Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 2 hits in this display   

TargetNACHT, LRR and PYD domains-containing protein 3(Mus musculus)
The Noguchi Institute

Curated by ChEMBL

LigandBDBM50276374(CHEMBL4126946)Copy SMILESCopy InChI

Affinity DataIC50:  1.60E+6nMAssay Description:Inhibition of nigericin-induced NLRP3 inflammasome activation in C57BL/6 mouse bone marrow derived macrophages assessed as reduction in LPS-stimulate...More data for this Ligand-Target Pair

Target InfoPDBReactome pathway
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI

TargetNACHT, LRR and PYD domains-containing protein 3(Homo sapiens (Human))
The Noguchi Institute

Curated by ChEMBL

LigandBDBM50276374(CHEMBL4126946)Copy SMILESCopy InChI

Affinity DataIC50:  2.30E+6nMAssay Description:Inhibition of nigericin-induced NLRP3 inflammasome activation in PMA-differentiated human THP1 cells assessed as reduction in LPS-stimulated IL-1beta...More data for this Ligand-Target Pair

Target InfoPDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADGoogleScholar

Ligand InfoPC cidPC sidSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI