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Compile Data Set for Download or QSAR
maximum 50k data
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
9
hits in this display
Target
Interleukin-1 receptor-associated kinase 4
(Homo sapiens (Human))
Biocon Bristol Myers Squibb Research Center
Curated by
ChEMBL
Ligand
BDBM210300
(US9546153, ex. 367)
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Affinity Data
IC50: 3.40nM
Assay Description:
Inhibition of IRAK4 (unknown origin) using FL-IPTSPITTTYFFFKKK peptide and ATP as substrate incubated for 60 mins by fluorescence based caliper assay
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
PDB
In Depth
Details
Article
PubMed
PDB
3D Structure (crystal)
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Target
Interleukin-1 receptor-associated kinase 4
(Homo sapiens (Human))
Biocon Bristol Myers Squibb Research Center
Curated by
ChEMBL
Ligand
BDBM210300
(US9546153, ex. 367)
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Copy InChI
Affinity Data
IC50: 4.80nM
pH: 7.2 T: 2°C
Assay Description:
The assays were performed in U-bottom 384-well plates. The final assay volume was 30 μL prepared from 15 μL additions of enzyme and substra...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
PDB
In Depth
Details
US Patent
PDB
3D Structure (crystal)
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Target
TRAF2 and NCK-interacting protein kinase
(Homo sapiens (Human))
Biocon Bristol Myers Squibb Research Center
Curated by
ChEMBL
Ligand
BDBM210300
(US9546153, ex. 367)
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Affinity Data
IC50: 130nM
Assay Description:
Inhibition of human wild type partial length TNIK (D4-K311 residues) expressed in bacterial expression system
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/SwissProt
B.MOAD
GoogleScholar
Ligand Info
PC cid
PC sid
PDB
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Interleukin-1 receptor-associated kinase 4
(Homo sapiens (Human))
Biocon Bristol Myers Squibb Research Center
Curated by
ChEMBL
Ligand
BDBM210300
(US9546153, ex. 367)
Copy SMILES
Copy InChI
Affinity Data
IC50: 370nM
Assay Description:
Inhibition of IRAK4 in human PBMC assessed as inhibition of LTA-induced IL-6 production preincubated for 30 mins followed by LTA-stimulation and meas...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
PDB
In Depth
Details
Article
PubMed
PDB
3D Structure (crystal)
Copy BDB DOI
Target
Interleukin-1 receptor-associated kinase 3
(Homo sapiens (Human))
Biocon Bristol Myers Squibb Research Center
Curated by
ChEMBL
Ligand
BDBM210300
(US9546153, ex. 367)
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Affinity Data
IC50: 760nM
Assay Description:
Inhibition of human wild type partial length IRAK3 (147 to 596 residues) expressed in bacterial expression system
More data for this Ligand-Target Pair
Target Info
PDB
NCI pathway
UniProtKB/SwissProt
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
PDB
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Interleukin-1 receptor-associated kinase 4
(Homo sapiens (Human))
Biocon Bristol Myers Squibb Research Center
Curated by
ChEMBL
Ligand
BDBM210300
(US9546153, ex. 367)
Copy SMILES
Copy InChI
Affinity Data
IC50: 920nM
Assay Description:
Inhibition of IRAK4 in human whole blood assessed as inhibition of LTA-induced IL-6 production preincubated for 30 mins followed by LTA-stimulation a...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
PDB
In Depth
Details
Article
PubMed
PDB
3D Structure (crystal)
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Target
Tyrosine-protein kinase receptor TYRO3
(Homo sapiens (Human))
Biocon Bristol Myers Squibb Research Center
Curated by
ChEMBL
Ligand
BDBM210300
(US9546153, ex. 367)
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Affinity Data
IC50: 980nM
Assay Description:
Inhibition of human wild type partial length TYRO3 (497 to 814 residues) expressed in bacterial expression system
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
PDB
In Depth
Details
Article
PubMed
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Target
Mast/stem cell growth factor receptor Kit
(Homo sapiens (Human))
Biocon Bristol Myers Squibb Research Center
Curated by
ChEMBL
Ligand
BDBM210300
(US9546153, ex. 367)
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Affinity Data
IC50: >2.00E+3nM
Assay Description:
Inhibition of recombinant N-terminal GST-tagged human cKit (544 to end residues) expressed in baculovirus infected Sf21 cells
More data for this Ligand-Target Pair
Target Info
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Ligand Info
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PC sid
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In Depth
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Article
PubMed
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Target
Tyrosine-protein kinase Lck
(Homo sapiens (Human))
Biocon Bristol Myers Squibb Research Center
Curated by
ChEMBL
Ligand
BDBM210300
(US9546153, ex. 367)
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Affinity Data
IC50: >2.00E+3nM
Assay Description:
Inhibition of N-terminal His6-tagged human full length recombinant LCK expressed in baculovirus infected Sf21 cells
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/SwissProt
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
PDB
In Depth
Details
Article
PubMed
Copy BDB DOI