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Found 4 Enz. Inhib. hit(s) with Target = 'Beta-secretase 1' and Ligand = 'BDBM50131809'
TargetBeta-secretase 1(Homo sapiens (Human))
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50131809(CHEMBL3634342)
Affinity DataIC50:  7.20nMAssay Description:Inhibition of L1210 leukemia thymidylate synthase (TS) enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50131809(CHEMBL3634342)
Affinity DataIC50:  7.60nMAssay Description:Inhibition of BACE1 (unknown origin) using APP Swedish mutant harboring Lys-Met/Asn-Leu mutation in beta-secretase cleavage site as substrate by FRET...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50131809(CHEMBL3634342)
Affinity DataIC50:  8.10nMAssay Description:Inhibition of BACE1 in human SKNBE2 cells expressing wild type human APP695 assessed as reduction in amyloid beta-42 production after 18 hrs by sandw...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50131809(CHEMBL3634342)
Affinity DataIC50:  8.30nMAssay Description:In vivo inhibition of leutenising hormone in rats.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed