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Found 162 with Last Name = 'yan' and Initial = 'tp'
TargetHistone deacetylase 2(Homo sapiens (Human))
Methylgene

LigandPNGBDBM19428((2E)-N-hydroxy-3-(4-{[(2-hydroxyethyl)[2-(1H-indol...)
Affinity DataIC50:  7nMAssay Description:For the enzyme assay, the enzyme fraction was added to fluorescent substrate in the presence of test compounds, and the mixture was incubated for add...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Methylgene

LigandPNGBDBM19428((2E)-N-hydroxy-3-(4-{[(2-hydroxyethyl)[2-(1H-indol...)
Affinity DataIC50:  8nMAssay Description:For the enzyme assay, the enzyme fraction was added to fluorescent substrate in the presence of test compounds, and the mixture was incubated for add...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Methylgene

LigandPNGBDBM50277188(CHEMBL473270 | N1-(biphenyl-3-yl)-N8-hydroxyoctane...)
Affinity DataIC50:  9nMAssay Description:Inhibition of human recombinant C-terminal FLAG-tagged HDAC1 expressed in baculovirus by fluorimetryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Methylgene

Curated by ChEMBL
LigandPNGBDBM50277188(CHEMBL473270 | N1-(biphenyl-3-yl)-N8-hydroxyoctane...)
Affinity DataIC50:  9nMAssay Description:Inhibition of human recombinant N-terminal histidine-tagged HDAC6 expressed in baculovirus by fluorimetryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 3(Homo sapiens (Human))
Methylgene

LigandPNGBDBM19428((2E)-N-hydroxy-3-(4-{[(2-hydroxyethyl)[2-(1H-indol...)
Affinity DataIC50:  9nMAssay Description:For the enzyme assay, the enzyme fraction was added to fluorescent substrate in the presence of test compounds, and the mixture was incubated for add...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Methylgene

Curated by ChEMBL
LigandPNGBDBM50255852(4-(((R)-3-(4-hydroxybenzyl)-2,3-dihydro-2-oxoquino...)
Affinity DataIC50:  10nMAssay Description:Inhibition of human recombinant histone deacetylase 6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Methylgene

Curated by ChEMBL
LigandPNGBDBM50255096(4-(((R)-3-benzyl-2,3-dihydro-2-oxoquinoxalin-4(1H)...)
Affinity DataIC50:  10nMAssay Description:Inhibition of human recombinant histone deacetylase 6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Methylgene

Curated by ChEMBL
LigandPNGBDBM50255853(4-(((R)-2,3-dihydro-2-oxo-3-phenethylquinoxalin-4(...)
Affinity DataIC50:  10nMAssay Description:Inhibition of human recombinant histone deacetylase 6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 2(Homo sapiens (Human))
Methylgene

LigandPNGBDBM19130((2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4...)
Affinity DataIC50:  10nMAssay Description:Inhibition of human recombinant histone deacetylase 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Methylgene

Curated by ChEMBL
LigandPNGBDBM19130((2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4...)
Affinity DataIC50:  20nMAssay Description:Inhibition of human recombinant histone deacetylase 6More data for this Ligand-Target Pair
TargetHistone deacetylase 1(Homo sapiens (Human))
Methylgene

LigandPNGBDBM19412(CHEMBL235674 | benzamide-type inhibitor, 4 | pyrid...)
Affinity DataIC50:  20nMpH: 8.0 T: 2°CAssay Description:For the enzyme assay, the enzyme fraction was added to fluorescent substrate in the presence of test compounds, and the mixture was incubated for add...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Methylgene

LigandPNGBDBM19423(HDAC inhibitor, Compound 1 | N-[2-amino-5-(thiophe...)
Affinity DataIC50:  40nMAssay Description:For the enzyme assay, the enzyme fraction was added to fluorescent substrate in the presence of test compounds, and the mixture was incubated for add...More data for this Ligand-Target Pair
TargetHistone deacetylase 1(Homo sapiens (Human))
Methylgene

LigandPNGBDBM19421(4-{[(3,4-dimethoxyphenyl)amino]methyl}-N-[2-hydrox...)
Affinity DataIC50:  40nMpH: 8.0 T: 2°CAssay Description:For the enzyme assay, the enzyme fraction was added to fluorescent substrate in the presence of test compounds, and the mixture was incubated for add...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Methylgene

Curated by ChEMBL
LigandPNGBDBM50255854((R)-tert-butyl 4-(1-(4-(hydroxycarbamoyl)benzyl)-3...)
Affinity DataIC50:  40nMAssay Description:Inhibition of human recombinant histone deacetylase 6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Methylgene

Curated by ChEMBL
LigandPNGBDBM50255809(4-(((R)-3-(3,4-difluorobenzyl)-2,3-dihydro-2-oxoqu...)
Affinity DataIC50:  40nMAssay Description:Inhibition of human recombinant histone deacetylase 6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Methylgene

Curated by ChEMBL
LigandPNGBDBM50255914(4-(((R)-2,3-dihydro-2-oxo-3-((thiophen-2-yl)methyl...)
Affinity DataIC50:  40nMAssay Description:Inhibition of human recombinant histone deacetylase 6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Methylgene

LigandPNGBDBM19416(N-[2-amino-5-(thiophen-3-yl)phenyl]-4-{[(3,4-dimet...)
Affinity DataIC50:  50nMpH: 8.0 T: 2°CAssay Description:For the enzyme assay, the enzyme fraction was added to fluorescent substrate in the presence of test compounds, and the mixture was incubated for add...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Methylgene

Curated by ChEMBL
LigandPNGBDBM50255910(4-(((R)-3-(4-tert-butoxybenzyl)-2,3-dihydro-2-oxoq...)
Affinity DataIC50:  50nMAssay Description:Inhibition of human recombinant histone deacetylase 6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Methylgene

LigandPNGBDBM19414(N-[2-amino-5-(thiophen-2-yl)phenyl]-4-{[(3,4-dimet...)
Affinity DataIC50:  50nMpH: 8.0 T: 2°CAssay Description:For the enzyme assay, the enzyme fraction was added to fluorescent substrate in the presence of test compounds, and the mixture was incubated for add...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Methylgene

LigandPNGBDBM19427(N-[2-amino-5-(thiophen-2-yl)phenyl]-4-methoxybenza...)
Affinity DataIC50:  50nMAssay Description:For the enzyme assay, the enzyme fraction was added to fluorescent substrate in the presence of test compounds, and the mixture was incubated for add...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Methylgene

LigandPNGBDBM19417(N-[2-amino-5-(furan-3-yl)phenyl]-4-{[(3,4-dimethox...)
Affinity DataIC50:  50nMpH: 8.0 T: 2°CAssay Description:For the enzyme assay, the enzyme fraction was added to fluorescent substrate in the presence of test compounds, and the mixture was incubated for add...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Methylgene

LigandPNGBDBM19415(N-(2-amino-5-phenylphenyl)-4-{[(3,4-dimethoxypheny...)
Affinity DataIC50:  60nMpH: 8.0 T: 2°CAssay Description:For the enzyme assay, the enzyme fraction was added to fluorescent substrate in the presence of test compounds, and the mixture was incubated for add...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 2(Homo sapiens (Human))
Methylgene

LigandPNGBDBM19421(4-{[(3,4-dimethoxyphenyl)amino]methyl}-N-[2-hydrox...)
Affinity DataIC50:  60nMpH: 8.0 T: 2°CAssay Description:For the enzyme assay, the enzyme fraction was added to fluorescent substrate in the presence of test compounds, and the mixture was incubated for add...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Methylgene

LigandPNGBDBM19425(N-[2-amino-5-(thiophen-2-yl)phenyl]quinoxaline-6-c...)
Affinity DataIC50:  60nMAssay Description:For the enzyme assay, the enzyme fraction was added to fluorescent substrate in the presence of test compounds, and the mixture was incubated for add...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Methylgene

Curated by ChEMBL
LigandPNGBDBM50277329((S)-benzyl 1-(6-methoxyquinolin-8-ylamino)-1-oxo-6...)
Affinity DataIC50:  60nMAssay Description:Inhibition of human recombinant N-terminal histidine-tagged HDAC6 expressed in baculovirus by fluorimetryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 2(Homo sapiens (Human))
Methylgene

LigandPNGBDBM19416(N-[2-amino-5-(thiophen-3-yl)phenyl]-4-{[(3,4-dimet...)
Affinity DataIC50:  60nMpH: 8.0 T: 2°CAssay Description:For the enzyme assay, the enzyme fraction was added to fluorescent substrate in the presence of test compounds, and the mixture was incubated for add...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 2(Homo sapiens (Human))
Methylgene

LigandPNGBDBM19417(N-[2-amino-5-(furan-3-yl)phenyl]-4-{[(3,4-dimethox...)
Affinity DataIC50:  70nMpH: 8.0 T: 2°CAssay Description:For the enzyme assay, the enzyme fraction was added to fluorescent substrate in the presence of test compounds, and the mixture was incubated for add...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 2(Homo sapiens (Human))
Methylgene

LigandPNGBDBM19414(N-[2-amino-5-(thiophen-2-yl)phenyl]-4-{[(3,4-dimet...)
Affinity DataIC50:  80nMpH: 8.0 T: 2°CAssay Description:For the enzyme assay, the enzyme fraction was added to fluorescent substrate in the presence of test compounds, and the mixture was incubated for add...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 2(Homo sapiens (Human))
Methylgene

LigandPNGBDBM19423(HDAC inhibitor, Compound 1 | N-[2-amino-5-(thiophe...)
Affinity DataIC50:  100nMAssay Description:For the enzyme assay, the enzyme fraction was added to fluorescent substrate in the presence of test compounds, and the mixture was incubated for add...More data for this Ligand-Target Pair
TargetHistone deacetylase 1(Homo sapiens (Human))
Methylgene

LigandPNGBDBM19149(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Affinity DataIC50:  100nMAssay Description:Inhibition of human recombinant C-terminal FLAG-tagged HDAC1 expressed in baculovirus by fluorimetryMore data for this Ligand-Target Pair
TargetHistone deacetylase 2(Homo sapiens (Human))
Methylgene

LigandPNGBDBM19415(N-(2-amino-5-phenylphenyl)-4-{[(3,4-dimethoxypheny...)
Affinity DataIC50:  100nMpH: 8.0 T: 2°CAssay Description:For the enzyme assay, the enzyme fraction was added to fluorescent substrate in the presence of test compounds, and the mixture was incubated for add...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 2(Homo sapiens (Human))
Methylgene

LigandPNGBDBM19412(CHEMBL235674 | benzamide-type inhibitor, 4 | pyrid...)
Affinity DataIC50:  100nMpH: 8.0 T: 2°CAssay Description:For the enzyme assay, the enzyme fraction was added to fluorescent substrate in the presence of test compounds, and the mixture was incubated for add...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Methylgene

Curated by ChEMBL
LigandPNGBDBM50255912(4-(((R)-2-((1H-indol-3-yl)methyl)-3,6-dioxopiperaz...)
Affinity DataIC50:  110nMAssay Description:Inhibition of human recombinant histone deacetylase 6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Methylgene

Curated by ChEMBL
LigandPNGBDBM50255097(4-((2,3-dihydro-2-oxoquinoxalin-4(1H)-yl)methyl)-N...)
Affinity DataIC50:  150nMAssay Description:Inhibition of human recombinant histone deacetylase 6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Methylgene

LigandPNGBDBM50256888((S)-benzyl 1-oxo-1-(4-phenylthiazol-2-ylamino)-6-(...)
Affinity DataIC50:  160nMAssay Description:Inhibition of human recombinant C-terminal FLAG-tagged HDAC1 expressed in baculovirus by fluorimetryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Methylgene

Curated by ChEMBL
LigandPNGBDBM50255913(CHEMBL481726 | N-hydroxy-4-(((R)-3,6-dioxo-2-((thi...)
Affinity DataIC50:  160nMAssay Description:Inhibition of human recombinant histone deacetylase 6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Methylgene

Curated by ChEMBL
LigandPNGBDBM50255911(4-(((R)-2-benzyl-3,6-dioxopiperazin-1-yl)methyl)-N...)
Affinity DataIC50:  170nMAssay Description:Inhibition of human recombinant histone deacetylase 6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Methylgene

Curated by ChEMBL
LigandPNGBDBM50256888((S)-benzyl 1-oxo-1-(4-phenylthiazol-2-ylamino)-6-(...)
Affinity DataIC50:  180nMAssay Description:Inhibition of human recombinant N-terminal histidine-tagged HDAC6 expressed in baculovirus by fluorimetryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 2(Homo sapiens (Human))
Methylgene

LigandPNGBDBM19427(N-[2-amino-5-(thiophen-2-yl)phenyl]-4-methoxybenza...)
Affinity DataIC50:  200nMAssay Description:For the enzyme assay, the enzyme fraction was added to fluorescent substrate in the presence of test compounds, and the mixture was incubated for add...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Methylgene

Curated by ChEMBL
LigandPNGBDBM19149(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Affinity DataIC50:  200nMAssay Description:Inhibition of human recombinant N-terminal histidine-tagged HDAC6 expressed in baculovirus by fluorimetryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetHistone deacetylase 2(Homo sapiens (Human))
Methylgene

LigandPNGBDBM19420(4-{[(3,4-dimethoxyphenyl)amino]methyl}-N-(2-hydrox...)
Affinity DataIC50:  200nMpH: 8.0 T: 2°CAssay Description:For the enzyme assay, the enzyme fraction was added to fluorescent substrate in the presence of test compounds, and the mixture was incubated for add...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 2(Homo sapiens (Human))
Methylgene

LigandPNGBDBM19425(N-[2-amino-5-(thiophen-2-yl)phenyl]quinoxaline-6-c...)
Affinity DataIC50:  200nMAssay Description:For the enzyme assay, the enzyme fraction was added to fluorescent substrate in the presence of test compounds, and the mixture was incubated for add...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 8(Homo sapiens (Human))
Methylgene

Curated by ChEMBL
LigandPNGBDBM50255095(4-(((S)-3-benzyl-2,3-dihydro-2-oxoquinoxalin-4(1H)...)
Affinity DataIC50:  210nMAssay Description:Inhibition of human recombinant histone deacetylase 8More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Methylgene

Curated by ChEMBL
LigandPNGBDBM50255095(4-(((S)-3-benzyl-2,3-dihydro-2-oxoquinoxalin-4(1H)...)
Affinity DataIC50:  220nMAssay Description:Inhibition of human recombinant histone deacetylase 6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 8(Homo sapiens (Human))
Methylgene

Curated by ChEMBL
LigandPNGBDBM50255910(4-(((R)-3-(4-tert-butoxybenzyl)-2,3-dihydro-2-oxoq...)
Affinity DataIC50:  250nMAssay Description:Inhibition of human recombinant histone deacetylase 8More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 2(Homo sapiens (Human))
Methylgene

LigandPNGBDBM50255096(4-(((R)-3-benzyl-2,3-dihydro-2-oxoquinoxalin-4(1H)...)
Affinity DataIC50:  260nMAssay Description:Inhibition of human recombinant histone deacetylase 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Methylgene

LigandPNGBDBM19420(4-{[(3,4-dimethoxyphenyl)amino]methyl}-N-(2-hydrox...)
Affinity DataIC50:  300nMpH: 8.0 T: 2°CAssay Description:For the enzyme assay, the enzyme fraction was added to fluorescent substrate in the presence of test compounds, and the mixture was incubated for add...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Methylgene

Curated by ChEMBL
LigandPNGBDBM50255851(4-(((S)-2,3-dihydro-2-oxo-3-((thiophen-2-yl)methyl...)
Affinity DataIC50:  310nMAssay Description:Inhibition of human recombinant histone deacetylase 6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 2(Homo sapiens (Human))
Methylgene

LigandPNGBDBM50255852(4-(((R)-3-(4-hydroxybenzyl)-2,3-dihydro-2-oxoquino...)
Affinity DataIC50:  330nMAssay Description:Inhibition of human recombinant histone deacetylase 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Methylgene

Curated by ChEMBL
LigandPNGBDBM50277289(CHEMBL507114 | N-(quinolin-8-yl)-6-(sulfamoylamino...)
Affinity DataIC50:  390nMAssay Description:Inhibition of human recombinant N-terminal histidine-tagged HDAC6 expressed in baculovirus by fluorimetryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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