Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 162 hits for monomerid = 18771,18795,242739,50008294,50027655,18771,18795,242739,50008294,50027655
Affinity DataKi: 3nMAssay Description:Inhibition of Thymidylate synthase of Escherichia coli (Ki)More data for this Ligand-Target Pair
Affinity DataKi: 3.40nMAssay Description:Binding affinity against Thymidylate synthase was measured in vitroMore data for this Ligand-Target Pair
Affinity DataKi: 4.5nMAssay Description:Inhibitory activity against thymidylate synthaseMore data for this Ligand-Target Pair
Affinity DataKi: 4.5nMAssay Description:Binding affinity against thymidylate synthaseMore data for this Ligand-Target Pair
Affinity DataIC50: 6.30nMAssay Description:Inhibition of RFC (unknown origin) expressed in Chinese hamster PC43-10 cells assessed as cell growth inhibition incubated up to 96 hrs by Celltiter-...More data for this Ligand-Target Pair
Affinity DataIC50: 6.30nMAssay Description:Binding affinity to human RFC expressed in Chinese hamster PC43-10 cells assessed as antiproliferative activity measured as reduction in cell viabili...More data for this Ligand-Target Pair
Affinity DataKi: 7nMAssay Description:Inhibitory constant of thymidylate synthase was determined in human AML cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 9nMAssay Description:Inhibition of Thymidylate synthase (unknown origin)More data for this Ligand-Target Pair
3D Structure (crystal)Affinity DataIC50: 9nMAssay Description:Inhibition of DHFR (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 9nMAssay Description:Inhibition of Lactobacillus casei thymidylate synthaseMore data for this Ligand-Target Pair
Affinity DataKi: 10nMAssay Description:Compound was tested for inhibition of Thymidylate Synthase in Lactobacillus casei,More data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:Inhibition of pure human thymidylate synthase from extract of Manca human lymphoma cellsMore data for this Ligand-Target Pair
Affinity DataKi: 12nMAssay Description:Inhibition of human Thymidylate synthase (Ki)More data for this Ligand-Target Pair
Affinity DataIC50: 13nMAssay Description:Inhibitory activity against thymidylate synthase derived from Lactobacillus caseiMore data for this Ligand-Target Pair
Affinity DataKi: 14nMAssay Description:Binding affinity was evaluated against dihydrofolate reductaseMore data for this Ligand-Target Pair
Affinity DataIC50: 15nMAssay Description:Inhibition of FRalpha (unknown origin) expressed in Chinese hamster RT16 cells assessed as cell growth inhibition incubated up to 96 hrs by Celltiter...More data for this Ligand-Target Pair
Affinity DataIC50: 15nMAssay Description:Binding affinity to human FR-alpha receptor expressed in Chinese hamster RT16 cells assessed as antiproliferative activity measured as reduction in c...More data for this Ligand-Target Pair
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Duquesne University
Duquesne University
Affinity DataIC50: 18nMAssay Description:DHFRs were assayed spectrophotometrically in the reaction buffer solution containing dihydrofolate. The reaction was initiated with an amount of enzy...More data for this Ligand-Target Pair
Affinity DataIC50: 19nMAssay Description:TS was assayed spectrophotometrically in the reaction buffer solution containing (6R, 6S)-5, 10-CH2H4folate. The reaction was initiated by the additi...More data for this Ligand-Target Pair
Affinity DataIC50: 19nMAssay Description:Inhibition of Escherichia coli thymidylate synthaseMore data for this Ligand-Target Pair
Affinity DataIC50: 19nMAssay Description:TS was assayed spectrophotometrically in the reaction buffer solution containing (6R, 6S)-5, 10-CH2H4folate. The reaction was initiated by the additi...More data for this Ligand-Target Pair
Affinity DataIC50: 20nMAssay Description:Inhibition of isolated thymidylate synthase partially purified from L1210 mouse leukemia cellsMore data for this Ligand-Target Pair
Affinity DataKi: 20nMAssay Description:Tested for inhibitory activity against thymidylate synthase of L1210 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 20nMAssay Description:Inhibitory concentration of compound to inhibit Thymidylate synthase (TS) in L1210 cells at conc. of 200 uMMore data for this Ligand-Target Pair
Affinity DataIC50: 20nMAssay Description:Concentration required for in vitro inhibition of thymidylate synthaseMore data for this Ligand-Target Pair
Affinity DataIC50: 20nMAssay Description:Inhibition of thymidylate synthaseMore data for this Ligand-Target Pair
Affinity DataIC50: 20nMAssay Description:In vitro inhibitory activity against thymidylate synthase (TS) from L1210 mouse leukemia cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 20nMAssay Description:Concentration required to inhibit 50% activity of Thymidylate synthase was determinedMore data for this Ligand-Target Pair
Affinity DataIC50: 20nMAssay Description:Inhibitory activity against thymidylate synthaseMore data for this Ligand-Target Pair
Affinity DataIC50: 21nMAssay Description:Inhibition of thymidylate synthase in Lactobacillus caseiMore data for this Ligand-Target Pair
Affinity DataIC50: 21nMAssay Description:Evaluated for the inhibition of thymidylate synthase in Lactobacillus caseiMore data for this Ligand-Target Pair
Affinity DataIC50: 22nMAssay Description:Inhibition of FRbeta (unknown origin) expressed in Chinese hamster D4 cells assessed as cell growth inhibition incubated up to 96 hrs by Celltiter-bl...More data for this Ligand-Target Pair
Affinity DataIC50: 22nMAssay Description:Binding affinity to human FR-beta receptor expressed in Chinese hamster D4 cells assessed as antiproliferative activity measured as reduction in cell...More data for this Ligand-Target Pair
Affinity DataIC50: 22nMAssay Description:Inhibitory activity against dihydrofolate reductase derived from Lactobacillus caseiMore data for this Ligand-Target Pair
Affinity DataIC50: 28nMAssay Description:Evaluated for the inhibition of thymidylate synthase in permeabilised L1210 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 30nMAssay Description:TS was assayed spectrophotometrically in the reaction buffer solution containing (6R, 6S)-5, 10-CH2H4folate. The reaction was initiated by the additi...More data for this Ligand-Target Pair
Affinity DataKi: 30nM ΔG°: -10.1kcal/molepH: 7.0 T: 2°CAssay Description:The inhibition assay pattern for all of the compounds was determined by steady-state kinetic analysis of the dependence of the TS enzyme activity on ...More data for this Ligand-Target Pair
Affinity DataIC50: 36nMAssay Description:Inhibitory activity against thymidylate Synthase from human recombinant sourcesMore data for this Ligand-Target Pair
Affinity DataIC50: 36nMAssay Description:Compound was evaluated for the inhibition at a given concentration against recombinant human TSMore data for this Ligand-Target Pair
Affinity DataIC50: 36nMAssay Description:Inhibitory activity against thymidylate Synthase from Lactobacillus caseiMore data for this Ligand-Target Pair
Affinity DataIC50: 36nMAssay Description:Compound was evaluated for the inhibition at a given concentration against Lactobacillus casei TSMore data for this Ligand-Target Pair
Affinity DataIC50: 37nMAssay Description:Ability to inhibit thymidylate synthase derived from human leukemia K562 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 48nMAssay Description:Inhibition of Escherichia coli TS assessed as oxidation of tetrahydrofolate to dihydrofolate after 2 to 12 mins by spectrophotometryMore data for this Ligand-Target Pair
Affinity DataIC50: 50nMAssay Description:The compound was not tested for inhibition of L1210 Thymidylate synthase due to insolubilityMore data for this Ligand-Target Pair
Affinity DataIC50: 55nMAssay Description:Inhibitory concentration against Lactobacillus casei Thymidylate synthase (TS).More data for this Ligand-Target Pair
Affinity DataIC50: 55nMAssay Description:Inhibitory concentration against isolated Lactobacillus casei Thymidylate synthaseMore data for this Ligand-Target Pair
Affinity DataIC50: 55nMAssay Description:Compound was evaluated as inhibitor of Lactobacillus casei thymidylate synthaseMore data for this Ligand-Target Pair
Affinity DataIC50: 60nMAssay Description:Inhibition of various kinase enzyme.More data for this Ligand-Target Pair
Affinity DataKi: 60nM ΔG°: -9.68kcal/molepH: 7.4 T: 2°CAssay Description:TS was assayed spectrophotometrically in the reaction buffer solution containing (6R, 6S)-5, 10-CH2H4folate. The reaction was initiated by the additi...More data for this Ligand-Target Pair
Affinity DataKi: 60nMAssay Description:TS was assayed spectrophotometrically in the reaction buffer solution containing (6R, 6S)-5, 10-CH2H4folate. The reaction was initiated by the additi...More data for this Ligand-Target Pair
| Displayed 1 to 50 (of 162 total ) | Next | Last >> |
