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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 4 hits in this display   

TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Children''S Hospital Medical Center

US Patent
LigandPNGBDBM538640(NCGC 00249356 | US11254667, Compound I-45 | US115...)
Affinity DataIC50:  460nMAssay Description:AlphaScreen SureFire STAT5 (pTyr694;Tyr699) Assay kit (Perkin Elmer). Assay was performed according to manufacturer protocol.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDimer of Receptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Children'S Hospital Medical Center

US Patent
LigandPNGBDBM538640(NCGC 00249356 | US11254667, Compound I-45 | US115...)
Affinity DataIC50:  460nMAssay Description:Table 8-10: Compounds were tested in 10-dose IC50 mode with 3-fold serial dilution starting at 10 uM, and are relative to DMSO, the negative control....More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGTPase NRas(Homo sapiens (Human))
Children'S Hospital Medical Center

US Patent
LigandPNGBDBM538640(NCGC 00249356 | US11254667, Compound I-45 | US115...)
Affinity DataIC50:  4.29E+3nMAssay Description:Table 8-10: Compounds were tested in 10-dose IC50 mode with 3-fold serial dilution starting at 10 uM, and are relative to DMSO, the negative control....More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGTPase NRas(Homo sapiens (Human))
Children'S Hospital Medical Center

US Patent
LigandPNGBDBM538640(NCGC 00249356 | US11254667, Compound I-45 | US115...)
Affinity DataIC50:  4.29E+3nMAssay Description:AlphaScreen SureFire STAT5 (pTyr694;Tyr699) Assay kit (Perkin Elmer). Assay was performed according to manufacturer protocol.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent