BindingDB PrimarySearch

Found 2 Enz. Inhib. hit(s) with Target = 'HLA class II histocompatibility antigen gamma chain/Proto-oncogene tyrosine-protein kinase ROS'

HLA class II histocompatibility antigen gamma chain/Proto-oncogene tyrosine-protein kinase ROS(Homo sapiens (Human))
Pfizer

Curated by ChEMBL

BDBM50018830(CHEMBL3286830 | US10543199, Compound PF-06463922 |...)

IC50: 0.230nMAssay Description:Inhibition of CD74-ROS1 (unknown origin) expressed in mouse BaF3 cells assessed as reduction in cell viabilityMore data for this Ligand-Target Pair

PDB MMDB KEGG
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar

Purchase CHEMBL MCE
PC cid PC sid Similars

Details Article PubMed

HLA class II histocompatibility antigen gamma chain/Proto-oncogene tyrosine-protein kinase ROS(Homo sapiens (Human))
Pfizer

Curated by ChEMBL

BDBM50306682((R)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(1...)

IC50: 3.90nMAssay Description:Inhibition of CD74-ROS1 (unknown origin) expressed in mouse BaF3 cells assessed as reduction in cell viabilityMore data for this Ligand-Target Pair

PDB MMDB KEGG
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar

Purchase ChEBI
CHEMBL DrugBank MCE
MMDB PC cid PC sid PDB Patents Similars

Details Article PubMed PDB

3D Structure (crystal)