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Found 3 Enz. Inhib. hit(s) with Target = 'Bcl2-associated agonist of cell death' and Ligand = 'BDBM50270877'
TargetBcl2-associated agonist of cell death(Homo sapiens (Human))
Astex Therapeutics

Curated by ChEMBL
LigandPNGBDBM50270877((R)-4-(4-((2-(4-chlorophenyl)-5,5-dimethylcyclohex...)
Affinity DataKi: <0.5nMAssay Description:Binding affinity to BH3 binding groove of BclXLMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl2-associated agonist of cell death(Homo sapiens (Human))
Astex Therapeutics

Curated by ChEMBL
LigandPNGBDBM50270877((R)-4-(4-((2-(4-chlorophenyl)-5,5-dimethylcyclohex...)
Affinity DataIC50: <10nMAssay Description:Table 2: Binding to Bcl-2 proteins Bcl-2, and Bcl-XL was also assessed using an HTRF assay. Background: FAM-Bak/Bad binds to surface pocket of the Bc...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBcl2-associated agonist of cell death(Homo sapiens (Human))
Astex Therapeutics

Curated by ChEMBL
LigandPNGBDBM50270877((R)-4-(4-((2-(4-chlorophenyl)-5,5-dimethylcyclohex...)
Affinity DataKd:  55nMAssay Description:Table 1: Binding to Bcl-2 proteins Bcl-2, and Bcl-XL was assessed using the Bcl2scan™ platform: T7 phage strains displaying BCL2 proteins were grown ...More data for this Ligand-Target Pair
In DepthDetails US Patent