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Compile Data Set for Download or QSAR
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
7
hits in this display
Target
72 kDa type IV collagenase
(Homo sapiens (Human))
Pomona College
Curated by
ChEMBL
Ligand
BDBM8466
((2R)-N-hydroxy-2-[(4-methoxybenzene)sulfonamido]-3...)
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Affinity Data
Ki: 81nM
Assay Description:
Inhibition of MMP2
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Patents
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In Depth
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Article
PubMed
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Target
Matrix metalloproteinase-9
(Homo sapiens (Human))
Pomona College
Curated by
ChEMBL
Ligand
BDBM8466
((2R)-N-hydroxy-2-[(4-methoxybenzene)sulfonamido]-3...)
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Affinity Data
Ki: 126nM
Assay Description:
Inhibition of MMP9
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Patents
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In Depth
Details
Article
PubMed
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Target
Collagenase 3
(Homo sapiens (Human))
Pfizer
Curated by
ChEMBL
Ligand
BDBM8466
((2R)-N-hydroxy-2-[(4-methoxybenzene)sulfonamido]-3...)
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Affinity Data
IC50: 1.70nM
Assay Description:
Inhibitory activity against matrix metalloprotease-13 (MMP-13)
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
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Target
Interstitial collagenase
(Homo sapiens (Human))
Pfizer
Curated by
ChEMBL
Ligand
BDBM8466
((2R)-N-hydroxy-2-[(4-methoxybenzene)sulfonamido]-3...)
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Affinity Data
IC50: 170nM
Assay Description:
Inhibitory activity against human matrix metalloprotease-1 (MMP-1)
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
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Target
Lethal factor
(Bacillus anthracis)
Merck Research Laboratories
Ligand
BDBM8466
((2R)-N-hydroxy-2-[(4-methoxybenzene)sulfonamido]-3...)
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Affinity Data
IC50: 900nM
pH: 7.0 T: 2°C
Assay Description:
The assay was performed in a 96-well plate, each well contained substrate peptide, LF, and the test compound. The C-terminally fluorophore of substra...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
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Target
Stromelysin-1
(Homo sapiens (Human))
Duke University
Curated by
ChEMBL
Ligand
BDBM8466
((2R)-N-hydroxy-2-[(4-methoxybenzene)sulfonamido]-3...)
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Affinity Data
Kd: 43nM
Assay Description:
Binding affinity to stromelysin-1 catalytic domain expressed in Escherichia coli BL21 (DE3) by isothermal titration colorimetry
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Stromelysin-1
(Homo sapiens (Human))
Duke University
Curated by
ChEMBL
Ligand
BDBM8466
((2R)-N-hydroxy-2-[(4-methoxybenzene)sulfonamido]-3...)
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Affinity Data
Kd: 113nM
Assay Description:
Binding affinity to stromelysin-1 catalytic domain
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI