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Found 137 with Last Name = 'wiechmann' and Initial = 'k'
TargetProstaglandin E synthase(Homo sapiens (Human))
University Of Innsbruck

Curated by ChEMBL
LigandPNGBDBM50270591(2-(6-chloro-9-(3-hydroxy-3-methylbutyl)-1H-phenant...)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of human microsomal PGES1 in cell-free system assessed as inhibition of conversion of PGH2 to PGE2 by HPLC assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
University Of Innsbruck

Curated by ChEMBL
LigandPNGBDBM50168766(3-(1-(4-chlorobenzyl)-5-(2-fluoro-2'-methylbipheny...)
Affinity DataIC50:  3nMAssay Description:Inhibition of human microsomal PGES1 in cell-free system assessed as inhibition of conversion of PGH2 to PGE2 by HPLC assayMore data for this Ligand-Target Pair
TargetProstaglandin E synthase(Homo sapiens (Human))
University Of Innsbruck

Curated by ChEMBL
LigandPNGBDBM50168776(3-(5-(2'-chloro-2-fluorobiphenyl-4-yl)-1-(4-chloro...)
Affinity DataIC50:  4nMAssay Description:Inhibition of human microsomal PGES1 in cell-free system assessed as inhibition of conversion of PGH2 to PGE2 by HPLC assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
University Of Innsbruck

Curated by ChEMBL
LigandPNGBDBM50168761(3-(1-(4-chlorobenzyl)-5-(2-fluorobiphenyl-4-yl)-3-...)
Affinity DataIC50:  7nMAssay Description:Inhibition of human microsomal PGES1 in cell-free system assessed as inhibition of conversion of PGH2 to PGE2 by HPLC assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
University Of Innsbruck

Curated by ChEMBL
LigandPNGBDBM50168768(3-(5-(biphenyl-4-yl)-1-(4-chlorobenzyl)-3-methyl-1...)
Affinity DataIC50:  16nMAssay Description:Inhibition of human microsomal PGES1 in cell-free system assessed as inhibition of conversion of PGH2 to PGE2 by HPLC assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
University Of Innsbruck

Curated by ChEMBL
LigandPNGBDBM50343537(5-(4-tert-butylbenzyl)-1-(4-isopropoxyphenyl)-1H-i...)
Affinity DataIC50:  60nMAssay Description:Inhibition of human microsomal PGES1 in cell-free system assessed as inhibition of conversion of PGH2 to PGE2 by HPLC assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
University Of Innsbruck

Curated by ChEMBL
LigandPNGBDBM50343535(3-(1-(4-chlorobenzyl)-3-(benzylthio)-5-(2-(4-chlor...)
Affinity DataIC50:  60nMAssay Description:Inhibition of human microsomal PGES1 in cell-free system assessed as inhibition of conversion of PGH2 to PGE2 by HPLC assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
University Of Innsbruck

Curated by ChEMBL
LigandPNGBDBM50343539(5-(4-tert-butylbenzyl)-3-(4-isopropoxyphenyl)-1-(4...)
Affinity DataIC50:  70nMAssay Description:Inhibition of human microsomal PGES1 in cell-free system assessed as inhibition of conversion of PGH2 to PGE2 by HPLC assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
University Of Innsbruck

Curated by ChEMBL
LigandPNGBDBM50114564(CHEMBL3608378)
Affinity DataIC50:  80nMAssay Description:Inhibition of mPGES-1 in microsomal membranes isolated from interleukin-1beta-stimulated human A549 cells using PGH2 as substrate assessed as PGE2 fo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
University Of Innsbruck

Curated by ChEMBL
LigandPNGBDBM22334(BW A4C | BW4C | BWA4C | BWA4C, 10 | CHEMBL314360 |...)
Affinity DataIC50:  110nMAssay Description:Inhibition of 5-LO in human polymorphonuclear leukocytes assessed as inhibition of LTB4 production after 10 mins by RP-HPLC assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
University Of Innsbruck

Curated by ChEMBL
LigandPNGBDBM50114565(CHEMBL3608855)
Affinity DataIC50:  180nMAssay Description:Inhibition of mPGES-1 in microsomal membranes isolated from interleukin-1beta-stimulated human A549 cells using PGH2 as substrate assessed as PGE2 fo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
University Of Innsbruck

Curated by ChEMBL
LigandPNGBDBM50114427(CHEMBL3608361)
Affinity DataIC50:  220nMAssay Description:Inhibition of mPGES-1 in microsomal membranes isolated from interleukin-1beta-stimulated human A549 cells using PGH2 as substrate assessed as PGE2 fo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
University Of Innsbruck

Curated by ChEMBL
LigandPNGBDBM50114425(CHEMBL3608359)
Affinity DataIC50:  240nMAssay Description:Inhibition of mPGES-1 in microsomal membranes isolated from interleukin-1beta-stimulated human A549 cells using PGH2 as substrate assessed as PGE2 fo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
University Of Innsbruck

Curated by ChEMBL
LigandPNGBDBM50168771(3-[1-(4-Chloro-benzyl)-3-(3,3-dimethyl-butyryl)-5-...)
Affinity DataIC50:  260nMAssay Description:Inhibition of human microsomal PGES1 in cell-free system assessed as inhibition of conversion of PGH2 to PGE2 by HPLC assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
University Of Innsbruck

Curated by ChEMBL
LigandPNGBDBM50114426(CHEMBL3608360)
Affinity DataIC50:  290nMAssay Description:Inhibition of mPGES-1 in microsomal membranes isolated from interleukin-1beta-stimulated human A549 cells using PGH2 as substrate assessed as PGE2 fo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
University Of Innsbruck

Curated by ChEMBL
LigandPNGBDBM50114563(CHEMBL3608377)
Affinity DataIC50:  300nMAssay Description:Inhibition of mPGES-1 in microsomal membranes isolated from interleukin-1beta-stimulated human A549 cells using PGH2 as substrate assessed as PGE2 fo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
University Of Innsbruck

Curated by ChEMBL
LigandPNGBDBM50114428(Myrtucommulone H)
Affinity DataIC50:  300nMAssay Description:Inhibition of mPGES-1 in microsomal membranes isolated from interleukin-1beta-stimulated human A549 cells using PGH2 as substrate assessed as PGE2 fo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
University Of Innsbruck

Curated by ChEMBL
LigandPNGBDBM22334(BW A4C | BW4C | BWA4C | BWA4C, 10 | CHEMBL314360 |...)
Affinity DataIC50:  360nMAssay Description:Inhibition of human recombinant 5-LO in cell-free system assessed as inhibition of LTB4 production after 10 mins by RP-HPLC assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
University Of Innsbruck

Curated by ChEMBL
LigandPNGBDBM50270594(4-(3-chlorobenzyl)-2,6-bis(4-(trifluoromethoxy)phe...)
Affinity DataIC50:  390nMAssay Description:Inhibition of human microsomal PGES1 in cell-free system assessed as inhibition of conversion of PGH2 to PGE2 by HPLC assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
University Of Innsbruck

Curated by ChEMBL
LigandPNGBDBM50114430(CHEMBL3608363)
Affinity DataIC50:  390nMAssay Description:Inhibition of mPGES-1 in microsomal membranes isolated from interleukin-1beta-stimulated human A549 cells using PGH2 as substrate assessed as PGE2 fo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
University Of Innsbruck

Curated by ChEMBL
LigandPNGBDBM50343531(2-chloro-5-(4-chloro-2-(3-(3-(trifluoromethyl)phen...)
Affinity DataIC50:  400nMAssay Description:Inhibition of human microsomal PGES1 in cell-free system assessed as inhibition of conversion of PGH2 to PGE2 by HPLC assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
University Of Innsbruck

Curated by ChEMBL
LigandPNGBDBM50114420(CHEMBL3608858)
Affinity DataIC50:  430nMAssay Description:Inhibition of mPGES-1 in microsomal membranes isolated from interleukin-1beta-stimulated human A549 cells using PGH2 as substrate assessed as PGE2 fo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
University Of Innsbruck

Curated by ChEMBL
LigandPNGBDBM50114420(CHEMBL3608858)
Affinity DataIC50:  460nMAssay Description:Inhibition of recombinant human 5-LO expressed in Escherichia coli BL21 using arachidonic acid as substrate assessed as formation of all-trans isomer...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
University Of Innsbruck

Curated by ChEMBL
LigandPNGBDBM50114425(CHEMBL3608359)
Affinity DataIC50:  460nMAssay Description:Inhibition of 5-LO in ionophore A23187-stimulated human PMNL using arachidonic acid as substrate assessed as formation of LTB4, 5(S),12(S)-DiHETE, 5-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
University Of Innsbruck

Curated by ChEMBL
LigandPNGBDBM50114422(CHEMBL3608860)
Affinity DataIC50:  480nMAssay Description:Inhibition of mPGES-1 in microsomal membranes isolated from interleukin-1beta-stimulated human A549 cells using PGH2 as substrate assessed as PGE2 fo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
University Of Innsbruck

Curated by ChEMBL
LigandPNGBDBM50114551(CHEMBL3608367)
Affinity DataIC50:  490nMAssay Description:Inhibition of mPGES-1 in microsomal membranes isolated from interleukin-1beta-stimulated human A549 cells using PGH2 as substrate assessed as PGE2 fo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
University Of Innsbruck

Curated by ChEMBL
LigandPNGBDBM50343533(2,2'-(biphenyl-4,4'-diyl)bis(6-chloroquinoline-4-c...)
Affinity DataIC50:  500nMAssay Description:Inhibition of human microsomal PGES1 in cell-free system assessed as inhibition of conversion of PGH2 to PGE2 by HPLC assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
University Of Innsbruck

Curated by ChEMBL
LigandPNGBDBM50114560(CHEMBL3608374)
Affinity DataIC50:  570nMAssay Description:Inhibition of mPGES-1 in microsomal membranes isolated from interleukin-1beta-stimulated human A549 cells using PGH2 as substrate assessed as PGE2 fo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
University Of Innsbruck

Curated by ChEMBL
LigandPNGBDBM50114567(Myrtucommulone F)
Affinity DataIC50:  600nMAssay Description:Inhibition of mPGES-1 in microsomal membranes isolated from interleukin-1beta-stimulated human A549 cells using PGH2 as substrate assessed as PGE2 fo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
University Of Innsbruck

Curated by ChEMBL
LigandPNGBDBM50114552(CHEMBL3608368)
Affinity DataIC50:  610nMAssay Description:Inhibition of mPGES-1 in microsomal membranes isolated from interleukin-1beta-stimulated human A549 cells using PGH2 as substrate assessed as PGE2 fo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
University Of Innsbruck

Curated by ChEMBL
LigandPNGBDBM50114431(CHEMBL3608364)
Affinity DataIC50:  640nMAssay Description:Inhibition of mPGES-1 in microsomal membranes isolated from interleukin-1beta-stimulated human A549 cells using PGH2 as substrate assessed as PGE2 fo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
University Of Innsbruck

Curated by ChEMBL
LigandPNGBDBM50114421(CHEMBL3608859)
Affinity DataIC50:  650nMAssay Description:Inhibition of mPGES-1 in microsomal membranes isolated from interleukin-1beta-stimulated human A549 cells using PGH2 as substrate assessed as PGE2 fo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
University Of Innsbruck

Curated by ChEMBL
LigandPNGBDBM50114427(CHEMBL3608361)
Affinity DataIC50:  660nMAssay Description:Inhibition of 5-LO in ionophore A23187-stimulated human PMNL using arachidonic acid as substrate assessed as formation of LTB4, 5(S),12(S)-DiHETE, 5-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
University Of Innsbruck

Curated by ChEMBL
LigandPNGBDBM50114554(CHEMBL3608370)
Affinity DataIC50:  680nMAssay Description:Inhibition of mPGES-1 in microsomal membranes isolated from interleukin-1beta-stimulated human A549 cells using PGH2 as substrate assessed as PGE2 fo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
University Of Innsbruck

Curated by ChEMBL
LigandPNGBDBM50114566(CHEMBL3608856)
Affinity DataIC50:  680nMAssay Description:Inhibition of mPGES-1 in microsomal membranes isolated from interleukin-1beta-stimulated human A549 cells using PGH2 as substrate assessed as PGE2 fo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
University Of Innsbruck

Curated by ChEMBL
LigandPNGBDBM50114420(CHEMBL3608858)
Affinity DataIC50:  690nMAssay Description:Inhibition of 5-LO in ionophore A23187-stimulated human PMNL using arachidonic acid as substrate assessed as formation of LTB4, 5(S),12(S)-DiHETE, 5-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
University Of Innsbruck

Curated by ChEMBL
LigandPNGBDBM50114419(CHEMBL3608857)
Affinity DataIC50:  730nMAssay Description:Inhibition of recombinant human 5-LO expressed in Escherichia coli BL21 using arachidonic acid as substrate assessed as formation of all-trans isomer...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
University Of Innsbruck

Curated by ChEMBL
LigandPNGBDBM50343526((Z)-4-(3-((5-(4-Bromophenyl)furan-2-yl)methylene)-...)
Affinity DataIC50:  800nMAssay Description:Inhibition of human recombinant 5-LO in cell-free system assessed as inhibition of LTB4 production after 10 mins by RP-HPLC assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
University Of Innsbruck

Curated by ChEMBL
LigandPNGBDBM50114419(CHEMBL3608857)
Affinity DataIC50:  810nMAssay Description:Inhibition of mPGES-1 in microsomal membranes isolated from interleukin-1beta-stimulated human A549 cells using PGH2 as substrate assessed as PGE2 fo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
University Of Innsbruck

Curated by ChEMBL
LigandPNGBDBM50114562(CHEMBL3608376)
Affinity DataIC50:  810nMAssay Description:Inhibition of mPGES-1 in microsomal membranes isolated from interleukin-1beta-stimulated human A549 cells using PGH2 as substrate assessed as PGE2 fo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
University Of Innsbruck

Curated by ChEMBL
LigandPNGBDBM50114429(CHEMBL3608362)
Affinity DataIC50:  820nMAssay Description:Inhibition of mPGES-1 in microsomal membranes isolated from interleukin-1beta-stimulated human A549 cells using PGH2 as substrate assessed as PGE2 fo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
University Of Innsbruck

Curated by ChEMBL
LigandPNGBDBM50343530(5,7-dichloro-4-((3-(4-methoxyphenylthio)benzyl)(me...)
Affinity DataIC50:  850nMAssay Description:Inhibition of 5-LO in human polymorphonuclear leukocytes assessed as inhibition of LTB4 production after 10 mins by RP-HPLC assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
University Of Innsbruck

Curated by ChEMBL
LigandPNGBDBM50168781(3-[1-(4-Chloro-benzyl)-5-isopropyl-3-(2-methyl-ben...)
Affinity DataIC50:  900nMAssay Description:Inhibition of human microsomal PGES1 in cell-free system assessed as inhibition of conversion of PGH2 to PGE2 by HPLC assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
University Of Innsbruck

Curated by ChEMBL
LigandPNGBDBM50114426(CHEMBL3608360)
Affinity DataIC50:  970nMAssay Description:Inhibition of 5-LO in ionophore A23187-stimulated human PMNL using arachidonic acid as substrate assessed as formation of LTB4, 5(S),12(S)-DiHETE, 5-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
University Of Innsbruck

Curated by ChEMBL
LigandPNGBDBM50114551(CHEMBL3608367)
Affinity DataIC50:  980nMAssay Description:Inhibition of 5-LO in ionophore A23187-stimulated human PMNL using arachidonic acid as substrate assessed as formation of LTB4, 5(S),12(S)-DiHETE, 5-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
University Of Innsbruck

Curated by ChEMBL
LigandPNGBDBM50114423(MYRTUCOMMULONE A)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of mPGES-1 in microsomal membranes isolated from interleukin-1beta-stimulated human A549 cells using PGH2 as substrate assessed as PGE2 fo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
University Of Innsbruck

Curated by ChEMBL
LigandPNGBDBM50114556(CHEMBL3608372)
Affinity DataIC50:  1.10E+3nMAssay Description:Inhibition of mPGES-1 in microsomal membranes isolated from interleukin-1beta-stimulated human A549 cells using PGH2 as substrate assessed as PGE2 fo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
University Of Innsbruck

Curated by ChEMBL
LigandPNGBDBM50114421(CHEMBL3608859)
Affinity DataIC50:  1.20E+3nMAssay Description:Inhibition of recombinant human 5-LO expressed in Escherichia coli BL21 using arachidonic acid as substrate assessed as formation of all-trans isomer...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
University Of Innsbruck

Curated by ChEMBL
LigandPNGBDBM50114565(CHEMBL3608855)
Affinity DataIC50:  1.30E+3nMAssay Description:Inhibition of 5-LO in ionophore A23187-stimulated human PMNL using arachidonic acid as substrate assessed as formation of LTB4, 5(S),12(S)-DiHETE, 5-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
University Of Innsbruck

Curated by ChEMBL
LigandPNGBDBM50343540((R)-2-(4-(biphenyl-4-ylmethylamino)-6-chloropyrimi...)
Affinity DataIC50:  1.30E+3nMAssay Description:Inhibition of human microsomal PGES1 in cell-free system assessed as inhibition of conversion of PGH2 to PGE2 by HPLC assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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