BindingDB PrimarySearch

Found 39 of ic50 for monomerid = 50507645

Receptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL

IC50: 0.735nMAssay Description:Inhibition of human FLT3 D835Y mutant using EAIYAAPFAKKK as substrate preincubated for 20 mins followed by [gamma-33P]-ATP addition and measured afte...More data for this Ligand-Target Pair

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Receptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL

BDBM50507645(CHEMBL4473820)

IC50: 0.940nMAssay Description:Inhibition of human FLT3 ITD mutant using EAIYAAPFAKKK as substrate preincubated for 20 mins followed by [gamma-33P]-ATP addition and measured after ...More data for this Ligand-Target Pair

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Receptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL

BDBM50507645(CHEMBL4473820)

IC50: 0.940nMAssay Description:Inhibition of human FLT3 ITD mutant using EAIYAAPFAKKK peptide as substrate in presence of 33P-gamma ATP by hotspot kinase assayMore data for this Ligand-Target Pair

PDB NCI pathway Reactome pathway
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Receptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL

BDBM50507645(CHEMBL4473820)

IC50: 3nMAssay Description:Inhibition of human FLT3 using EAIYAAPFAKKK as substrate preincubated for 20 mins followed by [gamma-33P]-ATP addition and measured after 120 mins by...More data for this Ligand-Target Pair

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Receptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL

BDBM50507645(CHEMBL4473820)

IC50: 3.20nMAssay Description:Inhibition of human FLT3 using EAIYAAPFAKKK as substrate preincubated for 20 mins followed by [gamma-33P]-ATP addition and measured after 120 mins by...More data for this Ligand-Target Pair

PDB NCI pathway Reactome pathway
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Mast/stem cell growth factor receptor Kit(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL

BDBM50507645(CHEMBL4473820)

IC50: 47nMAssay Description:Inhibition of human c-KIT using poly[Glu:Tyr] (4:1) as substrate preincubated for 20 mins followed by [gamma-33P]-ATP addition and measured after 120...More data for this Ligand-Target Pair

PDB Reactome pathway
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Macrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL

BDBM50507645(CHEMBL4473820)

IC50: 50nMAssay Description:Inhibition of human FMS using poly[Glu:Tyr] (4:1) as substrate preincubated for 20 mins followed by [gamma-33P]-ATP addition and measured after 120 m...More data for this Ligand-Target Pair

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Mast/stem cell growth factor receptor Kit(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL

BDBM50507645(CHEMBL4473820)

IC50: 50nMAssay Description:Inhibition of human c-KIT using poly[Glu:Tyr] (4:1) as substrate preincubated for 20 mins followed by [gamma-33P]-ATP addition and measured after 120...More data for this Ligand-Target Pair

PDB Reactome pathway
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Macrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL

BDBM50507645(CHEMBL4473820)

IC50: 53nMAssay Description:Inhibition of human FMS using poly[Glu:Tyr] (4:1) as substrate preincubated for 20 mins followed by [gamma-33P]-ATP addition and measured after 120 m...More data for this Ligand-Target Pair

PDB
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Serine/threonine-protein kinase pim-1(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL

BDBM50507645(CHEMBL4473820)

IC50: 792nMAssay Description:Inhibition of human PIM1 using KKRNRTLTK as substrate preincubated for 20 mins followed by [gamma-33P]-ATP addition and measured after 120 mins by Ho...More data for this Ligand-Target Pair

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Serine/threonine-protein kinase pim-1(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL

BDBM50507645(CHEMBL4473820)

IC50: 794nMAssay Description:Inhibition of human PIM1 using KKRNRTLTK as substrate preincubated for 20 mins followed by [gamma-33P]-ATP addition and measured after 120 mins by Ho...More data for this Ligand-Target Pair

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Tyrosine-protein kinase ABL1(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL

BDBM50507645(CHEMBL4473820)

IC50: 931nMAssay Description:Inhibition of human ABL1 using EAIYAAPFAKKK as substrate preincubated for 20 mins followed by [gamma-33P]-ATP addition and measured after 120 mins by...More data for this Ligand-Target Pair

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Fibroblast growth factor receptor 1(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL

BDBM50507645(CHEMBL4473820)

IC50: 962nMAssay Description:Inhibition of human FGFR1 using KKKSPGEYVNIEFG as substrate preincubated for 20 mins followed by [gamma-33P]-ATP addition and measured after 120 mins...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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Tyrosine-protein kinase Lck(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL

BDBM50507645(CHEMBL4473820)

IC50: 1.00E+3nMAssay Description:Inhibition of human LCK using poly[Glu:Tyr] (4:1) as substrate preincubated for 20 mins followed by [gamma-33P]-ATP addition and measured after 120 m...More data for this Ligand-Target Pair

PDB Reactome pathway
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Fibroblast growth factor receptor 1(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL

BDBM50507645(CHEMBL4473820)

IC50: 1.00E+3nMAssay Description:Inhibition of human FGFR1 using KKKSPGEYVNIEFG as substrate preincubated for 20 mins followed by [gamma-33P]-ATP addition and measured after 120 mins...More data for this Ligand-Target Pair

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Tyrosine-protein kinase ABL1(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL

BDBM50507645(CHEMBL4473820)

IC50: 1.00E+3nMAssay Description:Inhibition of human ABL1 using EAIYAAPFAKKK as substrate preincubated for 20 mins followed by [gamma-33P]-ATP addition and measured after 120 mins by...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
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Tyrosine-protein kinase Lck(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL

BDBM50507645(CHEMBL4473820)

IC50: 1.01E+3nMAssay Description:Inhibition of human LCK using poly[Glu:Tyr] (4:1) as substrate preincubated for 20 mins followed by [gamma-33P]-ATP addition and measured after 120 m...More data for this Ligand-Target Pair

PDB Reactome pathway
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Serine/threonine-protein kinase Chk1(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL

BDBM50507645(CHEMBL4473820)

IC50: 1.53E+3nMAssay Description:Inhibition of human CHK1 using KKKVSRSGLYRSPSMPENLNRPR as substrate preincubated for 20 mins followed by [gamma-33P]-ATP addition and measured after ...More data for this Ligand-Target Pair

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Tyrosine-protein kinase BTK(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL

BDBM50507645(CHEMBL4473820)

IC50: 1.59E+3nMAssay Description:Inhibition of human BTK using KVEKIGEGTYGVVYK as substrate preincubated for 20 mins followed by [gamma-33P]-ATP addition and measured after 120 mins ...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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Serine/threonine-protein kinase Chk1(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL

BDBM50507645(CHEMBL4473820)

IC50: 1.59E+3nMAssay Description:Inhibition of human CHK1 using KKKVSRSGLYRSPSMPENLNRPR as substrate preincubated for 20 mins followed by [gamma-33P]-ATP addition and measured after ...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
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Tyrosine-protein kinase BTK(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL

BDBM50507645(CHEMBL4473820)

IC50: 1.64E+3nMAssay Description:Inhibition of human BTK using KVEKIGEGTYGVVYK as substrate preincubated for 20 mins followed by [gamma-33P]-ATP addition and measured after 120 mins ...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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Serine/threonine-protein kinase Nek2(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL

BDBM50507645(CHEMBL4473820)

IC50: 2.00E+3nMAssay Description:Inhibition of human NEK2 using MBP as substrate preincubated for 20 mins followed by [gamma-33P]-ATP addition and measured after 120 mins by Hotspot ...More data for this Ligand-Target Pair

PDB Reactome pathway
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Serine/threonine-protein kinase Nek2(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL

BDBM50507645(CHEMBL4473820)

IC50: 2.09E+3nMAssay Description:Inhibition of human NEK2 using MBP as substrate preincubated for 20 mins followed by [gamma-33P]-ATP addition and measured after 120 mins by Hotspot ...More data for this Ligand-Target Pair

PDB Reactome pathway
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Proto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL

BDBM50507645(CHEMBL4473820)

IC50: 2.40E+3nMAssay Description:Inhibition of human c-SRC using poly[Glu:Tyr] (4:1) as substrate preincubated for 20 mins followed by [gamma-33P]-ATP addition and measured after 120...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
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Proto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL

BDBM50507645(CHEMBL4473820)

IC50: 2.51E+3nMAssay Description:Inhibition of human c-SRC using poly[Glu:Tyr] (4:1) as substrate preincubated for 20 mins followed by [gamma-33P]-ATP addition and measured after 120...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
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Cyclin-dependent kinase 6/G1/S-specific cyclin-D1(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL

BDBM50507645(CHEMBL4473820)

IC50: 3.06E+3nMAssay Description:Inhibition of human CDK6/cyclin-D1 using RB protein as substrate preincubated for 20 mins followed by [gamma-33P]-ATP addition and measured after 120...More data for this Ligand-Target Pair

PDB KEGG
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Cyclin-dependent kinase 6/G1/S-specific cyclin-D1(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL

BDBM50507645(CHEMBL4473820)

IC50: 3.16E+3nMAssay Description:Inhibition of human CDK6/cyclin-D1 using RB protein as substrate preincubated for 20 mins followed by [gamma-33P]-ATP addition and measured after 120...More data for this Ligand-Target Pair

PDB KEGG
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Discoidin domain-containing receptor 2(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL

BDBM50507645(CHEMBL4473820)

IC50: 3.16E+3nMAssay Description:Inhibition of human DDR2 using KKSRGDYMTMQIG as substrate preincubated for 20 mins followed by [gamma-33P]-ATP addition and measured after 120 mins b...More data for this Ligand-Target Pair

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Discoidin domain-containing receptor 2(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL

BDBM50507645(CHEMBL4473820)

IC50: 3.47E+3nMAssay Description:Inhibition of human DDR2 using KKSRGDYMTMQIG as substrate preincubated for 20 mins followed by [gamma-33P]-ATP addition and measured after 120 mins b...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
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Platelet-derived growth factor receptor alpha(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL

BDBM50507645(CHEMBL4473820)

IC50: 3.64E+3nMAssay Description:Inhibition of human PDGFRalpha using poly[Glu:Tyr] (4:1) as substrate preincubated for 20 mins followed by [gamma-33P]-ATP addition and measured afte...More data for this Ligand-Target Pair

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Platelet-derived growth factor receptor alpha(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL

BDBM50507645(CHEMBL4473820)

IC50: 3.98E+3nMAssay Description:Inhibition of human PDGFRalpha using poly[Glu:Tyr] (4:1) as substrate preincubated for 20 mins followed by [gamma-33P]-ATP addition and measured afte...More data for this Ligand-Target Pair

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ALK tyrosine kinase receptor(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL

BDBM50507645(CHEMBL4473820)

IC50: 5.01E+3nMAssay Description:Inhibition of human ALK using poly[Glu:Tyr] (4:1) as substrate preincubated for 20 mins followed by [gamma-33P]-ATP addition and measured after 120 m...More data for this Ligand-Target Pair

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ALK tyrosine kinase receptor(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL

BDBM50507645(CHEMBL4473820)

IC50: 5.14E+3nMAssay Description:Inhibition of human ALK using poly[Glu:Tyr] (4:1) as substrate preincubated for 20 mins followed by [gamma-33P]-ATP addition and measured after 120 m...More data for this Ligand-Target Pair

PDB KEGG
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Vascular endothelial growth factor receptor 2(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL

BDBM50507645(CHEMBL4473820)

IC50: 6.26E+3nMAssay Description:Inhibition of human KDR using poly[Glu:Tyr] (4:1) as substrate preincubated for 20 mins followed by [gamma-33P]-ATP addition and measured after 120 m...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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Vascular endothelial growth factor receptor 2(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL

BDBM50507645(CHEMBL4473820)

IC50: 6.31E+3nMAssay Description:Inhibition of human KDR using poly[Glu:Tyr] (4:1) as substrate preincubated for 20 mins followed by [gamma-33P]-ATP addition and measured after 120 m...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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Cyclin-H/Cyclin-dependent kinase 7(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL

BDBM50507645(CHEMBL4473820)

IC50: 7.91E+3nMAssay Description:Inhibition of human CDK7/cyclin-H using MBP as substrate preincubated for 20 mins followed by [gamma-33P]-ATP addition and measured after 120 mins by...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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Cyclin-H/Cyclin-dependent kinase 7(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL

BDBM50507645(CHEMBL4473820)

IC50: 7.94E+3nMAssay Description:Inhibition of human CDK7/cyclin-H using MBP as substrate preincubated for 20 mins followed by [gamma-33P]-ATP addition and measured after 120 mins by...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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Cyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL

BDBM50507645(CHEMBL4473820)

IC50: 1.00E+4nMAssay Description:Inhibition of human CDK4/cyclin-D1 using RB protein as substrate preincubated for 20 mins followed by [gamma-33P]-ATP addition and measured after 120...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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Cyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL

BDBM50507645(CHEMBL4473820)

IC50: >1.00E+4nMAssay Description:Inhibition of human CDK4/cyclin-D1 using RB protein as substrate preincubated for 20 mins followed by [gamma-33P]-ATP addition and measured after 120...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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Filter my 39 hits

Targets 18▿
- Receptor-type tyrosine-protein kinase FLT3 5
- Tyrosine-protein kinase Lck 2
- Discoidin domain-containing receptor 2 2
- Serine/threonine-protein kinase Nek2 2
- Tyrosine-protein kinase BTK 2
- Tyrosine-protein kinase ABL1 2
- Macrophage colony-stimulating factor 1 receptor 2
- Serine/threonine-protein kinase pim-1 2
- Platelet-derived growth factor receptor alpha 2
- Mast/stem cell growth factor receptor Kit 2
- Serine/threonine-protein kinase Chk1 2
- ALK tyrosine kinase receptor 2
- Cyclin-H/Cyclin-dependent kinase 7 2
- Proto-oncogene tyrosine-protein kinase Src 2
- Cyclin-dependent kinase 6/G1/S-specific cyclin-D1 2
- Vascular endothelial growth factor receptor 2 2
- Fibroblast growth factor receptor 1 2
- Cyclin-dependent kinase 4/G1/S-specific cyclin-D1 2
Publications 2▿
- Eur J Med Chem 163: 195-206 (2019) 38
- Eur J Med Chem 176: 248-267 (2019) 1
Institutions 1▿
- China Pharmaceutical University 39
Affinity: 0.73 to 1.0E+4 nM▿
- IC50 39
- Affinity ≤ nM
Xtal structures: 0
Docked structures: 0
Catalog Cmpds: 0