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Report error Found 3 Enz. Inhib. hit(s) with Target = 'Nicotinamide phosphoribosyltransferase' and Ligand = 'BDBM215863'
TargetNicotinamide phosphoribosyltransferase(Human)
Abbvie

Curated by ChEMBL
LigandPNGBDBM215863(US9302989, 59)
Affinity DataKi:  16nMAssay Description:Inhibition of C-terminal His-tagged human recombinant NAMPT using FK866 or isoindoline urea-based Oregon green (488) probe incubated for 3 hrs by TR-...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNicotinamide phosphoribosyltransferase(Human)
Abbvie

Curated by ChEMBL
LigandPNGBDBM215863(US9302989, 59)
Affinity DataIC50:  15.4nMpH: 7.5Assay Description:Probe 2:The assay was carried out in 18 uL low volume plates (Owens Corning) in reaction buffer (50 mM HEPES (NaOH), pH 7.5, 100 mM NaCl, 10 mM MgCl2...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetNicotinamide phosphoribosyltransferase(Human)
Abbvie

Curated by ChEMBL
LigandPNGBDBM215863(US9302989, 59)
Affinity DataIC50:  22.9nMpH: 7.5Assay Description:Probe 1:The assay was carried out in 18 uL low volume plates (Owens Corning) in reaction buffer (50 mM HEPES (NaOH), pH 7.5, 100 mM NaCl, 10 mM MgCl2...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent