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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 20 hits in this display   

TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
University of Basel

Curated by ChEMBL
LigandPNGBDBM50469457(CHEMBL4286698)
Affinity DataKi:  11nMAssay Description:Binding affinity to recombinant human GST-tagged mTOR catalytic domain (1360 to 2549 residues) expressed in baculovirus after 1 hr by TR-FRET displac...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
University of Basel

Curated by ChEMBL
LigandPNGBDBM50469457(CHEMBL4286698)
Affinity DataKi:  11nMAssay Description:Inhibition of alexa fluor 647-labeled kinase tracer 314 binding to recombinant human N-terminal GST-fused mTOR (1360 to 2549 residues) expressed in b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
University of Basel

Curated by ChEMBL
LigandPNGBDBM50469457(CHEMBL4286698)
Affinity DataKi:  4.20E+3nMAssay Description:Binding affinity to recombinant N-terminal His6-tagged P110alpha catalytic domain (unknown origin) after 1 hr by TR-FRET displacement assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50469457(CHEMBL4286698)
Affinity DataKi:  4.20E+3nMAssay Description:Inhibition of alexa fluor 647-labeled kinase tracer 314 binding to recombinant human full-length N-terminal His6-tagged p110alpha/p85alpha expressed ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTarget of rapamycin complex subunit LST8(Homo sapiens)
University of Basel

Curated by ChEMBL
LigandPNGBDBM50469457(CHEMBL4286698)
Affinity DataIC50:  85nMAssay Description:Inhibition of mTORC1 in human A2058 cells assessed as reduction in ribosomal protein S6 phosphorylation at Ser235/236 residues incubated for 1 hr by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTarget of rapamycin complex 2 subunit MAPKAP1(Homo sapiens)
University of Basel

Curated by ChEMBL
LigandPNGBDBM50469457(CHEMBL4286698)
Affinity DataIC50:  190nMAssay Description:Inhibition of mTORC2 in human A2058 cells assessed as reduction in PKB phosphorylation at S473 residues incubated for 1 hr by Western blot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 3-kinase catalytic subunit type 3(Homo sapiens (Human))
University of Basel

Curated by ChEMBL
LigandPNGBDBM50469457(CHEMBL4286698)
Affinity DataKd:  2.75E+3nMAssay Description:Inhibition of human VPS34 (282 to 879 residues) expressed in mammalian expression system by KINOMEscan assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Homo sapiens (Human))
University of Basel

Curated by ChEMBL
LigandPNGBDBM50469457(CHEMBL4286698)
Affinity DataKd:  2.20E+4nMAssay Description:Binding affinity to human wild-type partial length PI3Kbeta (P118 to S1070 residues) expressed in mammalian expression system by kinome scan assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
University of Basel

Curated by ChEMBL
LigandPNGBDBM50469457(CHEMBL4286698)
Affinity DataKd:  2.30E+4nMAssay Description:Binding affinity to human wild-type partial length PI3Kdelta (R108 to Q1044 residues) expressed in mammalian expression system by kinome scan assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
University of Basel

Curated by ChEMBL
LigandPNGBDBM50469457(CHEMBL4286698)
Affinity DataKd:  1.00E+3nMAssay Description:Binding affinity to human wild-type partial length PI3Kalpha (R108 to N1068 residues) expressed in mammalian expression system by kinome scan assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
University of Basel

Curated by ChEMBL
LigandPNGBDBM50469457(CHEMBL4286698)
Affinity DataKd:  1.80E+4nMAssay Description:Binding affinity to human wild-type partial length PI3Kgamma (S144 to A1102 residues) expressed in mammalian expression system by kinome scan assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
University of Basel

Curated by ChEMBL
LigandPNGBDBM50469457(CHEMBL4286698)
Affinity DataKd:  0.270nMAssay Description:Binding affinity to wild-type human partial length mTOR (L1382 to W2549 residues) expressed in mammalian expression system by kinome scan assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4-kinase beta(Homo sapiens (Human))
University of Basel

Curated by ChEMBL
LigandPNGBDBM50469457(CHEMBL4286698)
Affinity DataKd: >3.00E+4nMAssay Description:Binding affinity to wild-type human full-length PI4Kbeta (M1 to M828 residues) expressed in mammalian expression system by kinome scan assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
University of Basel

Curated by ChEMBL
LigandPNGBDBM50469457(CHEMBL4286698)
Affinity DataKd:  1.00E+3nMAssay Description:Inhibition of human PI3Kalpha (108 to 1068 residues) expressed in mammalian expression system by KINOMEscan assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4-kinase beta(Homo sapiens (Human))
University of Basel

Curated by ChEMBL
LigandPNGBDBM50469457(CHEMBL4286698)
Affinity DataKd: >3.00E+4nMAssay Description:Inhibition of human PI4Kbeta (1 to 828 residues) expressed in mammalian expression system by KINOMEscan assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
University of Basel

Curated by ChEMBL
LigandPNGBDBM50469457(CHEMBL4286698)
Affinity DataKd:  1.80E+4nMAssay Description:Inhibition of human PI3Kgamma (144 to 1102 residues) expressed in mammalian expression system by KINOMEscan assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
University of Basel

Curated by ChEMBL
LigandPNGBDBM50469457(CHEMBL4286698)
Affinity DataKd:  2.30E+4nMAssay Description:Inhibition of human PI3Kdelta (108 to 1044 residues) expressed in mammalian expression system by KINOMEscan assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 3-kinase catalytic subunit type 3(Homo sapiens (Human))
University of Basel

Curated by ChEMBL
LigandPNGBDBM50469457(CHEMBL4286698)
Affinity DataKd:  2.75E+3nMAssay Description:Binding affinity to human wild-type partial length VPS34 (S282 to H879 residues) expressed in mammalian expression system by kinome scan assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
University of Basel

Curated by ChEMBL
LigandPNGBDBM50469457(CHEMBL4286698)
Affinity DataKd:  0.270nMAssay Description:Inhibition of human mTOR (1382 to 2549 residues) expressed in mammalian expression system by KINOMEscan assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Homo sapiens (Human))
University of Basel

Curated by ChEMBL
LigandPNGBDBM50469457(CHEMBL4286698)
Affinity DataKd:  2.20E+4nMAssay Description:Inhibition of human PI3Kbeta (118 to 1070 residues) expressed in mammalian expression system by KINOMEscan assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed