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Found 2 Enz. Inhib. hit(s) with Target = 'Indoleamine 2,3-dioxygenase 1' and Ligand = 'BDBM370453'
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Newlink Genetics

US Patent
LigandPNGBDBM370453((Z)-1-cyclohexyl-2-(5H-imidazo[5,1-a]isoindol- 5-y...)
Affinity DataIC50:  550nMAssay Description:The IC50 values for each compound were determined by testing the activity of IDO in a mixture containing 50 mM potassium phosphate buffer at pH 6.5; ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Newlink Genetics

US Patent
LigandPNGBDBM370453((Z)-1-cyclohexyl-2-(5H-imidazo[5,1-a]isoindol- 5-y...)
Affinity DataIC50:  2.04E+4nMAssay Description:Inhibition of IDO1 in human IFN-gamma stimulated human HeLa cells assessed as inhibition of kynurenine production using L-tryptophan substrate incuba...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed