Found 29 Enz. Inhib. hit(s) with Target = '3-oxo-5-alpha-steroid 4-dehydrogenase 1' and Ligand = 'BDBM50334788' Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Rattus norvegicus)
Glaxo Inc. Research Institute
Curated by ChEMBL
Glaxo Inc. Research Institute
Curated by ChEMBL
Affinity DataKi: 6.80nMAssay Description:Inhibition of recombinant Steroid 5-alpha-reductase type I was evaluated as binding affinity (in vitro)More data for this Ligand-Target Pair
Affinity DataKi: 100nMAssay Description:Apparent inhibition constant towards human Steroid 5-alpha-reductase type IMore data for this Ligand-Target Pair
Affinity DataKi: 150nMAssay Description:Binding affinity for human 5 alpha reductase 1 isozymeMore data for this Ligand-Target Pair
Affinity DataKi: 366nMAssay Description:Inhibitory activity against recombinant Steroid 5-alpha-reductase type I expressed in CHO cellsMore data for this Ligand-Target Pair
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Rattus norvegicus)
Glaxo Inc. Research Institute
Curated by ChEMBL
Glaxo Inc. Research Institute
Curated by ChEMBL
Affinity DataIC50: 4.20nMAssay Description:Compound was tested for the inhibitory activity against Steroid 5-alpha-reductase type 1 in ratMore data for this Ligand-Target Pair
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Rattus norvegicus)
Glaxo Inc. Research Institute
Curated by ChEMBL
Glaxo Inc. Research Institute
Curated by ChEMBL
Affinity DataIC50: 10nMAssay Description:Inhibition of Steroid 5-alpha-reductase type I from rat ventral prostate (RVP)More data for this Ligand-Target Pair
Affinity DataIC50: 26nMAssay Description:In vitro inhibition of human steroid 5-alpha-reductase type I in Du-145 cellsMore data for this Ligand-Target Pair
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Rattus norvegicus)
Glaxo Inc. Research Institute
Curated by ChEMBL
Glaxo Inc. Research Institute
Curated by ChEMBL
Affinity DataIC50: 30nMAssay Description:Inhibition of type 1 5alpha reductase in rat prostateMore data for this Ligand-Target Pair
Affinity DataIC50: 40nMAssay Description:Evaluated for the inhibitory activity against human steroid 5-alpha-reductase type I in human DU-145 cell assay at 5 nM of androstenedioneMore data for this Ligand-Target Pair
Affinity DataIC50: 41nMAssay Description:In vitro inhibitory activity against Steroid 5-alpha-reductase type I of human DU 145 prostatic tumor cell lineMore data for this Ligand-Target Pair
Affinity DataIC50: 52nMAssay Description:Inhibition of type 1 steroid-5-alpha-reductaseMore data for this Ligand-Target Pair
Affinity DataIC50: 52nMAssay Description:Inhibition of recombinant human Steroid 5-alpha-reductase type IMore data for this Ligand-Target Pair
Affinity DataIC50: 52nMAssay Description:Inhibition of type 1 5alpha reductase in human prostateMore data for this Ligand-Target Pair
Affinity DataIC50: 60nMAssay Description:Inhibition of [1-beta-3H]-androstenedione binding to human steroid 5-alpha-reductase type I expressed in DU-145 cells at 10 uMMore data for this Ligand-Target Pair
Affinity DataIC50: 62nMAssay Description:Compound was tested for inhibition of Type I 5-alpha-reductase in Human genital skin (Hs68) foreskin fibroblast cells.More data for this Ligand-Target Pair
Affinity DataIC50: 150nMAssay Description:In vitro inhibitory activity against human type 1 5-alpha reductaseMore data for this Ligand-Target Pair
Affinity DataIC50: 150nMAssay Description:Inhibition of human type 1 5alpha reductaseMore data for this Ligand-Target Pair
Affinity DataIC50: 150nMAssay Description:Binding affinity to recombinant human Steroid 5-alpha-reductase type I was evaluatedMore data for this Ligand-Target Pair
Affinity DataIC50: 218nMAssay Description:In vitro inhibition of human Steroid 5-alpha-reductase type I in transfected 293 cells using [3H]- delta4-Androstenedione as substrateMore data for this Ligand-Target Pair
Affinity DataIC50: 453nMAssay Description:Inhibition of human 5alpha-1 reductase expressed in HEK293 cells assessed as suppression of conversion of [3]androstenedione incubated for 30 mins by...More data for this Ligand-Target Pair
Affinity DataIC50: 453nMAssay Description:Inhibition of human type-1 5-alpha reductase expressed in HEK293 cells using [3H]-androstenedione as substrate after 30 mins by HPLC analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 540nMAssay Description:Inhibition of Human steroid 5-alpha-reductase type I expressed in HEK293 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 630nMpH: 7.5Assay Description:The activity of the 5α-R type 1 isozyme was determined by following the conversion of T to DHT at pH 7.5. 2 nM of [1,2,6,7 3H] T, and different ...More data for this Ligand-Target Pair
Affinity DataIC50: 650nMAssay Description:Inhibition of human type 1 5alpha reductase expressed in HEK293 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 911nMAssay Description:Compound was evaluated for the inhibition of human Steroid 5-alpha-reductase type 1 from recombinant CHO cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 5.30E+4nMAssay Description:Inhibitory activity against 5-alpha-reductase type 1 in cell culture system using LNCaP cells (androgen-sensitive human prostatic cancer cell line)More data for this Ligand-Target Pair
Affinity DataIC50: 5.30E+4nMAssay Description:Inhibitory activity against 5-alpha-reductase type 1 in cell culture system using LNCaP cells (androgen-sensitive human prostatic cancer cell line)More data for this Ligand-Target Pair
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Rattus norvegicus)
Glaxo Inc. Research Institute
Curated by ChEMBL
Glaxo Inc. Research Institute
Curated by ChEMBL
Affinity DataIC50: 6.30E+5nMAssay Description:Inhibition of rat liver type 1 5alpha-reductase assessed as transformation of testosterone to dihydrotestosteroneMore data for this Ligand-Target Pair
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Rattus norvegicus)
Glaxo Inc. Research Institute
Curated by ChEMBL
Glaxo Inc. Research Institute
Curated by ChEMBL
Affinity DataIC50: 6.30E+5nMAssay Description:Inhibition of rat liver 5alpha-reductase type 1 assessed as conversion of [3H]testosterone to dihydrotestosteroneMore data for this Ligand-Target Pair
