TargetOrphan methyltransferase M.SssI(Spiroplasma monobiae strain MQ-1)
The Ohio State University
Curated by ChEMBL
The Ohio State University
Curated by ChEMBL
Affinity DataIC50: 30nMAssay Description:Inhibition of Spiroplasma sp. MQ-1 M.SssIMore data for this Ligand-Target Pair
Affinity DataIC50: 200nMAssay Description:Inhibition of tissue factor procoagulant activity in LPS-stimulated human THP1 cells preincubated for 1 hr before LPS addition measured after 5 hrsMore data for this Ligand-Target Pair
Affinity DataIC50: 200nMAssay Description:Inhibition of tissue factor in Homo sapiens (human) THP1-cells using factor 10a chromogenic substrate assessed as inhibition of LPS-iduced procoagula...More data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
University Jena
Curated by ChEMBL
University Jena
Curated by ChEMBL
Affinity DataIC50: 500nMAssay Description:Inhibition of human recombinant 5-LO expressed in Escherichia coli Bl21 (DE3) using arachidonic acid as substrate preincubated for 10 mins measured a...More data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
University Jena
Curated by ChEMBL
University Jena
Curated by ChEMBL
Affinity DataIC50: 600nMAssay Description:Inhibition of 5-LO-mediated 5,12-DiHETE formation in LPS-stimulated human monocytes preincubated for 15 mins before arachidonic acid substrate additi...More data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
University Jena
Curated by ChEMBL
University Jena
Curated by ChEMBL
Affinity DataIC50: 600nMAssay Description:Inhibition of 5-LO-mediated 5-HETE formation in LPS-stimulated human monocytes preincubated for 15 mins before arachidonic acid substrate addition me...More data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
University Jena
Curated by ChEMBL
University Jena
Curated by ChEMBL
Affinity DataIC50: 600nMAssay Description:Inhibition of 5-LO-mediated LTB4 formation in LPS-stimulated human monocytes preincubated for 15 mins before arachidonic acid substrate addition meas...More data for this Ligand-Target Pair
Affinity DataIC50: 600nMAssay Description:Inhibition of mPGES1-mediated PGE2 production in microsomes of IL-1beta stimulated human A549 cells preincubated for 15 mins by RP-HPLC analysisMore data for this Ligand-Target Pair
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Korea Institute Of Science And Technology
Curated by ChEMBL
Korea Institute Of Science And Technology
Curated by ChEMBL
Affinity DataIC50: 800nMAssay Description:Inhibition of amyloid beta 42 fibril formation by thioflavin T assayMore data for this Ligand-Target Pair
Affinity DataIC50: 800nMAssay Description:Inhibition of iNOS induction in mouse RAW264.7 cells assessed as NO productionMore data for this Ligand-Target Pair
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Korea Institute Of Science And Technology
Curated by ChEMBL
Korea Institute Of Science And Technology
Curated by ChEMBL
Affinity DataIC50: 800nMAssay Description:Inhibition of amyloid beta42 fibril formation by thioflavin T formationMore data for this Ligand-Target Pair
TargetPotassium two pore domain channel subfamily K member 2(Bos taurus)
The Ohio State University College Of Medicine And Public Health
Curated by ChEMBL
The Ohio State University College Of Medicine And Public Health
Curated by ChEMBL
Affinity DataIC50: 930nMAssay Description:Inhibition of TREK-1 K(+) channel in bovine AZF cellsMore data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Homo sapiens (Human))
University Jena
Curated by ChEMBL
University Jena
Curated by ChEMBL
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of 15-LO-mediated 15-HETE formation in LPS-stimulated human monocytes preincubated for 15 mins before arachidonic acid substrate addition ...More data for this Ligand-Target Pair
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of mPGES1-mediated PGE2 formation in LPS-stimulated human monocytes preincubated for 15 mins before arachidonic acid substrate addition me...More data for this Ligand-Target Pair
Target17-beta-hydroxysteroid dehydrogenase type 3(Rattus norvegicus)
School Of Pharmacy
Curated by ChEMBL
School Of Pharmacy
Curated by ChEMBL
Affinity DataIC50: 2.30E+3nMAssay Description:Inhibition of 17beta-HSD3 in Sprague-Dawley rat testis microsomesMore data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
University Jena
Curated by ChEMBL
University Jena
Curated by ChEMBL
Affinity DataIC50: 3.90E+3nMAssay Description:Inhibition of 5-LO in human neutrophils using arachidonic acid as substrate preincubated for 15 mins measured after 10 mins by HPLC analysisMore data for this Ligand-Target Pair
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Korea Institute Of Science And Technology
Curated by ChEMBL
Korea Institute Of Science And Technology
Curated by ChEMBL
Affinity DataIC50: 3.90E+3nMAssay Description:Inhibition of amyloid beta (1 to 42) (unknown origin) aggregation after 48 hrs by thioflavin T fluorescence assayMore data for this Ligand-Target Pair
Target11-beta-hydroxysteroid dehydrogenase 1(Rattus norvegicus (rat))
Wenzhou Medical College
Curated by ChEMBL
Wenzhou Medical College
Curated by ChEMBL
Affinity DataIC50: 3.92E+3nMAssay Description:Inhibition of 11beta-HSD1 in Sprague-Dawley rat leydig cells at 100 uMMore data for this Ligand-Target Pair
Target11-beta-hydroxysteroid dehydrogenase 1(Rattus norvegicus (rat))
Wenzhou Medical College
Curated by ChEMBL
Wenzhou Medical College
Curated by ChEMBL
Affinity DataIC50: 4.13E+3nMAssay Description:Inhibition of 11beta-HSD1 in rat testis microsomes using [3H]-11-DHC as substrate assessed as formation of CORT after 60 to 90 mins by radiometric an...More data for this Ligand-Target Pair
Affinity DataIC50: 4.30E+3nMAssay Description:Inhibition of human recombinant CYP2C9More data for this Ligand-Target Pair
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Wenzhou Medical College
Curated by ChEMBL
Wenzhou Medical College
Curated by ChEMBL
Affinity DataIC50: 4.50E+3nMAssay Description:Inhibition of human 11beta-HSD1 transfected in CHOP cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 5.30E+3nMAssay Description:Inhibition of beta-secretase (unknown origin) using 150 nM Rhodamine-EVNLDAEFK-quencher substrate proteolysis by fluorescence resonance energy transf...More data for this Ligand-Target Pair
Affinity DataIC50: 5.70E+3nMAssay Description:Inhibition of beta-secretase using rhodamine-EVNLDAEFK-quencher as substrate after 60 mins by fluorescence resonance energy transfer assayMore data for this Ligand-Target Pair
Affinity DataIC50: 6.00E+3nMAssay Description:Inhibition of nitric oxide synthase in activated macrophages in human A431 cellsChecked by AuthorMore data for this Ligand-Target Pair
Affinity DataIC50: 6.00E+3nMAssay Description:Inhibition of TLR4 in LPS-stimulated mouse RAW264.7 cells assessed as reduction of NO production after 24 hrsMore data for this Ligand-Target Pair
Affinity DataIC50: 6.50E+3nMAssay Description:Inhibition of P300 (unknown origin) using histone H3/[acetyl-3H]-acetyl coenzyme A as substrateMore data for this Ligand-Target Pair
TargetIntestinal-type alkaline phosphatase(Homo sapiens (Human))
Burnham Center For Chemical Genomics
Curated by PubChem BioAssay
Burnham Center For Chemical Genomics
Curated by PubChem BioAssay
Affinity DataIC50: 7.41E+3nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego, C...More data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
University Jena
Curated by ChEMBL
University Jena
Curated by ChEMBL
Affinity DataIC50: 8.00E+3nMAssay Description:Inhibition of 5LOXChecked by AuthorMore data for this Ligand-Target Pair
TargetNeuraminidase(Influenza A virus (strain A/USSR/90/1977 H1N1))
Chungnam National University
Curated by ChEMBL
Chungnam National University
Curated by ChEMBL
Affinity DataIC50: 8.10E+3nMAssay Description:Inhibition of Influenza A virus H5N1 neuraminidase using 4-methylumbelliferyl-alpha-D-Nacetylneuraminic acid sodium salt hydrate as substrate by fluo...More data for this Ligand-Target Pair
Affinity DataIC50: 8.10E+3nMAssay Description:Inhibition of COX1-mediated PGE2 production in human platelets assessed as formation of 12-HHT using arachidonic acid as substrate preincubated for 5...More data for this Ligand-Target Pair
Affinity DataIC50: 8.50E+3nMAssay Description:Reduction of MMP9 activity in TNF-alpha/IL1-beta-stimulated human Caco-2 cells treated 1 hr before stimulation by zymographyMore data for this Ligand-Target Pair
Affinity DataIC50: 8.60E+3nMAssay Description:Inhibition of EGFR cytoplasmic domain (amino acids 645 to 1186) (unknown origin) expressed in Sf9 cells assessed as reduction in enzyme autophosphory...More data for this Ligand-Target Pair
Affinity DataIC50: 8.80E+3nMAssay Description:Inhibition of COX1More data for this Ligand-Target Pair
Target17-beta-hydroxysteroid dehydrogenase type 3(Rattus norvegicus)
School Of Pharmacy
Curated by ChEMBL
School Of Pharmacy
Curated by ChEMBL
Affinity DataIC50: 9.00E+3nMAssay Description:Inhibition of 17beta-HSD3 in Sprague-Dawley rat laydig cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of aminopeptidase N (unknown origin)More data for this Ligand-Target Pair
TargetNeuraminidase(Influenza A virus (strain A/USSR/90/1977 H1N1))
Chungnam National University
Curated by ChEMBL
Chungnam National University
Curated by ChEMBL
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant Influenza A virus H1N1 neuraminidase using 4-methylumbelliferyl-alpha-D-Nacetylneuraminic acid sodium salt hydrate as subst...More data for this Ligand-Target Pair
Affinity DataIC50: 1.03E+4nMAssay Description:Inhibition of human recombinant MMP13 expressed in Escherichia coliMore data for this Ligand-Target Pair
TargetBeta-lactamase(Pseudomonas aeruginosa)
The Scripps Research Institute Molecular Screening Center
Curated by PubChem BioAssay
The Scripps Research Institute Molecular Screening Center
Curated by PubChem BioAssay
Affinity DataIC50: 1.08E+4nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Affiliation: The Scripps Research Institute, TSRI Assa...More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
National Institute Of Pharmaceutical Education And Research (Niper)
Curated by ChEMBL
National Institute Of Pharmaceutical Education And Research (Niper)
Curated by ChEMBL
Affinity DataIC50: 1.11E+4nMAssay Description:Anti-oxidant activity in DPPH radicak scavenging assay; n=3-4More data for this Ligand-Target Pair
TargetIntestinal-type alkaline phosphatase 1(Rattus norvegicus (Rat))
Burnham Center For Chemical Genomics
Curated by PubChem BioAssay
Burnham Center For Chemical Genomics
Curated by PubChem BioAssay
Affinity DataIC50: 1.20E+4nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego, C...More data for this Ligand-Target Pair
TargetCalcium/calmodulin-dependent protein kinase type II subunit alpha(Homo sapiens (Human))
Rajiv Gandhi Centre For Biotechnology
Curated by ChEMBL
Rajiv Gandhi Centre For Biotechnology
Curated by ChEMBL
Affinity DataIC50: 1.30E+4nMAssay Description:Inhibition of alphaCaMK2 using GST-NR2A as substrate incubated for 1 min prior to substrate addition measured after 1 minMore data for this Ligand-Target Pair
TargetMultidrug resistance protein CDR1(Candida albicans)
Jawaharlal Nehru University
Curated by ChEMBL
Jawaharlal Nehru University
Curated by ChEMBL
Affinity DataIC50: 1.42E+4nMAssay Description:Displacement of [125I]IAAP from GFP-tagged Candida albicans CDR1 expressed in Saccharomyces cerevisiaeMore data for this Ligand-Target Pair
Affinity DataIC50: 1.50E+4nMAssay Description:Inhibition of Homo sapiens (human) topoisomerase 2 assessed as decatenation of KDNA by agarose gel electrophoresisMore data for this Ligand-Target Pair
TargetToll-like receptor 9(Homo sapiens (Human))
The Scripps Research Institute Molecular Screening Center
Curated by PubChem BioAssay
The Scripps Research Institute Molecular Screening Center
Curated by PubChem BioAssay
Affinity DataIC50: 1.53E+4nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Affiliation: The Scripps Research Institute, TSRI Assa...More data for this Ligand-Target Pair
Affinity DataIC50: 1.55E+4nMAssay Description:Inhibition of pig microsomal aminopeptidase N using L-leu-p-nitroanilide as substrate incubated for 5 mins prior to substrate addition measured after...More data for this Ligand-Target Pair
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Wenzhou Medical College
Curated by ChEMBL
Wenzhou Medical College
Curated by ChEMBL
Affinity DataIC50: 1.60E+4nMAssay Description:Inhibition of 11beta-HSD1 in human liver microsomes using [3H]-cortisone as substrate assessed as formation of cortisol after 60 to 90 mins by radiom...More data for this Ligand-Target Pair
Affinity DataIC50: 1.63E+4nMAssay Description:Inhibition of human recombinant CYP3A4More data for this Ligand-Target Pair
TargetSignal transducer and activator of transcription 3(Homo sapiens (Human))
Fudan University
Curated by ChEMBL
Fudan University
Curated by ChEMBL
Affinity DataIC50: 1.93E+4nMAssay Description:Inhibition of STAT3 in IL-6-stimulated human HepG2 cells treated for 1 hr prior to IL-6 challenge measured after 5.5 hrs by luciferase reporter gene ...More data for this Ligand-Target Pair
TargetSignal transducer and activator of transcription 3(Homo sapiens (Human))
Fudan University
Curated by ChEMBL
Fudan University
Curated by ChEMBL
Affinity DataIC50: 1.93E+4nMAssay Description:Inhibition of IL-6-induced STAT3 pathway in human HepG2 cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
TargetReplicase polyprotein 1ab(Human SARS coronavirus (SARS-CoV) (Severe acute re...)
Korea Research Institute Of Bioscience And Biotechnology
Curated by ChEMBL
Korea Research Institute Of Bioscience And Biotechnology
Curated by ChEMBL
Affinity DataIC50: 2.35E+4nMAssay Description:Inhibition of 3C-like protease of SARS coronavirus assessed as concentration of FRET peptide for 60 minsMore data for this Ligand-Target Pair