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Found 50 Enz. Inhib. hit(s) with all data for entry = 50018412
TargetCarbonic anhydrase 12(Homo sapiens (Human))TBA
LigandPNGBDBM50561901(CHEMBL4746021)
Affinity DataKi:  69nMAssay Description:Binding affinity to human CA12 assessed as inhibition constantMore data for this Ligand-Target Pair
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TargetCarbonic anhydrase 12(Homo sapiens (Human))TBA
LigandPNGBDBM50279661(CHEMBL4166065)
Affinity DataKi:  71nMAssay Description:Binding affinity to human CA12 assessed as inhibition constantMore data for this Ligand-Target Pair
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TargetArginase-2, mitochondrial(Homo sapiens (Human))TBA
LigandPNGBDBM50294581(3-phenylprop-1-enylboronic acid | CHEMBL539140)
Affinity DataKi:  89nMAssay Description:Binding affinity to human Arg IIMore data for this Ligand-Target Pair
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TargetCarbonic anhydrase 2(Homo sapiens (Human))TBA
LigandPNGBDBM50561901(CHEMBL4746021)
Affinity DataKi:  89nMAssay Description:Binding affinity to human CA2 assessed as inhibition constantMore data for this Ligand-Target Pair
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TargetCarbonic anhydrase 9(Homo sapiens (Human))TBA
LigandPNGBDBM50279661(CHEMBL4166065)
Affinity DataKi:  93nMAssay Description:Binding affinity to human CA9 assessed as inhibition constantMore data for this Ligand-Target Pair
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TargetCarbonic anhydrase 1(Homo sapiens (Human))TBA
LigandPNGBDBM50561901(CHEMBL4746021)
Affinity DataKi:  98nMAssay Description:Binding affinity to human CA1 assessed as inhibition constantMore data for this Ligand-Target Pair
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TargetCarbonic anhydrase 9(Homo sapiens (Human))TBA
LigandPNGBDBM50561901(CHEMBL4746021)
Affinity DataKi:  414nMAssay Description:Binding affinity to human CA9 assessed as inhibition constantMore data for this Ligand-Target Pair
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TargetCarbonic anhydrase 1(Homo sapiens (Human))TBA
LigandPNGBDBM50279661(CHEMBL4166065)
Affinity DataKi:  417nMAssay Description:Binding affinity to human CA1 assessed as inhibition constantMore data for this Ligand-Target Pair
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TargetCarbonic anhydrase 2(Homo sapiens (Human))TBA
LigandPNGBDBM50279661(CHEMBL4166065)
Affinity DataKi:  1.84E+3nMAssay Description:Binding affinity to human CA2 assessed as inhibition constantMore data for this Ligand-Target Pair
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TargetArginase-1(Rattus norvegicus)TBA
LigandPNGBDBM50354832(CHEMBL1834160)
Affinity DataKi:  6.00E+4nMAssay Description:Binding affinity to rat Arg IMore data for this Ligand-Target Pair
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TargetArginase-1(Bos taurus)TBA
LigandPNGBDBM50608139(CHEMBL5287570)
Affinity DataKi:  9.00E+4nMAssay Description:Binding affinity to bovine liver Arg IMore data for this Ligand-Target Pair
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TargetArginase-1(Homo sapiens (Human))TBA
LigandPNGBDBM50316603(2-(S)-amino-5-(2-aminoimidazol-1-yl)pentanoic acid...)
Affinity DataKi:  3.00E+7nMAssay Description:Binding affinity to human Arg IMore data for this Ligand-Target Pair
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LigandPNGBDBM589753(US11559538, Example 16 | US11559538, Example 208 |...)
Affinity DataIC50:  0.0500nMAssay Description:Inhibition of human PDE4 catalytic domain expressed in Escherichia coliMore data for this Ligand-Target Pair
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LigandPNGBDBM50608137(CHEMBL5268265)
Affinity DataIC50:  0.120nMAssay Description:Inhibition of human PDE4 catalytic domain expressed in Escherichia coliMore data for this Ligand-Target Pair
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LigandPNGBDBM589895(US11559538, Example 147 | US11559538, Example 148)
Affinity DataIC50:  0.240nMAssay Description:Inhibition of human PDE4 catalytic domain expressed in Escherichia coliMore data for this Ligand-Target Pair
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LigandPNGBDBM50568657(CHEMBL4872870)
Affinity DataIC50:  0.420nMAssay Description:Inhibition of human PDE4 catalytic domain expressed in Escherichia coliMore data for this Ligand-Target Pair
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LigandPNGBDBM50608132(CHEMBL5290174)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of human PDE4 catalytic domain expressed in Escherichia coliMore data for this Ligand-Target Pair
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LigandPNGBDBM50322726(2-[(4-{[3-(4-Fluorobenzyl)-2,4-dioxo-1,3-thiazolan...)
Affinity DataIC50: >5nMAssay Description:Inhibition of human recombinant ATX using ABTS as substrate by absorbance based analysisMore data for this Ligand-Target Pair
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LigandPNGBDBM50347722(CHEMBL1802517)
Affinity DataIC50:  5.30nMAssay Description:Inhibition of human recombinant ATXMore data for this Ligand-Target Pair
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LigandPNGBDBM50322727(4-[(4-{[3-(4-Fluorobenzyl)-2,4-dioxo-1,3-thiazolan...)
Affinity DataIC50:  5.70nMAssay Description:Inhibition of human recombinant ATX using ABTS as substrate by absorbance based analysisMore data for this Ligand-Target Pair
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LigandPNGBDBM50347723(CHEMBL1802518)
Affinity DataIC50:  6.70nMAssay Description:Inhibition of human recombinant ATXMore data for this Ligand-Target Pair
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TargetVIM-1 metallo-beta-lactamase(Klebsiella pneumoniae)TBA
LigandPNGBDBM50608143(CHEMBL4463697)
Affinity DataIC50:  7.90nMAssay Description:Inhibition of Escherichia coli VIM-1More data for this Ligand-Target Pair
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LigandPNGBDBM50608136(CHEMBL1093374)
Affinity DataIC50: >10nMAssay Description:Inhibition of human PDE4 catalytic domain expressed in Escherichia coliMore data for this Ligand-Target Pair
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LigandPNGBDBM50322725(3-[(3-{[3-(4-Fluorobenzyl)-2,4-dioxo-1,3-thiazolan...)
Affinity DataIC50:  12nMAssay Description:Inhibition of human recombinant ATX using ABTS as substrate by absorbance based analysisMore data for this Ligand-Target Pair
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LigandPNGBDBM103575(ATX inhibitor 10 analogue 5 | US8551988, 65)
Affinity DataIC50:  13nMAssay Description:Inhibition of human recombinant ATXMore data for this Ligand-Target Pair
LigandPNGBDBM50608131(CHEMBL5278590)
Affinity DataIC50:  24nMAssay Description:Inhibition of human PDE4 catalytic domain expressed in Escherichia coliMore data for this Ligand-Target Pair
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LigandPNGBDBM103577(ATX inhibitor 10 analogue 7)
Affinity DataIC50:  25nMAssay Description:Inhibition of human recombinant ATXMore data for this Ligand-Target Pair
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LigandPNGBDBM50322724(3-[(4-{[3-(4-Fluorobenzyl)-2,4-dioxo-1,3-thiazolan...)
Affinity DataIC50:  28nMAssay Description:Inhibition of human recombinant ATX using ABTS as substrate by absorbance based analysisMore data for this Ligand-Target Pair
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TargetArginase-1(Homo sapiens (Human))TBA
LigandPNGBDBM50511658(Cb-1158 | INCB-001158 | Incb 001158 | Incb001158 |...)
Affinity DataIC50:  29nMAssay Description:Inhibition of human Arg IMore data for this Ligand-Target Pair
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LigandPNGBDBM50322728(4-[(3-{[3-(4-Fluorobenzyl)-2,4-dioxo-1,3-thiazolan...)
Affinity DataIC50:  30nMAssay Description:Inhibition of human recombinant ATX using ABTS as substrate by absorbance based analysisMore data for this Ligand-Target Pair
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LigandPNGBDBM50608135(CHEMBL1093373)
Affinity DataIC50:  47nMAssay Description:Inhibition of human PDE4 catalytic domain expressed in Escherichia coliMore data for this Ligand-Target Pair
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LigandPNGBDBM50532266(CHEMBL4467344)
Affinity DataIC50:  60nMAssay Description:Inhibition of human PDE4 catalytic domain expressed in Escherichia coliMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
LigandPNGBDBM50322727(4-[(4-{[3-(4-Fluorobenzyl)-2,4-dioxo-1,3-thiazolan...)
Affinity DataIC50:  88nMAssay Description:Inhibition of human recombinant ATXMore data for this Ligand-Target Pair
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LigandPNGBDBM50608133(CHEMBL5281157)
Affinity DataIC50: >100nMAssay Description:Inhibition of human PDE4 catalytic domain expressed in Escherichia coliMore data for this Ligand-Target Pair
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LigandPNGBDBM50277665(4-(1-hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-5-yl...)
Affinity DataIC50:  110nMAssay Description:Inhibition of human PDE4 catalytic domain expressed in Escherichia coliMore data for this Ligand-Target Pair
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LigandPNGBDBM50608138(CHEMBL5266101)
Affinity DataIC50:  130nMAssay Description:Inhibition of human recombinant ATXMore data for this Ligand-Target Pair
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LigandPNGBDBM50608134(CHEMBL1093962)
Affinity DataIC50:  180nMAssay Description:Inhibition of human PDE4 catalytic domain expressed in Escherichia coliMore data for this Ligand-Target Pair
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LigandPNGBDBM103961(ATX inhibitor 10 | Disubstituted aryl-Me ATX inhib...)
Affinity DataIC50:  180nMAssay Description:Inhibition of human recombinant ATXMore data for this Ligand-Target Pair
TargetArginase-2, mitochondrial(Homo sapiens (Human))TBA
LigandPNGBDBM50511658(Cb-1158 | INCB-001158 | Incb 001158 | Incb001158 |...)
Affinity DataIC50:  296nMAssay Description:Inhibition of human Arg IIMore data for this Ligand-Target Pair
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TargetArginase-1(Rattus norvegicus)TBA
LigandPNGBDBM50350311(CHEMBL1812661)
Affinity DataIC50:  800nMAssay Description:Inhibition of rat liver arginase using L-arginine as substrate incubated for 10 mins followed by substrate addition by scintillation counting analysi...More data for this Ligand-Target Pair
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TargetArginase-1(Homo sapiens (Human))TBA
LigandPNGBDBM50350311(CHEMBL1812661)
Affinity DataIC50:  1.45E+3nMAssay Description:Inhibition of human Arg IMore data for this Ligand-Target Pair
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TargetArginase-2, mitochondrial(Homo sapiens (Human))TBA
LigandPNGBDBM50350311(CHEMBL1812661)
Affinity DataIC50:  2.15E+3nMAssay Description:Inhibition of human Arg IIMore data for this Ligand-Target Pair
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TargetArginase-1(Rattus norvegicus)TBA
LigandPNGBDBM50561034(CHEMBL4244287)
Affinity DataIC50:  5.00E+3nMAssay Description:Inhibition of rat liver arginase using L-arginine as substrate incubated for 10 mins followed by substrate addition by scintillation counting analysi...More data for this Ligand-Target Pair
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TargetArginase-1(Rattus norvegicus)TBA
LigandPNGBDBM50608142(CHEMBL5281769)
Affinity DataIC50:  1.50E+4nMAssay Description:Inhibition of rat liver arginase using L-arginine as substrate incubated for 10 mins followed by substrate addition by scintillation counting analysi...More data for this Ligand-Target Pair
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TargetArginase-1(Rattus norvegicus)TBA
LigandPNGBDBM50608141(CHEMBL298071 | P-(Dihydroxyboryl)Phenylalanine)
Affinity DataIC50:  6.00E+6nMAssay Description:Inhibition of rat liver arginase using L-arginine as substrate incubated for 10 mins followed by substrate addition by scintillation counting analysi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
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TargetArginase-1(Homo sapiens (Human))TBA
LigandPNGBDBM50350310(CHEMBL1812663)
Affinity DataKd:  3.40E+4nMAssay Description:Binding affinity to human Arg I assessed as inhibition constant by SPR analysisMore data for this Ligand-Target Pair
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TargetArginase-1(Homo sapiens (Human))TBA
LigandPNGBDBM50608140(CHEMBL1230498)
Affinity DataKd:  6.00E+4nMAssay Description:Binding affinity to human Arg IMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetArginase-1(Homo sapiens (Human))TBA
LigandPNGBDBM50350309(CHEMBL1812662)
Affinity DataKd:  880nMAssay Description:Binding affinity to human Arg I assessed as inhibition constant by SPR analysisMore data for this Ligand-Target Pair
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TargetArginase-1(Rattus norvegicus)TBA
LigandPNGBDBM50052549(2-Amino-heptanedioic acid | CHEMBL111050)
Affinity DataKd:  3.00E+7nMAssay Description:Binding affinity to rat Arg IMore data for this Ligand-Target Pair
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TargetArginase-1(Homo sapiens (Human))TBA
LigandPNGBDBM50350311(CHEMBL1812661)
Affinity DataKd:  5nMAssay Description:Binding affinity to wild type human Arg I using L-arginine as substrate by liquid scintillation counting analysisMore data for this Ligand-Target Pair
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