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Found 443 Enz. Inhib. hit(s) with Target = 'P2Y purinoceptor 6'
TargetP2Y purinoceptor 6(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50429534(CHEMBL2333773)
Affinity DataKi: >1.50E+4nMAssay Description:Inhibition of human P2Y6 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2Y purinoceptor 6(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50429535(CHEMBL2333772)
Affinity DataKi: >1.50E+4nMAssay Description:Inhibition of human P2Y6 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2Y purinoceptor 6(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50429538(CHEMBL2333767)
Affinity DataKi: >1.50E+4nMAssay Description:Inhibition of human P2Y6 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2Y purinoceptor 6(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50429537(CHEMBL2333770)
Affinity DataKi: >1.50E+4nMAssay Description:Inhibition of human P2Y6 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2Y purinoceptor 6(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50429536(CHEMBL2333771)
Affinity DataKi: >1.50E+4nMAssay Description:Inhibition of human P2Y6 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2Y purinoceptor 6(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50454137(CHEMBL1321988)
Affinity DataIC50:  37nMAssay Description:Antagonist activity at human P2Y6 receptor expressed in human 1321N1 cells assessed as inhibition of UDP-induced inositol-1-phosphate accumulation pr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2Y purinoceptor 6(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50454137(CHEMBL1321988)
Affinity DataIC50:  37nMAssay Description:Antagonist activity at P2Y6 receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2Y purinoceptor 6(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50454137(CHEMBL1321988)
Affinity DataIC50:  37nMMore data for this Ligand-Target Pair
In DepthDetails
TargetP2Y purinoceptor 6(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50454137(CHEMBL1321988)
Affinity DataIC50:  37nMAssay Description:Compound was tested for the contractile effects antagonized by mepyramine (1-1000 nM) against Histamine H1 receptor of guinea pig aorta.More data for this Ligand-Target Pair
In DepthDetails
TargetP2Y purinoceptor 6(Rattus norvegicus)
National Institute Of Diabetes And Digestive And Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50454137(CHEMBL1321988)
Affinity DataIC50:  98nMAssay Description:Antagonist activity at rat P2Y6 receptor expressed in human 1321N1 cells assessed as inhibition of UDP-induced inositol-1-phosphate accumulation prei...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2Y purinoceptor 6(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50614412(CHEMBL5272895)
Affinity DataIC50:  100nMMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails
TargetP2Y purinoceptor 6(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50569572(CHEMBL4877204)
Affinity DataIC50:  155nMAssay Description:Antagonist activity at human P2Y6 receptor expressed in human 1321N1 cells assessed as inhibition of UDP-induced inositol-1-phosphate accumulation pr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetP2Y purinoceptor 6(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50405434(CHEMBL5274312)
Affinity DataIC50:  461nMAssay Description:Compound was tested for the agonist activity against histamine H3 receptor of guinea pig ileumMore data for this Ligand-Target Pair
In DepthDetails
TargetP2Y purinoceptor 6(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50569551(CHEMBL4877977)
Affinity DataIC50:  604nMAssay Description:Antagonist activity at human P2Y6 receptor expressed in human 1321N1 cells assessed as inhibition of UDP-induced intracellular calcium mobilization b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetP2Y purinoceptor 6(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50569550(CHEMBL4851349)
Affinity DataIC50:  785nMAssay Description:Antagonist activity at human P2Y6 receptor expressed in human 1321N1 cells assessed as inhibition of UDP-induced intracellular calcium mobilization b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetP2Y purinoceptor 6(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50569547(CHEMBL4854398)
Affinity DataIC50:  900nMAssay Description:Antagonist activity at human P2Y6 receptor expressed in human 1321N1 cells assessed as inhibition of UDP-induced intracellular calcium mobilization p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetP2Y purinoceptor 6(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50569559(CHEMBL4857492)
Affinity DataIC50:  1.09E+3nMAssay Description:Antagonist activity at human P2Y6 receptor expressed in human 1321N1 cells assessed as inhibition of UDP-induced intracellular calcium mobilization b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetP2Y purinoceptor 6(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50405420(CHEMBL5287483)
Affinity DataIC50:  1.15E+3nMAssay Description:pA2 value against Tachykinin receptor 2 in rat vas deferensMore data for this Ligand-Target Pair
In DepthDetails
TargetP2Y purinoceptor 6(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50569557(CHEMBL4856060)
Affinity DataIC50:  1.20E+3nMAssay Description:Antagonist activity at human P2Y6 receptor expressed in human 1321N1 cells assessed as inhibition of UDP-induced intracellular calcium mobilization b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetP2Y purinoceptor 6(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50569549(CHEMBL4871107)
Affinity DataIC50:  1.33E+3nMAssay Description:Antagonist activity at human P2Y6 receptor expressed in human 1321N1 cells assessed as inhibition of UDP-induced intracellular calcium mobilization b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetP2Y purinoceptor 6(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50405421(CHEMBL5279730)
Affinity DataIC50:  1.79E+3nMAssay Description:pA2 value against Tachykinin receptor 2 in rat vas deferensMore data for this Ligand-Target Pair
In DepthDetails
TargetP2Y purinoceptor 6(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50405423(CHEMBL5283362)
Affinity DataIC50:  2.00E+3nMAssay Description:Compound was evaluated for antagonistic activity towards Tachykinin receptor 2 in rat vas deferensMore data for this Ligand-Target Pair
In DepthDetails
TargetP2Y purinoceptor 6(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50268874(CHEMBL499580 | Sodium 1-Amino-4-[3-(4,6-dichloro-[...)
Affinity DataIC50:  2.55E+3nMAssay Description:Antagonist activity against human P2Y6 receptor expressed in 1321N1 astrocytoma cells by calcium mobilization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2Y purinoceptor 6(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50405427(CHEMBL5287190)
Affinity DataIC50:  2.57E+3nMAssay Description:Contractile effects antagonized by mepyramine (0.3-100 nM) against Histamine H1 receptor in guinea pig ileumMore data for this Ligand-Target Pair
In DepthDetails
TargetP2Y purinoceptor 6(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50237574(CHEMBL4081274)
Affinity DataIC50:  2.67E+3nMAssay Description:Antagonist activity at human P2Y6 receptor transfected in human 1321N1 cells assessed as inhibition of UDP-activated intracellular calcium mobilizati...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2Y purinoceptor 6(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50227032(CHEMBL256057 | acid blue 25 | sodium 1-amino-9,10-...)
Affinity DataIC50:  2.79E+3nMAssay Description:Antagonist activity at human P2Y6 receptor transfected in human 1321N1 cells assessed as inhibition of UDP-activated intracellular calcium mobilizati...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2Y purinoceptor 6(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50569546(CHEMBL4876210)
Affinity DataIC50:  2.91E+3nMAssay Description:Antagonist activity at human P2Y6 receptor expressed in human 1321N1 cells assessed as inhibition of UDP-induced intracellular calcium mobilization b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetP2Y purinoceptor 6(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50569546(CHEMBL4876210)
Affinity DataIC50:  2.91E+3nMAssay Description:Contractile effects antagonized by mepyramine (0.3-100 nM) against Histamine H1 receptor in guinea pig ileumMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
TargetP2Y purinoceptor 6(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50405435(CHEMBL5280754)
Affinity DataIC50:  2.99E+3nMAssay Description:Compound was tested for the agonist activity against histamine H3 receptor of guinea pig ileumMore data for this Ligand-Target Pair
In DepthDetails
TargetP2Y purinoceptor 6(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50569547(CHEMBL4854398)
Affinity DataIC50:  3.49E+3nMAssay Description:Antagonist activity at human P2Y6 receptor expressed in human 1321N1 cells assessed as inhibition of UDP-induced intracellular calcium mobilization b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetP2Y purinoceptor 6(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50405432(CHEMBL5277295)
Affinity DataIC50:  3.69E+3nMAssay Description:Compound was tested for the contractile effects antagonized by mepyramine (1-1000 nM) against Histamine H1 receptor of guinea pig aorta.More data for this Ligand-Target Pair
In DepthDetails
TargetP2Y purinoceptor 6(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50336787(CHEMBL445413 | sodium 1-amino-9,10-dioxo-4-(m-toly...)
Affinity DataIC50:  3.92E+3nMAssay Description:Antagonist activity against human P2Y6 receptor expressed in 1321N1 astrocytoma cells by calcium mobilization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2Y purinoceptor 6(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50569558(CHEMBL4870366)
Affinity DataIC50:  3.97E+3nMAssay Description:In vitro inhibitory activity against angiotensin converting enzyme (ACE)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
TargetP2Y purinoceptor 6(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50405436(CHEMBL5286996)
Affinity DataIC50:  3.99E+3nMAssay Description:Contractile effects antagonized by mepyramine (0.3-100 nM) against Histamine H1 receptor in guinea pig ileumMore data for this Ligand-Target Pair
In DepthDetails
TargetP2Y purinoceptor 6(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50569548(CHEMBL4875858)
Affinity DataIC50:  4.00E+3nMAssay Description:Compound was tested for inhibition of cathepsin G serine protease to produce one-half maximal enzyme activity.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
TargetP2Y purinoceptor 6(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50569548(CHEMBL4875858)
Affinity DataIC50:  4.00E+3nMAssay Description:Antagonist activity at human P2Y6 receptor expressed in human 1321N1 cells assessed as inhibition of UDP-induced intracellular calcium mobilization b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetP2Y purinoceptor 6(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50405433(CHEMBL5283029)
Affinity DataIC50:  4.09E+3nMAssay Description:Compound was tested for the contractile effects antagonized by mepyramine (1-1000 nM) against Histamine H1 receptor of guinea pig aorta.More data for this Ligand-Target Pair
In DepthDetails
TargetP2Y purinoceptor 6(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50569546(CHEMBL4876210)
Affinity DataIC50:  4.30E+3nMAssay Description:Antagonist activity at human P2Y6 receptor expressed in human 1321N1 cells assessed as inhibition of UDP-induced intracellular calcium mobilization p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetP2Y purinoceptor 6(Rattus norvegicus)
National Institute Of Diabetes And Digestive And Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50029031(1-Amino-4-{4-[4-chloro-6-(3-sulfo-phenylamino)-[1,...)
Affinity DataIC50:  4.34E+3nMAssay Description:Antagonist activity at rat P2Y6 receptor expressed in astrocytoma cells assessed as inhibition of intracellular calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2Y purinoceptor 6(Rattus norvegicus)
National Institute Of Diabetes And Digestive And Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50029031(1-Amino-4-{4-[4-chloro-6-(3-sulfo-phenylamino)-[1,...)
Affinity DataIC50:  4.34E+3nMAssay Description:Antagonist activity at rat P2Y6 receptor expressed in human 1321N1 cells assessed as inhibition of UDP-induced intracellular calcium mobilization by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2Y purinoceptor 6(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50029031(1-Amino-4-{4-[4-chloro-6-(3-sulfo-phenylamino)-[1,...)
Affinity DataIC50:  4.34E+3nMAssay Description:Antagonist activity against human P2Y6 receptor expressed in 1321N1 astrocytoma cells by calcium mobilization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2Y purinoceptor 6(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50237587(CHEMBL4099292)
Affinity DataIC50:  4.36E+3nMAssay Description:Antagonist activity at human P2Y6 receptor transfected in human 1321N1 cells assessed as inhibition of UDP-activated intracellular calcium mobilizati...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2Y purinoceptor 6(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50336800(CHEMBL1672101 | Sodium 1-Amino-4-(3-phenoxyphenyla...)
Affinity DataIC50:  4.56E+3nMAssay Description:Antagonist activity against human P2Y6 receptor expressed in 1321N1 astrocytoma cells by calcium mobilization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2Y purinoceptor 6(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50569565(CHEMBL4845850)
Affinity DataIC50:  4.65E+3nMAssay Description:Antagonist activity at human P2Y6 receptor expressed in human 1321N1 cells assessed as inhibition of UDP-induced intracellular calcium mobilization b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetP2Y purinoceptor 6(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50237576(CHEMBL4069492)
Affinity DataIC50:  4.75E+3nMAssay Description:Inhibition of human Potassium channel HERG expressed in mammalian cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2Y purinoceptor 6(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50405430(CHEMBL5278019)
Affinity DataIC50:  4.77E+3nMAssay Description:Compound was tested for the agonist activity against histamine H3 receptor of guinea pig ileumMore data for this Ligand-Target Pair
In DepthDetails
TargetP2Y purinoceptor 6(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50569553(CHEMBL4864185)
Affinity DataIC50:  4.87E+3nMAssay Description:Antagonist activity at human P2Y6 receptor expressed in human 1321N1 cells assessed as inhibition of UDP-induced intracellular calcium mobilization b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetP2Y purinoceptor 6(Mus musculus)TBA
LigandPNGBDBM50569551(CHEMBL4877977)
Affinity DataIC50:  4.94E+3nMAssay Description:Functional affinity was evaluated by measuring the intracellular calcium concentration in CHO cells transfected with the human Tachykinin receptor 2 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
TargetP2Y purinoceptor 6(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50405426(CHEMBL5280827)
Affinity DataIC50:  5.22E+3nMAssay Description:Compound was tested for the agonist activity against histamine H3 receptor of guinea pig ileumMore data for this Ligand-Target Pair
In DepthDetails
TargetP2Y purinoceptor 6(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50569561(CHEMBL4858554)
Affinity DataIC50:  5.23E+3nMAssay Description:Antagonist activity at human P2Y6 receptor expressed in human 1321N1 cells assessed as inhibition of UDP-induced intracellular calcium mobilization b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
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