Found 32 Enz. Inhib. hit(s) with all data for entry = 50018701 
Affinity DataKi: 1.10nMAssay Description:Inhibition of N-terminal His6-tagged human FLAP expressed in Sf9 insect cells assessed as inhibition constant incubated for 2 hr by HTRF assayMore data for this Ligand-Target Pair
Affinity DataKi: 450nMAssay Description:Inhibition of N-terminal His6-tagged human FLAP expressed in Sf9 insect cells assessed as inhibition constant incubated for 2 hr by HTRF assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.5nMAssay Description:Inhibition of FLAP in human Leucocyte membrane incubated for 20 mins by radioactivity based gamma-scintillation counter assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.700nMAssay Description:Inhibition of FLAP in human Leucocyte membrane incubated for 20 mins by radioactivity based gamma-scintillation counter assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.700nMAssay Description:Displacement of [125I]-L-691831 from recombinant human FLAP expressed in Sf9 insect cells incubated for 2 hr by scintillation proximity assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.10nMAssay Description:Inhibition of FLAP in human Leucocyte membrane incubated for 20 mins by radioactivity based gamma-scintillation counter assayMore data for this Ligand-Target Pair
Affinity DataIC50: 2nMAssay Description:Displacement of [125I]-L-691831 from FLAP in human Leucocyte membrane incubated for 20 mins by radioactivity based gamma-scintillation counter assayMore data for this Ligand-Target Pair
3D Structure (crystal)
Affinity DataIC50: 7nMAssay Description:Inhibition of FLAP in human PMNL cells assessed as reduction in all-trans isomers of LTB4 and 5-HETE formation preincubated with enzyme for 15 mins f...More data for this Ligand-Target Pair
Affinity DataIC50: 7nMAssay Description:Inhibition of FLAP in human monocyte assessed as reduction in all-trans isomers of LTB4 and 5-HETE formation preincubated with enzyme for 15 mins fol...More data for this Ligand-Target Pair
Affinity DataIC50: 20nMAssay Description:Inhibition of 5-LOX in indomethacin stimulated rat PMNL cells assessed as reduction in 5-LO product level incubated for 3 mins by scintillation count...More data for this Ligand-Target Pair
Affinity DataIC50: 23nMAssay Description:Displacement of [125I]-L-691831 from FLAP in human Leucocyte membrane incubated for 20 mins by radioactivity based gamma-scintillation counter assayMore data for this Ligand-Target Pair
Affinity DataIC50: 29nMAssay Description:Inhibition of FLAP in human whole blood assessed as reduction of LTB4 formation preincubated with enzyme for 15 mins followed by calcium ionophore A2...More data for this Ligand-Target Pair
Affinity DataIC50: 38nMAssay Description:Inhibition of FLAP in human whole blood assessed as reduction in LTB4 level preincubated for 15 mins followed by calcium ionophore A23187 addition an...More data for this Ligand-Target Pair
Affinity DataIC50: 40nMAssay Description:Inhibition of FLAP in human monocyte assessed as reduction in all-trans isomers of LTB4 and 5-HETE formation preincubated with enzyme for 15 mins fol...More data for this Ligand-Target Pair
Affinity DataIC50: 42nMAssay Description:Inhibition of 5-LOX in human PMNL cells assessed as inhibition of LTB4 formation preincubated for 5 mins followed by calcium ionophore A23187 additio...More data for this Ligand-Target Pair
Affinity DataIC50: 66nMAssay Description:Inhibition of FLAP in human whole blood assessed as reduction in LTB4 level preincubated for 15 mins followed by calcium ionophore A23187 addition an...More data for this Ligand-Target Pair
Affinity DataIC50: 70nMAssay Description:Inhibition of 5-LOX in indomethacin stimulated rat PMNL cells assessed as reduction in 5-LO product level incubated for 3 mins by scintillation count...More data for this Ligand-Target Pair
Affinity DataIC50: 94nMAssay Description:Inhibition of FLAP in human whole blood assessed as reduction of LTB4 formation preincubated with enzyme for 15 mins followed by calcimycin addition ...More data for this Ligand-Target Pair
Affinity DataIC50: 130nMAssay Description:Inhibition of FLAP in human whole blood assessed as reduction of LTB4 formation preincubated with enzyme for 15 mins followed by calcimycin addition ...More data for this Ligand-Target Pair
Affinity DataIC50: 150nMAssay Description:Inhibition of FLAP in human neutrophil assessed as reduction in all-trans isomers of LTB4 and 5-HETE formation using arachidonic acid as substrate pr...More data for this Ligand-Target Pair
Affinity DataIC50: 200nMAssay Description:Inhibition of mPGES-1 activity in IL-1beta human A549 microsome using PGH2 as substrate preincubated for 15 mins followed by substrate addition for 1...More data for this Ligand-Target Pair
Affinity DataIC50: 220nMAssay Description:Inhibition of 5-LOX in human PMNL cells assessed as inhibition of LTB4 formation preincubated for 5 mins followed by calcium ionophore A23187 additio...More data for this Ligand-Target Pair
Affinity DataIC50: 380nMAssay Description:Inhibition of FLAP in human whole blood assessed as reduction of LTB4 formation preincubated with enzyme for 15 mins followed by calcium ionophore A2...More data for this Ligand-Target Pair
Affinity DataIC50: 390nMAssay Description:Inhibition of FLAP in human whole blood assessed as reduction in LTB4 level preincubated for 15 mins followed by calcium ionophore A23187 addition an...More data for this Ligand-Target Pair
Affinity DataIC50: 600nMAssay Description:Inhibition of FLAP in human whole blood assessed as reduction in LTB4 level preincubated for 15 mins followed by calcium ionophore A23187 addition an...More data for this Ligand-Target Pair
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of 5-LOX in human whole blood assessed as inhibition of LTB4 formation preincubated for 10 mins followed by calcium ionophore A23187 addit...More data for this Ligand-Target Pair
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of FLAP in human PMNL cells assessed as inhibition of 5-LO product LT formation preincubated for 15 mins followed by calcium ionophore A23...More data for this Ligand-Target Pair
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibition of 5-LOX in indomethacin stimulated rat PMNL cells assessed as reduction in 5-LO product level incubated for 3 mins by scintillation count...More data for this Ligand-Target Pair
Affinity DataIC50: 2.70E+3nMAssay Description:Inhibition of FLAP in human whole blood assessed as reduction of LTB4 formation preincubated with enzyme for 15 mins followed by calcimycin addition ...More data for this Ligand-Target Pair
Affinity DataIC50: 4.80E+3nMAssay Description:Inhibition of FLAP in human whole blood assessed as reduction in all-trans isomers of LTB4 and 5-HETE formation preincubated with enzyme for 15 mins ...More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of recombinant human 5-LO expressed in Escherichia coli JM109 using arachidonic acid as substrate incubated for 10 mins by HPLC analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 1.16E+4nMAssay Description:Inhibition of 5-LOX in human whole blood assessed as inhibition of LTB4 formation preincubated for 10 mins followed by calcium ionophore A23187 addit...More data for this Ligand-Target Pair
