Found 209 with Last Name = 'viswanathan' and Initial = 'k' TargetBifunctional dihydrofolate reductase-thymidylate synthase(Cryptosporidium hominis)
University of Connecticut
US Patent
University of Connecticut
US Patent
Affinity DataIC50: 1.10nMAssay Description:Compounds were evaluated in spectrophotometric enzyme assays using ChDHFR-TS and hDHFR. Inhibition constants (IC50) were measured (see Table 4). The ...More data for this Ligand-Target Pair
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Cryptosporidium hominis)
University of Connecticut
US Patent
University of Connecticut
US Patent
Affinity DataIC50: 1.80nMAssay Description:Compounds were evaluated in spectrophotometric enzyme assays using ChDHFR-TS and hDHFR. Inhibition constants (IC50) were measured (see Table 4). The ...More data for this Ligand-Target Pair
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Cryptosporidium hominis)
University of Connecticut
US Patent
University of Connecticut
US Patent
Affinity DataIC50: 2.10nMAssay Description:Compounds were evaluated in spectrophotometric enzyme assays using ChDHFR-TS and hDHFR. Inhibition constants (IC50) were measured (see Table 4). The ...More data for this Ligand-Target Pair
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Cryptosporidium hominis)
University of Connecticut
US Patent
University of Connecticut
US Patent
Affinity DataIC50: 2.10nMAssay Description:Compounds were evaluated in spectrophotometric enzyme assays using ChDHFR-TS and hDHFR. Inhibition constants (IC50) were measured (see Table 4). The ...More data for this Ligand-Target Pair
Affinity DataIC50: 2.40nMAssay Description:Heterocyclic analogs of propargyl-linked inhibitors of the third
generation analogs were evaluated in enzyme inhibition assays, assessed
for S. aur...More data for this Ligand-Target Pair
3D Structure (crystal)TargetNACHT, LRR and PYD domains-containing protein 3(Homo sapiens (Human))
Cadila Healthcare
Curated by ChEMBL
Cadila Healthcare
Curated by ChEMBL
Affinity DataIC50: 5.30nMAssay Description:Inhibition of NLRP3 inflammasome activation in LPS-primed human THP1 cells assessed as reduction in IL-1beta level preincubated for 1 hr followed by ...More data for this Ligand-Target Pair
Affinity DataIC50: 5.90nMAssay Description:Heterocyclic analogs of propargyl-linked inhibitors of the third
generation analogs were evaluated in enzyme inhibition assays, assessed
for S. aur...More data for this Ligand-Target Pair
TargetNACHT, LRR and PYD domains-containing protein 3(Homo sapiens (Human))
Cadila Healthcare
Curated by ChEMBL
Cadila Healthcare
Curated by ChEMBL
Affinity DataIC50: 6.80nMAssay Description:Inhibition of NLRP3 inflammasome activation in LPS-primed human THP1 cells assessed as reduction in IL-1beta level preincubated for 1 hr followed by ...More data for this Ligand-Target Pair
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Cryptosporidium hominis)
University of Connecticut
US Patent
University of Connecticut
US Patent
Affinity DataIC50: 7.40nMAssay Description:Compounds were evaluated in spectrophotometric enzyme assays using ChDHFR-TS and hDHFR. Inhibition constants (IC50) were measured (see Table 4). The ...More data for this Ligand-Target Pair
TargetNACHT, LRR and PYD domains-containing protein 3(Homo sapiens (Human))
Cadila Healthcare
Curated by ChEMBL
Cadila Healthcare
Curated by ChEMBL
Affinity DataIC50: 8nMAssay Description:Inhibition of NLRP3 in human THP1 cells assessed as inhibition of IL-1beta productionMore data for this Ligand-Target Pair
TargetNACHT, LRR and PYD domains-containing protein 3(Homo sapiens (Human))
Cadila Healthcare
Curated by ChEMBL
Cadila Healthcare
Curated by ChEMBL
Affinity DataIC50: 8nMAssay Description:Inhibition of NLRP3 inflammasome activation in LPS-primed human THP1 cells assessed as reduction in IL-1beta level preincubated for 1 hr followed by ...More data for this Ligand-Target Pair
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Cryptosporidium hominis)
University of Connecticut
US Patent
University of Connecticut
US Patent
Affinity DataIC50: 10nMAssay Description:Compounds were evaluated in spectrophotometric enzyme assays using ChDHFR-TS and hDHFR. Inhibition constants (IC50) were measured (see Table 4). The ...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
University Of Connecticut
Curated by ChEMBL
University Of Connecticut
Curated by ChEMBL
Affinity DataIC50: 11.9nMAssay Description:Inhibition of human recombinant P110alpha/p85alpha using phosphatidyl inositol as substrate after 1 hr by ADP-Glo Kinase assayMore data for this Ligand-Target Pair
TargetNACHT, LRR and PYD domains-containing protein 3(Homo sapiens (Human))
Cadila Healthcare
Curated by ChEMBL
Cadila Healthcare
Curated by ChEMBL
Affinity DataIC50: 12nMAssay Description:Inhibition of NLRP3 inflammasome activation in LPS-primed human THP1 cells assessed as reduction in IL-1beta level preincubated for 1 hr followed by ...More data for this Ligand-Target Pair
Affinity DataIC50: 12nMAssay Description:Inhibition of Staphylococcus aureus DHFR assessed as reduction in rate of NADPH consumptionMore data for this Ligand-Target Pair
Affinity DataIC50: 12nMAssay Description:Heterocyclic analogs of propargyl-linked inhibitors of the third
generation analogs were evaluated in enzyme inhibition assays, assessed
for S. aur...More data for this Ligand-Target Pair
TargetNACHT, LRR and PYD domains-containing protein 3(Homo sapiens (Human))
Cadila Healthcare
Curated by ChEMBL
Cadila Healthcare
Curated by ChEMBL
Affinity DataIC50: 15nMAssay Description:Inhibition of NLRP3 inflammasome activation in LPS-primed human THP1 cells assessed as reduction in IL-1beta level preincubated for 1 hr followed by ...More data for this Ligand-Target Pair
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Cryptosporidium hominis)
University of Connecticut
US Patent
University of Connecticut
US Patent
Affinity DataIC50: 16nMAssay Description:Compounds were evaluated in spectrophotometric enzyme assays using ChDHFR-TS and hDHFR. Inhibition constants (IC50) were measured (see Table 4). The ...More data for this Ligand-Target Pair
Affinity DataIC50: 17nMAssay Description:Inhibition of Candida albicans DHFRMore data for this Ligand-Target Pair
Affinity DataIC50: 18nMAssay Description:Inhibition of Candida albicans DHFR using dihydrofolate as substrate preincubated for 5 mins followed by substrate addition in presence of NADPHMore data for this Ligand-Target Pair
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Cryptosporidium hominis)
University of Connecticut
US Patent
University of Connecticut
US Patent
Affinity DataIC50: 19nMAssay Description:Compounds were evaluated in spectrophotometric enzyme assays using ChDHFR-TS and hDHFR. Inhibition constants (IC50) were measured (see Table 4). The ...More data for this Ligand-Target Pair
Affinity DataIC50: 19nMAssay Description:Inhibition of Staphylococcus aureus DHFR assessed as reduction in rate of NADPH consumptionMore data for this Ligand-Target Pair
Affinity DataIC50: 19nMAssay Description:Heterocyclic analogs of propargyl-linked inhibitors of the third
generation analogs were evaluated in enzyme inhibition assays, assessed
for S. aur...More data for this Ligand-Target Pair
Affinity DataIC50: 19nMAssay Description:Heterocyclic analogs of propargyl-linked inhibitors of the third
generation analogs were evaluated in enzyme inhibition assays, assessed
for S. aur...More data for this Ligand-Target Pair
Affinity DataIC50: 20nMAssay Description:Inhibition of Candida albicans DHFR using dihydrofolate as substrate preincubated for 5 mins followed by substrate addition in presence of NADPHMore data for this Ligand-Target Pair
Affinity DataIC50: 20nMAssay Description:Heterocyclic analogs of propargyl-linked inhibitors of the third
generation analogs were evaluated in enzyme inhibition assays, assessed
for S. aur...More data for this Ligand-Target Pair
Affinity DataIC50: 21nMAssay Description:Inhibition of Candida albicans DHFRMore data for this Ligand-Target Pair
Affinity DataIC50: 21nMAssay Description:Inhibition of Staphylococcus aureus DHFR assessed as reduction in rate of NADPH consumptionMore data for this Ligand-Target Pair
Affinity DataIC50: 21nMAssay Description:Heterocyclic analogs of propargyl-linked inhibitors of the third
generation analogs were evaluated in enzyme inhibition assays, assessed
for S. aur...More data for this Ligand-Target Pair
TargetNACHT, LRR and PYD domains-containing protein 3(Homo sapiens (Human))
Cadila Healthcare
Curated by ChEMBL
Cadila Healthcare
Curated by ChEMBL
Affinity DataIC50: 21nMAssay Description:Inhibition of NLRP3 inflammasome activation in LPS-primed human THP1 cells assessed as reduction in IL-1beta level preincubated for 1 hr followed by ...More data for this Ligand-Target Pair
Affinity DataIC50: 22nMAssay Description:Inhibition of Candida albicans DHFRMore data for this Ligand-Target Pair
Affinity DataIC50: 23nMAssay Description:Inhibition of Candida albicans DHFRMore data for this Ligand-Target Pair
Affinity DataIC50: 23nMAssay Description:Inhibition of Candida albicans DHFRMore data for this Ligand-Target Pair
Affinity DataIC50: 23nMAssay Description:Inhibition of Candida albicans DHFR using dihydrofolate as substrate preincubated for 5 mins followed by substrate addition in presence of NADPHMore data for this Ligand-Target Pair
Affinity DataIC50: 23nMAssay Description:Heterocyclic analogs of propargyl-linked inhibitors of the third
generation analogs were evaluated in enzyme inhibition assays, assessed
for S. aur...More data for this Ligand-Target Pair
Affinity DataIC50: 23nMAssay Description:Heterocyclic analogs of propargyl-linked inhibitors of the third
generation analogs were evaluated in enzyme inhibition assays, assessed
for S. aur...More data for this Ligand-Target Pair
TargetNACHT, LRR and PYD domains-containing protein 3(Homo sapiens (Human))
Cadila Healthcare
Curated by ChEMBL
Cadila Healthcare
Curated by ChEMBL
Affinity DataIC50: 23nMAssay Description:Inhibition of NLRP3 inflammasome activation in LPS-primed human THP1 cells assessed as reduction in IL-1beta level preincubated for 1 hr followed by ...More data for this Ligand-Target Pair
TargetNACHT, LRR and PYD domains-containing protein 3(Homo sapiens (Human))
Cadila Healthcare
Curated by ChEMBL
Cadila Healthcare
Curated by ChEMBL
Affinity DataIC50: 24nMAssay Description:Inhibition of NLRP3 inflammasome activation in human THP1 cells assessed as inhibition of IL-1beta release in presence of MSUMore data for this Ligand-Target Pair
TargetNACHT, LRR and PYD domains-containing protein 3(Homo sapiens (Human))
Cadila Healthcare
Curated by ChEMBL
Cadila Healthcare
Curated by ChEMBL
Affinity DataIC50: 26nMAssay Description:Inhibition of NLRP3 inflammasome activation in human THP1 cells assessed as inhibition of IL-1beta release in presence of nigericinMore data for this Ligand-Target Pair
Affinity DataIC50: 26nMAssay Description:Heterocyclic analogs of propargyl-linked inhibitors of the third
generation analogs were evaluated in enzyme inhibition assays, assessed
for S. aur...More data for this Ligand-Target Pair
Affinity DataIC50: 26nMAssay Description:Heterocyclic analogs of propargyl-linked inhibitors of the third
generation analogs were evaluated in enzyme inhibition assays, assessed
for S. aur...More data for this Ligand-Target Pair
Affinity DataIC50: 26nMAssay Description:Inhibition of Staphylococcus aureus DHFR assessed as reduction in rate of NADPH consumptionMore data for this Ligand-Target Pair
Affinity DataIC50: 26nMAssay Description:Heterocyclic analogs of propargyl-linked inhibitors of the third
generation analogs were evaluated in enzyme inhibition assays, assessed
for S. aur...More data for this Ligand-Target Pair
Affinity DataIC50: 26nMAssay Description:Inhibition of Staphylococcus aureus DHFR assessed as reduction in rate of NADPH consumptionMore data for this Ligand-Target Pair
Affinity DataIC50: 26nMAssay Description:Heterocyclic analogs of propargyl-linked inhibitors of the third
generation analogs were evaluated in enzyme inhibition assays, assessed
for S. aur...More data for this Ligand-Target Pair
Affinity DataIC50: 28nMAssay Description:Heterocyclic analogs of propargyl-linked inhibitors of the third
generation analogs were evaluated in enzyme inhibition assays, assessed
for S. aur...More data for this Ligand-Target Pair
Affinity DataIC50: 28nMAssay Description:Heterocyclic analogs of propargyl-linked inhibitors of the third
generation analogs were evaluated in enzyme inhibition assays, assessed
for S. aur...More data for this Ligand-Target Pair
Affinity DataIC50: 29nMAssay Description:Inhibition of Staphylococcus aureus DHFR assessed as reduction in rate of NADPH consumptionMore data for this Ligand-Target Pair
Affinity DataIC50: 29nMAssay Description:Heterocyclic analogs of propargyl-linked inhibitors of the third
generation analogs were evaluated in enzyme inhibition assays, assessed
for S. aur...More data for this Ligand-Target Pair
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Cryptosporidium hominis)
University of Connecticut
US Patent
University of Connecticut
US Patent
Affinity DataIC50: 30nMAssay Description:Compounds were evaluated in spectrophotometric enzyme assays using ChDHFR-TS and hDHFR. Inhibition constants (IC50) were measured (see Table 4). The ...More data for this Ligand-Target Pair
