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Found 91 with Last Name = 'wonacott' and Initial = 'aj'
TargetNeutrophil elastase(Homo sapiens (Human))
Gsk

Curated by ChEMBL
LigandPNGBDBM50118030(4-(5-Cyclopropylaminomethyl-pyrazine-2-carbonyl)-3...)
Affinity DataKi:  0.0140nMAssay Description:The compound was evaluated for its binding affinity towards human neutrophil elastase (HNE)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Gsk

Curated by ChEMBL
LigandPNGBDBM50118028(3-Isopropyl-1-methanesulfonyl-4-(2-pyrrolidin-1-yl...)
Affinity DataKi:  0.160nMAssay Description:The compound was evaluated for its binding affinity towards human neutrophil elastase (HNE)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Gsk

Curated by ChEMBL
LigandPNGBDBM50118028(3-Isopropyl-1-methanesulfonyl-4-(2-pyrrolidin-1-yl...)
Affinity DataKi:  0.160nM Kon:  4.90M-1s-1 Koff:  3.05E+4s-1Assay Description:The compound was evaluated for its inhibitory activity against human neutrophil elastase (HNE) using whole blood assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Gsk

Curated by ChEMBL
LigandPNGBDBM50118029(3-Isopropyl-1-methanesulfonyl-4-(4-piperidin-1-yl-...)
Affinity DataKi:  0.310nM Kon:  0.00000207M-1s-1 Koff:  6.63E+3s-1Assay Description:The compound was evaluated for its inhibitory activity against human neutrophil elastase (HNE) using whole blood assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Gsk

Curated by ChEMBL
LigandPNGBDBM50118029(3-Isopropyl-1-methanesulfonyl-4-(4-piperidin-1-yl-...)
Affinity DataKi:  0.310nMAssay Description:The compound was evaluated for its binding affinity towards human neutrophil elastase (HNE)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Gsk

Curated by ChEMBL
LigandPNGBDBM50118027(4-[1-(2,2-Dimethyl-propyl)-azetidine-3-carbonyl]-3...)
Affinity DataKi:  1.70nMAssay Description:The compound was evaluated for its binding affinity towards human neutrophil elastase (HNE)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Gsk

Curated by ChEMBL
LigandPNGBDBM50118027(4-[1-(2,2-Dimethyl-propyl)-azetidine-3-carbonyl]-3...)
Affinity DataKi:  1.73nM Kon:  0.0000109M-1s-1 Koff:  6.31E+3s-1Assay Description:The compound was evaluated for its inhibitory activity against human neutrophil elastase (HNE) using whole blood assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuraminidase(Influenza A virus (A/Puerto Rico/8/34/Mount Sinai(...)
Glaxowellcome Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50097655((4S,5R,6R)-4-Amino-6-dipropylcarbamoyl-5-(2,2,2-tr...)
Affinity DataIC50:  0.300nMAssay Description:Inhibitory activity against influenza A sialidase (Aichi)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuraminidase(Influenza A virus (A/Puerto Rico/8/34/Mount Sinai(...)
Glaxowellcome Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50097648((4S,5R,6R)-4-Amino-6-(phenethyl-propyl-carbamoyl)-...)
Affinity DataIC50:  0.700nMAssay Description:Inhibitory activity against influenza A sialidase (Aichi)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuraminidase(Influenza A virus (A/Puerto Rico/8/34/Mount Sinai(...)
Glaxowellcome Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50330326((4S,5R,6R)-5-Acetylamino-4-guanidino-6-((1R,3R)-1,...)
Affinity DataIC50:  2nMAssay Description:Inhibitory activity against influenza A sialidase (Aichi)More data for this Ligand-Target Pair
TargetNeuraminidase(Influenza A virus (A/Puerto Rico/8/34/Mount Sinai(...)
Glaxowellcome Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM4945((2R,3R,4S)-4-amino-3-acetamido-2-[(2-phenylethyl)(...)
Affinity DataIC50:  2nMAssay Description:Compound was tested for inhibitory concentration against Influenza sialidase type AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuraminidase(Influenza A virus (A/Puerto Rico/8/34/Mount Sinai(...)
Glaxowellcome Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM4945((2R,3R,4S)-4-amino-3-acetamido-2-[(2-phenylethyl)(...)
Affinity DataIC50:  3nMAssay Description:Inhibitory activity against influenza A sialidase (Aichi)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuraminidase(Influenza A virus (A/Puerto Rico/8/34/Mount Sinai(...)
Glaxowellcome Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM4945((2R,3R,4S)-4-amino-3-acetamido-2-[(2-phenylethyl)(...)
Affinity DataIC50:  3nMAssay Description:Inhibitory activity against influenza A sialidase (Aichi)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuraminidase(Influenza A virus (A/Puerto Rico/8/34/Mount Sinai(...)
Glaxowellcome Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50097659((4S,5R,6R)-4-Amino-6-(phenethyl-propyl-carbamoyl)-...)
Affinity DataIC50:  3nMAssay Description:Inhibitory activity against influenza A sialidase (Aichi)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuraminidase(Influenza B virus (B/Lee/40))
Glaxo Wellcome Research And Development

Curated by ChEMBL
LigandPNGBDBM50330326((4S,5R,6R)-5-Acetylamino-4-guanidino-6-((1R,3R)-1,...)
Affinity DataIC50:  4nMAssay Description:Compound was tested for inhibitory concentration against Influenza sialidase type BMore data for this Ligand-Target Pair
TargetNeuraminidase(Influenza B virus (B/Lee/40))
Glaxo Wellcome Research And Development

Curated by ChEMBL
LigandPNGBDBM50330326((4S,5R,6R)-5-Acetylamino-4-guanidino-6-((1R,3R)-1,...)
Affinity DataIC50:  4nMAssay Description:Inhibitory activity against influenza B sialidase (Victoria)More data for this Ligand-Target Pair
TargetNeuraminidase(Influenza A virus (A/Puerto Rico/8/34/Mount Sinai(...)
Glaxowellcome Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50097654((4S,5R,6R)-4-Amino-6-dipropylcarbamoyl-5-propionyl...)
Affinity DataIC50:  5nMAssay Description:Inhibitory activity against influenza A sialidase (Aichi)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuraminidase(Influenza A virus (A/Puerto Rico/8/34/Mount Sinai(...)
Glaxowellcome Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50330326((4S,5R,6R)-5-Acetylamino-4-guanidino-6-((1R,3R)-1,...)
Affinity DataIC50:  5nMAssay Description:Compound was tested for inhibitory concentration against Influenza sialidase type AMore data for this Ligand-Target Pair
TargetNeuraminidase(Influenza A virus (A/Puerto Rico/8/34/Mount Sinai(...)
Glaxowellcome Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM4952((2R,3R,4S)-4-amino-3-acetamido-2-[ethyl(2-phenylet...)
Affinity DataIC50:  5nMAssay Description:Compound was tested for inhibitory concentration against Influenza sialidase type AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuraminidase(Influenza A virus (A/Puerto Rico/8/34/Mount Sinai(...)
Glaxowellcome Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50097650((4S,5R,6R)-5-Acetylamino-4-hydroxy-6-(phenethyl-pr...)
Affinity DataIC50:  7nMAssay Description:Inhibitory activity against influenza A sialidase (Aichi)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuraminidase(Influenza A virus (A/Puerto Rico/8/34/Mount Sinai(...)
Glaxowellcome Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50097661((5R,6R)-5-Acetylamino-6-(phenethyl-propyl-carbamoy...)
Affinity DataIC50:  7nMAssay Description:Inhibitory activity against influenza A sialidase (Aichi)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Gsk

Curated by ChEMBL
LigandPNGBDBM50118028(3-Isopropyl-1-methanesulfonyl-4-(2-pyrrolidin-1-yl...)
Affinity DataIC50:  10nMAssay Description:The compound was evaluated for its inhibitory activity against human neutrophil elastase (HNE)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Gsk

Curated by ChEMBL
LigandPNGBDBM50118030(4-(5-Cyclopropylaminomethyl-pyrazine-2-carbonyl)-3...)
Affinity DataIC50:  11nMAssay Description:The compound was evaluated for its inhibitory activity against human neutrophil elastase (HNE)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuraminidase(Influenza A virus (A/Puerto Rico/8/34/Mount Sinai(...)
Glaxowellcome Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM4929((2R,3R,4S)-4-amino-2-(dipropylcarbamoyl)-3-acetami...)
Affinity DataIC50:  12nMAssay Description:Inhibitory activity against influenza A sialidase (Aichi)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuraminidase(Influenza A virus (A/Puerto Rico/8/34/Mount Sinai(...)
Glaxowellcome Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM4958((2R,3R,4S)-4-amino-3-acetamido-2-[(2-methylpropyl)...)
Affinity DataIC50:  14nMAssay Description:Compound was tested for inhibitory concentration against Influenza sialidase type AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuraminidase(Influenza A virus (A/Puerto Rico/8/34/Mount Sinai(...)
Glaxowellcome Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50097649((4R,5R,6R)-5-Acetylamino-4-hydroxy-6-(phenethyl-pr...)
Affinity DataIC50:  17nMAssay Description:Inhibitory activity against influenza A sialidase (Aichi)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Gsk

Curated by ChEMBL
LigandPNGBDBM50118029(3-Isopropyl-1-methanesulfonyl-4-(4-piperidin-1-yl-...)
Affinity DataIC50:  22nMAssay Description:The compound was evaluated for its inhibitory activity against human neutrophil elastase (HNE)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Gsk

Curated by ChEMBL
LigandPNGBDBM50118029(3-Isopropyl-1-methanesulfonyl-4-(4-piperidin-1-yl-...)
Affinity DataIC50:  22nMAssay Description:The compound was evaluated for its inhibitory activity against dog neutrophil elastase using whole blood assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymotrypsinogen A(Bos taurus (bovine))
Gsk

Curated by ChEMBL
LigandPNGBDBM50118029(3-Isopropyl-1-methanesulfonyl-4-(4-piperidin-1-yl-...)
Affinity DataIC50:  22nMAssay Description:The compound was evaluated for its inhibitory activity against Chymotrypsinogen using selectivity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Gsk

Curated by ChEMBL
LigandPNGBDBM50118027(4-[1-(2,2-Dimethyl-propyl)-azetidine-3-carbonyl]-3...)
Affinity DataIC50:  37nMAssay Description:The compound was evaluated for its inhibitory activity against human neutrophil elastase (HNE)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuraminidase(Influenza A virus (A/Puerto Rico/8/34/Mount Sinai(...)
Glaxowellcome Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50097656((4S,5R,6R)-4-Amino-5-(cyclopropanecarbonyl-amino)-...)
Affinity DataIC50:  50nMAssay Description:Inhibitory activity against influenza A sialidase (Aichi)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuraminidase(Influenza B virus (B/Lee/40))
Glaxo Wellcome Research And Development

Curated by ChEMBL
LigandPNGBDBM50097659((4S,5R,6R)-4-Amino-6-(phenethyl-propyl-carbamoyl)-...)
Affinity DataIC50:  100nMAssay Description:Inhibitory activity against influenza B sialidase (Victoria)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuraminidase(Influenza A virus (A/Puerto Rico/8/34/Mount Sinai(...)
Glaxowellcome Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50097658((4R,5R,6R)-5-Acetylamino-4-amino-6-dipropylcarbamo...)
Affinity DataIC50:  140nMAssay Description:Inhibitory activity against influenza A sialidase (Aichi)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Gsk

Curated by ChEMBL
LigandPNGBDBM50118030(4-(5-Cyclopropylaminomethyl-pyrazine-2-carbonyl)-3...)
Affinity DataIC50:  150nMAssay Description:The compound was evaluated for its inhibitory activity against human neutrophil elastase (HNE) using whole blood assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Gsk

Curated by ChEMBL
LigandPNGBDBM50118027(4-[1-(2,2-Dimethyl-propyl)-azetidine-3-carbonyl]-3...)
Affinity DataIC50:  170nMAssay Description:The compound was evaluated for its inhibitory activity against dog neutrophil elastase using whole blood assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Gsk

Curated by ChEMBL
LigandPNGBDBM50118027(4-[1-(2,2-Dimethyl-propyl)-azetidine-3-carbonyl]-3...)
Affinity DataIC50:  190nMAssay Description:The compound was evaluated for its inhibitory activity against human neutrophil elastase (HNE) using whole blood assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuraminidase(Influenza B virus (B/Lee/40))
Glaxo Wellcome Research And Development

Curated by ChEMBL
LigandPNGBDBM50097655((4S,5R,6R)-4-Amino-6-dipropylcarbamoyl-5-(2,2,2-tr...)
Affinity DataIC50:  200nMAssay Description:Inhibitory activity against influenza B sialidase (Victoria)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuraminidase(Influenza A virus (A/Puerto Rico/8/34/Mount Sinai(...)
Glaxowellcome Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50097660((4S,5R,6R)-5-Acetylamino-6-dipropylcarbamoyl-4-met...)
Affinity DataIC50:  240nMAssay Description:Inhibitory activity against influenza A sialidase (Aichi)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Gsk

Curated by ChEMBL
LigandPNGBDBM50118028(3-Isopropyl-1-methanesulfonyl-4-(2-pyrrolidin-1-yl...)
Affinity DataIC50:  250nMAssay Description:The compound was evaluated for its inhibitory activity against human neutrophil elastase (HNE) using whole blood assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Gsk

Curated by ChEMBL
LigandPNGBDBM50118030(4-(5-Cyclopropylaminomethyl-pyrazine-2-carbonyl)-3...)
Affinity DataIC50:  260nMAssay Description:The compound was evaluated for its inhibitory activity against dog neutrophil elastase using whole blood assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuraminidase(Influenza A virus (A/Puerto Rico/8/34/Mount Sinai(...)
Glaxowellcome Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM4951((2R,3R,4S)-4-amino-3-acetamido-2-[methyl(2-phenyle...)
Affinity DataIC50:  320nMAssay Description:Compound was tested for inhibitory concentration against Influenza sialidase type AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuraminidase(Influenza A virus (A/Puerto Rico/8/34/Mount Sinai(...)
Glaxowellcome Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50063303((2R,3R,4S)-3-acetamido-4-amino-2-((1R,2R)-1,2,3-tr...)
Affinity DataIC50:  320nMAssay Description:Compound was tested for inhibitory concentration against Influenza sialidase type AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Gsk

Curated by ChEMBL
LigandPNGBDBM50118028(3-Isopropyl-1-methanesulfonyl-4-(2-pyrrolidin-1-yl...)
Affinity DataIC50:  390nMAssay Description:The compound was evaluated for its inhibitory activity against dog neutrophil elastase using whole blood assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuraminidase(Influenza B virus (B/Lee/40))
Glaxo Wellcome Research And Development

Curated by ChEMBL
LigandPNGBDBM50063303((2R,3R,4S)-3-acetamido-4-amino-2-((1R,2R)-1,2,3-tr...)
Affinity DataIC50:  410nMAssay Description:Compound was tested for inhibitory concentration against Influenza sialidase type BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuraminidase(Influenza A virus (A/Puerto Rico/8/34/Mount Sinai(...)
Glaxowellcome Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50097651((4S,5R,6R)-5-Acetylamino-6-dipropylcarbamoyl-4-eth...)
Affinity DataIC50:  420nMAssay Description:Inhibitory activity against influenza A sialidase (Aichi)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymotrypsinogen A(Bos taurus (bovine))
Gsk

Curated by ChEMBL
LigandPNGBDBM50118030(4-(5-Cyclopropylaminomethyl-pyrazine-2-carbonyl)-3...)
Affinity DataIC50:  540nMAssay Description:The compound was evaluated for its inhibitory activity against Chymotrypsinogen using selectivity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Gsk

Curated by ChEMBL
LigandPNGBDBM50118029(3-Isopropyl-1-methanesulfonyl-4-(4-piperidin-1-yl-...)
Affinity DataIC50:  670nMAssay Description:The compound was evaluated for its inhibitory activity against human neutrophil elastase (HNE) using whole blood assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuraminidase(Influenza B virus (B/Lee/40))
Glaxo Wellcome Research And Development

Curated by ChEMBL
LigandPNGBDBM4929((2R,3R,4S)-4-amino-2-(dipropylcarbamoyl)-3-acetami...)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibitory activity against influenza B sialidase (Victoria)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuraminidase(Influenza A virus (A/Puerto Rico/8/34/Mount Sinai(...)
Glaxowellcome Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50097652((4S,5R,6R)-4-Amino-6-dipropylcarbamoyl-5-methanesu...)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibitory activity against influenza A sialidase (Aichi)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymotrypsinogen A(Bos taurus (bovine))
Gsk

Curated by ChEMBL
LigandPNGBDBM50118028(3-Isopropyl-1-methanesulfonyl-4-(2-pyrrolidin-1-yl...)
Affinity DataIC50:  3.00E+3nMAssay Description:The compound was evaluated for its inhibitory activity against Chymotrypsinogen using selectivity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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