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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 9 hits in this display   

TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
Hokuriku University

LigandPNGBDBM18364((2R,3R,4R,5S,6R)-2-(hydroxymethyl)-6-nonylpiperidi...)
Affinity DataKi:  200nM ΔG°:  -39.8kJ/mole IC50:  270nMpH: 5.5 T: 2°CAssay Description:Enzyme activity was determined as the production of fluorescent 4-MU from the substrate. The fluorescence was measured (excitation 362 nm, emission 4...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSucrase-isomaltase, intestinal(Rattus norvegicus (Rat))
Universit£

Curated by ChEMBL
LigandPNGBDBM50156360(2-Hydroxymethyl-6-nonyl-piperidine-3,4,5-triol | C...)
Affinity DataIC50:  3.5nMAssay Description:Inhibition of rat intestinal isomaltase using disaccharideMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPutative alpha-glucosidase(Oryza sativa subsp. japonica)
Universit£

Curated by ChEMBL
LigandPNGBDBM50156360(2-Hydroxymethyl-6-nonyl-piperidine-3,4,5-triol | C...)
Affinity DataIC50:  1.50E+3nMAssay Description:Inhibitory activity against alpha-Glucosidase from riceMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSucrase-isomaltase, intestinal(Rattus norvegicus (Rat))
Universit£

Curated by ChEMBL
LigandPNGBDBM50156360(2-Hydroxymethyl-6-nonyl-piperidine-3,4,5-triol | C...)
Affinity DataIC50:  2.50E+3nMAssay Description:Inhibition of rat intestinal sucrase using disaccharideMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSucrase-isomaltase, intestinal(Rattus norvegicus (Rat))
Universit£

Curated by ChEMBL
LigandPNGBDBM50156360(2-Hydroxymethyl-6-nonyl-piperidine-3,4,5-triol | C...)
Affinity DataIC50:  4.00E+3nMAssay Description:Inhibition of rat intestinal maltase using disaccharideMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein-lysine 6-oxidase(Homo sapiens (Human))
Hokuriku University

LigandPNGBDBM18364((2R,3R,4R,5S,6R)-2-(hydroxymethyl)-6-nonylpiperidi...)
Affinity DataIC50:  4.80E+3nMpH: 4.5 T: 2°CAssay Description:Enzyme activity was determined as the production of fluorescent 4-MU from the substrate. The fluorescence was measured (excitation 362 nm, emission 4...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-glucosidase A(Caldocellum saccharolyticum)
Universit£

Curated by ChEMBL
LigandPNGBDBM50156360(2-Hydroxymethyl-6-nonyl-piperidine-3,4,5-triol | C...)
Affinity DataIC50:  8.00E+4nMAssay Description:Inhibitory activity against beta-Glucosidase from Caldocellum saccharolyticumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-glucosidase(Prunus avium)
Universit£

Curated by ChEMBL
LigandPNGBDBM50156360(2-Hydroxymethyl-6-nonyl-piperidine-3,4,5-triol | C...)
Affinity DataIC50:  1.50E+5nMAssay Description:Inhibitory activity against beta-Glucosidase from sweet almondMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal alpha-glucosidase(Mus musculus (Mouse))
Amicus Therapeutics

US Patent
LigandPNGBDBM18364((2R,3R,4R,5S,6R)-2-(hydroxymethyl)-6-nonylpiperidi...)
Affinity DataEC50:  7.00E+3nMpH: 4.0Assay Description:Cells were washed two times with 200 μL dPBS followed by the addition of 70 μL of substrate (2.11 mM 3 mM 4-MU-α-D-glu) in citrate-pho...More data for this Ligand-Target Pair
In DepthDetails US Patent