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Found 3 Enz. Inhib. hit(s) with Target = '5'-AMP-activated protein kinase catalytic subunit alpha-1/subunit beta-1/subunit gamma-1' and Ligand = 'BDBM60978'
LigandPNGBDBM60978(6-Chloro-5-(4-methoxyphenyl)-1H-indazole-3-carboxy...)
Affinity DataEC50:  202nMpH: 7.5 T: 2°CAssay Description:The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass...More data for this Ligand-Target Pair
In DepthDetails US Patent
LigandPNGBDBM60978(6-Chloro-5-(4-methoxyphenyl)-1H-indazole-3-carboxy...)
Affinity DataKd:  1.78E+3nMAssay Description:Binding affinity to recombinant human AMPK alpha1/beta1/gamma1 by SPR binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM60978(6-Chloro-5-(4-methoxyphenyl)-1H-indazole-3-carboxy...)
Affinity DataEC50:  323nMAssay Description:Activation of recombinant human AMPK alpha1/beta1/gamma1 using Cy5-labelled SAMS as substrate assessed as protection from Thr172 residue dephosphoryl...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed