BindingDB PrimarySearch

Found 26 Enz. Inhib. hit(s) with Target = 'Amyloid-beta precursor protein' and Ligand = 'BDBM50129793'

Amyloid-beta precursor protein(Homo sapiens (Human))
University Of Pennsylvania

Curated by ChEMBL

BDBM50129793(2-(4''-methylaminophenyl)-6-hydroxybenzothiazole |...)

Ki: 0.800nMAssay Description:Binding affinity to human amyloid beta plaqueMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

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Amyloid-beta precursor protein(Homo sapiens (Human))
University Of Pennsylvania

Curated by ChEMBL

BDBM50129793(2-(4''-methylaminophenyl)-6-hydroxybenzothiazole |...)

Ki: 0.870nMAssay Description:Displacement of [18F]-amyvid from amyloid-beta aggregates in alzheimer's disease patient brain homogenates after 1 hrMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

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Amyloid-beta precursor protein(Homo sapiens (Human))
University Of Pennsylvania

Curated by ChEMBL

BDBM50129793(2-(4''-methylaminophenyl)-6-hydroxybenzothiazole |...)

Ki: 0.870nMAssay Description:Binding affinity to Beta amyloid aggregates in Alzheimer's disease patient brain by competitive binding assayMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

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Amyloid-beta precursor protein(Homo sapiens (Human))
University Of Pennsylvania

Curated by ChEMBL

BDBM50129793(2-(4''-methylaminophenyl)-6-hydroxybenzothiazole |...)

Ki: 1.60nMAssay Description:Displacement of [3H]PIB from amyloid beta (1 to 42) aggregates in Alzheimer's disease-human brain homogenate after 3 hrs by gamma countingMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

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Amyloid-beta precursor protein(Homo sapiens (Human))
University Of Pennsylvania

Curated by ChEMBL

BDBM50129793(2-(4''-methylaminophenyl)-6-hydroxybenzothiazole |...)

Ki: 2.80nMAssay Description:Displacement of [125I]IMPY from beta-amyloid plaques in Alzheimer's disease patient brain homogenateMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

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Amyloid-beta precursor protein(Homo sapiens (Human))
University Of Pennsylvania

Curated by ChEMBL

BDBM50129793(2-(4''-methylaminophenyl)-6-hydroxybenzothiazole |...)

Ki: 2.80nMAssay Description:Displacement of [125I]IMPY from beta-amyloid plaques in Alzheimer's disease patient brain homogenateMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

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Amyloid-beta precursor protein(Homo sapiens (Human))
University Of Pennsylvania

Curated by ChEMBL

BDBM50129793(2-(4''-methylaminophenyl)-6-hydroxybenzothiazole |...)

Ki: 2.80nMAssay Description:Displacement of [125I]2-(4'-dimethylaminophenyl)-6-iodoimidazo[1,2-a]pyridine from beta amyloid peptide in brain tissue at 50 uLMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

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Amyloid-beta precursor protein(Homo sapiens (Human))
University Of Pennsylvania

Curated by ChEMBL

BDBM50129793(2-(4''-methylaminophenyl)-6-hydroxybenzothiazole |...)

Ki: 2.80nMAssay Description:Displacement of [125I]IMPY from beta-amyloid plaques in Alzheimer's disease patient brain homogenateMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

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Amyloid-beta precursor protein(Homo sapiens (Human))
University Of Pennsylvania

Curated by ChEMBL

BDBM50129793(2-(4''-methylaminophenyl)-6-hydroxybenzothiazole |...)

Ki: 2.80nMAssay Description:Displacement of [125I]IMPY from beta-amyloid plaques in brain homogenate of patient with Alzheimer's disease by gamma countingMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

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Amyloid-beta precursor protein(Homo sapiens (Human))
University Of Pennsylvania

Curated by ChEMBL

BDBM50129793(2-(4''-methylaminophenyl)-6-hydroxybenzothiazole |...)

Ki: 2.80nMAssay Description:Inhibition constant for I-125-IMPY binding to amyloid plaques in Alzheimers disease brain homogenatesMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

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Amyloid-beta precursor protein(Homo sapiens (Human))
University Of Pennsylvania

Curated by ChEMBL

BDBM50129793(2-(4''-methylaminophenyl)-6-hydroxybenzothiazole |...)

Ki: 4.30nMAssay Description:Binding affinity for Amyloid beta 1-40 aggregates in competition with [N-methyl-3H] BTA-1.More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

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Amyloid-beta precursor protein(Homo sapiens (Human))
University Of Pennsylvania

Curated by ChEMBL

BDBM50129793(2-(4''-methylaminophenyl)-6-hydroxybenzothiazole |...)

Ki: 4.30nMAssay Description:Binding affinity to beta amyloid in human corpse AD brainMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

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Amyloid-beta precursor protein(Homo sapiens (Human))
University Of Pennsylvania

Curated by ChEMBL

BDBM50129793(2-(4''-methylaminophenyl)-6-hydroxybenzothiazole |...)

Ki: 5.80nMAssay Description:Displacement of [125I]TZDM from amyloid beta (1 to 42) aggregates in Alzheimer's disease-human brain homogenate after 3 hrs by gamma countingMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

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Amyloid-beta precursor protein(Homo sapiens (Human))
University Of Pennsylvania

Curated by ChEMBL

BDBM50129793(2-(4''-methylaminophenyl)-6-hydroxybenzothiazole |...)

Ki: 6nMAssay Description:Displacement of [3H]PiB from human amyloid beta (1-40) at 100 nM after 180 mins by liquid scintillation counterMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

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Amyloid-beta precursor protein(Homo sapiens (Human))
University Of Pennsylvania

Curated by ChEMBL

BDBM50129793(2-(4''-methylaminophenyl)-6-hydroxybenzothiazole |...)

Ki: 7.70nMAssay Description:Displacement of [3H]Pittsburgh compound B from human Abeta1-42 after 3 hrs by liquid scintillation countingMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

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Amyloid-beta precursor protein(Homo sapiens (Human))
University Of Pennsylvania

Curated by ChEMBL

BDBM50129793(2-(4''-methylaminophenyl)-6-hydroxybenzothiazole |...)

Ki: 12nMAssay Description:Displacement of [3H]Pittsburgh compound B from human Abeta1-40 after 3 hrs by liquid scintillation countingMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

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Amyloid-beta precursor protein(Homo sapiens (Human))
University Of Pennsylvania

Curated by ChEMBL

BDBM50129793(2-(4''-methylaminophenyl)-6-hydroxybenzothiazole |...)

Ki: 13nMAssay Description:Displacement of [3H]PiB from human amyloid beta (1-42) at 100 nM after 180 mins by liquid scintillation counterMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

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Amyloid-beta precursor protein(Homo sapiens (Human))
University Of Pennsylvania

Curated by ChEMBL

BDBM50129793(2-(4''-methylaminophenyl)-6-hydroxybenzothiazole |...)

Ki: 19nMAssay Description:Displacement of [3H]PIB from beta amyloid in brain homogenate from Alzheimer's patientMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

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Amyloid-beta precursor protein(Homo sapiens (Human))
University Of Pennsylvania

Curated by ChEMBL

BDBM50129793(2-(4''-methylaminophenyl)-6-hydroxybenzothiazole |...)

Ki: 39nMAssay Description:Displacement of [125I]BOB-4 from Amyloid beta (1 to 42) (unknown origin)More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

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Amyloid-beta precursor protein(Homo sapiens (Human))
University Of Pennsylvania

Curated by ChEMBL

BDBM50129793(2-(4''-methylaminophenyl)-6-hydroxybenzothiazole |...)

Ki: 39nMAssay Description:Displacement of [125I]1-Iodo-4-((4-methoxyphenoxy)methyl)benzene from amyloid beta42 (unknown origin) after 3 hrs by gamma countingMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

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Amyloid-beta precursor protein(Homo sapiens (Human))
University Of Pennsylvania

Curated by ChEMBL

BDBM50129793(2-(4''-methylaminophenyl)-6-hydroxybenzothiazole |...)

Ki: 39nMAssay Description:Displacement of [125I]1-Iodo-4-((4-methoxyphenoxy)methyl)benzene from amyloid beta42 (unknown origin) after 3 hrs by gamma countingMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

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Amyloid-beta precursor protein(Homo sapiens (Human))
University Of Pennsylvania

Curated by ChEMBL

BDBM50129793(2-(4''-methylaminophenyl)-6-hydroxybenzothiazole |...)

Ki: >1.00E+3nMAssay Description:Displacement of [125I-N-Methyl-4-(4-bromoanilino)phthalimide from beta-amyloid plaques isolated from Alzheimer's disease patient brainMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

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Amyloid-beta precursor protein(Homo sapiens (Human))
University Of Pennsylvania

Curated by ChEMBL

BDBM50129793(2-(4''-methylaminophenyl)-6-hydroxybenzothiazole |...)

Ki: >1.00E+4nMAssay Description:Displacement of [125I](E,E)-1-iodo-2,5-bis-(3-hydroxycarbonyl-4-methoxy)styrylbenzene from beta amyloid peptide in brain tissue at 50 uLMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

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Amyloid-beta precursor protein(Homo sapiens (Human))
University Of Pennsylvania

Curated by ChEMBL

BDBM50129793(2-(4''-methylaminophenyl)-6-hydroxybenzothiazole |...)

IC50: 19nMAssay Description:Displacement of [3H]AZD2184 from human amyloid beta(1 to 40)More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

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Amyloid-beta precursor protein(Homo sapiens (Human))
University Of Pennsylvania

Curated by ChEMBL

BDBM50129793(2-(4''-methylaminophenyl)-6-hydroxybenzothiazole |...)

IC50: 27nMAssay Description:Displacement of [3H]PIB from human amyloid beta (1 to 40) after 30 mins by liquid scintillation countingMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

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Amyloid-beta precursor protein(Homo sapiens (Human))
University Of Pennsylvania

Curated by ChEMBL

BDBM50129793(2-(4''-methylaminophenyl)-6-hydroxybenzothiazole |...)

Kd: 7.20nMAssay Description:Binding affinity to beta amyloid plaque in human Alzheimer's disease brain tissueMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

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Filter my 26 hits

Targets 1▿
- Amyloid-beta precursor protein 26
Publications 21▿
- ACS Med Chem Lett 2: 673-7 (2011) 2
- J Med Chem 54: 949-56 (2011) 2
- J Med Chem 57: 6030-42 (2014) 2
- Bioorg Med Chem 19: 2980-90 (2011) 2
- J Med Chem 49: 2841-4 (2006) 2
- J Med Chem 48: 5980-8 (2005) 1
- J Med Chem 46: 2740-54 (2003) 1
- J Med Chem 54: 8085-98 (2011) 1
- J Med Chem 51: 148-58 (2008) 1
- Eur J Med Chem 44: 1415-26 (2009) 1
- Bioorg Med Chem Lett 22: 4332-7 (2012) 1
- ACS Med Chem Lett 3: 265-7 (2012) 1
- Bioorg Med Chem 15: 2789-96 (2007) 1
- Eur J Med Chem 104: 86-96 (2015) 1
- Bioorg Med Chem 18: 1337-43 (2010) 1
- J Med Chem 52: 7090-102 (2009) 1
- Bioorg Med Chem Lett 20: 1976-80 (2010) 1
- J Med Chem 52: 1428-37 (2009) 1
- J Med Chem 53: 933-41 (2010) 1
- Bioorg Med Chem Lett 19: 602-5 (2009) 1
- J Med Chem 49: 2725-30 (2006) 1
Institutions 12▿
- University Of Pennsylvania 6
- Technische Universit£T M£Nchen 4
- Beijing Normal University 4
- Astrazeneca 2
- Katholieke Universiteit Leuven 2
- Seoul National University Bundang Hospital 2
- K.U.Leuven 1
- University Of Pittsburgh 1
- K.U. Leuven 1
- Case Western Reserve University 1
- Nagasaki University 1
- National Institute Of Mental Health 1
Affinity: 0.80 to 1.0E+4 nM▿
- Ki 23
- IC50 2
- Kd 1
- Affinity ≤ nM
Xtal structures: 0
Docked structures: 0
Catalog Cmpds: 1