = 'vaz' and Initial = 'r'
TargetNeprilysin(Rattus norvegicus (Rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50175518((3R,7S)-7-((R)-2-Mercapto-3-phenyl-propionylamino)...)
Affinity DataKi:  0.0700nMAssay Description:Compound was tested for inhibition of neutral endopeptidase (NEP).More data for this Ligand-Target Pair
In DepthDetails Article
TargetNeprilysin(Rattus norvegicus (Rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50289194((S)-2-[(S)-4-((R)-2-Mercapto-3-phenyl-propionylami...)
Affinity DataKi:  0.400nMAssay Description:Compound was tested for inhibition of neutral endopeptidase (NEP).More data for this Ligand-Target Pair
In DepthDetails Article
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50001786(1-(2-{4-[5-chloro-1-(4-fluorophenyl)-1H-indol-3-yl...)
Affinity DataKi:  0.600nMAssay Description:Binding affinity towards Serotonin 5-hydroxytryptamine 2A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50156461(3-[4-(5-Aminomethyl-2-fluoro-phenyl)-piperidine-1-...)
Affinity DataKi:  1.30nMAssay Description:Inhibitory activity against human mast cell tryptase betaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50156460(3-[4-(3-Aminomethyl-phenyl)-piperidine-1-carbonyl]...)
Affinity DataKi:  1.5nMAssay Description:Inhibitory activity against human mast cell tryptase betaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM24226(1-[(4-fluorophenyl)methyl]-N-{1-[2-(4-methoxypheny...)
Affinity DataKi:  3nMAssay Description:Binding affinity towards histamine H1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetTryptase beta-2(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50156457(CHEMBL186730 | [4-(5-Aminomethyl-2-fluoro-phenyl)-...)
Affinity DataKi:  4.30nMAssay Description:Inhibitory activity against human mast cell tryptase betaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-1 catalytic subunit(Gallus gallus)
Hoechst Marion Roussel

Curated by ChEMBL
LigandPNGBDBM50073850((S)-2-((S)-2-Benzyloxycarbonylamino-3-methyl-butyr...)
Affinity DataKi:  10nMAssay Description:Inhibitory activity against chicken gizzard smooth muscle calpainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-1 catalytic subunit(Homo sapiens (Human))
Hoechst Marion Roussel

Curated by ChEMBL
LigandPNGBDBM50073850((S)-2-((S)-2-Benzyloxycarbonylamino-3-methyl-butyr...)
Affinity DataKi:  10nMAssay Description:Tested for inhibitory activity against calpain.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50334150(1-(1-(4,4-bis(4-fluorophenyl)butyl)piperidin-4-yl)...)
Affinity DataKi:  12nMAssay Description:Binding affinity towards Dopamine receptor D2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetD(2) dopamine receptor(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50002338((Thioridazine)10-[2-(1-Methyl-piperidin-2-yl)-ethy...)
Affinity DataKi:  27nMAssay Description:Binding affinity towards Dopamine receptor D2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

Target5-hydroxytryptamine receptor 4(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50005836(4-Amino-5-chloro-N-{1-[3-(4-fluoro-phenoxy)-propyl...)
Affinity DataKi:  29nMAssay Description:Binding affinity towards Serotonin 5-hydroxytryptamine 4 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50167517(CHEMBL191546 | [4-(3-Aminomethyl-phenyl)-piperidin...)
Affinity DataKi:  32nMAssay Description:In vitro inhibitory activity against tryptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-1 catalytic subunit(Homo sapiens (Human))
Hoechst Marion Roussel

Curated by ChEMBL
LigandPNGBDBM50080206(CHEMBL311735 | [1-((4S,5R)-4-Benzyl-5-hydroxy-oxaz...)
Affinity DataKi:  33nMAssay Description:Tested for inhibitory activity against calpain.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50167534(CHEMBL370284 | [4-(3-Aminomethyl-phenyl)-piperidin...)
Affinity DataKi:  41nMAssay Description:In vitro inhibitory activity against tryptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50167531(CHEMBL365527 | [4-(3-Aminomethyl-phenyl)-piperidin...)
Affinity DataKi:  41nMAssay Description:In vitro inhibitory activity against tryptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50167524(CHEMBL192963 | [4-(3-Aminomethyl-phenyl)-piperidin...)
Affinity DataKi:  49nMAssay Description:In vitro inhibitory activity against tryptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50167525(CHEMBL193514 | [4-(3-Aminomethyl-phenyl)-piperidin...)
Affinity DataKi:  57nMAssay Description:In vitro inhibitory activity against tryptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50017376((+/-)1-(4-tert-butylphenyl)-4-(4-(hydroxydiphenylm...)
Affinity DataKi:  58nMAssay Description:Binding affinity towards histamine H1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50156459(3-[4-(5-Aminomethyl-2-fluoro-phenyl)-piperidine-1-...)
Affinity DataKi:  59nMAssay Description:Inhibitory activity against human mast cell tryptase betaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50167530(CHEMBL189101 | [4-(3-Aminomethyl-phenyl)-piperidin...)
Affinity DataKi:  61nMAssay Description:In vitro inhibitory activity against tryptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50167514(CHEMBL370463 | [4-(3-Aminomethyl-phenyl)-piperidin...)
Affinity DataKi:  68nMAssay Description:Binding affinity of compound towards Factor XaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50156458(3-[4-(5-Aminomethyl-2-fluoro-phenyl)-piperidine-1-...)
Affinity DataKi:  88nMAssay Description:Inhibitory activity against human mast cell tryptase betaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50167520(CHEMBL365148 | [4-(3-Aminomethyl-phenyl)-piperidin...)
Affinity DataKi:  101nMAssay Description:In vitro inhibitory activity against tryptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50167526(CHEMBL365189 | [4-(3-Aminomethyl-phenyl)-piperidin...)
Affinity DataKi:  116nMAssay Description:In vitro inhibitory activity against tryptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin B(Bos taurus (bovine))
Hoechst Marion Roussel

Curated by ChEMBL
LigandPNGBDBM50080206(CHEMBL311735 | [1-((4S,5R)-4-Benzyl-5-hydroxy-oxaz...)
Affinity DataKi:  120nMAssay Description:Tested for inhibitory activity against bovine cathepsin B.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50167522(CHEMBL372028 | [4-(3-Aminomethyl-phenyl)-piperidin...)
Affinity DataKi:  124nMAssay Description:In vitro inhibitory activity against tryptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50167521(CHEMBL364661 | [4-(3-Aminomethyl-phenyl)-piperidin...)
Affinity DataKi:  125nMAssay Description:In vitro inhibitory activity against tryptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50167511(CHEMBL189531 | [4-(3-Aminomethyl-phenyl)-piperidin...)
Affinity DataKi:  128nMAssay Description:In vitro inhibitory activity against tryptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM16127(2,2 -methanediylbis(1H-benzimidazole-6-carboximida...)
Affinity DataKi:  140nMAssay Description:In vitro inhibitory activity against tryptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50167523(CHEMBL190103 | [4-(3-Aminomethyl-phenyl)-piperidin...)
Affinity DataKi:  141nMAssay Description:In vitro inhibitory activity against tryptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50167535(CHEMBL191007 | [4-(3-Aminomethyl-phenyl)-piperidin...)
Affinity DataKi:  155nMAssay Description:In vitro inhibitory activity against tryptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50167533(CHEMBL435694 | [4-(3-Aminomethyl-phenyl)-piperidin...)
Affinity DataKi:  162nMAssay Description:In vitro inhibitory activity against tryptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50167510(CHEMBL361040 | [4-(3-Aminomethyl-phenyl)-piperidin...)
Affinity DataKi:  185nMAssay Description:In vitro inhibitory activity against tryptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50167529(CHEMBL372912 | [4-(3-Aminomethyl-phenyl)-piperidin...)
Affinity DataKi:  197nMAssay Description:In vitro inhibitory activity against tryptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50167515(1-{3-[4-(3-Aminomethyl-phenyl)-piperidine-1-carbon...)
Affinity DataKi:  240nMAssay Description:In vitro inhibitory activity against tryptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50167513(CHEMBL192214 | [4-(3-Aminomethyl-phenyl)-piperidin...)
Affinity DataKi:  246nMAssay Description:In vitro inhibitory activity against tryptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50167528(CHEMBL436537 | [4-(3-Aminomethyl-phenyl)-piperidin...)
Affinity DataKi:  290nMAssay Description:In vitro inhibitory activity against tryptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50167519(CHEMBL190135 | [4-(3-Aminomethyl-phenyl)-piperidin...)
Affinity DataKi:  310nMAssay Description:In vitro inhibitory activity against tryptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Rattus norvegicus (Rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50281462((R)-2-[(6S,7S)-6-((R)-2-Mercapto-3-phenyl-propiony...)
Affinity DataKi:  330nMAssay Description:Compound was tested for inhibition of neutral endopeptidase (NEP).More data for this Ligand-Target Pair
In DepthDetails Article
TargetTryptase beta-2(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50167527(CHEMBL189983 | [4-(3-Aminomethyl-phenyl)-piperidin...)
Affinity DataKi:  368nMAssay Description:In vitro inhibitory activity against tryptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50167518(CHEMBL189372 | [4-(3-Aminomethyl-phenyl)-piperidin...)
Affinity DataKi:  373nMAssay Description:In vitro inhibitory activity against tryptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-1 catalytic subunit(Homo sapiens (Human))
Hoechst Marion Roussel

Curated by ChEMBL
LigandPNGBDBM50080207(CHEMBL80142 | {1-[((S)-1-Formyl-2-phenyl-ethyl)-hy...)
Affinity DataKi:  400nMAssay Description:Tested for inhibitory activity against calpain.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-1 catalytic subunit(Homo sapiens (Human))
Hoechst Marion Roussel

Curated by ChEMBL
LigandPNGBDBM50080209(CHEMBL78324 | {1-[((S)-1-Formyl-2-phenyl-ethyl)-me...)
Affinity DataKi:  400nMAssay Description:Tested for inhibitory activity against calpain.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50167516(CHEMBL191731 | [4-(3-Aminomethyl-phenyl)-piperidin...)
Affinity DataKi:  497nMAssay Description:In vitro inhibitory activity against tryptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-1 catalytic subunit(Homo sapiens (Human))
Hoechst Marion Roussel

Curated by ChEMBL
LigandPNGBDBM50366611(CHEMBL1794816)
Affinity DataKi:  1.50E+3nMAssay Description:Tested for inhibitory activity against calpain.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-1 catalytic subunit(Homo sapiens (Human))
Hoechst Marion Roussel

Curated by ChEMBL
LigandPNGBDBM50080210(Acetic acid (4S,5S)-4-benzyl-3-(2-benzyloxycarbony...)
Affinity DataKi:  2.00E+3nMAssay Description:Tested for inhibitory activity against calpainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-1 catalytic subunit(Gallus gallus)
Hoechst Marion Roussel

Curated by ChEMBL
LigandPNGBDBM50073851(((1S,4R)-4-Benzyl-1-isopropyl-2,5-dioxo-pentyl)-ca...)
Affinity DataKi:  2.50E+3nMAssay Description:Inhibitory activity against chicken gizzard smooth muscle calpainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-1 catalytic subunit(Homo sapiens (Human))
Hoechst Marion Roussel

Curated by ChEMBL
LigandPNGBDBM50366612(CHEMBL1794817)
Affinity DataKi:  3.20E+3nMAssay Description:Tested for inhibitory activity against calpain.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50167532(CHEMBL191072 | [4-(3-Aminomethyl-phenyl)-piperidin...)
Affinity DataKi: >2.00E+4nMAssay Description:In vitro inhibitory activity against tryptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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