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Compile Data Set for Download or QSAR
maximum 50k data
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
48
hits in this display
Target
Motilin receptor
(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by
ChEMBL
Ligand
BDBM50344942
(CHEMBL532 | E-MYCIN E | ERYTHROMYCIN | ERYTHROMYCI...)
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Affinity Data
Ki: 3.70E+4nM
Assay Description:
In vitro binding affinity towards human motilin receptor
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Target
ATP-dependent translocase ABCB1
(Homo sapiens (Human))
Eli Lilly
Curated by
ChEMBL
Ligand
BDBM50344942
(CHEMBL532 | E-MYCIN E | ERYTHROMYCIN | ERYTHROMYCI...)
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Affinity Data
Ki: 3.78E+4nM
Assay Description:
TP_TRANSPORTER: increase in Vinblastine intracellular accumulation in MDR1-expressing LLC-PK1 cells
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Target
Solute carrier organic anion transporter family member
(Danio rerio (Zebrafish))
Rudjer Boskovic Institute
Ligand
BDBM50344942
(CHEMBL532 | E-MYCIN E | ERYTHROMYCIN | ERYTHROMYCI...)
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Affinity Data
Ki: 8.82E+5nM
Assay Description:
In the inhibition experiments, the cells were preincubated for 20 s with test compounds, followed by a 5-min incubation with [3H]E3S (5 nM) or 30-min...
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Target
ATP-dependent translocase ABCB1
(Homo sapiens (Human))
Eli Lilly
Curated by
ChEMBL
Ligand
BDBM50344942
(CHEMBL532 | E-MYCIN E | ERYTHROMYCIN | ERYTHROMYCI...)
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Affinity Data
Ki: >1.00E+6nM
Assay Description:
TP_TRANSPORTER: increase in Calcein-AM intracellular accumulation in MDR1-expressing LLC-PK1 cells
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Target
ATP-dependent translocase ABCB1
(Mus musculus)
St. Jude Children'S Research Hospital
Curated by
ChEMBL
Ligand
BDBM50344942
(CHEMBL532 | E-MYCIN E | ERYTHROMYCIN | ERYTHROMYCI...)
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Affinity Data
Ki: >1.00E+6nM
Assay Description:
TP_TRANSPORTER: increase in Calcein-AM intracellular accumulation in mdr1b-expressing LLC-PK1 cells
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Target
ATP-dependent translocase ABCB1
(Mus musculus (Mouse))
St. Jude Children'S Research Hospital
Curated by
ChEMBL
Ligand
BDBM50344942
(CHEMBL532 | E-MYCIN E | ERYTHROMYCIN | ERYTHROMYCI...)
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Affinity Data
Ki: >1.00E+6nM
Assay Description:
TP_TRANSPORTER: increase in Calcein-AM intracellular accumulation in mdr1a-expressing LLC-PK1 cells
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Target
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human))
Kosan Biosciences
Curated by
ChEMBL
Ligand
BDBM50344942
(CHEMBL532 | E-MYCIN E | ERYTHROMYCIN | ERYTHROMYCI...)
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Affinity Data
IC50: 39nM
Assay Description:
Inhibition of human ERG expressed in HEK cells
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Target
Motilin receptor
(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by
ChEMBL
Ligand
BDBM50344942
(CHEMBL532 | E-MYCIN E | ERYTHROMYCIN | ERYTHROMYCI...)
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Affinity Data
IC50: 44nM
Assay Description:
Compound was tested for in vitro motilin receptor binding affinity
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Target
Motilin receptor
(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by
ChEMBL
Ligand
BDBM50344942
(CHEMBL532 | E-MYCIN E | ERYTHROMYCIN | ERYTHROMYCI...)
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Affinity Data
IC50: 71nM
pH: 2.5
Assay Description:
Compound was tested for in vitro motilin receptor binding affinity after treatment with hydrochloric acid solution (pH 2.5)
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Target
Cytochrome P450 3A4
(Homo sapiens (Human))
Glaxosmithkline
Curated by
ChEMBL
Ligand
BDBM50344942
(CHEMBL532 | E-MYCIN E | ERYTHROMYCIN | ERYTHROMYCI...)
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Affinity Data
IC50: 190nM
Assay Description:
Inhibition of human CYP3A4 expressed in Escherichia coli using diethoxyfluorescein substrate measured in 25 to 30 mins by time dependent inhibition a...
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Target
Cytochrome P450 3A4
(Homo sapiens (Human))
Glaxosmithkline
Curated by
ChEMBL
Ligand
BDBM50344942
(CHEMBL532 | E-MYCIN E | ERYTHROMYCIN | ERYTHROMYCI...)
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Affinity Data
IC50: 1.90E+3nM
Assay Description:
Inhibition of human CYP3A4 expressed in Escherichia coli using diethoxyfluorescein substrate measured in 0 to 5 mins by time dependent inhibition ass...
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Target
Bile salt export pump
(Homo sapiens (Human))
Amgen
Curated by
ChEMBL
Ligand
BDBM50344942
(CHEMBL532 | E-MYCIN E | ERYTHROMYCIN | ERYTHROMYCI...)
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Affinity Data
IC50: 1.30E+4nM
Assay Description:
Inhibition of human BSEP overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-taurocholate in presence of ATP measured after 15 to ...
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Target
Cytochrome P450 3A4
(Homo sapiens (Human))
Glaxosmithkline
Curated by
ChEMBL
Ligand
BDBM50344942
(CHEMBL532 | E-MYCIN E | ERYTHROMYCIN | ERYTHROMYCI...)
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Affinity Data
IC50: 3.30E+4nM
Assay Description:
Inhibition of human cytochrome P450 3A4
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Target
ATP-dependent translocase ABCB1
(Mus musculus)
St. Jude Children'S Research Hospital
Curated by
ChEMBL
Ligand
BDBM50344942
(CHEMBL532 | E-MYCIN E | ERYTHROMYCIN | ERYTHROMYCI...)
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Affinity Data
IC50: >3.50E+4nM
Assay Description:
Inhibition of P-glycoprotein, mouse L-mdr1b expressed in LLC-PK1 epithelial cells using calcein-AM polarisation assay
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Target
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human))
Kosan Biosciences
Curated by
ChEMBL
Ligand
BDBM50344942
(CHEMBL532 | E-MYCIN E | ERYTHROMYCIN | ERYTHROMYCI...)
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Affinity Data
IC50: 3.90E+4nM
Assay Description:
Inhibitory concentration against IKr potassium channel
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Target
Cytochrome P450 1B1
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM50344942
(CHEMBL532 | E-MYCIN E | ERYTHROMYCIN | ERYTHROMYCI...)
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Affinity Data
IC50: 4.00E+4nM
Assay Description:
Inhibition of CYP1B1 (unknown origin) expressed in Escherichia coli DH5alpha coexpressing human NADPH-P450 reductase using 7-Ethoxyresorufin as subst...
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Target
ATP-dependent translocase ABCB1
(Homo sapiens (Human))
Eli Lilly
Curated by
ChEMBL
Ligand
BDBM50344942
(CHEMBL532 | E-MYCIN E | ERYTHROMYCIN | ERYTHROMYCI...)
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Affinity Data
IC50: 4.30E+4nM
Assay Description:
Inhibition of P-glycoprotein using calcein-AM assay transfected in porcine PBCEC
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Target
Low molecular weight phosphotyrosine protein phosphatase
(Homo sapiens (Human))
Burnham Center For Chemical Genomics
Curated by
PubChem BioAssay
Ligand
BDBM50344942
(CHEMBL532 | E-MYCIN E | ERYTHROMYCIN | ERYTHROMYCI...)
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IC50: 4.71E+4nM
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Target
ATP-dependent translocase ABCB1
(Homo sapiens (Human))
Eli Lilly
Curated by
ChEMBL
Ligand
BDBM50344942
(CHEMBL532 | E-MYCIN E | ERYTHROMYCIN | ERYTHROMYCI...)
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Affinity Data
IC50: >5.00E+4nM
Assay Description:
Inhibition of P-glycoprotein, human L-MDR1 expressed in LLC-PK1 epithelial cells using calcein-AM polarisation assay
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Target
ATP-dependent translocase ABCB1
(Homo sapiens (Human))
Eli Lilly
Curated by
ChEMBL
Ligand
BDBM50344942
(CHEMBL532 | E-MYCIN E | ERYTHROMYCIN | ERYTHROMYCI...)
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Affinity Data
IC50: >5.00E+4nM
Assay Description:
TP_TRANSPORTER: inhibition of Calcein-AM efflux in MDR1-expressing LLC-PK1 cells
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Target
Cytochrome P450 2J2
(Homo sapiens (Human))
Tongji University
Curated by
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Ligand
BDBM50344942
(CHEMBL532 | E-MYCIN E | ERYTHROMYCIN | ERYTHROMYCI...)
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IC50: >5.00E+4nM
Assay Description:
Inhibition of human recombinant CYP2J2 assessed as reduction in astemizole O-demethylation by LC-MS/MS method
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Target
ATP-dependent translocase ABCB1
(Mus musculus (Mouse))
St. Jude Children'S Research Hospital
Curated by
ChEMBL
Ligand
BDBM50344942
(CHEMBL532 | E-MYCIN E | ERYTHROMYCIN | ERYTHROMYCI...)
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Affinity Data
IC50: >5.00E+4nM
Assay Description:
Inhibition of P-glycoprotein, mouse L-mdr1a expressed in LLC-PK1 epithelial cells using calcein-AM polarisation assay
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Target
ATP-binding cassette sub-family C member 4
(Homo sapiens (Human))
Amgen
Curated by
ChEMBL
Ligand
BDBM50344942
(CHEMBL532 | E-MYCIN E | ERYTHROMYCIN | ERYTHROMYCI...)
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IC50: 6.82E+4nM
Assay Description:
Inhibition of human MRP4 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...
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Target
Low molecular weight phosphotyrosine protein phosphatase
(Homo sapiens (Human))
Burnham Center For Chemical Genomics
Curated by
PubChem BioAssay
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BDBM50344942
(CHEMBL532 | E-MYCIN E | ERYTHROMYCIN | ERYTHROMYCI...)
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IC50: >8.00E+4nM
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Target
60 kDa heat shock protein, mitochondrial
(Homo sapiens)
Indiana University School Of Medicine
Curated by
ChEMBL
Ligand
BDBM50344942
(CHEMBL532 | E-MYCIN E | ERYTHROMYCIN | ERYTHROMYCI...)
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IC50: >1.00E+5nM
Assay Description:
Inhibition of human N-terminal octa-His-tagged HSP60 expressed in Escherichia coli Rosetta(DE3) pLysS/human HSP10 expressed in Escherichia coli Roset...
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Target
Thiosulfate sulfurtransferase
(Homo sapiens)
Indiana University School Of Medicine
Curated by
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Ligand
BDBM50344942
(CHEMBL532 | E-MYCIN E | ERYTHROMYCIN | ERYTHROMYCI...)
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IC50: >1.00E+5nM
Assay Description:
Inhibition of native rhodanese (unknown origin) assessed as reduction in rhodanese enzyme activity after 45 mins by Fe(SCN)3 dye based spectrometric ...
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Target
Co-chaperonin GroES
(Escherichia coli)
Indiana University School Of Medicine
Curated by
ChEMBL
Ligand
BDBM50344942
(CHEMBL532 | E-MYCIN E | ERYTHROMYCIN | ERYTHROMYCI...)
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IC50: >1.00E+5nM
Assay Description:
Inhibition of Escherichia coli GroEL expressed in Escherichia coliDH5alpha/Escherichia coli GroES expressed in Escherichia coli BL21 (DE3) assessed a...
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Target
Bile salt export pump
(Homo sapiens (Human))
Amgen
Curated by
ChEMBL
Ligand
BDBM50344942
(CHEMBL532 | E-MYCIN E | ERYTHROMYCIN | ERYTHROMYCI...)
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Affinity Data
IC50: >1.33E+5nM
Assay Description:
Inhibition of human BSEP overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-taurocholate in presence of ATP measured after 15 to ...
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Target
ATP-binding cassette sub-family C member 3
(Homo sapiens (Human))
Amgen
Curated by
ChEMBL
Ligand
BDBM50344942
(CHEMBL532 | E-MYCIN E | ERYTHROMYCIN | ERYTHROMYCI...)
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Affinity Data
IC50: >1.33E+5nM
Assay Description:
Inhibition of human MRP3 overexpressed in Sf9 insect cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ...
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Target
ATP-binding cassette sub-family C member 2
(Homo sapiens (Human))
Amgen
Curated by
ChEMBL
Ligand
BDBM50344942
(CHEMBL532 | E-MYCIN E | ERYTHROMYCIN | ERYTHROMYCI...)
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Affinity Data
IC50: >1.33E+5nM
Assay Description:
Inhibition of human MRP2 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...
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ATP-binding cassette sub-family C member 3
(Homo sapiens (Human))
Amgen
Curated by
ChEMBL
Ligand
BDBM50344942
(CHEMBL532 | E-MYCIN E | ERYTHROMYCIN | ERYTHROMYCI...)
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Affinity Data
IC50: >1.33E+5nM
Assay Description:
Inhibition of human MRP3 overexpressed in Sf9 insect cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ...
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ATP-binding cassette sub-family C member 4
(Homo sapiens (Human))
Amgen
Curated by
ChEMBL
Ligand
BDBM50344942
(CHEMBL532 | E-MYCIN E | ERYTHROMYCIN | ERYTHROMYCI...)
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Affinity Data
IC50: >1.33E+5nM
Assay Description:
Inhibition of human MRP4 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...
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ATP-binding cassette sub-family C member 2
(Homo sapiens (Human))
Amgen
Curated by
ChEMBL
Ligand
BDBM50344942
(CHEMBL532 | E-MYCIN E | ERYTHROMYCIN | ERYTHROMYCI...)
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Affinity Data
IC50: >1.33E+5nM
Assay Description:
Inhibition of human MRP2 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...
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Co-chaperonin GroES
(Escherichia coli)
Indiana University School Of Medicine
Curated by
ChEMBL
Ligand
BDBM50344942
(CHEMBL532 | E-MYCIN E | ERYTHROMYCIN | ERYTHROMYCI...)
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Affinity Data
IC50: 1.78E+5nM
Assay Description:
Inhibition of Escherichia coli GroEL expressed in Escherichia coli DH5alpha/Escherichia coli GroES expressed in Escherichia coli BL21 (DE3) assessed ...
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Lanosterol 14-alpha demethylase
(Homo sapiens (Human))
Act
Curated by
ChEMBL
Ligand
BDBM50344942
(CHEMBL532 | E-MYCIN E | ERYTHROMYCIN | ERYTHROMYCI...)
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Affinity Data
IC50: >2.00E+5nM
Assay Description:
Inhibition of human CYP51 expressed in Topp 3 cells by lanosterol demethylase assay
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Chaperonin GroEL
(Escherichia coli)
Indiana University School Of Medicine
Curated by
ChEMBL
Ligand
BDBM50344942
(CHEMBL532 | E-MYCIN E | ERYTHROMYCIN | ERYTHROMYCI...)
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Affinity Data
IC50: >2.50E+5nM
Assay Description:
Inhibition of ATPase activity of Escherichia coli GroEL expressed in Escherichia coliDH5alpha incubated for 60 mins using ATP by spectrometric analys...
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Chitinase B
(Serratia marcescens)
Kitasato University
Curated by
ChEMBL
Ligand
BDBM50344942
(CHEMBL532 | E-MYCIN E | ERYTHROMYCIN | ERYTHROMYCI...)
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Affinity Data
IC50: >3.00E+5nM
Assay Description:
Inhibition of Serratia marcescens chitinase ChiB assessed as reduction in chitinolytic activity using 4MU-(GlcNAc)2 substrate by fluorescence based a...
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Multidrug and toxin extrusion protein 1
(Homo sapiens (Human))
University Of California
Curated by
ChEMBL
Ligand
BDBM50344942
(CHEMBL532 | E-MYCIN E | ERYTHROMYCIN | ERYTHROMYCI...)
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Affinity Data
IC50: >5.00E+5nM
Assay Description:
Inhibition of human MATE1-mediated ASP+ uptake expressed in HEK293 cells after 1.5 mins by fluorescence assay
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Target
Motilin receptor
(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by
ChEMBL
Ligand
BDBM50344942
(CHEMBL532 | E-MYCIN E | ERYTHROMYCIN | ERYTHROMYCI...)
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Affinity Data
EC50: 50.1nM
Assay Description:
Agonist activity at human recombinant motilin receptor expressed in CHO cells by FLIPR assay
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Motilin receptor
(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by
ChEMBL
Ligand
BDBM50344942
(CHEMBL532 | E-MYCIN E | ERYTHROMYCIN | ERYTHROMYCI...)
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Affinity Data
EC50: 50.1nM
Assay Description:
Agonist activity at human recombinant motilin receptor expressed in CHO cells assessed as increase in intracellular calcium by FLIPR assay
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Motilin receptor
(Oryctolagus cuniculus)
Kosan Biosciences
Curated by
ChEMBL
Ligand
BDBM50344942
(CHEMBL532 | E-MYCIN E | ERYTHROMYCIN | ERYTHROMYCI...)
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Affinity Data
EC50: 1.20E+3nM
Assay Description:
Agonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contraction
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Motilin receptor
(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by
ChEMBL
Ligand
BDBM50344942
(CHEMBL532 | E-MYCIN E | ERYTHROMYCIN | ERYTHROMYCI...)
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Affinity Data
EC50: 1.00E+3nM
Assay Description:
Agonist activity at motilin receptor
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Target
Motilin receptor
(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by
ChEMBL
Ligand
BDBM50344942
(CHEMBL532 | E-MYCIN E | ERYTHROMYCIN | ERYTHROMYCI...)
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Affinity Data
EC50: 400nM
Assay Description:
In vitro effective concentration towards human motilin receptor
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Target
Motilin receptor
(Oryctolagus cuniculus)
Kosan Biosciences
Curated by
ChEMBL
Ligand
BDBM50344942
(CHEMBL532 | E-MYCIN E | ERYTHROMYCIN | ERYTHROMYCI...)
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Affinity Data
EC50: 1.20E+3nM
Assay Description:
Agonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contraction
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Motilin receptor
(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute
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ChEMBL
Ligand
BDBM50344942
(CHEMBL532 | E-MYCIN E | ERYTHROMYCIN | ERYTHROMYCI...)
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Affinity Data
EC50: 1.00E+3nM
Assay Description:
Agonist activity at motilin receptor
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Target
Motilin receptor
(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute
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ChEMBL
Ligand
BDBM50344942
(CHEMBL532 | E-MYCIN E | ERYTHROMYCIN | ERYTHROMYCI...)
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Affinity Data
EC50: 631nM
Assay Description:
Agonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assay
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Target
Albumin
(Homo sapiens (Human))
Cnrs-Cpbs/Umr 5236
Curated by
ChEMBL
Ligand
BDBM50344942
(CHEMBL532 | E-MYCIN E | ERYTHROMYCIN | ERYTHROMYCI...)
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Affinity Data
Kd: 1.20E+4nM
Assay Description:
Binding affinity to first site on human serum albumin by SPR
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Motilin receptor
(Oryctolagus cuniculus)
Kosan Biosciences
Curated by
ChEMBL
Ligand
BDBM50344942
(CHEMBL532 | E-MYCIN E | ERYTHROMYCIN | ERYTHROMYCI...)
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Affinity Data
EC50: 1.20E+3nM
Assay Description:
Agonist activity at motilin receptor in rabbit smooth muscle assessed as increase of muscle contraction
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