Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 13 hits in this display   

TargetMitogen-activated protein kinase kinase kinase 5(Homo sapiens (Human))
Takeda Research In California

Curated by ChEMBL

LigandBDBM50560385(CHEMBL4759397)Copy SMILESCopy InChI

Affinity DataIC50:  251nMAssay Description:Inhibition of ASK1 (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADantibodypediaGoogleScholar

Ligand InfoPC cidPC sidPDB

In DepthDetails ArticlePubMedPDB3D Structure (crystal)
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TargetMitogen-activated protein kinase kinase kinase 5(Homo sapiens (Human))
Takeda Research In California

Curated by ChEMBL

LigandBDBM50560385(CHEMBL4759397)Copy SMILESCopy InChI

Affinity DataIC50:  270nMAssay Description:Inhibition of ASK1 (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADantibodypediaGoogleScholar

Ligand InfoPC cidPC sidPDB

In DepthDetails ArticlePubMedPDB3D Structure (crystal)
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TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Takeda Research In California

Curated by ChEMBL

LigandBDBM50560385(CHEMBL4759397)Copy SMILESCopy InChI

Affinity DataIC50:  3.16E+3nMAssay Description:Inhibition of CDK2 (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPC cidPC sidPDB

In DepthDetails ArticlePubMed
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TargetTyrosine-protein kinase Mer(Homo sapiens (Human))
Takeda Research In California

Curated by ChEMBL

LigandBDBM50560385(CHEMBL4759397)Copy SMILESCopy InChI

Affinity DataIC50: <2.00E+4nMAssay Description:Inhibition of MER (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPC cidPC sidPDB

In DepthDetails ArticlePubMed
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Target5'-AMP-activated protein kinase catalytic subunit alpha-1(Homo sapiens (Human))
Takeda Research In California

Curated by ChEMBL

LigandBDBM50560385(CHEMBL4759397)Copy SMILESCopy InChI

Affinity DataIC50: <2.00E+4nMAssay Description:Inhibition of PRKKA1 (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBReactome pathway
UniProtKB/SwissProt
antibodypediaGoogleScholar

Ligand InfoPC cidPC sidPDB

In DepthDetails ArticlePubMed
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TargetRho-associated protein kinase 1(Homo sapiens (Human))
Takeda Research In California

Curated by ChEMBL

LigandBDBM50560385(CHEMBL4759397)Copy SMILESCopy InChI

Affinity DataIC50: <2.00E+4nMAssay Description:Inhibition of ROCK1 (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPC cidPC sidPDB

In DepthDetails ArticlePubMed
Copy BDB DOI

TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
Takeda Research In California

Curated by ChEMBL

LigandBDBM50560385(CHEMBL4759397)Copy SMILESCopy InChI

Affinity DataIC50: <2.00E+4nMAssay Description:Inhibition of ITK (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPC cidPC sidPDB

In DepthDetails ArticlePubMed
Copy BDB DOI

TargetReceptor tyrosine-protein kinase erbB-4(Homo sapiens (Human))
Takeda Research In California

Curated by ChEMBL

LigandBDBM50560385(CHEMBL4759397)Copy SMILESCopy InChI

Affinity DataIC50: <2.00E+4nMAssay Description:Inhibition of ERBB4 (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBMMDB
UniProtKB/SwissProt
B.MOADantibodypediaGoogleScholar

Ligand InfoPC cidPC sidPDB

In DepthDetails ArticlePubMed
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TargetEphrin type-A receptor 3(Homo sapiens (Human))
Takeda Research In California

Curated by ChEMBL

LigandBDBM50560385(CHEMBL4759397)Copy SMILESCopy InChI

Affinity DataIC50: <2.00E+4nMAssay Description:Inhibition of EPHA3 (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathway
UniProtKB/SwissProt
B.MOADantibodypediaGoogleScholar

Ligand InfoPC cidPC sidPDB

In DepthDetails ArticlePubMed
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TargetReceptor tyrosine-protein kinase erbB-4(Homo sapiens (Human))
Takeda Research In California

Curated by ChEMBL

LigandBDBM50560385(CHEMBL4759397)Copy SMILESCopy InChI

Affinity DataIC50: <2.00E+4nMAssay Description:Inhibition of HER4 (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBMMDB
UniProtKB/SwissProt
B.MOADantibodypediaGoogleScholar

Ligand InfoPC cidPC sidPDB

In DepthDetails ArticlePubMed
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TargetEpidermal growth factor receptor(Homo sapiens (Human))
Takeda Research In California

Curated by ChEMBL

LigandBDBM50560385(CHEMBL4759397)Copy SMILESCopy InChI

Affinity DataIC50: <2.00E+4nMAssay Description:Inhibition of EGFR (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPC cidPC sidPDB

In DepthDetails ArticlePubMed
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TargetMitogen-activated protein kinase 11/12/13/14(Homo sapiens (Human))
Takeda Research In California

Curated by ChEMBL

LigandBDBM50560385(CHEMBL4759397)Copy SMILESCopy InChI

Affinity DataIC50: <2.00E+4nMAssay Description:Inhibition of p38 (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
antibodypediaantibodypediaantibodypediaantibodypediaGoogleScholar

Ligand InfoPC cidPC sidPDB

In DepthDetails ArticlePubMed
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TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Takeda Research In California

Curated by ChEMBL

LigandBDBM50560385(CHEMBL4759397)Copy SMILESCopy InChI

Affinity DataIC50: <2.00E+4nMAssay Description:Inhibition of RET (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPC cidPC sidPDB

In DepthDetails ArticlePubMed
Copy BDB DOI