Compile Data Set for Download or QSAR
Report error Found 20 Enz. Inhib. hit(s) with Target = 'Arginase-1' and Ligand = 'BDBM50350311'
TargetArginase-1(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50350311(CHEMBL1812661)
Affinity DataIC50: 5nMAssay Description:Binding affinity to human ARG1 assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetArginase-1(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50350311(CHEMBL1812661)
Affinity DataKd:  5nMAssay Description:Inhibition of human Arginase I in human myeloid-derived suppressor cells using L-arginine as substrate assessed as L-ornithine product formation by m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetArginase-1(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50350311(CHEMBL1812661)
Affinity DataKd:  5nMAssay Description:Binding affinity to human Arg1 at pH 8.5More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetArginase-1(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50350311(CHEMBL1812661)
Affinity DataKd:  5nMAssay Description:Binding affinity to human arginase 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetArginase-1(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50350311(CHEMBL1812661)
Affinity DataKd:  5nMAssay Description:Binding affinity to wild type human Arg I using L-arginine as substrate by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetArginase-1(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50350311(CHEMBL1812661)
Affinity DataKd:  18nMAssay Description:Binding affinity to human arginase 1 using L-arginine as substrate by surface plasmon resonance assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetArginase-1(Rat)
Flinders University

Curated by ChEMBL
LigandPNGBDBM50350311(CHEMBL1812661)
Affinity DataKi:  110nMAssay Description:Inhibition of N-terminal hexa-histidine tagged thrombin-cleavable rat arginase 1 expressed in Escherichia coli DE3 cells measured after 90 mins by co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetArginase-1(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50350311(CHEMBL1812661)
Affinity DataIC50: 311nMAssay Description:Inhibition of human arginase1 in presence of DNTB by thio ornithine generation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMed
TargetArginase-1(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50350311(CHEMBL1812661)
Affinity DataIC50: 311nMAssay Description:Inhibition of human recombinant ARG1 expressed in Escherichia coli using thioarginine as a substrate preincubated for 30 mins followed by substrate a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetArginase-1(Rat)
Flinders University

Curated by ChEMBL
LigandPNGBDBM50350311(CHEMBL1812661)
Affinity DataIC50: 800nMAssay Description:Inhibition of rat ARG1More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetArginase-1(Rat)
Flinders University

Curated by ChEMBL
LigandPNGBDBM50350311(CHEMBL1812661)
Affinity DataIC50: 800nMAssay Description:Inhibition of rat Arg1 at pH 7.4More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetArginase-1(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50350311(CHEMBL1812661)
Affinity DataIC50: 800nMAssay Description:Inhibition of human Arg1More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetArginase-1(Rat)
Flinders University

Curated by ChEMBL
LigandPNGBDBM50350311(CHEMBL1812661)
Affinity DataIC50: 800nMAssay Description:Inhibition of rat liver arginase using L-arginine as substrate incubated for 10 mins followed by substrate addition by scintillation counting analysi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetArginase-1(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50350311(CHEMBL1812661)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of recombinant human arginase 1 using L-arginine as substrate measured after 60 mins in presence of manganese chloride by o-phthaldialdehy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetArginase-1(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50350311(CHEMBL1812661)
Affinity DataIC50: 1.45E+3nMAssay Description:Inhibition of human recombinant full length Arg1 using L-arginine as substrate assessed as urea level after 1 hr by colorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetArginase-1(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50350311(CHEMBL1812661)
Affinity DataIC50: 1.45E+3nMAssay Description:Inhibition of N-terminal hexa-histidine tagged thrombin-cleavable human arginase 1 expressed in Escherichia coli DE3 cells measured after 90 mins by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetArginase-1(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50350311(CHEMBL1812661)
Affinity DataIC50: 1.45E+3nMAssay Description:Inhibition of human Arg IMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetArginase-1(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50350311(CHEMBL1812661)
Affinity DataIC50: 1.47E+3nMAssay Description:Inhibition of human arginase-1 assessed as L-arginine conversion to L-ornithine measured as urea level after 1 hr by colorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetArginase-1(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50350311(CHEMBL1812661)
Affinity DataIC50: 1.55E+3nMAssay Description:Inhibition of human recombinant arginase 1 expressed in Escherichia coli BL21 (DE3) assessed as reduction in urea production using L-arginine as subs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetArginase-1(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50350311(CHEMBL1812661)
Affinity DataIC50: 1.68E+4nMAssay Description:Inhibition of recombinant human ARG1 expressed in CHO-K1 cells assessed as reduction in urea level incubated for 24 hrs by colorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed