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Found 51 Enz. Inhib. hit(s) with Target = '5-hydroxytryptamine receptor 1D' and Ligand = 'BDBM50005835'
Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Theravance

Curated by ChEMBL
LigandPNGBDBM50005835((3-[2-(dimethylamino)ethyl]-1H-indol-5-yl)-N-methy...)
Affinity DataKi:  1.20nMAssay Description:Displacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

Target5-hydroxytryptamine receptor 1D(Dog)
University of Alberta

Curated by PDSP Ki Database
LigandPNGBDBM50005835((3-[2-(dimethylamino)ethyl]-1H-indol-5-yl)-N-methy...)
Affinity DataKi:  1.62nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Theravance

Curated by ChEMBL
LigandPNGBDBM50005835((3-[2-(dimethylamino)ethyl]-1H-indol-5-yl)-N-methy...)
Affinity DataKi:  1.70nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Theravance

Curated by ChEMBL
LigandPNGBDBM50005835((3-[2-(dimethylamino)ethyl]-1H-indol-5-yl)-N-methy...)
Affinity DataKi:  1.99nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Theravance

Curated by ChEMBL
LigandPNGBDBM50005835((3-[2-(dimethylamino)ethyl]-1H-indol-5-yl)-N-methy...)
Affinity DataKi:  2nMAssay Description:The compound was tested for CNS binding affinity towards 5-hydroxytryptamine 1D receptor from cloned gorilla membranes expressed in cultured HEK 293 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Theravance

Curated by ChEMBL
LigandPNGBDBM50005835((3-[2-(dimethylamino)ethyl]-1H-indol-5-yl)-N-methy...)
Affinity DataKi:  3.38nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Theravance

Curated by ChEMBL
LigandPNGBDBM50005835((3-[2-(dimethylamino)ethyl]-1H-indol-5-yl)-N-methy...)
Affinity DataKi:  3.40nMAssay Description:Binding affinity of the compound was evaluated at the cloned human 5-hydroxytryptamine 1D receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Theravance

Curated by ChEMBL
LigandPNGBDBM50005835((3-[2-(dimethylamino)ethyl]-1H-indol-5-yl)-N-methy...)
Affinity DataKi:  3.40nMAssay Description:Binding affinity towards cloned human 5-hydroxytryptamine 1D receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Theravance

Curated by ChEMBL
LigandPNGBDBM50005835((3-[2-(dimethylamino)ethyl]-1H-indol-5-yl)-N-methy...)
Affinity DataKi:  3.70nMMore data for this Ligand-Target Pair
In DepthDetails PubMedDrugBank

Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Theravance

Curated by ChEMBL
LigandPNGBDBM50005835((3-[2-(dimethylamino)ethyl]-1H-indol-5-yl)-N-methy...)
Affinity DataKi:  3.71nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Theravance

Curated by ChEMBL
LigandPNGBDBM50005835((3-[2-(dimethylamino)ethyl]-1H-indol-5-yl)-N-methy...)
Affinity DataKi:  4.40nMAssay Description:In vitro receptor binding affinity for cloned human 5-hydroxytryptamine 1D receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Theravance

Curated by ChEMBL
LigandPNGBDBM50005835((3-[2-(dimethylamino)ethyl]-1H-indol-5-yl)-N-methy...)
Affinity DataKi:  5.5nMAssay Description:Binding affinity for human 5-hydroxytryptamine 1D receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Theravance

Curated by ChEMBL
LigandPNGBDBM50005835((3-[2-(dimethylamino)ethyl]-1H-indol-5-yl)-N-methy...)
Affinity DataKi:  5.70nMAssay Description:Compound was tested for binding affinity against cloned human 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Theravance

Curated by ChEMBL
LigandPNGBDBM50005835((3-[2-(dimethylamino)ethyl]-1H-indol-5-yl)-N-methy...)
Affinity DataKi:  7.70nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

Target5-hydroxytryptamine receptor 1D(Dog)
University of Alberta

Curated by PDSP Ki Database
LigandPNGBDBM50005835((3-[2-(dimethylamino)ethyl]-1H-indol-5-yl)-N-methy...)
Affinity DataKi:  7.94nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Theravance

Curated by ChEMBL
LigandPNGBDBM50005835((3-[2-(dimethylamino)ethyl]-1H-indol-5-yl)-N-methy...)
Affinity DataKi:  8.40nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Theravance

Curated by ChEMBL
LigandPNGBDBM50005835((3-[2-(dimethylamino)ethyl]-1H-indol-5-yl)-N-methy...)
Affinity DataKi:  8.5nMAssay Description:Binding affinity to recombinant human 5-hydroxytryptamine 1D receptor alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Theravance

Curated by ChEMBL
LigandPNGBDBM50005835((3-[2-(dimethylamino)ethyl]-1H-indol-5-yl)-N-methy...)
Affinity DataKi:  8.5nMAssay Description:Binding affinity towards cloned human 5-hydroxytryptamine 1D receptor alpha was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticleDrugBank

Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Theravance

Curated by ChEMBL
LigandPNGBDBM50005835((3-[2-(dimethylamino)ethyl]-1H-indol-5-yl)-N-methy...)
Affinity DataKi:  8.5nMAssay Description:Ability to inhibit the forskolin-stimulated c-AMP formation mediated by human 5-hydroxytryptamine 1D receptor in CHO-K1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Theravance

Curated by ChEMBL
LigandPNGBDBM50005835((3-[2-(dimethylamino)ethyl]-1H-indol-5-yl)-N-methy...)
Affinity DataKi:  8.60nMAssay Description:In vitro binding affinity was determined towards cloned human 5-hydroxytryptamine 1D receptor using [3H]-5-CT radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

Target5-hydroxytryptamine receptor 1D(RAT)
University of Alberta

Curated by PDSP Ki Database
LigandPNGBDBM50005835((3-[2-(dimethylamino)ethyl]-1H-indol-5-yl)-N-methy...)
Affinity DataKi:  9.54nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Theravance

Curated by ChEMBL
LigandPNGBDBM50005835((3-[2-(dimethylamino)ethyl]-1H-indol-5-yl)-N-methy...)
Affinity DataKi:  11nMAssay Description:Binding affinity for human 5-hydroxytryptamine 1D receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Theravance

Curated by ChEMBL
LigandPNGBDBM50005835((3-[2-(dimethylamino)ethyl]-1H-indol-5-yl)-N-methy...)
Affinity DataKi:  23nMAssay Description:Binding affinity towards cloned human 5-hydroxytryptamine 1D receptor beta was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticleDrugBank

Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Theravance

Curated by ChEMBL
LigandPNGBDBM50005835((3-[2-(dimethylamino)ethyl]-1H-indol-5-yl)-N-methy...)
Affinity DataKi:  30nMAssay Description:Compound was tested for intrinsic efficacy against human 5-hydroxytryptamine 1D receptor alpha measured as the reduction of forskolin-stimulated cAMP...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Theravance

Curated by ChEMBL
LigandPNGBDBM50005835((3-[2-(dimethylamino)ethyl]-1H-indol-5-yl)-N-methy...)
Affinity DataIC50:  3nMAssay Description:Binding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Theravance

Curated by ChEMBL
LigandPNGBDBM50005835((3-[2-(dimethylamino)ethyl]-1H-indol-5-yl)-N-methy...)
Affinity DataIC50:  5nMAssay Description:Displacement of [3H]-5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Theravance

Curated by ChEMBL
LigandPNGBDBM50005835((3-[2-(dimethylamino)ethyl]-1H-indol-5-yl)-N-methy...)
Affinity DataIC50:  5nMAssay Description:Binding affinity by displacement to human cloned 5-hydroxytryptamine 1D receptor in CHO cells by [3H]-5-HT displacement.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Theravance

Curated by ChEMBL
LigandPNGBDBM50005835((3-[2-(dimethylamino)ethyl]-1H-indol-5-yl)-N-methy...)
Affinity DataIC50:  6.70nMAssay Description:Displacement of [3H]-5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Theravance

Curated by ChEMBL
LigandPNGBDBM50005835((3-[2-(dimethylamino)ethyl]-1H-indol-5-yl)-N-methy...)
Affinity DataIC50:  6.70nMAssay Description:Displacement of [3H]-5-HT binding from human 5-hydroxytryptamine 1D receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Theravance

Curated by ChEMBL
LigandPNGBDBM50005835((3-[2-(dimethylamino)ethyl]-1H-indol-5-yl)-N-methy...)
Affinity DataIC50:  6.80nMAssay Description:Compound was tested for the displacement of [3H]-5-HT binding to cloned 5-hydroxytryptamine 1D receptor stably expressed in CHO cells.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

Target5-hydroxytryptamine receptor 1D(Sus scrofa)TBA
LigandPNGBDBM50005835((3-[2-(dimethylamino)ethyl]-1H-indol-5-yl)-N-methy...)
Affinity DataIC50:  7.70nMAssay Description:Compound was tested for its ability to displace [125I]GTI binding to 5-hydroxytryptamine 1D receptor recognition sites in pig caudate membranesMore data for this Ligand-Target Pair
In DepthDetails
Target5-hydroxytryptamine receptor 1D(Sus scrofa)TBA
LigandPNGBDBM50005835((3-[2-(dimethylamino)ethyl]-1H-indol-5-yl)-N-methy...)
Affinity DataIC50:  19nMAssay Description:Compound was tested for its ability to displace [3H]-5-HT binding to 5-hydroxytryptamine 1D receptor recognition sites in pig caudate membranesMore data for this Ligand-Target Pair
In DepthDetails
Target5-hydroxytryptamine receptor 1D(Sus scrofa)TBA
LigandPNGBDBM50005835((3-[2-(dimethylamino)ethyl]-1H-indol-5-yl)-N-methy...)
Affinity DataIC50:  19.9nMAssay Description:Binding activity radioligand.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1D(Sus scrofa)TBA
LigandPNGBDBM50005835((3-[2-(dimethylamino)ethyl]-1H-indol-5-yl)-N-methy...)
Affinity DataIC50:  20nMAssay Description:Compound was tested for the displacement of [3H]-5-HT to 5-hydroxytryptamine 1D receptor recognition sites in pig caudate membranesMore data for this Ligand-Target Pair
In DepthDetails Article
Target5-hydroxytryptamine receptor 1D(Sus scrofa)TBA
LigandPNGBDBM50005835((3-[2-(dimethylamino)ethyl]-1H-indol-5-yl)-N-methy...)
Affinity DataIC50:  20nMAssay Description:Displacement of [3H]5-HT binding to 5-hydroxytryptamine 1D receptor from pig caudate membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1D(Sus scrofa)TBA
LigandPNGBDBM50005835((3-[2-(dimethylamino)ethyl]-1H-indol-5-yl)-N-methy...)
Affinity DataIC50:  20nMAssay Description:Displacement of radioligand [3H]5-HT binding to 5-hydroxytryptamine 1D receptor in pig caudate membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Theravance

Curated by ChEMBL
LigandPNGBDBM50005835((3-[2-(dimethylamino)ethyl]-1H-indol-5-yl)-N-methy...)
Affinity DataIC50:  39.8nMAssay Description:Binding activity radioligand.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

Target5-hydroxytryptamine receptor 1D(RAT)
University of Alberta

Curated by PDSP Ki Database
LigandPNGBDBM50005835((3-[2-(dimethylamino)ethyl]-1H-indol-5-yl)-N-methy...)
Affinity DataIC50:  61nMAssay Description:Binding affinity of the compound was measured against serotonin 5-hydroxytryptamine 1D receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Theravance

Curated by ChEMBL
LigandPNGBDBM50005835((3-[2-(dimethylamino)ethyl]-1H-indol-5-yl)-N-methy...)
Affinity DataIC50:  100nMAssay Description:Ability to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigraMore data for this Ligand-Target Pair
In DepthDetails ArticleDrugBank

Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Theravance

Curated by ChEMBL
LigandPNGBDBM50005835((3-[2-(dimethylamino)ethyl]-1H-indol-5-yl)-N-methy...)
Affinity DataIC50:  2.40E+3nMAssay Description:Compound was evaluated for the affinity at 5-hydroxytryptamine 1D receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Theravance

Curated by ChEMBL
LigandPNGBDBM50005835((3-[2-(dimethylamino)ethyl]-1H-indol-5-yl)-N-methy...)
Affinity DataEC50:  30nMAssay Description:Compound was tested for its affinity towards 5-hydroxytryptamine 3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticleDrugBank

Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Theravance

Curated by ChEMBL
LigandPNGBDBM50005835((3-[2-(dimethylamino)ethyl]-1H-indol-5-yl)-N-methy...)
Affinity DataEC50:  14nMAssay Description:Stimulation of [35S]-GTP-gammaS, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

Target5-hydroxytryptamine receptor 1D(Sus scrofa)TBA
LigandPNGBDBM50005835((3-[2-(dimethylamino)ethyl]-1H-indol-5-yl)-N-methy...)
Affinity DataKd:  25nMAssay Description:Binding affinity for 5-hydroxytryptamine 1D receptor in piglet caudate using [3H]5-HTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Theravance

Curated by ChEMBL
LigandPNGBDBM50005835((3-[2-(dimethylamino)ethyl]-1H-indol-5-yl)-N-methy...)
Affinity DataEC50:  16nMAssay Description:Measurement of agonist induced [35S]-GTP-gammaS, binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Theravance

Curated by ChEMBL
LigandPNGBDBM50005835((3-[2-(dimethylamino)ethyl]-1H-indol-5-yl)-N-methy...)
Affinity DataEC50:  14nMAssay Description:Stimulation of [35S]-GTP-gammaS, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Theravance

Curated by ChEMBL
LigandPNGBDBM50005835((3-[2-(dimethylamino)ethyl]-1H-indol-5-yl)-N-methy...)
Affinity DataEC50:  220nMAssay Description:Compound was tested for 5-hydroxytryptamine 1D like receptor-mediated vascular effect in rabbit saphenous vein (RSV)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Theravance

Curated by ChEMBL
LigandPNGBDBM50005835((3-[2-(dimethylamino)ethyl]-1H-indol-5-yl)-N-methy...)
Affinity DataEC50:  4.30nMAssay Description:Ability to inhibit forskolin-stimulated adenylate cyclase in a cell line expressing human 5-hydroxytryptamine 1D receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Theravance

Curated by ChEMBL
LigandPNGBDBM50005835((3-[2-(dimethylamino)ethyl]-1H-indol-5-yl)-N-methy...)
Affinity DataEC50:  5.30nMAssay Description:Ability to inhibit foskolin-stimulated adenylate cyclase activity in Chinese hamster ovary (CHO) stable cell lines expressing human 5-hydroxytryptami...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Theravance

Curated by ChEMBL
LigandPNGBDBM50005835((3-[2-(dimethylamino)ethyl]-1H-indol-5-yl)-N-methy...)
Affinity DataEC50:  12nMAssay Description:Agonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

Target5-hydroxytryptamine receptor 1D(RAT)
University of Alberta

Curated by PDSP Ki Database
LigandPNGBDBM50005835((3-[2-(dimethylamino)ethyl]-1H-indol-5-yl)-N-methy...)
Affinity DataEC50:  97nMAssay Description:Inhibition of forskolin stimulated adenylate cyclase at 5-hydroxytryptamine 1D receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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