Compile Data Set for Download or QSAR
Report error Found 5 Enz. Inhib. hit(s) with Target = 'Aldo-keto reductase family 1 member B1' and Ligand = 'BDBM50038843'
TargetAldo-keto reductase family 1 member B1(Human)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50038843BDBM50038843(2-(4-bromo-2-fluorobenzyl)-6-fluoro-1H,2'H,5'H-spi...)
Affinity DataIC50: 12.2nMAssay Description:Compound was evaluated In vitro for inhibition of aldose reductase activity by 50% in dog RBCMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2012
Entry Details Article
PubMed
TargetAldo-keto reductase family 1 member B1(Human)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50038843BDBM50038843(2-(4-bromo-2-fluorobenzyl)-6-fluoro-1H,2'H,5'H-spi...)
Affinity DataIC50: 25nMAssay Description:Inhibition of N-terminal 6His-tagged human aldose reductase expressed in Escherichia coli BL21(DE3) mediated NADPH linked pyridine-3-aldehyde reducti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2010
Entry Details Article
PubMed
TargetAldo-keto reductase family 1 member B1(Human)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50038843BDBM50038843(2-(4-bromo-2-fluorobenzyl)-6-fluoro-1H,2'H,5'H-spi...)
Affinity DataIC50: 70nMAssay Description:Inhibition of human recombinant aldose reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetAldo-keto reductase family 1 member B1(Human)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50038843BDBM50038843(2-(4-bromo-2-fluorobenzyl)-6-fluoro-1H,2'H,5'H-spi...)
Affinity DataIC50: 72.6nMAssay Description:Inhibitory Activity against Human recombinant Aldose Reductase (wild type)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
TargetAldo-keto reductase family 1 member B1(Human)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50038843BDBM50038843(2-(4-bromo-2-fluorobenzyl)-6-fluoro-1H,2'H,5'H-spi...)
Affinity DataIC50: 73nMAssay Description:Inhibition of aldose reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed