Compile Data Set for Download or QSAR
maximum 50k data

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 67 hits in this display   

TargetPoly [ADP-ribose] polymerase 1(Mus musculus)
Nerviano Medical Sciences

US Patent
LigandPNGBDBM138348(US8877944, 99)
Affinity DataIC50:  10nMAssay Description:Affinity evaluation of the tested compounds and their selectivity with respect to the different PARP isoforms of interest was assessed in a displacem...More data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM138348(US8877944, 99)
Affinity DataIC50:  40nMAssay Description:Inhibition of PARP1 in human HeLa cells assessed as reduction of H2O2-induced PAR formation preincubated for 30 mins followed by H2O2 addition measur...More data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM138348(US8877944, 99)
Affinity DataIC50:  79nMAssay Description:Inhibition of human recombinant N-terminal 6His-6Lys-TEV tagged PARP1 full length expressed in pFastBac expression system incubated for 4 hrs by fluo...More data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 2(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM138348(US8877944, 99)
Affinity DataIC50:  6.60E+3nMAssay Description:Inhibition of human recombinant N-terminal Avi-6His-TEV tagged PARP2 full length expressed in pFastBac expression system incubated for 4 hrs by fluor...More data for this Ligand-Target Pair
TargetCytochrome P450 2B6(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM138348(US8877944, 99)
Affinity DataIC50:  8.15E+3nMAssay Description:Inhibition of CYP2B6 in human liver microsomes after 20 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM138348(US8877944, 99)
Affinity DataIC50:  9.51E+3nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using midazolam as substrate after 10 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 2(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM138348(US8877944, 99)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human MNK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEphrin type-A receptor 2(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM138348(US8877944, 99)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human EphA2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C beta type(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM138348(US8877944, 99)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human PKCbetaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM138348(US8877944, 99)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human GSK3betaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity protein kinase TTK(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM138348(US8877944, 99)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human MPS1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lyn(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM138348(US8877944, 99)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human LYNMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM138348(US8877944, 99)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human SYKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM138348(US8877944, 99)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human AKT1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM138348(US8877944, 99)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human CDK2/CYCAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM138348(US8877944, 99)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human VEGFR2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM138348(US8877944, 99)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human AUR2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-dependent protein kinase catalytic subunit alpha(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM138348(US8877944, 99)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human PKAalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM138348(US8877944, 99)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human JAK3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM138348(US8877944, 99)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human IKK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PAK 4(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM138348(US8877944, 99)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human PAK4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM138348(US8877944, 99)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human FLT3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM138348(US8877944, 99)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human ERK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase 26(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM138348(US8877944, 99)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human MST4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM138348(US8877944, 99)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human EGFR1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM138348(US8877944, 99)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human ALKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM138348(US8877944, 99)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human MAPKAPK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM138348(US8877944, 99)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human PDGFRbMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEukaryotic translation initiation factor 2-alpha kinase 3(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM138348(US8877944, 99)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human PERKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Nek6(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM138348(US8877944, 99)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human NEK6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIGF-like family receptor 1(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM138348(US8877944, 99)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human IGFR1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM138348(US8877944, 99)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human KITMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase pim-2(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM138348(US8877944, 99)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human PIM2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCell division cycle 7-related protein kinase/Protein DBF4 homolog A(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM138348(US8877944, 99)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human CDC7/DBF4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM138348(US8877944, 99)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human RETMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM138348(US8877944, 99)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human FGFR1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM138348(US8877944, 99)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human TRKAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM138348(US8877944, 99)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human ABLMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEukaryotic elongation factor 2 kinase(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM138348(US8877944, 99)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human EEF2KMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMaternal embryonic leucine zipper kinase(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM138348(US8877944, 99)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human MELKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM138348(US8877944, 99)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human JAK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase NIM1(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM138348(US8877944, 99)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human NIM1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-phosphoinositide-dependent protein kinase 1(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM138348(US8877944, 99)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human PDK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM138348(US8877944, 99)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human PIM1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase haspin(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM138348(US8877944, 99)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human HaspinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitotic checkpoint serine/threonine-protein kinase BUB1(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM138348(US8877944, 99)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human BUB1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFocal adhesion kinase 1(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM138348(US8877944, 99)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human FAKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetActivated CDC42 kinase 1(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM138348(US8877944, 99)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human ACK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM138348(US8877944, 99)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human METMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase tousled-like 2(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM138348(US8877944, 99)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human TLK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PLK1(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM138348(US8877944, 99)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human PLK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM138348(US8877944, 99)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human LCKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM138348(US8877944, 99)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human AUR1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM138348(US8877944, 99)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human JAK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin receptor(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM138348(US8877944, 99)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human IRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein-tyrosine kinase 6(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM138348(US8877944, 99)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human BRKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM138348(US8877944, 99)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human TYK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM138348(US8877944, 99)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human P38alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM138348(US8877944, 99)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human CHK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ZAP-70(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM138348(US8877944, 99)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human ZAP70More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM138348(US8877944, 99)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human recombinant PARP5a (E1023 to T1327 amino acids) incubated for 4 hrs by fluorescence anisotropy binding assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetPoly [ADP-ribose] polymerase 1(Mus musculus)
Nerviano Medical Sciences

US Patent
LigandPNGBDBM138348(US8877944, 99)
Affinity DataKd: <10nMAssay Description:The assay is based on the use of a probe of formula (IP) that binds to the NAD binding pocket and takes advantage of the significant change in the po...More data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM138348(US8877944, 99)
Affinity DataKd:  8.60nMAssay Description:Binding affinity to recombinant human HisGST-tagged PARP-1 catalytic domain by surface plasmon resonance analysisMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 2(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM138348(US8877944, 99)
Affinity DataKd:  1.40E+3nMAssay Description:Inhibition of PARP-2 (unknown origin)More data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 2(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM138348(US8877944, 99)
Affinity DataKd:  1.39E+3nMAssay Description:Binding affinity to recombinant human HisGST-tagged PARP-2 catalytic domain by surface plasmon resonance analysisMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM138348(US8877944, 99)
Affinity DataKd:  9nMAssay Description:Inhibition of PARP-1 (unknown origin)More data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM138348(US8877944, 99)
Affinity DataKd: <30nMAssay Description:Binding affinity to full length recombinant human PARP-1 by fluorescence polarization displacement assayMore data for this Ligand-Target Pair
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