Compile Data Set for Download or QSAR
maximum 50k data
Found 39 Enz. Inhib. hit(s) with all data for entry = 50018379
LigandPNGBDBM50607921(CHEMBL5278357)
Affinity DataKi:  1.60nMAssay Description:Inhibition of human PI3Kalpha assessed as inhibition constantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
LigandPNGBDBM50607921(CHEMBL5278357)
Affinity DataKi:  1.60nMAssay Description:Inhibition of human PI3Kbeta assessed as inhibition constantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
LigandPNGBDBM50607921(CHEMBL5278357)
Affinity DataKi:  1.60nMAssay Description:Inhibition of human PI3Kgamma assessed as inhibition constantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
LigandPNGBDBM50607921(CHEMBL5278357)
Affinity DataKi:  1.60nMAssay Description:Inhibition of human PI3Kdelta assessed as inhibition constantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))TBA
LigandPNGBDBM50607921(CHEMBL5278357)
Affinity DataKi:  16nMAssay Description:Inhibition of human mTOR assessed as inhibition constantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))TBA
LigandPNGBDBM50070942((-)-Epigallocatechin gallate | (-)-Epigallocatechi...)
Affinity DataKi:  320nMAssay Description:Inhibition of mTOR (unknown origin) assessed as inhibition constant using GFP-4EBP1 as substrate by Lanthascreen based time resolved fluorescence bas...More data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM50070942((-)-Epigallocatechin gallate | (-)-Epigallocatechi...)
Affinity DataKi:  380nMAssay Description:Inhibition of PIK3alpha (unknown origin) expressed in baculovirus assessed as inhibition constant using PIP2 as substrate in presence of [gamma-32P]A...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))TBA
LigandPNGBDBM50306633(1-(4-(4-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-1-(1...)
Affinity DataIC50:  0.190nMAssay Description:Inhibition of human recombinant mTOR assessed as decrease in phosphorylation of S6K level at Thr389 incubated for 2 hrs in presence of ATP and His6-S...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))TBA
LigandPNGBDBM50348452(AZD-8055 | CHEMBL1801204 | US9102670, 1a)
Affinity DataIC50:  0.800nMAssay Description:Inhibition of full length mTOR in human HeLa cells using 4EBP1 as substrate by immunoprecipitation based ELISA assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))TBA
LigandPNGBDBM50607922(CHEMBL2132692)
Affinity DataIC50:  4nMAssay Description:Inhibition of mTOR (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
LigandPNGBDBM92862(US9284315, BEZ-235 | mTOR Inhibitor, BEZ235)
Affinity DataIC50:  4nMAssay Description:Inhibition of C-terminal His-tagged full-length PI3K p110alpha (unknown origin) expressed in baculovirus incubated for 60 mins by Kinase-Glo luminesc...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))TBA
LigandPNGBDBM35587(pyrazolo pyrimidine, 19)
Affinity DataIC50:  5nMAssay Description:Inhibition of recombinant FLAG-tagged mTOR (unknown origin) expressed in HEK293 cells assessed as decrease in phosphorylation of S6K level at Thr389 ...More data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM92862(US9284315, BEZ-235 | mTOR Inhibitor, BEZ235)
Affinity DataIC50:  5nMAssay Description:Inhibition of C-terminal His-tagged full-length PI3K p110delta (unknown origin) expressed in baculovirus incubated for 120 mins by Kinase-Glo lumines...More data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM50607920(LY 3023414 | LY-3023414 | LY3023414 | Ly-3023414 |...)
Affinity DataIC50:  6.10nMAssay Description:Inhibition of human recombinant PI3Kalpha in presence of ATP by scintillation proximity assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
LigandPNGBDBM92862(US9284315, BEZ-235 | mTOR Inhibitor, BEZ235)
Affinity DataIC50:  7nMAssay Description:Inhibition of C-terminal His-tagged full-length PI3K p110gamma (unknown origin) expressed in baculovirus incubated for 60 mins by Kinase-Glo luminesc...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))TBA
LigandPNGBDBM35575(pyrazolo pyrimidine, 9)
Affinity DataIC50:  7nMAssay Description:Inhibition of recombinant FLAG-tagged mTOR (unknown origin) expressed in HEK293 cells assessed as decrease in phosphorylation of S6K level at Thr389 ...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))TBA
LigandPNGBDBM36409(2-(4-amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin...)
Affinity DataIC50:  8nMAssay Description:Inhibition of recombinant mTOR (unknown origin) using 4EBP1 as substrate in presence of [gamma-32P]ATP by radiometric scintillation assayMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))TBA
LigandPNGBDBM35615(pyrazolo pyrimidine, 5u)
Affinity DataIC50:  9nMAssay Description:Inhibition of recombinant FLAG-tagged mTOR (unknown origin) expressed in HEK293 cells assessed as decrease in phosphorylation of S6K level at Thr389 ...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))TBA
LigandPNGBDBM50313645(1-cyclopentyl-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H...)
Affinity DataIC50:  10nMAssay Description:Inhibition of recombinant mTOR (unknown origin) using 4EBP1 as substrate in presence of [gamma-32P]ATP by radiometric scintillation assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM50310989((5-(2-((2R,6S)-2,6-dimethylmorpholino)-4-morpholin...)
Affinity DataIC50:  10nMAssay Description:Inhibition of mTORC1 in human HEK293 cells assessed as decrease in phosphorylated S6K level incubated for 30 mins by immunoblot assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM50310989((5-(2-((2R,6S)-2,6-dimethylmorpholino)-4-morpholin...)
Affinity DataIC50:  10nMAssay Description:Inhibition of mTORC2 in human HEK293 cells assessed as decrease in phosphorylated Akt level incubated for 30 mins by immunoblot assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSerine-protein kinase ATM(Homo sapiens (Human))TBA
LigandPNGBDBM50341209(9-(6-aminopyridin-3-yl)-1-(3-(trifluoromethyl)phen...)
Affinity DataIC50: <10nMAssay Description:Inhibition of ATM in human HCT-116 cells preincubated for 1 hr followed by UV radiation and measured after 1 hr by Bradford assay based immunoblottin...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSerine/threonine-protein kinase ATR(Homo sapiens (Human))TBA
LigandPNGBDBM50341209(9-(6-aminopyridin-3-yl)-1-(3-(trifluoromethyl)phen...)
Affinity DataIC50: <10nMAssay Description:Inhibition of ATR in human HCT-116 cells preincubated for 1 hr followed by UV radiation and measured after 1 hr by Bradford assay based immunoblottin...More data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM50059635(CHEMBL3393066)
Affinity DataIC50:  16nMAssay Description:Inhibition of PI3Kgamma (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM50059635(CHEMBL3393066)
Affinity DataIC50:  17nMAssay Description:Inhibition of PI3Kdelta (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM50059635(CHEMBL3393066)
Affinity DataIC50:  18nMAssay Description:Inhibition of PI3Kalpha (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM50059635(CHEMBL3393066)
Affinity DataIC50:  19nMAssay Description:Inhibition of PI3Kbeta (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))TBA
LigandPNGBDBM92862(US9284315, BEZ-235 | mTOR Inhibitor, BEZ235)
Affinity DataIC50:  21nMAssay Description:Inhibition of mTOR (unknown origin) by K-LISA assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM50607920(LY 3023414 | LY-3023414 | LY3023414 | Ly-3023414 |...)
Affinity DataIC50:  24nMAssay Description:Inhibition of PI3Kdelta (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))TBA
LigandPNGBDBM50059635(CHEMBL3393066)
Affinity DataIC50:  37nMAssay Description:Inhibition of mTOR (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM50607920(LY 3023414 | LY-3023414 | LY3023414 | Ly-3023414 |...)
Affinity DataIC50:  38nMAssay Description:Inhibition of PI3Kgamma (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))TBA
LigandPNGBDBM50607919(CHEMBL1241578)
Affinity DataIC50:  72nMAssay Description:Inhibition of recombinant mTOR (unknown origin) using 4EBP1 as substrate in presence of [gamma-32P]ATP by radiometric scintillation assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
LigandPNGBDBM92862(US9284315, BEZ-235 | mTOR Inhibitor, BEZ235)
Affinity DataIC50:  75nMAssay Description:Inhibition of C-terminal His-tagged full-length PI3K p110beta (unknown origin) expressed in baculovirus incubated for 60 mins by Kinase-Glo luminesce...More data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM50607920(LY 3023414 | LY-3023414 | LY3023414 | Ly-3023414 |...)
Affinity DataIC50:  78nMAssay Description:Inhibition of human recombinant PI3Kbeta in presence of ATP by scintillation proximity assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))TBA
LigandPNGBDBM50503139(CHEMBL1242115)
Affinity DataIC50:  80nMAssay Description:Inhibition of recombinant mTOR (unknown origin) using 4EBP1 as substrate in presence of [gamma-32P]ATP by radiometric scintillation assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))TBA
LigandPNGBDBM50607920(LY 3023414 | LY-3023414 | LY3023414 | Ly-3023414 |...)
Affinity DataIC50:  165nMAssay Description:Inhibition of mTOR (unknown origin) by Lanthascreen kinase assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))TBA
LigandPNGBDBM35596(pyrazolo pyrimidine, 5a)
Affinity DataIC50:  220nMAssay Description:Inhibition of recombinant FLAG-tagged mTOR (unknown origin) expressed in HEK293 cells assessed as decrease in phosphorylation of S6K level at Thr389 ...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSerine/threonine-protein kinase mTOR(Rattus norvegicus)TBA
LigandPNGBDBM15234((1R,3R,5S,9R,18S)-18-(methoxymethyl)-1,5-dimethyl-...)
Affinity DataIC50:  300nMAssay Description:Inhibition of mTOR in rat brain by [3H]-thymidine incorporation based immunoblot assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM50607923(CHEMBL5274229)
Affinity DataIC50:  310nMAssay Description:Inhibition of mTORC2 in human LN-229 cells assessed as decrease in phosphorylation of AKT at Ser473 level incubated for 24 hrs by immunoblot assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed