Affinity DataEC50: 7nMpH: 7.2 T: 2°CAssay Description:EC50 was defined as the concentration of the compound at which there was 50% degradation of the Her-2/neu protein in MCF7 breast carcinoma cells. Sam...More data for this Ligand-Target Pair
TargetHeat shock protein HSP 90-alpha/90-beta(Homo sapiens (Human))
Infinity Pharmaceuticals
Curated by ChEMBL
Infinity Pharmaceuticals
Curated by ChEMBL
Affinity DataEC50: 19nMAssay Description:Degradation of Her2 in SKOV3 cellsMore data for this Ligand-Target Pair
TargetHeat shock protein HSP 90-alpha/90-beta(Homo sapiens (Human))
Infinity Pharmaceuticals
Curated by ChEMBL
Infinity Pharmaceuticals
Curated by ChEMBL
Affinity DataEC50: 22nMAssay Description:Upregulation of Hsp70 in SKBR3 cellsMore data for this Ligand-Target Pair
TargetHeat shock protein HSP 90-alpha/90-beta(Homo sapiens (Human))
Infinity Pharmaceuticals
Curated by ChEMBL
Infinity Pharmaceuticals
Curated by ChEMBL
Affinity DataEC50: 35nMAssay Description:Degradation of Her2 in SKBR3 cellsMore data for this Ligand-Target Pair
TargetHeat shock protein HSP 90-alpha/90-beta(Homo sapiens (Human))
Infinity Pharmaceuticals
Curated by ChEMBL
Infinity Pharmaceuticals
Curated by ChEMBL
Affinity DataEC50: 45nMAssay Description:Displacement of GM-BODIPY from Hsp90More data for this Ligand-Target Pair
Affinity DataEC50: 60nMAssay Description:Inhibition of Hsp90alpha in human SKBR3 cells assessed as up-regulation of HSP70 protein by Western blot analysisMore data for this Ligand-Target Pair
Affinity DataEC50: 64.9nMAssay Description:Displacement of cy3B-GM from Hsp90alphaMore data for this Ligand-Target Pair
TargetHeat shock protein HSP 90-alpha/90-beta(Homo sapiens (Human))
Infinity Pharmaceuticals
Curated by ChEMBL
Infinity Pharmaceuticals
Curated by ChEMBL
Affinity DataEC50: 110nMAssay Description:Binding affinity towards Heat shock protein HSP 90-alpha inhibitorMore data for this Ligand-Target Pair
Affinity DataEC50: 120nMAssay Description:Inhibition of Hsp90alpha in human H1299 cells assessed as HIF-1alpha degradation by luciferase reporter assayMore data for this Ligand-Target Pair
Affinity DataEC50: 124nMAssay Description:Inhibition of BODIPY-AG binding to dog Grp94More data for this Ligand-Target Pair
Affinity DataIC50: 1.27E+3nM EC50: 160nMpH: 7.4 T: 2°CAssay Description:The assay is based upon displacement of a fluorescently labeled molecule, which binds specifically to the ATP-binding site of full-length human Hsp90...More data for this Ligand-Target Pair
Affinity DataEC50: 1.00E+3nMAssay Description:Inhibition of Hsp90More data for this Ligand-Target Pair
Affinity DataEC50: 1.00E+3nMAssay Description:Competitive binding towards Heat shock protein HSP 90-alphaMore data for this Ligand-Target Pair