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Found 642 with Last Name = 'watson' and Initial = 'i'
TargetFocal adhesion kinase 1(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50318884(CHEMBL1084546 | CHEMBL2430359 | N-methyl-N-(3-((2-...)
Affinity DataIC50:  1nMAssay Description:Inhibition of PTK2 (unknown origin)More data for this Ligand-Target Pair
TargetPlatelet-derived growth factor receptor alpha(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM13530(4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[...)
Affinity DataIC50:  2nMAssay Description:Inhibition of PDGFRA (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM31085(1-[4-[(4-ethyl-1-piperazinyl)methyl]-3-(trifluorom...)
Affinity DataIC50:  5nMAssay Description:Inhibition of FLT3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50306682((R)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(1...)
Affinity DataIC50:  5nMAssay Description:Inhibition of ALK (unknown origin)More data for this Ligand-Target Pair
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM13216(BMS-354825 | CHEMBL1421 | DASATINIB | N-(2-Chloro-...)
Affinity DataIC50:  5nMAssay Description:Inhibition of CSF1R (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM12985(5-Amido-pyrrolopyrazole 9d | CHEMBL402548 | N-{5-[...)
Affinity DataIC50:  7.90nMAssay Description:Inhibition of ABL1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 9(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50439561(CHEMBL1965660 | US9670191, F26)
Affinity DataIC50:  10nMAssay Description:Inhibition of CDK9 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM6866(1-Acyl-1H-[1,2,4]triazole-3,5-diamine Analogue 3b ...)
Affinity DataIC50:  13nMAssay Description:Inhibition of CDK5 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50277583(2-amino-4-methyl-1,3-thiazol-5-yl)-N-[4-(morpholin...)
Affinity DataIC50:  25nMAssay Description:Inhibition of FLT3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM13534(CHEMBL572878 | N-[4-({4-[(3-methyl-1H-pyrazol-5-yl...)
Affinity DataIC50:  32nMAssay Description:Inhibition of AURKA (unknown origin)More data for this Ligand-Target Pair
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50396934(CHEMBL2001019 | CHEMBL2170804 | US9062045, Compara...)
Affinity DataIC50:  50nMAssay Description:Inhibition of MET (unknown origin)More data for this Ligand-Target Pair
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM482158(BDBM50242742 | TAE684)
Affinity DataIC50:  50nMAssay Description:Inhibition of CSF1R (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM33971(AEB071 | Sotrastaurin | med.21724, Compound 190)
Affinity DataIC50:  50nMAssay Description:Inhibition of PIM1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM6309(6-Acetyl-8-cyclopentyl-5-methyl-2-(5-piperazin-1-y...)
Affinity DataIC50:  63nMAssay Description:Inhibition of JAK3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50277545(4-(9-chloro-7-(2-fluoro-6-methoxyphenyl)-5H-benzo[...)
Affinity DataIC50:  100nMAssay Description:Inhibition of AURKA (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM26300(2-{3-[(7-{3-[ethyl(2-hydroxyethyl)amino]propoxy}qu...)
Affinity DataIC50:  100nMAssay Description:Inhibition of FLT3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 5(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM30185(CHEMBL226403 | Pyrrolopyridine, 16)
Affinity DataIC50:  100nMAssay Description:Inhibition of MAPKAPK5 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM30192(Pyrrolopyridine, 23)
Affinity DataIC50:  501nMAssay Description:Inhibition of JAK3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk2(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50299272(4-(6-(1H-indol-6-yloxy)-5-aminopyrazin-2-yl)-N-(py...)
Affinity DataIC50:  580nMAssay Description:Inhibition of recombinant CHK2 by [gamma-33-P]-ATP based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk2(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50299273((R)-4-(6-(1H-indol-6-yloxy)-5-aminopyrazin-2-yl)-N...)
Affinity DataIC50:  610nMAssay Description:Inhibition of recombinant CHK2 by [gamma-33-P]-ATP based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 9(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50439560(CHEMBL1967252)
Affinity DataIC50:  631nMAssay Description:Inhibition of CDK9 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 9(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM6309(6-Acetyl-8-cyclopentyl-5-methyl-2-(5-piperazin-1-y...)
Affinity DataIC50:  794nMAssay Description:Inhibition of CDK9 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor alpha(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM31093(4-[[7-[2,6-bis(fluoranyl)phenyl]-9-chloranyl-5H-py...)
Affinity DataIC50:  794nMAssay Description:Inhibition of PDGFRA (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk2(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50299274(4-(6-(1H-indol-6-yloxy)-5-aminopyrazin-2-yl)-N-(pi...)
Affinity DataIC50:  800nMAssay Description:Inhibition of recombinant CHK2 by [gamma-33-P]-ATP based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk2(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50299275(4-(6-(1H-indol-6-yloxy)-5-aminopyrazin-2-yl)-N-(pi...)
Affinity DataIC50:  890nMAssay Description:Inhibition of recombinant CHK2 by [gamma-33-P]-ATP based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk2(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50299270(4-(6-(1H-indol-6-yloxy)-5-aminopyrazin-2-yl)-N-(py...)
Affinity DataIC50:  960nMAssay Description:Inhibition of recombinant CHK2 by [gamma-33-P]-ATP based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB-cell lymphoma 6 protein [5-128](Homo sapiens (Human))
Ontario Institute for Cancer Research

LigandPNGBDBM648376(acsmedchemlett.2c00502 OICR 10525D, 29)
Affinity DataIC50:  980nMAssay Description:To identify small molecule BCL6 inhibitors, we developed a Fluorescence Polarization (FP) assay to assess the ability of ligands to compete with a fl...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetB-cell lymphoma 6 protein [5-128](Homo sapiens (Human))
Ontario Institute for Cancer Research

LigandPNGBDBM648377(acsmedchemlett.2c00502 OICR 9483A, 30)
Affinity DataIC50:  980nMAssay Description:To identify small molecule BCL6 inhibitors, we developed a Fluorescence Polarization (FP) assay to assess the ability of ligands to compete with a fl...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetB-cell lymphoma 6 protein [5-128](Homo sapiens (Human))
Ontario Institute for Cancer Research

LigandPNGBDBM648372(acsmedchemlett.2c00502 OICR 9451A, 25)
Affinity DataIC50:  1.00E+3nMAssay Description:To identify small molecule BCL6 inhibitors, we developed a Fluorescence Polarization (FP) assay to assess the ability of ligands to compete with a fl...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM92862(US9284315, BEZ-235 | mTOR Inhibitor, BEZ235)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of JAK3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB-cell lymphoma 6 protein [5-128](Homo sapiens (Human))
Ontario Institute for Cancer Research

LigandPNGBDBM648373(acsmedchemlett.2c00502 OICR 9453A, 26)
Affinity DataIC50:  1.10E+3nMAssay Description:To identify small molecule BCL6 inhibitors, we developed a Fluorescence Polarization (FP) assay to assess the ability of ligands to compete with a fl...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetB-cell lymphoma 6 protein [5-128](Homo sapiens (Human))
Ontario Institute for Cancer Research

LigandPNGBDBM648371(acsmedchemlett.2c00502 OICR 9320D, 24)
Affinity DataIC50:  1.10E+3nMAssay Description:To identify small molecule BCL6 inhibitors, we developed a Fluorescence Polarization (FP) assay to assess the ability of ligands to compete with a fl...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails PubMed
TargetSerine/threonine-protein kinase Chk2(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50299271(4-(6-(1H-indol-6-yloxy)-5-aminopyrazin-2-yl)-N-(pi...)
Affinity DataIC50:  1.12E+3nMAssay Description:Inhibition of recombinant CHK2 by [gamma-33-P]-ATP based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk2(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50299276(4-(5-amino-6-(1-(2,6-dichlorophenyl)ethoxy)pyrazin...)
Affinity DataIC50:  1.13E+3nMAssay Description:Inhibition of recombinant CHK2 by [gamma-33-P]-ATP based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50299276(4-(5-amino-6-(1-(2,6-dichlorophenyl)ethoxy)pyrazin...)
Affinity DataIC50:  1.21E+3nMAssay Description:Inhibition of recombinant MET by [gamma-33-P]-ATP based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB-cell lymphoma 6 protein [5-128](Homo sapiens (Human))
Ontario Institute for Cancer Research

LigandPNGBDBM648374(acsmedchemlett.2c00502 OICR 9452A, 27)
Affinity DataIC50:  1.50E+3nMAssay Description:To identify small molecule BCL6 inhibitors, we developed a Fluorescence Polarization (FP) assay to assess the ability of ligands to compete with a fl...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetB-cell lymphoma 6 protein [5-128](Homo sapiens (Human))
Ontario Institute for Cancer Research

LigandPNGBDBM648375(acsmedchemlett.2c00502 Compound 28)
Affinity DataIC50:  3.20E+3nMAssay Description:To identify small molecule BCL6 inhibitors, we developed a Fluorescence Polarization (FP) assay to assess the ability of ligands to compete with a fl...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50299271(4-(6-(1H-indol-6-yloxy)-5-aminopyrazin-2-yl)-N-(pi...)
Affinity DataIC50:  3.33E+3nMAssay Description:Inhibition of recombinant MET by [gamma-33-P]-ATP based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50299272(4-(6-(1H-indol-6-yloxy)-5-aminopyrazin-2-yl)-N-(py...)
Affinity DataIC50:  3.55E+3nMAssay Description:Inhibition of recombinant MET by [gamma-33-P]-ATP based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50299270(4-(6-(1H-indol-6-yloxy)-5-aminopyrazin-2-yl)-N-(py...)
Affinity DataIC50:  4.27E+3nMAssay Description:Inhibition of recombinant MET by [gamma-33-P]-ATP based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50299274(4-(6-(1H-indol-6-yloxy)-5-aminopyrazin-2-yl)-N-(pi...)
Affinity DataIC50:  5.52E+3nMAssay Description:Inhibition of recombinant MET by [gamma-33-P]-ATP based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50299275(4-(6-(1H-indol-6-yloxy)-5-aminopyrazin-2-yl)-N-(pi...)
Affinity DataIC50:  7.09E+3nMAssay Description:Inhibition of recombinant MET by [gamma-33-P]-ATP based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB-cell lymphoma 6 protein [5-128](Homo sapiens (Human))
Ontario Institute for Cancer Research

LigandPNGBDBM648369(acsmedchemlett.2c00502 OICR 9058A, 22)
Affinity DataIC50:  1.20E+4nMAssay Description:To identify small molecule BCL6 inhibitors, we developed a Fluorescence Polarization (FP) assay to assess the ability of ligands to compete with a fl...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50299273((R)-4-(6-(1H-indol-6-yloxy)-5-aminopyrazin-2-yl)-N...)
Affinity DataIC50:  1.37E+4nMAssay Description:Inhibition of recombinant MET by [gamma-33-P]-ATP based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB-cell lymphoma 6 protein [5-128](Homo sapiens (Human))
Ontario Institute for Cancer Research

LigandPNGBDBM648368(acsmedchemlett.2c00502 OICR 7859A, 21)
Affinity DataIC50:  1.60E+4nMAssay Description:To identify small molecule BCL6 inhibitors, we developed a Fluorescence Polarization (FP) assay to assess the ability of ligands to compete with a fl...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails PubMed
TargetB-cell lymphoma 6 protein [5-128](Homo sapiens (Human))
Ontario Institute for Cancer Research

LigandPNGBDBM648364(acsmedchemlett.2c00502 OICR 7629A, 17)
Affinity DataIC50:  2.00E+4nMAssay Description:To identify small molecule BCL6 inhibitors, we developed a Fluorescence Polarization (FP) assay to assess the ability of ligands to compete with a fl...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails PubMed
TargetB-cell lymphoma 6 protein [5-128](Homo sapiens (Human))
Ontario Institute for Cancer Research

LigandPNGBDBM648370(acsmedchemlett.2c00502 OICR 9398A, 23)
Affinity DataIC50:  2.30E+4nMAssay Description:To identify small molecule BCL6 inhibitors, we developed a Fluorescence Polarization (FP) assay to assess the ability of ligands to compete with a fl...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetB-cell lymphoma 6 protein [5-128](Homo sapiens (Human))
Ontario Institute for Cancer Research

LigandPNGBDBM648365(acsmedchemlett.2c00502 OICR 7780A, 18)
Affinity DataIC50:  8.00E+4nMAssay Description:To identify small molecule BCL6 inhibitors, we developed a Fluorescence Polarization (FP) assay to assess the ability of ligands to compete with a fl...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetB-cell lymphoma 6 protein [5-128](Homo sapiens (Human))
Ontario Institute for Cancer Research

LigandPNGBDBM648358(acsmedchemlett.2c00502 OICR 4425A, 11)
Affinity DataIC50:  1.32E+5nMAssay Description:To identify small molecule BCL6 inhibitors, we developed a Fluorescence Polarization (FP) assay to assess the ability of ligands to compete with a fl...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails PubMed
TargetB-cell lymphoma 6 protein [5-128](Homo sapiens (Human))
Ontario Institute for Cancer Research

LigandPNGBDBM648359(acsmedchemlett.2c00502 OICR 7510A, 12)
Affinity DataIC50:  1.67E+5nMAssay Description:To identify small molecule BCL6 inhibitors, we developed a Fluorescence Polarization (FP) assay to assess the ability of ligands to compete with a fl...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
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