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Found 3 Enz. Inhib. hit(s) with Target = 'Beta-secretase 1' and Ligand = 'BDBM50432600'
TargetBeta-secretase 1(Homo sapiens (Human))
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50432600(CHEMBL2347369)
Affinity DataIC50:  2.63E+3nMAssay Description:Inhibition of BACE1 in human SH-SY5Y cells expressing wild type betaAPP assessed as reduction in amyloidbeta (1 to 40 residues) level incubated for 2...More data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50432600(CHEMBL2347369)
Affinity DataIC50:  4.12E+4nMAssay Description:Inhibition of human BACE1 using MR121-labeled substrate incubated for 4 mins prior to substrate addition measured after 2 mins by spectrophotometric ...More data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50432600(CHEMBL2347369)
Affinity DataIC50:  7.33E+4nMAssay Description:Inhibition of recombinant human BACE1 (43 to 454 residues) expressed in Escherichia coli BL21 (DE3) using Biotin-XSEVNLDAEFRHDSGC-Eu fluorogenic pept...More data for this Ligand-Target Pair