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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 6 hits in this display   

TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM553969(US11325906, Example 32)
Affinity DataIC50:  3nMAssay Description:PARP1: Recombinant full length 6HIS tagged PARP1 protein was diluted to 6 nM with 50 mM Tris pH 8, 0.001% Triton X100, 10 mM MgCl2, 150 mM NaCl and i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtein mono-ADP-ribosyltransferase PARP3(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM553969(US11325906, Example 32)
Affinity DataIC50:  1.90E+3nMAssay Description:PARP3: Recombinant full length PARP3 protein was diluted to 100 nM with 50 mM Tris pH 8, 0.001% Triton X100, 10 mM MgCl2, 150 mM NaCl and incubated f...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPoly [ADP-ribose] polymerase 2(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM553969(US11325906, Example 32)
Affinity DataIC50:  2.10E+3nMAssay Description:PARP2: Recombinant full length PARP2 protein was diluted to 6 nM with 50 mM Tris pH 8, 0.001% Triton X100, 10 mM MgCl2, 150 mM NaCl and incubated for...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtein mono-ADP-ribosyltransferase PARP6(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM553969(US11325906, Example 32)
Affinity DataIC50:  1.00E+4nMAssay Description:PARP6: Recombinant full length GST tagged PARP6 protein was diluted to 160 nM with 50 mM Tris pH 8, 0.001% Triton X100, 10 mM MgCl2, 150 mM NaCl and ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM553969(US11325906, Example 32)
Affinity DataIC50: >4.00E+4nMAssay Description:Electrophysiological recordings (all performed at RT) from stably transfected CHO hKv11.1 cells were obtained using the Nanion Syncropatch 768PE. Tes...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM553969(US11325906, Example 32)
Affinity DataIC50: >1.00E+5nMAssay Description:PARP5a: Recombinant PARP5a binding domain was diluted to 160 nM with 50 mM Tris pH 8, 0.001% Triton X100, 10 mM MgCl2, 150 mM NaCl and incubated for ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent