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Report error Found 37 Enz. Inhib. hit(s) with Target = 'Adenosine receptor A2a' and Ligand = 'BDBM10847'
TargetAdenosine receptor A2a(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM10847(Theophylline (1,3-dimethylxanthine) | 1,3-dimethyl...)
Affinity DataKd:  3.63E+3nMAssay Description:Binding affinity to human wild type adenosine A2A receptor expressed in Expi293F cells assessed as dissociation constant by surface plasmon resonance...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetAdenosine receptor A2a(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM10847(Theophylline (1,3-dimethylxanthine) | 1,3-dimethyl...)
Affinity DataEC50:  2.82E+4nMAssay Description:Relaxant activity on the spontaneous tone of isolated guinea pig tracheal ring chains.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM10847(Theophylline (1,3-dimethylxanthine) | 1,3-dimethyl...)
Affinity DataKi:  0.600nMAssay Description:Binding affinity for adenosine A2a receptor by using as [3H]ZM-241385 radioligand in membranes from HEK-A2A cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM10847(Theophylline (1,3-dimethylxanthine) | 1,3-dimethyl...)
Affinity DataKi:  1.71E+3nMAssay Description:Antagonist activity at adenosine A2A receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetAdenosine receptor A2a(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM10847(Theophylline (1,3-dimethylxanthine) | 1,3-dimethyl...)
Affinity DataKi:  1.71E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/3/2012
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM10847(Theophylline (1,3-dimethylxanthine) | 1,3-dimethyl...)
Affinity DataKi:  4.20E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2012
Entry Details
PubMed
TargetAdenosine receptor A2a(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM10847(Theophylline (1,3-dimethylxanthine) | 1,3-dimethyl...)
Affinity DataKi:  4.20E+3nMAssay Description:Binding affinity to human adenosine A2A receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2012
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM10847(Theophylline (1,3-dimethylxanthine) | 1,3-dimethyl...)
Affinity DataKi:  6.70E+3nMAssay Description:Displacement of [3H]MSX2 from human adenosine A2A receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2012
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Rat)
National Institute of Diabetes & Digestive & Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM10847(Theophylline (1,3-dimethylxanthine) | 1,3-dimethyl...)
Affinity DataKi:  6.70E+3nMAssay Description:Binding affinity at rat Adenosine A2A receptor by [3H]-CGS- 21680 displacement.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM10847(Theophylline (1,3-dimethylxanthine) | 1,3-dimethyl...)
Affinity DataKi:  6.70E+3nMAssay Description:Displacement of [3H]ZM-241385 from human adenosine A2a receptor expressed in HEK cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM10847(Theophylline (1,3-dimethylxanthine) | 1,3-dimethyl...)
Affinity DataKi:  7.90E+3nMAssay Description:Displacement of [3H]NECA from cloned human adenosine A2A receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM10847(Theophylline (1,3-dimethylxanthine) | 1,3-dimethyl...)
Affinity DataKi:  7.90E+3nMAssay Description:Displacement of [3H]NECA from human adenosine A2A receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM10847(Theophylline (1,3-dimethylxanthine) | 1,3-dimethyl...)
Affinity DataKi:  7.90E+3nMAssay Description:Displacement of [3H]NECA from human adenosine A2A receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM10847(Theophylline (1,3-dimethylxanthine) | 1,3-dimethyl...)
Affinity DataKi:  7.90E+3nMAssay Description:Displacement of [125I]NECA from human cloned adenosine A2A receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM10847(Theophylline (1,3-dimethylxanthine) | 1,3-dimethyl...)
Affinity DataKi:  7.90E+3nMAssay Description:Displacement of [3H]NECA from human cloned adenosine A2A receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Rat)
National Institute of Diabetes & Digestive & Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM10847(Theophylline (1,3-dimethylxanthine) | 1,3-dimethyl...)
Affinity DataKi:  8.00E+3nMAssay Description:Binding affinity for adenosine A2A receptor from rat brain membranes using [3H]CGS-21680More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Rat)
National Institute of Diabetes & Digestive & Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM10847(Theophylline (1,3-dimethylxanthine) | 1,3-dimethyl...)
Affinity DataKi:  9.40E+3nMAssay Description:Ability to inhibit binding of [3H]-CGS- 21680 to adenosine A2A receptor in rat brain striatal membranes.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM10847(Theophylline (1,3-dimethylxanthine) | 1,3-dimethyl...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]ZM241385 from stabilized human adenosine receptor A2a expressed in HEK293 cells followed by receptor capturing on Biocore chips b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM10847(Theophylline (1,3-dimethylxanthine) | 1,3-dimethyl...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/24/2011
Entry Details
PubMed
TargetAdenosine receptor A2a(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM10847(Theophylline (1,3-dimethylxanthine) | 1,3-dimethyl...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/24/2011
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM10847(Theophylline (1,3-dimethylxanthine) | 1,3-dimethyl...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/23/2011
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Guinea pig)
TBA

Curated by ChEMBL
LigandPNGBDBM10847(Theophylline (1,3-dimethylxanthine) | 1,3-dimethyl...)
Affinity DataKi:  1.30E+4nMAssay Description:Antagonist binding of N6-cyclohexyl-[3H]-adenosine to guinea pig brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2012
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Guinea pig)
TBA

Curated by ChEMBL
LigandPNGBDBM10847(Theophylline (1,3-dimethylxanthine) | 1,3-dimethyl...)
Affinity DataKi:  1.40E+4nMAssay Description:Antagonism of cyclic [3H]AMP accumulation elicited by 15 uM 2-chloroadenosine in [3H]adenine-labeled guinea pig cerebral cortical slices at A2 recept...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2012
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Guinea pig)
TBA

Curated by ChEMBL
LigandPNGBDBM10847(Theophylline (1,3-dimethylxanthine) | 1,3-dimethyl...)
Affinity DataKi:  1.40E+4nMAssay Description:Compound was evaluated for its ability to antagonise cyclic [3H]AMP accumulation in [3H]adenine-labeled guinea pig cerebral cortical slices.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Guinea pig)
TBA

Curated by ChEMBL
LigandPNGBDBM10847(Theophylline (1,3-dimethylxanthine) | 1,3-dimethyl...)
Affinity DataKi:  1.66E+4nMAssay Description:Affinity against adenosine A2 receptor in the brain membranes measured by the displacement of [3H]-CPXMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM10847(Theophylline (1,3-dimethylxanthine) | 1,3-dimethyl...)
Affinity DataKi:  1.85E+4nMAssay Description:Displacement of [3H]ZM241385 from human recombinant adenosine A2A receptor expressed in in human HeLa cell membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Rat)
National Institute of Diabetes & Digestive & Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM10847(Theophylline (1,3-dimethylxanthine) | 1,3-dimethyl...)
Affinity DataKi:  1.90E+4nMAssay Description:Ability to inhibit binding of [3H]NECA to Adenosine A2A receptor in rat brain striatal membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM10847(Theophylline (1,3-dimethylxanthine) | 1,3-dimethyl...)
Affinity DataKi:  2.10E+4nMAssay Description:Displacement of [3H]CGS 21680 from adenosine A2A receptor in bovine striatal membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM10847(Theophylline (1,3-dimethylxanthine) | 1,3-dimethyl...)
Affinity DataKi:  2.10E+4nMAssay Description:Displacement of [3H]-CGS- 21680 from adenosine A2a receptor of bovine striatal membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM10847(Theophylline (1,3-dimethylxanthine) | 1,3-dimethyl...)
Affinity DataKi:  2.10E+4nMAssay Description:Displacement of [3H]CGS 21680 from adenosine A2A receptor in bovine striatal membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM10847(Theophylline (1,3-dimethylxanthine) | 1,3-dimethyl...)
Affinity DataKi:  2.10E+4nMAssay Description:Displacement of [3H]-CGS- 21680 from adenosine A2A receptor in bovine striatal membranes.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Rat)
National Institute of Diabetes & Digestive & Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM10847(Theophylline (1,3-dimethylxanthine) | 1,3-dimethyl...)
Affinity DataKi:  2.20E+4nMAssay Description:Displacement of [3H]CGS21680 from adenosine A2A receptor in rat brain striatal membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Rat)
National Institute of Diabetes & Digestive & Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM10847(Theophylline (1,3-dimethylxanthine) | 1,3-dimethyl...)
Affinity DataKi:  2.20E+4nMAssay Description:Displacement of [3H]MSX2 from adenosine A2A receptor in rat brain striatum membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2012
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Rat)
National Institute of Diabetes & Digestive & Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM10847(Theophylline (1,3-dimethylxanthine) | 1,3-dimethyl...)
Affinity DataKi:  2.50E+4nMAssay Description:Displacement of [3H]-CGS- 21680 from adenosine A2a receptors of rat striatal membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM10847(Theophylline (1,3-dimethylxanthine) | 1,3-dimethyl...)
Affinity DataKi:  2.50E+4nMAssay Description:Affinity to A2 adenosine receptor was measured by the displacement of [3H]-CGS- 21680 in bovine brain striatal membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Rat)
National Institute of Diabetes & Digestive & Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM10847(Theophylline (1,3-dimethylxanthine) | 1,3-dimethyl...)
Affinity DataKi:  2.50E+4nMAssay Description:Inhibition of rat recombinant adenosine receptor A2aMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2015
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Rat)
National Institute of Diabetes & Digestive & Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM10847(Theophylline (1,3-dimethylxanthine) | 1,3-dimethyl...)
Affinity DataKi:  2.50E+4nMAssay Description:Binding affinity to rat adenosine A2A receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2012
Entry Details Article
PubMed