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Found 1325 with Last Name = 'vincent' and Initial = 'l'
TargetSubstance-P receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50030332((R)-(2-Methoxy-benzyl)-((S)-2-phenyl-piperidin-3-y...)
Affinity DataKi:  0.170nMAssay Description:In vitro binding affinity against substance P (NK-1) receptor in human IM-9 cell using [125I]-BH-SPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A/3B(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50014174(2-(1H-Imidazol-4-ylmethyl)-4-phenyl-thiazole | CHE...)
Affinity DataKi:  0.990nMAssay Description:In vitro inhibition of rat liver dihydrofolate reductase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A/3B(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50014154(2-(5-Methyl-1H-imidazol-4-ylmethyl)-4-phenyl-thiaz...)
Affinity DataKi:  1.5nMAssay Description:Antibacterial activity against Escherichia coli DHFRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50030333((3S,6S,7S)-3-(2-Methoxy-phenyl)-7-phenyl-1,8-diaza...)
Affinity DataKi:  2nMAssay Description:In vitro binding affinity against substance P (NK-1) receptor in human IM-9 cell using [125I]-BH-SPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Mus musculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50279827(2-((S)-2-Formyl-pyrrolidine-1-carbonyl)-2,3-dihydr...)
Affinity DataKi:  2.40nM Kon:  0.000300M-1s-1 Koff:  1.40E+5s-1Assay Description:Compound was evaluated for the enzyme kinetic data (kon) for binding inhibition against Prolyl Endopeptidase (PEP)More data for this Ligand-Target Pair
In DepthDetails Article
Target5-hydroxytryptamine receptor 3A/3B(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50108392((3-ENDO)-8-METHYL-8-AZABICYCLO[3.2.1]OCT-3-YL 1H-I...)
Affinity DataKi:  2.70nMAssay Description:In vitro inhibition of rat liver dihydrofolate reductase.More data for this Ligand-Target Pair
TargetProlyl endopeptidase(Mus musculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50279826((1S,2S)-2-((S)-2-Formyl-pyrrolidine-1-carbonyl)-cy...)
Affinity DataKi:  3nM Kon:  0.000700M-1s-1 Koff:  2.30E+5s-1Assay Description:Compound was evaluated for the enzyme kinetic data (kon) for binding inhibition against Prolyl Endopeptidase (PEP)More data for this Ligand-Target Pair
In DepthDetails Article
TargetProlyl endopeptidase(Mus musculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50279825((1R,2S)-2-((S)-2-Formyl-pyrrolidine-1-carbonyl)-cy...)
Affinity DataKi:  3nM Kon:  0.00200M-1s-1 Koff:  7.00E+5s-1Assay Description:Compound was evaluated for the enzyme kinetic data (kon) for binding inhibition against Prolyl Endopeptidase (PEP)More data for this Ligand-Target Pair
In DepthDetails Article
TargetProlyl endopeptidase(Mus musculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50279825((1R,2S)-2-((S)-2-Formyl-pyrrolidine-1-carbonyl)-cy...)
Affinity DataKi:  3nMAssay Description:Compound was evaluated for binding inhibition against Prolyl Endopeptidase (PEP).More data for this Ligand-Target Pair
In DepthDetails Article
Target5-hydroxytryptamine receptor 3A/3B(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50013039(CHEMBL40260 | N-[4-(1H-Indol-3-yl)-thiazol-2-ylmet...)
Affinity DataKi:  3.30nMAssay Description:In vitro inhibition of dihydrofolate reductase of Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A/3B(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50013043(3-[2-(5-Methyl-1H-imidazol-4-ylmethyl)-thiazol-4-y...)
Affinity DataKi:  10nMAssay Description:In vitro inhibition of rat liver dihydrofolate reductase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A/3B(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50014600(3-[2-(1H-Imidazol-4-ylmethyl)-thiazol-4-yl]-1H-ind...)
Affinity DataKi:  14nMAssay Description:In vitro inhibition of rat liver dihydrofolate reductase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A/3B(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM85330(CAS_68647 | NSC_68647 | ONDANSETRON | Ondansetron ...)
Affinity DataKi:  16nMAssay Description:In vitro inhibition of rat liver dihydrofolate reductase.More data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 3A/3B(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50014601(2-(2-Methyl-1H-imidazol-4-ylmethyl)-4-phenyl-thiaz...)
Affinity DataKi:  226nMAssay Description:In vitro inhibition of Escherichia coli dihydrofolate reductase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A/3B(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50013045(3-[2-(2-Methyl-imidazol-1-ylmethyl)-thiazol-4-yl]-...)
Affinity DataKi: >1.00E+3nMAssay Description:In vitro inhibition of rat liver dihydrofolate reductase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A/3B(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50014406(2-Me 5-HT | 2-Methyl-5-hydroxytryptamine | 2-methy...)
Affinity DataKi:  1.22E+3nMAssay Description:In vitro inhibition of Escherichia coli dihydrofolate reductase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50030331((2S,5R,6S)-2-(2-Methoxy-phenyl)-6-phenyl-1,7-diaza...)
Affinity DataKi: >1.00E+4nMAssay Description:In vitro binding affinity against substance P (NK-1) receptor in human IM-9 cell using [125I]-BH-SPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50134778((S)-3-(6-Methoxy-pyridin-3-yl)-3-{2-oxo-3-[3-(5,6,...)
Affinity DataIC50:  0.300nMAssay Description:Antagonist activity at integrin alphaVbeta3 in human A375M cells assessed as cell adhesion to fibrinogen in presence of Mg2+More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50383866(CHEMBL2031174)
Affinity DataIC50:  0.300nMAssay Description:Antagonist activity at integrin alphavbeta3 in human A375M cells assessed as inhibition of cell adhesion to fibrinogen in presence of Mg2+More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50183849((S)-2-(((4-(3-chloro-2-fluorophenylamino)-7-methox...)
Affinity DataIC50: <1nMAssay Description:Inhibition of EGFR in presence of 2 uM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-5/beta-1(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50383865(CHEMBL2031169)
Affinity DataIC50:  1nMAssay Description:Binding affinity to integrin alpha5beta1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50383861(CHEMBL2031160)
Affinity DataIC50:  1nMAssay Description:Antagonist activity at integrin alphavbeta3 in human A375M cells assessed as inhibition of cell adhesion to fibrinogen in presence of Mg2+More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-5/beta-1(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50383801(CHEMBL2030968)
Affinity DataIC50:  1nMAssay Description:Binding affinity to integrin alpha5beta1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-5/beta-1(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50383787(CHEMBL2030806)
Affinity DataIC50:  1nMAssay Description:Binding affinity to integrin alpha5beta1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50447088(CHEMBL3112850)
Affinity DataIC50:  1nMAssay Description:Inhibition of N-terminal ploy-His-tagged human PI3Kbeta expressed in baculovirus-infected sf21 cells using PI(4,5)P2 as substrate after 15 mins by HT...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-5/beta-1(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50383799(CHEMBL2030805)
Affinity DataIC50:  1nMAssay Description:Binding affinity to integrin alpha5beta1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50447089(CHEMBL3112849)
Affinity DataIC50:  1nMAssay Description:Inhibition of N-terminal ploy-His-tagged human PI3Kbeta expressed in baculovirus-infected sf21 cells using PI(4,5)P2 as substrate after 15 mins by HT...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-5/beta-1(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50383784(CHEMBL2030810)
Affinity DataIC50:  1nMAssay Description:Binding affinity to integrin alpha5beta1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-5/beta-1(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50383862(CHEMBL2031168)
Affinity DataIC50:  1nMAssay Description:Binding affinity to integrin alpha5beta1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-5/beta-1(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50383793(CHEMBL2030799)
Affinity DataIC50:  2nMAssay Description:Binding affinity to integrin alpha5beta1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-5/beta-1(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50383861(CHEMBL2031160)
Affinity DataIC50:  2nMAssay Description:Antagonist activity at integrin alpha5beta1 in human A375M cells assessed as inhibition of cell adhesion to fibronectin in presence of Mg2+ and MK-04...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-5/beta-1(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50383803(CHEMBL2030961)
Affinity DataIC50:  2nMAssay Description:Binding affinity to integrin alpha5beta1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-5/beta-1(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50383802(CHEMBL2030964)
Affinity DataIC50:  2nMAssay Description:Binding affinity to integrin alpha5beta1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50392456(CHEMBL2151926)
Affinity DataIC50:  2nMAssay Description:Inhibition of PI3KbetaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50447078(CHEMBL3112860 | US9133168, Example 18d)
Affinity DataIC50:  2nMAssay Description:Inhibition of N-terminal ploy-His-tagged human PI3Kdelta expressed in baculovirus-infected sf9 cells using PI(4,5)P2 as substrate after 15 mins by HT...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-5/beta-1(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50383863(CHEMBL2031162)
Affinity DataIC50:  3nMAssay Description:Binding affinity to integrin alpha5beta1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-5/beta-1(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50383788(CHEMBL2030804)
Affinity DataIC50:  3nMAssay Description:Binding affinity to integrin alpha5beta1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-5/beta-1(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50383794(CHEMBL2030798)
Affinity DataIC50:  3nMAssay Description:Binding affinity to integrin alpha5beta1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50447089(CHEMBL3112849)
Affinity DataIC50:  3nMAssay Description:Inhibition of N-terminal ploy-His-tagged human PI3Kbeta expressed in baculovirus-infected sf21 cells using PI(4,5)P2 as substrate after 15 mins by HT...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50389047(CHEMBL2064328)
Affinity DataIC50:  3nMAssay Description:Inhibition of human PI3Kbeta-mediated Akt phosphorylation at Ser473 residue expressed in PTEN-deficient human PC3 cells by chemiluminescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50365890(CHEMBL1957875)
Affinity DataIC50:  3nMAssay Description:Inhibition of human PI3Kbeta-mediated Akt phosphorylation at T308 residue expressed in PTEN-deficient human PC3 cells after 2 hrs by Western blot ana...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-5/beta-1(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50383804(CHEMBL2030960)
Affinity DataIC50:  3nMAssay Description:Binding affinity to integrin alpha5beta1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50392457(CHEMBL2151927)
Affinity DataIC50:  3nMAssay Description:Inhibition of PI3KbetaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50389047(CHEMBL2064328)
Affinity DataIC50:  3nMAssay Description:Inhibition of human PI3Kbeta-mediated Akt phosphorylation at T308 residue expressed in PTEN-deficient human PC3 cells after 2 hrs by Western blot ana...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50447087(CHEMBL3112851)
Affinity DataIC50:  3nMAssay Description:Inhibition of N-terminal ploy-His-tagged human PI3Kbeta expressed in baculovirus-infected sf21 cells using PI(4,5)P2 as substrate after 15 mins by HT...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-5/beta-1(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50383875(CHEMBL2031172)
Affinity DataIC50:  3nMAssay Description:Binding affinity to integrin alpha5beta1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50447093(CHEMBL3112690)
Affinity DataIC50:  4nMAssay Description:Inhibition of N-terminal ploy-His-tagged human PI3Kbeta expressed in baculovirus-infected sf21 cells using PI(4,5)P2 as substrate after 15 mins by HT...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50447100(CHEMBL3112862)
Affinity DataIC50:  4nMAssay Description:Inhibition of N-terminal ploy-His-tagged human PI3Kbeta expressed in baculovirus-infected sf21 cells using PI(4,5)P2 as substrate after 15 mins by HT...More data for this Ligand-Target Pair
LigandPNGBDBM50447092(CHEMBL3112847)
Affinity DataIC50:  4nMAssay Description:Inhibition of N-terminal ploy-His-tagged human PI3Kbeta expressed in baculovirus-infected sf21 cells using PI(4,5)P2 as substrate after 15 mins by HT...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-5/beta-1(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50383789(CHEMBL2030803)
Affinity DataIC50:  4nMAssay Description:Binding affinity to integrin alpha5beta1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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