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Compile Data Set for Download or QSAR
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
31
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Target
Enoyl-acyl-carrier protein reductase
(Plasmodium falciparum)
National Institute Of Immunology
Curated by
ChEMBL
Ligand
BDBM50153015
((-)-Epicatechin-3-gallate | (-)-epicatechin 3-O-ga...)
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Affinity Data
Ki: 16nM
Assay Description:
Inhibition of Plasmodium falciparum ENR in presence of triclosan
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Target
Enoyl-acyl-carrier protein reductase
(Plasmodium falciparum)
National Institute Of Immunology
Curated by
ChEMBL
Ligand
BDBM50153015
((-)-Epicatechin-3-gallate | (-)-epicatechin 3-O-ga...)
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Affinity Data
Ki: 102nM
Assay Description:
Inhibition of Plasmodium falciparum ENR using crotonyl-CoA substrate
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Target
Enoyl-acyl-carrier protein reductase
(Plasmodium falciparum)
National Institute Of Immunology
Curated by
ChEMBL
Ligand
BDBM50153015
((-)-Epicatechin-3-gallate | (-)-epicatechin 3-O-ga...)
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Affinity Data
Ki: 291nM
Assay Description:
Inhibition of Plasmodium falciparum ENR using NADH substrate
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Target
Apoptosis regulator Bcl-2
(Homo sapiens (Human))
TBA
Ligand
BDBM50153015
((-)-Epicatechin-3-gallate | (-)-epicatechin 3-O-ga...)
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Affinity Data
Ki: 400nM
Assay Description:
Displacement of NLWAAQRYGRELRRMSD-K(FITC)-FVD from Bcl-2 (unknown origin) by fluorescence polarization assay
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Target
Solute carrier organic anion transporter family member 1B1
(Homo sapiens (Human))
Ku Leuven
Curated by
ChEMBL
Ligand
BDBM50153015
((-)-Epicatechin-3-gallate | (-)-epicatechin 3-O-ga...)
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Affinity Data
Ki: 2.07E+3nM
Assay Description:
Ki values for sodium fluorescein (10 uM) uptake in OATP1B1-transfected CHO cells
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Target
Solute carrier organic anion transporter family member 1B3
(Homo sapiens (Human))
Ku Leuven
Curated by
ChEMBL
Ligand
BDBM50153015
((-)-Epicatechin-3-gallate | (-)-epicatechin 3-O-ga...)
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Affinity Data
Ki: 3.46E+3nM
Assay Description:
Ki values for sodium fluorescein (10 uM) uptake in OATP1B3-transfected CHO cells
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Target
Cannabinoid receptor 1
(Homo sapiens (Human))
Concordia University Wisconsin
Curated by
ChEMBL
Ligand
BDBM50153015
((-)-Epicatechin-3-gallate | (-)-epicatechin 3-O-ga...)
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Affinity Data
Ki: 4.73E+4nM
Assay Description:
Displacement of [3H]-CP55940 from CB1 receptor (unknown origin)
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Target
Cannabinoid receptor 2
(Homo sapiens (Human))
Concordia University Wisconsin
Curated by
ChEMBL
Ligand
BDBM50153015
((-)-Epicatechin-3-gallate | (-)-epicatechin 3-O-ga...)
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Affinity Data
Ki: 9.56E+4nM
Assay Description:
Displacement of [3H]-CP55940 from CB2 receptor (unknown origin)
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Target
A disintegrin and metalloproteinase with thrombospondin motifs 5
(Homo sapiens (Human))
TBA
Ligand
BDBM50153015
((-)-Epicatechin-3-gallate | (-)-epicatechin 3-O-ga...)
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IC50: 100nM
Assay Description:
Inhibition of ADAMTS-5 (unknown origin)
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Target
A disintegrin and metalloproteinase with thrombospondin motifs 4
(Homo sapiens (Human))
TBA
Ligand
BDBM50153015
((-)-Epicatechin-3-gallate | (-)-epicatechin 3-O-ga...)
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Affinity Data
IC50: 100nM
Assay Description:
Inhibition of ADAMTS-4 (unknown origin)
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Target
Glucose-6-phosphate 1-dehydrogenase
(Saccharomyces cerevisiae S288c)
Amorepacific
Curated by
ChEMBL
Ligand
BDBM50153015
((-)-Epicatechin-3-gallate | (-)-epicatechin 3-O-ga...)
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IC50: 180nM
Assay Description:
Inhibition of yeast G6PD
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Target
Proteasome subunit beta type-5
(Homo sapiens (Human))
Institute Of Agricultural And Food Biotechnology
Curated by
ChEMBL
Ligand
BDBM50153015
((-)-Epicatechin-3-gallate | (-)-epicatechin 3-O-ga...)
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Affinity Data
IC50: 194nM
Assay Description:
Inhibition of chymotrypsin-like activity of purified human 20S proteasome assessed as decrease in AMC hydrolysis using Suc-Leu-Leu-Val-Tyr-AMC as sub...
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Target
ELAV-like protein 3
(Homo sapiens)
University of Pavia
Curated by
ChEMBL
Ligand
BDBM50153015
((-)-Epicatechin-3-gallate | (-)-epicatechin 3-O-ga...)
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IC50: 200nM
Assay Description:
Inhibition of ELAV3 (unknown origin)-artificial ARE complex formation after 30 mins in the presence of biotin-labeled RNA probe by chemiluminescence ...
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Target
Enoyl-acyl-carrier protein reductase
(Plasmodium falciparum)
National Institute Of Immunology
Curated by
ChEMBL
Ligand
BDBM50153015
((-)-Epicatechin-3-gallate | (-)-epicatechin 3-O-ga...)
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Affinity Data
IC50: 200nM
Assay Description:
Inhibition of FabI
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Target
6-phosphogluconate dehydrogenase, decarboxylating
(Homo sapiens (Human))
Amorepacific
Curated by
ChEMBL
Ligand
BDBM50153015
((-)-Epicatechin-3-gallate | (-)-epicatechin 3-O-ga...)
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Affinity Data
IC50: 210nM
Assay Description:
Inhibition of 6PGD
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Target
3-hydroxyacyl-[acyl-carrier-protein] dehydratase
(Plasmodium falciparum)
University Of Zurich
Curated by
ChEMBL
Ligand
BDBM50153015
((-)-Epicatechin-3-gallate | (-)-epicatechin 3-O-ga...)
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IC50: 400nM
Assay Description:
Inhibition of FabZ
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Target
Enoyl-acyl-carrier protein reductase
(Plasmodium falciparum)
National Institute Of Immunology
Curated by
ChEMBL
Ligand
BDBM50153015
((-)-Epicatechin-3-gallate | (-)-epicatechin 3-O-ga...)
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Affinity Data
IC50: 500nM
Assay Description:
Inhibition of Plasmodium falciparum ENR
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Target
Dual specificity tyrosine-phosphorylation-regulated kinase 1A
(Homo sapiens (Human))
Avanti Biosciences
Curated by
ChEMBL
Ligand
BDBM50153015
((-)-Epicatechin-3-gallate | (-)-epicatechin 3-O-ga...)
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Affinity Data
IC50: 523nM
Assay Description:
Inhibition of DYRK1A (unknown origin) using HT-497 as substrate preincubated with compound followed by substrate addition and measured after 30 mins ...
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Target
Reverse transcriptase/RNaseH
(Human immunodeficiency virus 1)
University Of Toledo
Curated by
ChEMBL
Ligand
BDBM50153015
((-)-Epicatechin-3-gallate | (-)-epicatechin 3-O-ga...)
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Affinity Data
IC50: 760nM
Assay Description:
Inhibition of polymerization in wild type HIV-1 RT with poly rC/dG12-18 template primer and [3H]dGTP
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Target
3-oxoacyl-acyl-carrier protein reductase
(Plasmodium falciparum)
University Of Zurich
Curated by
ChEMBL
Ligand
BDBM50153015
((-)-Epicatechin-3-gallate | (-)-epicatechin 3-O-ga...)
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Affinity Data
IC50: 1.00E+3nM
Assay Description:
Inhibition of FabG
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Target
Mitogen-activated protein kinase 14
(Homo sapiens (Human))
Albert-Ludwigs-University Of Freiburg
Curated by
ChEMBL
Ligand
BDBM50153015
((-)-Epicatechin-3-gallate | (-)-epicatechin 3-O-ga...)
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Affinity Data
IC50: 1.47E+3nM
Assay Description:
Inhibition of p38alpha after 1 hr by ELISA
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Target
Solute carrier organic anion transporter family member 1B1
(Homo sapiens (Human))
Ku Leuven
Curated by
ChEMBL
Ligand
BDBM50153015
((-)-Epicatechin-3-gallate | (-)-epicatechin 3-O-ga...)
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Affinity Data
IC50: 3.80E+3nM
Assay Description:
pIC50 values for sodium fluorescein (10 uM) uptake in OATP1B1-transfected CHO cells
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Target
Solute carrier organic anion transporter family member 1B3
(Homo sapiens (Human))
Ku Leuven
Curated by
ChEMBL
Ligand
BDBM50153015
((-)-Epicatechin-3-gallate | (-)-epicatechin 3-O-ga...)
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Affinity Data
IC50: 4.47E+3nM
Assay Description:
pIC50 values for sodium fluorescein (10 uM) uptake in OATP1B3-transfected CHO cells
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Target
Alpha-synuclein
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM50153015
((-)-Epicatechin-3-gallate | (-)-epicatechin 3-O-ga...)
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Affinity Data
IC50: 9.80E+3nM
Assay Description:
Inhibition of human alpha-synuclein filament formation expressed in Escherichia coli BL21(DE3) cells incubated for 72 hrs by thioflavin S based fluor...
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Target
Enoyl-[acyl-carrier-protein] reductase [NADH] FabI
(Escherichia coli)
National Institute Of Immunology
Curated by
ChEMBL
Ligand
BDBM50153015
((-)-Epicatechin-3-gallate | (-)-epicatechin 3-O-ga...)
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IC50: 1.00E+4nM
Assay Description:
Inhibition of Escherichia coli ENR
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Target
Hepatocyte growth factor receptor
(Homo sapiens (Human))
Oregon State University
Curated by
ChEMBL
Ligand
BDBM50153015
((-)-Epicatechin-3-gallate | (-)-epicatechin 3-O-ga...)
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IC50: 1.00E+4nM
Assay Description:
Inhibition of MET kinase
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Target
Fatty acid synthase
(Gallus gallus (Chicken))
Wayne State University
Curated by
ChEMBL
Ligand
BDBM50153015
((-)-Epicatechin-3-gallate | (-)-epicatechin 3-O-ga...)
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IC50: 4.20E+4nM
Assay Description:
Inhibition of chicken liver FASN after 3 hrs
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Target
Solute carrier organic anion transporter family member 2B1
(Homo sapiens)
TBA
Ligand
BDBM50153015
((-)-Epicatechin-3-gallate | (-)-epicatechin 3-O-ga...)
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IC50: 4.72E+4nM
Assay Description:
Inhibition of human OATP2B1 expressed in Flp-In-CHO cells assessed as inhibition of OATP2B1 mediated DBF uptake using DBF as fluorescent substrate in...
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Target
Fatty acid synthase
(Gallus gallus (Chicken))
Wayne State University
Curated by
ChEMBL
Ligand
BDBM50153015
((-)-Epicatechin-3-gallate | (-)-epicatechin 3-O-ga...)
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IC50: 6.80E+4nM
Assay Description:
Inhibition of chicken liver FASN ketoreductase activity
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Target
Nonstructural protein 3
(Zika virus)
University Of North Carolina At Chapel Hill
Curated by
ChEMBL
Ligand
BDBM50153015
((-)-Epicatechin-3-gallate | (-)-epicatechin 3-O-ga...)
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Affinity Data
IC50: 8.90E+4nM
Assay Description:
Inhibition of Zika virus NS2B (1421 to 1469 residues) - NS3 (1503 to 1688 residues) expressed in Escherichia coli BL21(DE3) cells using Dabcyl-KTSAVL...
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Target
Death-associated protein kinase 1
(Homo sapiens (Human))
University Of Toyama
Curated by
ChEMBL
Ligand
BDBM50153015
((-)-Epicatechin-3-gallate | (-)-epicatechin 3-O-ga...)
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IC50: >3.00E+5nM
Assay Description:
Displacement of ANS from DAPK1 catalytic domain (1 to 285) (unknown origin) after 30 mins by fluorescence assay
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