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Compile Data Set for Download or QSAR
maximum 50k data
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
42
hits in this display
Target
Hepatocyte growth factor receptor [1078-1345,H1094R,L1272V]
(Homo sapiens (Human))
Amgen
Ligand
BDBM24466
(1-(2-hydroxy-2-methylpropyl)-N-{5-[(7-methoxyquino...)
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Affinity Data
Ki: 0.5nM ΔG°: -52.6kJ/mole
pH: 7.4 T: 2°C
Assay Description:
In vitro kinase assays were done to establish IC50 values against recombinant enzymes using homogeneous time-resolved fluorescence (HTRF) assay. For ...
More data for this Ligand-Target Pair
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Target
Hepatocyte growth factor receptor
(Homo sapiens (Human))
Amgen
Curated by
ChEMBL
Ligand
BDBM24466
(1-(2-hydroxy-2-methylpropyl)-N-{5-[(7-methoxyquino...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 1nM
Assay Description:
Inhibition of c-Met by HTRF assay
More data for this Ligand-Target Pair
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Target
Hepatocyte growth factor receptor
(Homo sapiens (Human))
Amgen
Curated by
ChEMBL
Ligand
BDBM24466
(1-(2-hydroxy-2-methylpropyl)-N-{5-[(7-methoxyquino...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 1nM
Assay Description:
Inhibition of c-Met by HTRF assay
More data for this Ligand-Target Pair
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Target
Hepatocyte growth factor receptor [1078-1345,V1092I,L1272V]
(Homo sapiens (Human))
Amgen
Ligand
BDBM24466
(1-(2-hydroxy-2-methylpropyl)-N-{5-[(7-methoxyquino...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 1.10nM ΔG°: -50.6kJ/mole
pH: 7.4 T: 2°C
Assay Description:
In vitro kinase assays were done to establish IC50 values against recombinant enzymes using homogeneous time-resolved fluorescence (HTRF) assay. For ...
More data for this Ligand-Target Pair
Target Info
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Target
Hepatocyte growth factor receptor
(Homo sapiens (Human))
Amgen
Curated by
ChEMBL
Ligand
BDBM24466
(1-(2-hydroxy-2-methylpropyl)-N-{5-[(7-methoxyquino...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 1.20nM ΔG°: -50.4kJ/mole
pH: 7.4 T: 2°C
Assay Description:
In vitro kinase assays were done to establish IC50 values against recombinant enzymes using homogeneous time-resolved fluorescence (HTRF) assay. For ...
More data for this Ligand-Target Pair
Target Info
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Target
Hepatocyte growth factor receptor
(Homo sapiens (Human))
Amgen
Curated by
ChEMBL
Ligand
BDBM24466
(1-(2-hydroxy-2-methylpropyl)-N-{5-[(7-methoxyquino...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 1.20nM
Assay Description:
Inhibition of c-Met (unknown origin)
More data for this Ligand-Target Pair
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Target
Hepatocyte growth factor receptor
(Mus musculus)
Amgen
Ligand
BDBM24466
(1-(2-hydroxy-2-methylpropyl)-N-{5-[(7-methoxyquino...)
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Affinity Data
Ki: 2nM ΔG°: -49.2kJ/mole
pH: 7.4 T: 2°C
Assay Description:
In vitro kinase assays were done to establish IC50 values against recombinant enzymes using homogeneous time-resolved fluorescence (HTRF) assay. For ...
More data for this Ligand-Target Pair
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Target
Hepatocyte growth factor receptor [1078-1345,D1228H,L1272V]
(Homo sapiens (Human))
Amgen
Ligand
BDBM24466
(1-(2-hydroxy-2-methylpropyl)-N-{5-[(7-methoxyquino...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 2.20nM ΔG°: -48.9kJ/mole
pH: 7.4 T: 2°C
Assay Description:
In vitro kinase assays were done to establish IC50 values against recombinant enzymes using homogeneous time-resolved fluorescence (HTRF) assay. For ...
More data for this Ligand-Target Pair
Target Info
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Target
Hepatocyte growth factor receptor [1078-1345,M1250T,L1272V]
(Homo sapiens (Human))
Amgen
Ligand
BDBM24466
(1-(2-hydroxy-2-methylpropyl)-N-{5-[(7-methoxyquino...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 4.10nM ΔG°: -47.4kJ/mole
pH: 7.4 T: 2°C
Assay Description:
In vitro kinase assays were done to establish IC50 values against recombinant enzymes using homogeneous time-resolved fluorescence (HTRF) assay. For ...
More data for this Ligand-Target Pair
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Target
Hepatocyte growth factor receptor [1078-1345,Y1230H,L1272V]
(Homo sapiens (Human))
Amgen
Ligand
BDBM24466
(1-(2-hydroxy-2-methylpropyl)-N-{5-[(7-methoxyquino...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 4.5nM ΔG°: -47.2kJ/mole
pH: 7.4 T: 2°C
Assay Description:
In vitro kinase assays were done to establish IC50 values against recombinant enzymes using homogeneous time-resolved fluorescence (HTRF) assay. For ...
More data for this Ligand-Target Pair
Target Info
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Target
Insulin-like growth factor 1 receptor
(Homo sapiens (Human))
Amgen
Curated by
ChEMBL
Ligand
BDBM24466
(1-(2-hydroxy-2-methylpropyl)-N-{5-[(7-methoxyquino...)
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Affinity Data
Ki: 2.15E+3nM
Assay Description:
Inhibition of IGF1R by HTRF assay
More data for this Ligand-Target Pair
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Target
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human))
Amgen
Curated by
ChEMBL
Ligand
BDBM24466
(1-(2-hydroxy-2-methylpropyl)-N-{5-[(7-methoxyquino...)
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Affinity Data
Ki: 2.43E+3nM
Assay Description:
Inhibition of VEGFR2 by HTRF assay
More data for this Ligand-Target Pair
Target Info
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Target
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human))
Amgen
Curated by
ChEMBL
Ligand
BDBM24466
(1-(2-hydroxy-2-methylpropyl)-N-{5-[(7-methoxyquino...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 2.43E+3nM
Assay Description:
Inhibition of VEGFR2 by HTRF assay
More data for this Ligand-Target Pair
Target Info
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Target
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human))
Amgen
Curated by
ChEMBL
Ligand
BDBM24466
(1-(2-hydroxy-2-methylpropyl)-N-{5-[(7-methoxyquino...)
Copy SMILES
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Affinity Data
Ki: 4.10E+3nM ΔG°: -30.4kJ/mole
pH: 7.4 T: 2°C
Assay Description:
In vitro kinase assays were done to establish IC50 values against recombinant enzymes using homogeneous time-resolved fluorescence (HTRF) assay. For ...
More data for this Ligand-Target Pair
Target Info
PDB
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Target
Macrophage-stimulating protein receptor
(Homo sapiens (Human))
Amgen
Curated by
ChEMBL
Ligand
BDBM24466
(1-(2-hydroxy-2-methylpropyl)-N-{5-[(7-methoxyquino...)
Copy SMILES
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Affinity Data
IC50: 10nM
Assay Description:
Inhibition of RON by HTRF assay
More data for this Ligand-Target Pair
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Target
Hepatocyte growth factor receptor
(Homo sapiens (Human))
Amgen
Curated by
ChEMBL
Ligand
BDBM24466
(1-(2-hydroxy-2-methylpropyl)-N-{5-[(7-methoxyquino...)
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Affinity Data
IC50: 60nM
Assay Description:
Inhibition of HGF-mediated c-Met autophosphorylation in human PC3 cells after 10 mins by quantitative electrochemiluminescent immunoassay
More data for this Ligand-Target Pair
Target Info
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Target
Insulin-like growth factor 1 receptor
(Homo sapiens (Human))
Amgen
Curated by
ChEMBL
Ligand
BDBM24466
(1-(2-hydroxy-2-methylpropyl)-N-{5-[(7-methoxyquino...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 1.00E+3nM
Assay Description:
Inhibition of IGF1R by HTRF assay
More data for this Ligand-Target Pair
Target Info
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Target
Tyrosine-protein kinase ABL1
(Homo sapiens (Human))
Amgen
Curated by
ChEMBL
Ligand
BDBM24466
(1-(2-hydroxy-2-methylpropyl)-N-{5-[(7-methoxyquino...)
Copy SMILES
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Affinity Data
IC50: 1.00E+3nM
Assay Description:
Inhibition of Abl
More data for this Ligand-Target Pair
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Target
Tyrosine-protein kinase BTK
(Homo sapiens (Human))
Amgen
Curated by
ChEMBL
Ligand
BDBM24466
(1-(2-hydroxy-2-methylpropyl)-N-{5-[(7-methoxyquino...)
Copy SMILES
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Affinity Data
IC50: 1.00E+3nM
Assay Description:
Inhibition of BTK
More data for this Ligand-Target Pair
Target Info
PDB
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Target
Insulin receptor
(Homo sapiens (Human))
Amgen
Curated by
ChEMBL
Ligand
BDBM24466
(1-(2-hydroxy-2-methylpropyl)-N-{5-[(7-methoxyquino...)
Copy SMILES
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Affinity Data
IC50: 1.00E+3nM
Assay Description:
Inhibition of IRK
More data for this Ligand-Target Pair
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Target
Tyrosine-protein kinase JAK3
(Homo sapiens (Human))
Amgen
Curated by
ChEMBL
Ligand
BDBM24466
(1-(2-hydroxy-2-methylpropyl)-N-{5-[(7-methoxyquino...)
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Affinity Data
IC50: 1.00E+3nM
Assay Description:
Inhibition of JAK3
More data for this Ligand-Target Pair
Target Info
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Target
Aurora kinase B
(Homo sapiens (Human))
Amgen
Curated by
ChEMBL
Ligand
BDBM24466
(1-(2-hydroxy-2-methylpropyl)-N-{5-[(7-methoxyquino...)
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Affinity Data
IC50: 1.00E+3nM
Assay Description:
Inhibition of aurora-2
More data for this Ligand-Target Pair
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Target
Proto-oncogene tyrosine-protein kinase Src
(Homo sapiens (Human))
Amgen
Curated by
ChEMBL
Ligand
BDBM24466
(1-(2-hydroxy-2-methylpropyl)-N-{5-[(7-methoxyquino...)
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Affinity Data
IC50: 1.00E+3nM
Assay Description:
Inhibition of Src
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Target
Tyrosine-protein kinase Lck
(Homo sapiens (Human))
Amgen
Curated by
ChEMBL
Ligand
BDBM24466
(1-(2-hydroxy-2-methylpropyl)-N-{5-[(7-methoxyquino...)
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Affinity Data
IC50: 1.00E+3nM
Assay Description:
Inhibition of LCK
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Target
Aurora kinase A
(Homo sapiens (Human))
Amgen
Curated by
ChEMBL
Ligand
BDBM24466
(1-(2-hydroxy-2-methylpropyl)-N-{5-[(7-methoxyquino...)
Copy SMILES
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Affinity Data
IC50: 1.00E+3nM
Assay Description:
Inhibition of aurora-1
More data for this Ligand-Target Pair
Target Info
PDB
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Target
Angiopoietin-1 receptor
(Homo sapiens (Human))
Amgen
Curated by
ChEMBL
Ligand
BDBM24466
(1-(2-hydroxy-2-methylpropyl)-N-{5-[(7-methoxyquino...)
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Affinity Data
IC50: 1.00E+3nM
Assay Description:
Inhibition of TIE2
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Target
RAC-alpha serine/threonine-protein kinase
(Homo sapiens (Human))
Amgen
Curated by
ChEMBL
Ligand
BDBM24466
(1-(2-hydroxy-2-methylpropyl)-N-{5-[(7-methoxyquino...)
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Affinity Data
IC50: 1.00E+4nM
Assay Description:
Inhibition of PKBalpha
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Target
Mast/stem cell growth factor receptor Kit
(Homo sapiens (Human))
Amgen
Curated by
ChEMBL
Ligand
BDBM24466
(1-(2-hydroxy-2-methylpropyl)-N-{5-[(7-methoxyquino...)
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Affinity Data
IC50: 1.00E+4nM
Assay Description:
Inhibition of c-KIT
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Target
Proto-oncogene tyrosine-protein kinase receptor Ret
(Homo sapiens (Human))
Amgen
Curated by
ChEMBL
Ligand
BDBM24466
(1-(2-hydroxy-2-methylpropyl)-N-{5-[(7-methoxyquino...)
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Affinity Data
IC50: 2.50E+4nM
Assay Description:
Inhibition of RET
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Target
Ribosomal protein S6 kinase beta-1
(Homo sapiens (Human))
Amgen
Curated by
ChEMBL
Ligand
BDBM24466
(1-(2-hydroxy-2-methylpropyl)-N-{5-[(7-methoxyquino...)
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Affinity Data
IC50: 2.50E+4nM
Assay Description:
Inhibition of p70S6K
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Target
Serine/threonine-protein kinase pim-1
(Homo sapiens (Human))
Amgen
Curated by
ChEMBL
Ligand
BDBM24466
(1-(2-hydroxy-2-methylpropyl)-N-{5-[(7-methoxyquino...)
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Affinity Data
IC50: 2.50E+4nM
Assay Description:
Inhibition of PIM1
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Target
Fibroblast growth factor receptor 1
(Homo sapiens (Human))
Amgen
Curated by
ChEMBL
Ligand
BDBM24466
(1-(2-hydroxy-2-methylpropyl)-N-{5-[(7-methoxyquino...)
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Affinity Data
IC50: 2.50E+4nM
Assay Description:
Inhibition of FGFRK
More data for this Ligand-Target Pair
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Target
Tyrosine-protein kinase JAK1
(Homo sapiens (Human))
Amgen
Curated by
ChEMBL
Ligand
BDBM24466
(1-(2-hydroxy-2-methylpropyl)-N-{5-[(7-methoxyquino...)
Copy SMILES
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Affinity Data
IC50: 2.50E+4nM
Assay Description:
Inhibition of JAK1
More data for this Ligand-Target Pair
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Target
Tyrosine-protein kinase JAK2
(Homo sapiens (Human))
Amgen
Curated by
ChEMBL
Ligand
BDBM24466
(1-(2-hydroxy-2-methylpropyl)-N-{5-[(7-methoxyquino...)
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Affinity Data
IC50: 2.50E+4nM
Assay Description:
Inhibition of JAK2
More data for this Ligand-Target Pair
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Target
RAC-beta serine/threonine-protein kinase
(Homo sapiens (Human))
Amgen
Curated by
ChEMBL
Ligand
BDBM24466
(1-(2-hydroxy-2-methylpropyl)-N-{5-[(7-methoxyquino...)
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Affinity Data
IC50: 2.50E+4nM
Assay Description:
Inhibition of PKBbeta
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Target Info
PDB
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Serine/threonine-protein kinase pim-2
(Homo sapiens (Human))
Amgen
Curated by
ChEMBL
Ligand
BDBM24466
(1-(2-hydroxy-2-methylpropyl)-N-{5-[(7-methoxyquino...)
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Affinity Data
IC50: 2.50E+4nM
Assay Description:
Inhibition of PIM2
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
KEGG
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Target
Cyclin-dependent kinase 5 activator 1
(Homo sapiens (Human))
Amgen
Curated by
ChEMBL
Ligand
BDBM24466
(1-(2-hydroxy-2-methylpropyl)-N-{5-[(7-methoxyquino...)
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Affinity Data
IC50: 1.00E+5nM
Assay Description:
Inhibition of CDK5/p25
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
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KEGG
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Mitogen-activated protein kinase 3
(Homo sapiens (Human))
Amgen
Curated by
ChEMBL
Ligand
BDBM24466
(1-(2-hydroxy-2-methylpropyl)-N-{5-[(7-methoxyquino...)
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Affinity Data
IC50: 1.00E+5nM
Assay Description:
Inhibition of ERK1
More data for this Ligand-Target Pair
Target Info
PDB
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KEGG
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Target
Mitogen-activated protein kinase 9
(Homo sapiens (Human))
Amgen
Curated by
ChEMBL
Ligand
BDBM24466
(1-(2-hydroxy-2-methylpropyl)-N-{5-[(7-methoxyquino...)
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Affinity Data
IC50: 1.00E+5nM
Assay Description:
Inhibition of JNK2
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
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KEGG
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Target
Ribosomal protein S6 kinase alpha-5
(Homo sapiens (Human))
Amgen
Curated by
ChEMBL
Ligand
BDBM24466
(1-(2-hydroxy-2-methylpropyl)-N-{5-[(7-methoxyquino...)
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Affinity Data
IC50: 1.00E+5nM
Assay Description:
Inhibition of MSK1
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
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KEGG
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Mitogen-activated protein kinase 14
(Homo sapiens (Human))
Amgen
Curated by
ChEMBL
Ligand
BDBM24466
(1-(2-hydroxy-2-methylpropyl)-N-{5-[(7-methoxyquino...)
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Affinity Data
IC50: 1.00E+5nM
Assay Description:
Inhibition of p38alpha
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
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KEGG
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Target
cAMP-dependent protein kinase catalytic subunit alpha
(Homo sapiens (Human))
Amgen
Curated by
ChEMBL
Ligand
BDBM24466
(1-(2-hydroxy-2-methylpropyl)-N-{5-[(7-methoxyquino...)
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Affinity Data
IC50: 1.00E+5nM
Assay Description:
Inhibition of PKAalpha
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
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Ligand Info
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In Depth
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PubMed
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