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Found 26 Enz. Inhib. hit(s) with all data for entry = 50016521
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
University of Messina

Curated by ChEMBL
LigandPNGBDBM20878((2R,3S,4S,5R,6S)-2-(hydroxymethyl)-6-{2-[(4-methox...)
Affinity DataKi:  2.40nMAssay Description:Inhibition of human SGLT2 expressed in CHO-K1 cellsMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSodium/glucose cotransporter 1(Homo sapiens (Human))
University of Messina

Curated by ChEMBL
LigandPNGBDBM50595439(CHEMBL5178665)
Affinity DataKi:  97nMAssay Description:Inhibition of recombinant human SGLT1 expressed in COS-7 cells assessed as inhibition of [14C]AMG uptakeMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
University of Messina

Curated by ChEMBL
LigandPNGBDBM50351429(CHEMBL450044)
Affinity DataKi:  151nMAssay Description:Inhibition of human SGLT2 expressed in CHO-K1 cellsMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSodium/glucose cotransporter 1(Homo sapiens (Human))
University of Messina

Curated by ChEMBL
LigandPNGBDBM20878((2R,3S,4S,5R,6S)-2-(hydroxymethyl)-6-{2-[(4-methox...)
Affinity DataKi:  708nMAssay Description:Inhibition of human SGLT1 expressed in CHO-K1 cellsMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSodium/glucose cotransporter 1(Homo sapiens (Human))
University of Messina

Curated by ChEMBL
LigandPNGBDBM50351429(CHEMBL450044)
Affinity DataKi:  7.54E+3nMAssay Description:Inhibition of human SGLT1 expressed in CHO-K1 cellsMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
University of Messina

Curated by ChEMBL
LigandPNGBDBM50595439(CHEMBL5178665)
Affinity DataKi:  1.36E+4nMAssay Description:Inhibition of recombinant human SGLT2 expressed in COS-7 cells assessed as inhibition of [14C]AMG uptakeMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
University of Messina

Curated by ChEMBL
LigandPNGBDBM50595437(CHEMBL5202047)
Affinity DataIC50:  1.80nMAssay Description:Inhibition of human SGLT2More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
University of Messina

Curated by ChEMBL
LigandPNGBDBM50438460(CHEMBL2414617)
Affinity DataIC50:  2nMAssay Description:Inhibition of human SGLT2 expressed in HEK293T cells using [14C] alpha-MDG as substrate incubated for 30 mins by scintillation counter methodMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
University of Messina

Curated by ChEMBL
LigandPNGBDBM50595438(CHEMBL5182632)
Affinity DataIC50:  2.10nMAssay Description:Inhibition of full length N-terminal HA-tagged human SGLT2 expressed in HEK293 cells assessed as inhibition of [14C]AMG uptakeMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
University of Messina

Curated by ChEMBL
LigandPNGBDBM50595436(CHEMBL5177502)
Affinity DataIC50:  3.10nMAssay Description:Inhibition of human SGLT2 expressed in HEK293 cell membrane assessed as inhibition of [14C]AMG uptakeMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSodium/glucose cotransporter 1(Homo sapiens (Human))
University of Messina

Curated by ChEMBL
LigandPNGBDBM50595438(CHEMBL5182632)
Affinity DataIC50:  16nMAssay Description:Inhibition of full length N-terminal HA-tagged human SGLT1 expressed in HEK293 cells assessed as inhibition of [14C]AMG uptakeMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
University of Messina

Curated by ChEMBL
LigandPNGBDBM50559517(Remogliflozin | Remogliflozin a)
Affinity DataIC50:  18nMAssay Description:Inhibition of human SGLT2 expressed in COS-7 cellsMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSodium/glucose cotransporter 1(Homo sapiens (Human))
University of Messina

Curated by ChEMBL
LigandPNGBDBM50595437(CHEMBL5202047)
Affinity DataIC50:  36nMAssay Description:Inhibition of human SGLT1More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
University of Messina

Curated by ChEMBL
LigandPNGBDBM50559516(GSK-189075 | GSK-189075A | GSK189075A | Remogliflo...)
Affinity DataIC50:  2.53E+3nMAssay Description:Inhibition of human SGLT2 expressed in COS-7 cellsMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSodium/glucose cotransporter 1(Homo sapiens (Human))
University of Messina

Curated by ChEMBL
LigandPNGBDBM50595436(CHEMBL5177502)
Affinity DataIC50:  8.30E+3nMAssay Description:Inhibition of human SGLT1 expressed in HEK293 cell membrane assessed as inhibition of [14C]AMG uptakeMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSodium/glucose cotransporter 1(Homo sapiens (Human))
University of Messina

Curated by ChEMBL
LigandPNGBDBM50559517(Remogliflozin | Remogliflozin a)
Affinity DataIC50:  1.66E+4nMAssay Description:Inhibition of human SGLT1 expressed in COS-7 cellsMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSodium/glucose cotransporter 1(Homo sapiens (Human))
University of Messina

Curated by ChEMBL
LigandPNGBDBM50559516(GSK-189075 | GSK-189075A | GSK189075A | Remogliflo...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human SGLT1 expressed in COS-7 cellsMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
University of Messina

Curated by ChEMBL
LigandPNGBDBM50595440(CHEMBL5169442)
Affinity DataEC50:  33nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C] labeled AMG accumulation incubated for 15 minsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
University of Messina

Curated by ChEMBL
LigandPNGBDBM50595444(CHEMBL5182440)
Affinity DataEC50:  455nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C] labeled AMG accumulation incubated for 15 minsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
University of Messina

Curated by ChEMBL
LigandPNGBDBM50595443(CHEMBL5169703)
Affinity DataEC50:  258nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C] labeled AMG accumulation incubated for 15 minsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
University of Messina

Curated by ChEMBL
LigandPNGBDBM50595442(CHEMBL5173206)
Affinity DataEC50:  286nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C] labeled AMG accumulation incubated for 15 minsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
University of Messina

Curated by ChEMBL
LigandPNGBDBM50595441(CHEMBL5198311)
Affinity DataEC50:  212nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C] labeled AMG accumulation incubated for 15 minsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSodium/glucose cotransporter 1(Homo sapiens (Human))
University of Messina

Curated by ChEMBL
LigandPNGBDBM50595440(CHEMBL5169442)
Affinity DataEC50:  37nMAssay Description:Inhibition of human SGLT1 expressed in CHO cells assessed as inhibition of [14C] labeled AMG accumulation incubated for 15 minsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
University of Messina

Curated by ChEMBL
LigandPNGBDBM50595445(CHEMBL5208273)
Affinity DataEC50:  63nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C] labeled AMG accumulation incubated for 15 minsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSodium/glucose cotransporter 1(Homo sapiens (Human))
University of Messina

Curated by ChEMBL
LigandPNGBDBM20877(3-(1-benzofuran-5-yl)-1-(2-hydroxy-4-methyl-6-{[(2...)
Affinity DataEC50:  240nMAssay Description:Inhibition of human SGLT1 expressed in xenopus oocytes assessed as inhibition of [14C]AMG uptakeMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
University of Messina

Curated by ChEMBL
LigandPNGBDBM20877(3-(1-benzofuran-5-yl)-1-(2-hydroxy-4-methyl-6-{[(2...)
Affinity DataEC50:  5.20nMAssay Description:Inhibition of human SGLT2 expressed in xenopus oocytes assessed as inhibition of [14C]AMG uptakeMore data for this Ligand-Target Pair
In DepthDetails PubMed