Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)
Found 32 hits in this display
Caspase-3(Homo sapiens (Human))University Hospital Of The WestfäLische Wilhelms-UniversitäT
Curated by ChEMBL
BDBM10305((S)-5-[1-(2-Methoxymethyl)pyrrolidinylsulfonyl]isa...)
Caspase-3(Homo sapiens (Human))University Hospital Of The WestfäLische Wilhelms-UniversitäT
Curated by ChEMBL
BDBM10305((S)-5-[1-(2-Methoxymethyl)pyrrolidinylsulfonyl]isa...)
Caspase-3(Homo sapiens (Human))University Hospital Of The WestfäLische Wilhelms-UniversitäT
Curated by ChEMBL
BDBM10305((S)-5-[1-(2-Methoxymethyl)pyrrolidinylsulfonyl]isa...)
Ki: 60nMAssay Description:Inhibition of human recombinant caspase 3 using Ac-DEVD-AMC substrate assessed as accumulation of cleaved fluorogenic productMore data for this Ligand-Target Pair
Caspase-3(Homo sapiens (Human))University Hospital Of The WestfäLische Wilhelms-UniversitäT
Curated by ChEMBL
BDBM10305((S)-5-[1-(2-Methoxymethyl)pyrrolidinylsulfonyl]isa...)
Caspase-7(Homo sapiens (Human))Westf£Lische Wilhelms-Universit£T M£Nster
Curated by ChEMBL
BDBM10305((S)-5-[1-(2-Methoxymethyl)pyrrolidinylsulfonyl]isa...)
Caspase-7(Homo sapiens (Human))Westf£Lische Wilhelms-Universit£T M£Nster
Curated by ChEMBL
BDBM10305((S)-5-[1-(2-Methoxymethyl)pyrrolidinylsulfonyl]isa...)
Ki: 170nMAssay Description:Inhibition of human recombinant caspase 7 using Ac-DEVD-AMC substrate assessed as accumulation of cleaved fluorogenic productMore data for this Ligand-Target Pair
Caspase-7(Homo sapiens (Human))Westf£Lische Wilhelms-Universit£T M£Nster
Curated by ChEMBL
BDBM10305((S)-5-[1-(2-Methoxymethyl)pyrrolidinylsulfonyl]isa...)
Caspase-9(Homo sapiens (Human))Glaxosmithkline
BDBM10305((S)-5-[1-(2-Methoxymethyl)pyrrolidinylsulfonyl]isa...)
Caspase-8(Homo sapiens (Human))Glaxosmithkline
BDBM10305((S)-5-[1-(2-Methoxymethyl)pyrrolidinylsulfonyl]isa...)
Ki: >2.50E+4nMAssay Description:The substrate peptides terminating in AMC/AFC are processed by caspases with or without inhibitors, and the accumulation of AMC/AFC was assessed with...More data for this Ligand-Target Pair
Caspase-6(Homo sapiens (Human))Glaxosmithkline
BDBM10305((S)-5-[1-(2-Methoxymethyl)pyrrolidinylsulfonyl]isa...)
Caspase-4(Homo sapiens (Human))Glaxosmithkline
BDBM10305((S)-5-[1-(2-Methoxymethyl)pyrrolidinylsulfonyl]isa...)
Ki: >2.50E+4nMAssay Description:The substrate peptides terminating in AMC/AFC are processed by caspases with or without inhibitors, and the accumulation of AMC/AFC was assessed with...More data for this Ligand-Target Pair
Caspase-2(Homo sapiens (Human))Glaxosmithkline
BDBM10305((S)-5-[1-(2-Methoxymethyl)pyrrolidinylsulfonyl]isa...)
Caspase-1(Homo sapiens (Human))Glaxosmithkline
BDBM10305((S)-5-[1-(2-Methoxymethyl)pyrrolidinylsulfonyl]isa...)
Ki: >2.50E+4nMAssay Description:The substrate peptides terminating in AMC/AFC are processed by caspases with or without inhibitors, and the accumulation of AMC/AFC was assessed with...More data for this Ligand-Target Pair
Caspase-3(Homo sapiens (Human))University Hospital Of The WestfäLische Wilhelms-UniversitäT
Curated by ChEMBL
BDBM10305((S)-5-[1-(2-Methoxymethyl)pyrrolidinylsulfonyl]isa...)
Caspase-3(Homo sapiens (Human))University Hospital Of The WestfäLische Wilhelms-UniversitäT
Curated by ChEMBL
BDBM10305((S)-5-[1-(2-Methoxymethyl)pyrrolidinylsulfonyl]isa...)
IC50: 85nMAssay Description:Inhibition of human recombinant caspase 3 assessed as accumulation of cleaved fluorogenic 7-amino-4-methylcoumarin after 10 minsMore data for this Ligand-Target Pair
Caspase-3(Homo sapiens (Human))University Hospital Of The WestfäLische Wilhelms-UniversitäT
Curated by ChEMBL
BDBM10305((S)-5-[1-(2-Methoxymethyl)pyrrolidinylsulfonyl]isa...)
IC50: 85nMAssay Description:Inhibition of human recombinant caspase 3 using Ac-DEVD-AMC substrate assessed as accumulation of cleaved fluorogenic productMore data for this Ligand-Target Pair
Caspase-3(Homo sapiens (Human))University Hospital Of The WestfäLische Wilhelms-UniversitäT
Curated by ChEMBL
BDBM10305((S)-5-[1-(2-Methoxymethyl)pyrrolidinylsulfonyl]isa...)
IC50: 85nMAssay Description:Inhibition of human recombinant caspase-3 assessed as Ac-DEVD-AMC conversion to 7-amino-4-methylcoumarin incubated for 10 mins prior to substrate add...More data for this Ligand-Target Pair
Caspase-3(Homo sapiens (Human))University Hospital Of The WestfäLische Wilhelms-UniversitäT
Curated by ChEMBL
BDBM10305((S)-5-[1-(2-Methoxymethyl)pyrrolidinylsulfonyl]isa...)
IC50: 120nMAssay Description:Inhibition of caspase 3 in human SK-N-SH cells assessed as accumulation of fluorogenic 7-amino-4-methyl coumarin by flurometric assayMore data for this Ligand-Target Pair
Caspase-3(Homo sapiens (Human))University Hospital Of The WestfäLische Wilhelms-UniversitäT
Curated by ChEMBL
BDBM10305((S)-5-[1-(2-Methoxymethyl)pyrrolidinylsulfonyl]isa...)
Caspase-3(Homo sapiens (Human))University Hospital Of The WestfäLische Wilhelms-UniversitäT
Curated by ChEMBL
BDBM10305((S)-5-[1-(2-Methoxymethyl)pyrrolidinylsulfonyl]isa...)
Caspase-7(Homo sapiens (Human))Westf£Lische Wilhelms-Universit£T M£Nster
Curated by ChEMBL
BDBM10305((S)-5-[1-(2-Methoxymethyl)pyrrolidinylsulfonyl]isa...)
Caspase-7(Homo sapiens (Human))Westf£Lische Wilhelms-Universit£T M£Nster
Curated by ChEMBL
BDBM10305((S)-5-[1-(2-Methoxymethyl)pyrrolidinylsulfonyl]isa...)
IC50: 1.29E+3nMAssay Description:Inhibition of human recombinant caspase 7 using Ac-DEVD-AMC substrate assessed as accumulation of cleaved fluorogenic productMore data for this Ligand-Target Pair
Caspase-7(Homo sapiens (Human))Westf£Lische Wilhelms-Universit£T M£Nster
Curated by ChEMBL
BDBM10305((S)-5-[1-(2-Methoxymethyl)pyrrolidinylsulfonyl]isa...)
Caspase-7(Homo sapiens (Human))Westf£Lische Wilhelms-Universit£T M£Nster
Curated by ChEMBL
BDBM10305((S)-5-[1-(2-Methoxymethyl)pyrrolidinylsulfonyl]isa...)
IC50: 1.29E+3nMAssay Description:Inhibition of human recombinant caspase-7 assessed as Ac-DEVD-AMC conversion to 7-amino-4-methylcoumarin incubated for 10 mins prior to substrate add...More data for this Ligand-Target Pair
Caspase-7(Homo sapiens (Human))Westf£Lische Wilhelms-Universit£T M£Nster
Curated by ChEMBL
BDBM10305((S)-5-[1-(2-Methoxymethyl)pyrrolidinylsulfonyl]isa...)
IC50: 1.29E+3nMAssay Description:Inhibition of human recombinant caspase 7 assessed as accumulation of cleaved fluorogenic 7-amino-4-methylcoumarin after 10 minsMore data for this Ligand-Target Pair
Caspase-1(Homo sapiens (Human))Glaxosmithkline
BDBM10305((S)-5-[1-(2-Methoxymethyl)pyrrolidinylsulfonyl]isa...)
Caspase-6(Homo sapiens (Human))Glaxosmithkline
BDBM10305((S)-5-[1-(2-Methoxymethyl)pyrrolidinylsulfonyl]isa...)
IC50: >5.00E+5nMAssay Description:Inhibition of human recombinant caspase 6 assessed as accumulation of cleaved fluorogenic 7-amino-4-methylcoumarin after 10 minsMore data for this Ligand-Target Pair
Caspase-1(Homo sapiens (Human))Glaxosmithkline
BDBM10305((S)-5-[1-(2-Methoxymethyl)pyrrolidinylsulfonyl]isa...)
IC50: >5.00E+5nMAssay Description:Inhibition of human recombinant caspase 1 assessed as accumulation of cleaved fluorogenic 7-amino-4-methylcoumarin after 10 minsMore data for this Ligand-Target Pair
Caspase-8(Homo sapiens (Human))Glaxosmithkline
BDBM10305((S)-5-[1-(2-Methoxymethyl)pyrrolidinylsulfonyl]isa...)
Caspase-1(Homo sapiens (Human))Glaxosmithkline
BDBM10305((S)-5-[1-(2-Methoxymethyl)pyrrolidinylsulfonyl]isa...)
IC50: 5.00E+5nMAssay Description:Inhibition of human recombinant caspase 1 using Ac-YVAD-AMC substrate assessed as accumulation of cleaved fluorogenic productMore data for this Ligand-Target Pair
Caspase-6(Homo sapiens (Human))Glaxosmithkline
BDBM10305((S)-5-[1-(2-Methoxymethyl)pyrrolidinylsulfonyl]isa...)
IC50: 5.00E+5nMAssay Description:Inhibition of human recombinant caspase 6 using Ac-VEID-AMC substrate assessed as accumulation of cleaved fluorogenic productMore data for this Ligand-Target Pair
Caspase-6(Homo sapiens (Human))Glaxosmithkline
BDBM10305((S)-5-[1-(2-Methoxymethyl)pyrrolidinylsulfonyl]isa...)